Cancer Institute of New Jersey (CINJ), Division of Molecular Oncology

Research Output 2005 2019

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2019

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

Simhadri, S., Vincelli, G., Huo, Y., Misenko, S., Foo, T. K., Ahlskog, J., Sørensen, C. S., Oakley, G. G., Ganesan, S., Bunting, S. & Xia, B., Mar 7 2019, In : Oncogene. 38, 10, p. 1585-1596 12 p.

Research output: Contribution to journalArticle

Maintenance
Homologous Recombination
DNA Damage
M Phase Cell Cycle Checkpoints
Tumor Suppressor Proteins
2018
3 Citations (Scopus)

Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma

Panda, A., de Cubas, A. A., Stein, M., Riedlinger, G., Kra, J., Mayer, T., Smith, C. C., Vincent, B. G., Serody, J. S., Beckermann, K. E., Ganesan, S., Bhanot, G. & Rathmell, W. K., Aug 23 2018, In : JCI insight. 3, 16

Research output: Contribution to journalArticle

Endogenous Retroviruses
Renal Cell Carcinoma
Neoplasms
Squamous Cell Neoplasms
Atlases
1 Citation (Scopus)

Evidence of intertissue differences in the DNA damage response and the pro-oncogenic role of NF-kB in mice with disengaged BRCA1–PALB2 interaction

Mahdi, A. H., Huo, Y., Tan, Y., Simhadri, S., Vincelli, G., Gao, J., Ganesan, S. & Xia, B., Jul 15 2018, In : Cancer Research. 78, 14, p. 3969-3981 13 p.

Research output: Contribution to journalArticle

NF-kappa B
DNA Damage
Neoplasms
Apoptosis
Recombinational DNA Repair
3 Citations (Scopus)

High-throughput adaptive sampling for whole-slide histopathology image analysis (HASHI) via convolutional neural networks: Application to invasive breast cancer detection

Cruz-Roa, A., Gilmore, H., Basavanhally, A., Feldman, M., Ganesan, S., Shih, N., Tomaszewski, J., Madabhushi, A. & González, F., May 1 2018, In : PloS one. 13, 5, e0196828.

Research output: Contribution to journalArticle

histopathology
breast neoplasms
neural networks
Image analysis
Throughput
19 Citations (Scopus)

Immune activation and benefit from avelumab in EBV-positive gastric cancer

Panda, A., Mehnert, J., Hirshfield, K., Riedlinger, G., Damare, S., Saunders, T., Kane, M., Sokol, L., Stein, M., Poplin, E., Rodriguez-Rodriguez, L., Silk, A., Aisner, J., Chan, N., Malhotra, J., Frankel, M., Kaufman, H. L., Ali, S., Ross, J. S., White, E. P. & 2 othersBhanot, G. & Ganesan, S., Mar 1 2018, In : Journal of the National Cancer Institute. 110, 3, p. 316-320 5 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Stomach Neoplasms
Microsatellite Repeats
Neoplasms
Mutation
4 Citations (Scopus)

Nuclear shape and orientation features from H&E images predict survival in early-stage estrogen receptor-positive breast cancers

Lu, C., Romo-Bucheli, D., Wang, X., Janowczyk, A., Ganesan, S., Gilmore, H., Rimm, D. & Madabhushi, A., Nov 1 2018, In : Laboratory Investigation. 98, 11, p. 1438-1448 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Survival
Lymph Nodes
Nonparametric Statistics
1 Citation (Scopus)

Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer

Whitney, J., Corredor, G., Janowczyk, A., Ganesan, S., Doyle, S., Tomaszewski, J., Feldman, M., Gilmore, H. & Madabhushi, A., May 30 2018, In : BMC cancer. 18, 1, 610.

Research output: Contribution to journalArticle

Estrogen Receptors
Area Under Curve
Breast Neoplasms
Discriminant Analysis
Hematoxylin
1 Citation (Scopus)

RET rearrangements are actionable alterations in breast cancer

Paratala, B. S., Chung, J. H., Williams, C. B., Yilmazel, B., Petrosky, W., Williams, K., Schrock, A. B., Gay, L. M., Lee, E., Dolfi, S. C., Pham, K., Lin, S., Yao, M., Kulkarni, A., DiClemente, F., Liu, C., Rodriguez-Rodriguez, L., Ganesan, S., Ross, J. S., Ali, S. M. & 2 othersLeyland-Jones, B. & Hirshfield, K., Nov 16 2018, In : Nature communications. 9, 1, 1 p.

