Cancer Institute of New Jersey (CINJ), Department of Medicine

Research Output 2002 2019

  • 1204 Citations
  • 17 h-Index
  • 29 Article
  • 3 Review article
  • 1 Comment/debate
  • 1 Letter
2019
3 Citations (Scopus)
Exons
Mutation
Lung Neoplasms
N-(4-(3-chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide
HM781-36B
2 Citations (Scopus)

Circulating Inflammation Proteins Associated With Lung Cancer in African Americans

Meaney, C. L., Mitchell, K. A., Zingone, A., Brown, D., Bowman, E., Yu, Y., Wenzlaff, A. S., Neslund-Dudas, C., Pine, S., Cao, L., Schwartz, A. G. & Ryan, B. M., Jul 1 2019, In : Journal of Thoracic Oncology. 14, 7, p. 1192-1203 12 p.

Research output: Contribution to journalArticle

African Americans
Lung Neoplasms
Confidence Intervals
Inflammation
Proteins
Open Access
Chemotherapy
adenocarcinoma
drug therapy
lungs
Drug Therapy

Strategy to enhance lung cancer treatment by five essential elements: Inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy

Garbuzenko, O. B., Kuzmov, A., Taratula, O., Pine, S. R. & Minko, T., Jan 1 2019, In : Theranostics. 9, 26, p. 8362-8376 15 p.

Research output: Contribution to journalArticle

Open Access
Nanotechnology
Genetic Therapy
Inhalation
Lung Neoplasms
Non-Small Cell Lung Carcinoma
2018

Identifying therapeutic vulnerabilities in lung cancer: Application of a chemistry-first approach

Pine, S. R. & Ryan, B. M., Sep 1 2018, In : Translational Lung Cancer Research. 7, p. S265-S269

Research output: Contribution to journalReview article

Lung Neoplasms
Therapeutics
2 Citations (Scopus)

Rethinking Gamma-secretase Inhibitors for Treatment of Non–small-Cell Lung Cancer: Is notch the target?

Pine, S. R., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6136-6141 6 p.

Research output: Contribution to journalReview article

Amyloid Precursor Protein Secretases
Non-Small Cell Lung Carcinoma
Biomarkers
Therapeutics
Lung Neoplasms
14 Citations (Scopus)

Utility of glioblastoma patient-derived orthotopic xenografts in drug discovery and personalized therapy

Patrizii, M., Bartucci, M., Pine, S. & Sabaawy, H., Feb 12 2018, In : Frontiers in Oncology. 8, FEB, 23.

Research output: Contribution to journalArticle

Drug Discovery
Glioblastoma
Heterografts
Neoplasms
Therapeutics
2017
21 Citations (Scopus)

BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAFV600E mutant melanoma

Kulkarni, A., Al-Hraishawi, H., Simhadri, S., Hirshfield, K. M., Chen, S., Pine, S., Jeyamohan, C., Sokol, L., Ali, S., Teo, M. L., White, E., Rodriguez-Rodriguez, L., Mehnert, J. M. & Ganesan, S., Sep 15 2017, In : Clinical Cancer Research. 23, 18, p. 5631-5638 8 p.

Research output: Contribution to journalArticle

Melanoma
Gene Fusion
Mitogen-Activated Protein Kinase Kinases
Mutation
PLX4032
11 Citations (Scopus)

Gamma secretase inhibition by BMS-906024 enhances efficacy of paclitaxel in lung adenocarcinoma

Morgan, K. M., Fischer, B. S., Lee, F. Y., Shah, J. J., Bertino, J., Rosenfeld, J., Singh, A., Khiabanian, H. & Pine, S., Dec 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Paclitaxel
Non-Small Cell Lung Carcinoma
Cell Line
BMS-906024
15 Citations (Scopus)

Patient-derived xenograft models of non-small cell lung cancer and their potential utility in personalized medicine

Morgan, K. M., Riedlinger, G. M., Rosenfeld, J., Ganesan, S. & Pine, S. R., Jan 19 2017, In : Frontiers in Oncology. 7, JAN, 2.

Research output: Contribution to journalArticle

Precision Medicine
Heterografts
Non-Small Cell Lung Carcinoma
Neoplasms
Therapeutics
2016
17 Citations (Scopus)

Differential serum cytokine levels and risk of lung cancer between African and European Americans

Pine, S. R., Mechanic, L. E., Enewold, L., Bowman, E. D., Ryan, B. M., Cote, M. L., Wenzlaff, A. S., Loffredo, C. A., Olivo-Marston, S., Chaturvedi, A., Caporaso, N. E., Schwartz, A. G. & Harris, C. C., Mar 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 3, p. 488-497 10 p.