Research output: Contribution to journalArticle

breast
Fusion reactions
fusion
cancer
Breast Neoplasms
2017
52 Citations (Scopus)

Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent

Cruz-Roa, A., Gilmore, H., Basavanhally, A., Feldman, M., Ganesan, S., Shih, N. N. C., Tomaszewski, J., González, F. A. & Madabhushi, A., Apr 18 2017, In : Scientific reports. 7, 46450.

Research output: Contribution to journalArticle

Tumors
Pixels
Pathology
Image analysis
Classifiers
11 Citations (Scopus)

BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAFV600E mutant melanoma

Kulkarni, A., Al-Hraishawi, H., Simhadri, S., Hirshfield, K., Chen, S., Pine, S., Jeyamohan, C., Sokol, L., Ali, S., Teo, M. L., White, E., Rodriguez-Rodriguez, L., Mehnert, J. & Ganesan, S., Sep 15 2017, In : Clinical Cancer Research. 23, 18, p. 5631-5638 8 p.

Research output: Contribution to journalArticle

Melanoma
Gene Fusion
Mitogen-Activated Protein Kinase Kinases
Mutation
PLX4032
9 Citations (Scopus)

Comprehensive genomic profiling of malignant phyllodes tumors of the breast

Nozad, S., Sheehan, C. E., Gay, L. M., Elvin, J. A., Vergilio, J. A., Suh, J., Ramkissoon, S., Schrock, A. B., Hirshfield, K., Ali, N., Ganesan, S., Ali, S. M., Miller, V. A., Stephens, P. J., Ross, J. S. & Chung, J. H., Apr 1 2017, In : Breast Cancer Research and Treatment. 162, 3, p. 597-602 6 p.

Research output: Contribution to journalArticle

Phyllodes Tumor
Breast Neoplasms
Tumor Burden
Microsatellite Repeats
DNA
18 Citations (Scopus)

Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

Anantha, R. W., Simhadri, S., Foo, T. K., Miao, S., Liu, J., Shen, Z., Ganesan, S. & Xia, B., Apr 11 2017, In : eLife. 6, e21350.

Research output: Contribution to journalArticle

Repair
Recombinational DNA Repair
Ubiquitin-Protein Ligases
Double-Stranded DNA Breaks
Homologous Recombination
21 Citations (Scopus)

Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer

Chung, J. H., Pavlick, D., Hartmaier, R., Schrock, A. B., Young, L., Forcier, B., Ye, P., Levin, M. K., Goldberg, M., Burris, H., Gay, L. M., Hoffman, A. D., Stephens, P. J., Frampton, G. M., Lipson, D. M., Nguyen, D. M., Ganesan, S., Park, B. H., Vahdat, L. T., Leyland-Jones, B. & 6 othersMughal, T. I., Pusztai, L., O'Shaughnessy, J., Miller, V. A., Ross, J. S. & Ali, S. M., Jan 1 2017, In : Annals of Oncology. 28, 11, p. 2866-2873 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
DNA
Neoplasms
Mutation
5 Citations (Scopus)

Nuclear topology modulates the mutational landscapes of cancer genomes

Smith, K. S., Liu, L. L., Ganesan, S., Michor, F. & De, S., Nov 1 2017, In : Nature Structural and Molecular Biology. 24, 11, p. 1000-1006 7 p.

Research output: Contribution to journalArticle

Genome
DNA Repair
DNA Damage
Chromatin
Neoplasms
11 Citations (Scopus)

Patient-derived xenograft models of non-small cell lung cancer and their potential utility in personalized medicine

Morgan, K. M., Riedlinger, G. M., Rosenfeld, J., Ganesan, S. & Pine, S., Jan 19 2017, In : Frontiers in Oncology. 7, JAN, 2.

Research output: Contribution to journalArticle

Precision Medicine
Heterografts
Non-Small Cell Lung Carcinoma
Neoplasms
Therapeutics
2 Citations (Scopus)

Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage

Ginjala, V., Rodriguez-Colon, L., Ganguly, B., Gangidi, P., Gallina, P., Al-Hraishawi, H., Kulkarni, A., Tang, J., Gheeya, J., Simhadri, S., Yao, M., Xia, B. & Ganesan, S., Dec 1 2017, In : Scientific reports. 7, 1, 16613.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
DNA Repair
DNA Damage
DNA Breaks
Genomic Instability
3 Citations (Scopus)

Regulation of spindle integrity and mitotic fidelity by BCCIP

Huhn, S. C., Liu, J., Ye, C., Lu, H., Jiang, X., Feng, X., Ganesan, S., White, E. & Shen, Z., Apr 10 2017, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Spindle Apparatus
Spindle Poles
Centrosome
Microtubules
Chromosomes
2 Citations (Scopus)

Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells

Dolfi, S. C., Medina, D., Kareddula, A., Paratala, B., Rose, A., Dhami, J., Chen, S., Ganesan, S., Mackay, G., Vazquez, A. & Hirshfield, K., Jan 1 2017, In : Oncotarget. 8, 27, p. 44639-44653 15 p.

Research output: Contribution to journalArticle

Riluzole
Breast Neoplasms
Glutamic Acid
Neoplasms
metabotropic glutamate receptor type 1
3 Citations (Scopus)

Roadmap to a comprehensive clinical data warehouse for precision medicine applications in oncology

Foran, D., Chen, W., Chu, H., Sadimin, E., Loh, D., Riedlinger, G., Goodell, L. A., Ganesan, S., Hirshfield, K., Rodriguez-Rust, L. & Dipaola, R. S., Mar 2 2017, In : Cancer Informatics. 16, 1176935117694349.

Research output: Contribution to journalArticle

Precision Medicine
Pathology
Physicians
Neoplasms
Electronic Health Records
1 Citation (Scopus)

Roles of BCCIP deficiency in mammary tumorigenesis

Droz-Rosario, R., Lu, H., Liu, J., Liu, N. A., Ganesan, S., Xia, B., Haffty, B. & Shen, Z., Oct 18 2017, In : Breast Cancer Research. 19, 1

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Breast Neoplasms
Triple Negative Breast Neoplasms
Down-Regulation
9 Citations (Scopus)

Surveillance nanotechnology for multi-organ cancer metastases

Kantamneni, H., Zevon, M., Donzanti, M. J., Zhao, X., Sheng, Y., Barkund, S. R., McCabe, L. H., Banach-Petrosky, W., Higgins, L. M., Ganesan, S., Riman, R., Roth, C., Tan, M. C., Pierce, M., Ganapathy, V. & Moghe, P., Dec 1 2017, In : Nature Biomedical Engineering. 1, 12, p. 993-1003 11 p.

Research output: Contribution to journalArticle

Radio Waves
Nanotechnology
Nanoprobes
Adrenal Glands
Neoplasm Metastasis
5 Citations (Scopus)

Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma

Bjørklund, S. S., Panda, A., Kumar, S., Seiler, M., Robinson, D., Gheeya, J., Yao, M., Alnæs, G. I. G., Toppmeyer, D., Riis, M., Naume, B., Børresen-Dale, A. L., Kristensen, V. N., Ganesan, S. & Bhanot, G., Dec 1 2017, In : Scientific reports. 7, 1, 5568.

Research output: Contribution to journalArticle

Ductal Carcinoma
Exons
Alternative Splicing
Atlases
Neoplasms
2016
3 Citations (Scopus)

A novel role of chromodomain protein CBX8 in DNA damage response

Oza, J., Ganguly, B., Kulkarni, A., Ginjala, V., Yao, M. & Ganesan, S., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 22881-22893 13 p.

Research output: Contribution to journalArticle

DNA Damage
DNA
DNA Repair
Proteins
Epigenomics
19 Citations (Scopus)

Biomarkers for Immunotherapy: Current Developments and Challenges

Spencer, K. R., Wang, J., Silk, A., Ganesan, S., Kaufman, H. L. & Mehnert, J., Jan 1 2016, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting. 35, p. e493-e503

Research output: Contribution to journalArticle

Immunotherapy
Biomarkers
Tumor Microenvironment
Neoplasms
Tumor-Infiltrating Lymphocytes
18 Citations (Scopus)

Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers

Hirshfield, K., Tolkunov, D., Zhong, H., Ali, S. M., Stein, M., Murphy, S., Vig, H., Vazquez, A., Glod, J., Moss, R. A., Belyi, V., Chan, C., Chen, S., Goodell, L., Foran, D., Yelensky, R., Palma, N. A., Sun, J. X., Miller, V. A., Stephens, P. J. & 10 othersRoss, J. S., Kaufman, H., Poplin, E., Mehnert, J., Tan, A. R., Bertino, J., Aisner, J., DiPaola, R. S., Rodriguez-Rodriguez, L. & Ganesan, S., Nov 1 2016, In : Oncologist. 21, 11, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