Research output: Contribution to journalArticle

African Americans
Lung Neoplasms
Cytokines
Serum
Interleukin-8
17 Citations (Scopus)

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

Hong, X., Liu, W., Song, R., Shah, J. J., Feng, X., Tsang, C. K., Morgan, K. M., Bunting, S., Inuzuka, H., Zheng, X. F. S., Shen, Z., Sabaawy, H., Liu, L. X. & Pine, S., Oct 14 2016, In : Nucleic acids research. 44, 18, p. 8855-8869 15 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
DNA Damage
F-Box Proteins
Neoplasms
Epithelial-Mesenchymal Transition
2015
32 Citations (Scopus)

Identification of a functional SNP in the 3′UTR of CXCR2 that is associated with reduced risk of lung cancer

Ryan, B. M., Robles, A. I., McClary, A. C., Haznadar, M., Bowman, E. D., Pine, S. R., Brown, D., Khan, M., Shiraishi, K., Kohno, T., Okayama, H., Modali, R., Yokota, J. & Harris, C. C., Feb 1 2015, In : Cancer Research. 75, 3, p. 566-575 10 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Lung Neoplasms
MicroRNAs
Binding Sites
Interleukin-8
2014
24 Citations (Scopus)

A combined prognostic serum interleukin-8 and interleukin-6 classifier for stage 1 lung cancer in the prostate, lung, colorectal, and ovarian cancer screening trial

Ryan, B. M., Pine, S. R., Chaturvedi, A. K., Caporaso, N. & Harris, C. C., Oct 1 2014, In : Journal of Thoracic Oncology. 9, 10, p. 1494-1503 10 p.

Research output: Contribution to journalArticle

Interleukin-8
Early Detection of Cancer
Ovarian Neoplasms
Colorectal Neoplasms
Interleukin-6
5 Citations (Scopus)

Activation of the Notch1 stem cell signaling pathway during routine cell line subculture

Liu, W., Morgan, K. M. & Pine, S. R., Jan 1 2014, In : Frontiers in Oncology. 4 JUL, 211.

Research output: Contribution to journalComment/debate

Stem Cells
Cell Culture Techniques
Cell Line
11 Citations (Scopus)

Asymmetric cell division and template DNA co-segregation in cancer stem cells

Pine, S. R. & Liu, W., Jan 1 2014, In : Frontiers in Oncology. 4 AUG, Article 226.

Research output: Contribution to journalArticle

Asymmetric Cell Division
Neoplastic Stem Cells
Stem Cells
DNA
Neoplasms
45 Citations (Scopus)

Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma

Capaccione, K. M., Hong, X., Morgan, K. M., Liu, W., Bishop, M. J., Liu, L. X., Markert, E., Deen, M., Minerowicz, C., Allen, T. & Pine, S. R., 2014, In : Oncotarget. 5, 11, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Lung
Cadherins
Cell Movement
Lung Neoplasms
Catenins
2013
9 Citations (Scopus)

Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines

Liu, W., Jeganathan, G., Amiri, S., Morgan, K. M., Ryan, B. M. & Pine, S. R., Dec 15 2013, In : Molecular Cancer. 12, 1, 139.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Line
DNA
Neoplastic Stem Cells
Chromosome Segregation
46 Citations (Scopus)

P53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

Mondal, A. M., Horikawa, I., Pine, S. R., Fujita, K., Morgan, K. M., Vera, E., Mazur, S. J., Appella, E., Vojtesek, B., Blasco, M. A., Lane, D. P. & Harris, C. C., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 5247-5257 11 p.

Research output: Contribution to journalArticle

Cell Aging
Protein Isoforms
T-Lymphocytes
Cell Proliferation
Neoplasms
150 Citations (Scopus)

The Notch signaling pathway as a mediator of tumor survival

Capaccione, K. M. & Pine, S. R., Jul 1 2013, In : Carcinogenesis. 34, 7, p. 1420-1430 11 p.

Research output: Contribution to journalArticle

Survival
Amyloid Precursor Protein Secretases
Neoplasms
Notch Receptors
Ligands
2012
48 Citations (Scopus)

Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy

Patel, S. A., Ramkissoon, S. H., Bryan, M., Pliner, L. F., Dontu, G., Patel, P. S., Amiri, S., Pine, S. R. & Rameshwar, P., Dec 14 2012, In : Scientific reports. 2, 906.

Research output: Contribution to journalArticle

Breast Neoplasms
Bone Marrow
Bone Neoplasms
Aptitude
Stem Cells
17 Citations (Scopus)

MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer

Ryan, B. M., Calhoun, K. M., Pine, S. R., Bowman, E. D., Robles, A. I., Ambs, S. & Harris, C. C., Dec 1 2012, In : International Journal of Cancer. 131, 11, p. 2710-2716 7 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Endometrial Neoplasms
Ovarian Neoplasms
Breast Neoplasms
Survival
2011
23 Citations (Scopus)

Admixture mapping of lung cancer in 1812 African-Americans

Schwartz, A. G., Wenzlaff, A. S., Bock, C. H., Ruterbusch, J. J., Chen, W., Cote, M. L., Artis, A. S., van Dyke, A. L., Land, S. J., Harris, C. C., Pine, S. R., Spitz, M. R., Amos, C. I., Levin, A. M. & McKeigue, P. M., Mar 10 2011, In : Carcinogenesis. 32, 3, p. 312-317 6 p.