Neoplasms
Histology
Proto-Oncogene Proteins c-akt
Genetic Testing
Receptor Protein-Tyrosine Kinases
46 Citations (Scopus)

Comprehensive genomic profiling identifies a subset of Crizotinib- responsive ALK-rearranged non-small cell lung cancer not detected by fluorescence in situ hybridization

Ali, S. M., Hensing, T., Schrock, A. B., Allen, J., Sanford, E., Gowen, K., Kulkarni, A., He, J., Suh, J. H., Lipson, D., Elvin, J. A., Yelensky, R., Chalmers, Z., Chmielecki, J., Peled, N., Klempner, S. J., Firozvi, K., Frampton, G. M., Molina, J. R., Amenon, S. & 14 othersBrahmer, J. R., MacMahon, H., Nowak, J., Ignatius Ou, S. H., Zauderer, M., Ladanyi, M., Zakowski, M., Fischbach, N., Ross, J. S., Stephens, P. J., Miller, V. A., Wakelee, H., Ganesan, S. & Salgia, R., Jun 1 2016, In : Oncologist. 21, 6, p. 762-770 9 p.

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
Non-Small Cell Lung Carcinoma
United States Food and Drug Administration
Standard of Care
crizotinib
85 Citations (Scopus)

Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer

Mehnert, J., Panda, A., Zhong, H., Hirshfield, K., Damare, S., Lane, K., Sokol, L., Stein, M., Rodriguez-Rodriquez, L., Kaufman, H. L., Ali, S., Ross, J. S., Pavlick, D. C., Bhanot, G., White, E., DiPaola, R. S., Lovell, A., Cheng, J. & Ganesan, S., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2334-2340 7 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Mutation
Programmed Cell Death 1 Receptor
Neoplasms
DNA Polymerase II
4 Citations (Scopus)

Precision Medicine: Implications for Science and Practice

Ganesan, S., Rodriguez-Rodriguez, L. & DiPaola, R. S., Jan 1 2016, In : Journal of the American College of Surgeons. 223, 3, p. 433-439.e1

Research output: Contribution to journalArticle

Precision Medicine
11 Citations (Scopus)

Use of comprehensive genomic profiling to direct point-of-care management of patients with gynecologic cancers

Rodriguez-Rodriguez, L., Hirshfield, K., Rojas, V., DiPaola, R. S., Gibbon, D., Hellmann, M., Isani, S., Leiser, A., Riedlinger, G. M., Wagreich, A., Ali, S. M., Elvin, J. A., Miller, V. A. & Ganesan, S., Apr 1 2016, In : Gynecologic Oncology. 141, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Neoplasms
Clinical Trials
Physicians
Therapeutics
2015
13 Citations (Scopus)

Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors

Labidi-Galy, S. I., Clauss, A., Ng, V., Duraisamy, S., Elias, K. M., Piao, H. Y., Bilal, E., Davidowitz, R. A., Lu, Y., Badalian-Very, G., Györffy, B., Kang, U. B., Ficarro, S., Ganesan, S., Mills, G. B., Marto, J. A. & Drapkin, R., Jan 15 2015, In : Oncogene. 34, 3, p. 299-309 11 p.

Research output: Contribution to journalArticle

Elafin
Ovarian Neoplasms
Breast Neoplasms
Carcinoma
Survival
3 Citations (Scopus)

Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas

Bjørklund, S. S., Kristensen, V. N., Seiler, M., Kumar, S., Alnæs, G. I. G., Ming, Y., Kerrigan, J., Naume, B., Sachidanandam, R., Bhanot, G., Børresen-Dale, A. L. & Ganesan, S., Jul 17 2015, In : BMC cancer. 15, 1, 524.

Research output: Contribution to journalArticle

Estrogen Receptors
Oxidoreductases
Estrogens
Fatty Acids
Breast Neoplasms
14 Citations (Scopus)

IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5 + B- and T-cell trafficking to tumor-conditioned media

Pimenta, E. M., De, S., Weiss, R., Feng, D., Hall, K., Kilic, S., Bhanot, G., Ganesan, S., Ran, S. & Barnes, B. J., May 28 2015, In : Immunology and Cell Biology. 93, 5, p. 486-499 14 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Conditioned Culture Medium
Breast Neoplasms
T-Lymphocytes
Neoplasms
9 Citations (Scopus)

Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells

Teh, J. L. F., Shah, R., La Cava, S., Dolfi, S. C., Mehta, M. S., Kongara, S., Price, S., Ganesan, S., Reuhl, K., Hirshfield, K., Karantza, V. & Chen, S., May 1 2015, In : Breast Cancer Research and Treatment. 151, 1, p. 57-73 17 p.

Research output: Contribution to journalArticle

Breast
Epithelial Cells
Breast Neoplasms
Cell Line
Glutamic Acid
23 Citations (Scopus)

Sparse Non-negative Matrix Factorization (SNMF) based color unmixing for breast histopathological image analysis

Xu, J., Xiang, L., Wang, G., Ganesan, S., Feldman, M., Shih, N. NC., Gilmore, H. & Madabhushi, A., Dec 1 2015, In : Computerized Medical Imaging and Graphics. 46, p. 20-29 10 p.

Research output: Contribution to journalArticle

Factorization
Image analysis
Breast
Color
Pathology
37 Citations (Scopus)

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis

Joshi, S., Tolkunov, D., Aviv, H., Hakimi, A. A., Yao, M., Hsieh, J. J., Ganesan, S., Chan, C. & White, E., Dec 1 2015, In : Cell Reports. 13, 9, p. 1895-1908 14 p.

Research output: Contribution to journalArticle

Mitochondria
Oxyphilic Adenoma
Tumors
Carcinogenesis
Autophagy
2014
19 Citations (Scopus)

ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss

Lozy, F., Cai-McRae, X., Teplova, I., Price, S., Reddy, A., Bhanot, G., Ganesan, S., Vazquez, A. & Karantza, V., Jan 1 2014, In : Autophagy. 10, 4, p. 662-676 15 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Breast
Breast Neoplasms
Pharmacology
8 Citations (Scopus)

ERG and CHDI heterogeneity in prostate cancer: Use of confocal microscopy in assessment of microscopic foci

Tereshchenko, I. V., Zhong, H., Chekmareva, M. A., Kane-Goldsmith, N., Santanam, U., Petrosky, W., Stein, M., Ganesan, S., Singer, E., Moore, D., Tischfield, J. & DiPaola, R. S., Nov 1 2014, In : Prostate. 74, 15, p. 1551-1559 9 p.

Research output: Contribution to journalArticle

Confocal Microscopy
Prostatic Neoplasms
Neoplasms
Genetic Heterogeneity
Gene Rearrangement
20 Citations (Scopus)

Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice

Simhadri, S., Peterson, S., Patel, D. S., Huo, Y., Cai, H., Bowman-Colin, C., Miller, S., Ludwig, T., Ganesan, S., Bhaumik, M., Bunting, S., Jasin, M. & Xia, B., Jan 1 2014, In : Journal of Biological Chemistry. 289, 35, p. 24617-24629 13 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Recombinational DNA Repair
Meiosis
Germ Cells
Fertility
79 Citations (Scopus)

Mutational landscape of the essential autophagy gene BECN1 in human cancers

Laddha, S. V., Ganesan, S., Chan, C. & White, E., Jan 1 2014, In : Molecular Cancer Research. 12, 4, p. 485-490 6 p.

Research output: Contribution to journalArticle

Essential Genes
Autophagy
Neoplasms
Breast Neoplasms
Ovarian Neoplasms
1 Citation (Scopus)

Next generation sequencing as an aid to diagnosis and treatment of an unusual pediatric brain cancer

Glod, J., Song, M., Sharma, A., Tyagi, R., Rhodes, R. H., Weissmann, D. J., Roychowdhury, S., Khan, A., Kane, M. P., Hirshfield, K., Ganesan, S., DiPaola, R. S. & Rodriguez-Rodriguez, L., Jan 1 2014, In : Journal of Personalized Medicine. 4, 3, p. 402-411 10 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Pediatrics
Neoplasms
Therapeutics
Pathologists
2013
53 Citations (Scopus)

Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2 -associated hereditary breast cancer

Huo, Y., Cai, H., Teplova, I., Bowman-Colin, C., Chen, G., Price, S., Barnard, N., Ganesan, S., Karantza, V., White, E. & Xia, B., Aug 1 2013, In : Cancer Discovery. 3, 8, p. 894-907 14 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Breast Neoplasms
DNA Damage
Neoplasms
200 Citations (Scopus)

Loss of 53BP1 causes PARP inhibitor resistance in BRCA1-mutated mouse mammary tumors