Research output: Contribution to journalArticle

African Americans
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Genome-Wide Association Study
Smoking
183 Citations (Scopus)

Increased levels of circulating interleukin 6, interleukin 8, c-reactive protein, and risk of lung cancer

Pine, S. R., Mechanic, L. E., Enewold, L., Chaturvedi, A. K., Katki, H. A., Zheng, Y. L., Bowman, E. D., Engels, E. A., Caporaso, N. E. & Harris, C. C., Jul 20 2011, In : Journal of the National Cancer Institute. 103, 14, p. 1112-1122 11 p.

Research output: Contribution to journalArticle

Interleukin-8
Interleukin-6
Lung Neoplasms
Proteins
Confidence Intervals
2010
122 Citations (Scopus)

C-reactive protein and risk of lung cancer

Chaturvedi, A. K., Caporaso, N. E., Katki, H. A., Wong, H. L., Chatterjee, N., Pine, S. R., Chanock, S. J., Goedert, J. J. & Engels, E. A., Jun 1 2010, In : Journal of Clinical Oncology. 28, 16, p. 2719-2726 8 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Lung Neoplasms
Odds Ratio
Single Nucleotide Polymorphism
Early Detection of Cancer
103 Citations (Scopus)

Microenvironmental modulation of asymmetric cell division in human lung cancer cells

Pine, S. R., Ryan, B. M., Varticovski, L., Robles, A. I. & Harris, C. C., Feb 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2195-2200 6 p.

Research output: Contribution to journalArticle

Asymmetric Cell Division
Lung Neoplasms
Cell Division
DNA
Neoplasms
2009
34 Citations (Scopus)

Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk

Olivo-Marston, S. E., Yang, P., Mechanic, L. E., Bowman, E. D., Pine, S. R., Loffredo, C. A., Alberg, A. J., Caporaso, N., Shields, P. G., Chanock, S., Wu, Y., Jiang, R., Cunningham, J., Jen, J. & Harris, C. C., Dec 1 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 12, p. 3375-3383 9 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Tobacco Smoke Pollution
Lung Neoplasms
National Cancer Institute (U.S.)
Odds Ratio
2008
26 Citations (Scopus)

Lung cancer stem cells

Pine, S. R., Marshall, B. & Varticovski, L., 2008, In : Disease Markers. 24, 4-5, p. 257-266 10 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Stem cells
Lung Neoplasms
Stem Cells
Cell signaling
3 Citations (Scopus)

Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population

Martin, R. C. G., Barker, D. F., Doll, M. A., Pine, S. R., Mechanic, L., Bowman, E. D., Harris, C. C. & Hein, D. W., Jun 1 2008, In : DNA and Cell Biology. 27, 6, p. 321-323 3 p.

Research output: Contribution to journalArticle

Superoxide Dismutase
Exons
Incidence
Single Nucleotide Polymorphism
Population
2007
84 Citations (Scopus)

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome

Pine, S. R., Guo, Q., Yin, C., Jayabose, S., Druschel, C. M. & Sandoval, C., Sep 15 2007, In : Blood. 110, 6, p. 2128-2131 4 p.

Research output: Contribution to journalArticle

Down Syndrome
Genes
Newborn Infant
Mutation
Leukemia, Megakaryoblastic, Acute
35 Citations (Scopus)

Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene

Pine, S. R., Mechanic, L. E., Ambs, S., Bowman, E. D., Chanock, S. J., Loffredo, C., Shields, P. G. & Harris, C. C., Sep 1 2007, In : Journal of the National Cancer Institute. 99, 18, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

Innate Immunity
Mannose-Binding Lectin
Lung Neoplasms
Survival
Haplotypes

Lymphoproliferative clonal origin of AIDS-related non-Hodgkin's lymphoma [4]

Sabaawy, H., Sandoval, C., Guo, Q., Yin, C., Kulangara, A., Lee, J., Wormser, G., Jayabose, S. & Pine, S., Apr 1 2007, In : Leukemia and Lymphoma. 48, 4, p. 812-815 4 p.

Research output: Contribution to journalLetter

Nucleic Acid Sequence Homology
Molecular Sequence Data
AIDS-Related Lymphoma
Lymphoproliferative Disorders
Non-Hodgkin's Lymphoma
2005
18 Citations (Scopus)

Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction

Pine, S., Yin, C., Matloub, Y. H., Sabaawy, H., Sandoval, C., Levendoglu-Tugal, O., Ozkaynak, M. F. & Jayabose, S., Feb 2005, In : Journal of Molecular Diagnostics. 7, 1, p. 127-132 6 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrospinal Fluid
Real-Time Polymerase Chain Reaction
Leukemia
Central Nervous System
2002
84 Citations (Scopus)

Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia

Wiemels, J. L., Leonard, B. C., Wang, Y., Segal, M. R., Hunger, S. P., Smith, M. T., Crouse, V., Ma, X., Buffler, P. A. & Pine, S. R., Nov 12 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 23, p. 15101-15106 6 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Immunoglobulin Heavy Chains
T-Cell Antigen Receptor
Introns