Jaspers, J. E., Kersbergen, A., Boon, U., Sol, W., Van Deemter, L., Zander, S. A., Drost, R., Wientjens, E., Ji, J., Aly, A., Doroshow, J. H., Cranston, A., Martin, N. M. B., Lau, A., O'Connor, M. J., Ganesan, S., Borst, P., Jonkers, J. & Rottenberg, S., Jan 1 2013, In : Cancer Discovery. 3, 1, p. 68-81 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Homologous Recombination
P-Glycoprotein
Neoplasms
Poly(ADP-ribose) Polymerase Inhibitors
14 Citations (Scopus)

Metabotropic Glutamate Receptor 1 Expression and Its Polymorphic Variants Associate with Breast Cancer Phenotypes

Mehta, M. S., Dolfi, S. C., Bronfenbrener, R., Bilal, E., Chen, C., Moore, D., Lin, Y., Rahim, H., Aisner, S., Kersellius, R. D., Teh, J., Chen, S., Toppmeyer, D., Medina, D., Ganesan, S., Vazquez, A. & Hirshfield, K., Jul 26 2013, In : PloS one. 8, 7, e69851.

Research output: Contribution to journalArticle

Tamoxifen
Estrogen Receptors
breast neoplasms
Tumors
Estrogens
51 Citations (Scopus)

Multi-field-of-view framework for distinguishing tumor grade in ER+ breast cancer from entire histopathology slides

Basavanhally, A., Ganesan, S., Feldman, M., Shih, N., Mies, C., Tomaszewski, J. & Madabhushi, A., Aug 5 2013, In : IEEE Transactions on Biomedical Engineering. 60, 8, p. 2089-2099 11 p., 6450064.

Research output: Contribution to journalArticle

Tumors
Classifiers
Textures
Histology
Estrogens
30 Citations (Scopus)

Tripartite motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with amplified in liver cancer 1 (ALC1) protein

Kulkarni, A., Oza, J., Yao, M., Sohail, H., Ginjala, V., Tomas-Loba, A., Horejsi, Z., Tan, A. R., Boulton, S. J. & Ganesan, S., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32357-32369 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Liver Neoplasms
Liver
DNA Damage
DNA
2012
64 Citations (Scopus)

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

Nacerddine, K., Beaudry, J. B., Ginjala, V., Westerman, B., Mattiroli, F., Song, J. Y., Van Der Poel, H., Ponz, O. B., Pritchard, C., Cornelissen-Steijger, P., Zevenhoven, J., Tanger, E., Sixma, T. K., Ganesan, S. & Van Lohuizen, M., May 1 2012, In : Journal of Clinical Investigation. 122, 5, p. 1920-1932 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
DNA Repair
DNA Damage
Prostatic Neoplasms
Phosphorylation
16 Citations (Scopus)

Amplified Loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers

Bilal, E., Vassallo, K., Toppmeyer, D., Barnard, N., Rye, I. H., Almendro, V., Russnes, H., Børresen-Dale, A. L., Levine, A. J., Bhanot, G. & Ganesan, S., Jun 13 2012, In : PloS one. 7, 6, e38575.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 17
relapse
Tamoxifen
Chromosomes
10 Citations (Scopus)

Automated Reconstruction Algorithm for Identification of 3D Architectures of Cribriform Ductal Carcinoma In Situ

Norton, K. A., Namazi, S., Barnard, N., Fujibayashi, M., Bhanot, G., Ganesan, S., Iyatomi, H., Ogawa, K. & Shinbrot, T., Sep 6 2012, In : PloS one. 7, 9, e44011.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
carcinoma
Adenocarcinoma
bubbles
fronds
21 Citations (Scopus)

ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers

Vermeer, P. D., Bell, M., Lee, K., Vermeer, D. W., Wieking, B. G., Bilal, E., Bhanot, G., Drapkin, R. I., Ganesan, S., Klingelhutz, A. J., Hendriks, W. J. & Lee, J. H., Jan 18 2012, In : PloS one. 7, 1, e30447.

Research output: Contribution to journalArticle

src-Family Kinases
mitogen-activated protein kinase
Phosphoric Monoester Hydrolases
phosphotransferases (kinases)
Phosphotransferases
20 Citations (Scopus)

Lactase Persistence and Lipid Pathway Selection in the Maasai

Wagh, K., Bhatia, A., Alexe, G., Reddy, A., Ravikumar, V., Seiler, M., Boemo, M., Yao, M., Cronk, L., Naqvi, A., Ganesan, S., Levine, A. J. & Bhanot, G., Sep 28 2012, In : PloS one. 7, 9, e44751.

Research output: Contribution to journalArticle

Lactase
beta-galactosidase
Polymorphism
Genes
Cholesterol