Cancer Institute of New Jersey (CINJ), Division of Surgical Oncology, Surgical Oncology Research

Research Output

2020

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Newman, J. H., Chesson, C. B., Herzog, N. L., Bommareddy, P. K., Aspromonte, S. M., Pepe, R., Estupinian, R., Aboelatta, M. M., Buddhadev, S., Tarabichi, S., Lee, M., Li, S., Medina, D. J., Giurini, E. F., Gupta, K. H., Guevara-Aleman, G., Rossi, M., Nowicki, C., Abed, A., Goldufsky, J. W. & 28 others, Broucek, J. R., Redondo, R. E., Rotter, D., Jhawar, S. R., Wang, S. J., Kohlhapp, F. J., Kaufman, H. L., Thomas, P. G., Gupta, V., Kuzel, T. M., Reiser, J., Paras, J., Kane, M. P., Singer, E. A., Malhotra, J., Denzin, L. K., Sant'Angelo, D. B., Rabson, A. B., Lee, L. Y., Lasfar, A., Langenfeld, J., Schenkel, J. M., Fidler, M. J., Ruiz, E. S., Marzo, A. L., Rudra, J. S., Silk, A. W. & Zloza, A., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 1119-1128 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2019

Double-humanized mouse model to study bone morphogenetic protein (BMP) signaling in tumor xenografts

Newman, J., NeMoyer, R., Zloza, A. & Langenfeld, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 257-262 6 p. (Methods in Molecular Biology; vol. 1891).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions

Nikolaev, E. V., Zloza, A. & Sontag, E. D., 2019, In : Frontiers in immunology. 10, JAN, 4.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Integrated stress response and immune cell infiltration in an ibrutinib-refractory mantle cell lymphoma patient following ONC201 treatment

Romaguera, J. E., Lee, H. J., Tarapore, R., Prabhu, V., Allen, J., Schalop, L., Zloza, A., Ok, C. Y., Sadimin, E. T., Schenkel, J., Badillo, M. & Wang, M., Apr 2019, In : British Journal of Haematology. 185, 1, p. 133-136 4 p.

Research output: Contribution to journalLetter

2 Scopus citations

Interferon Lambda: Toward a Dual Role in Cancer

Lasfar, A., Zloza, A., Silk, A. W., Lee, L. Y. & Cohen-Solal, K. A., Jan 2019, In : Journal of Interferon and Cytokine Research. 39, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

Bommareddy, P. K., Zloza, A., Rabkin, S. D. & Kaufman, H. L., Jul 3 2019, In : OncoImmunology. 8, 7, 1591875.

Research output: Contribution to journalArticle

13 Scopus citations

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

Stein, M. N., Malhotra, J., Tarapore, R. S., Malhotra, U., Silk, A. W., Chan, N., Rodriguez, L., Aisner, J., Aiken, R. D., Mayer, T., Haffty, B. G., Newman, J. H., Aspromonte, S. M., Bommareddy, P. K., Estupinian, R., Chesson, C. B., Sadimin, E. T., Li, S., Medina, D. J., Saunders, T. & 14 others, Frankel, M., Kareddula, A., Damare, S., Wesolowsky, E., Gabel, C., El-Deiry, W. S., Prabhu, V. V., Allen, J. E., Stogniew, M., Oster, W., Bertino, J. R., Libutti, S. K., Mehnert, J. M. & Zloza, A., May 22 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 136.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma

Mehnert, J. M., Silk, A. W., Lee, J. H., Dudek, L., Jeong, B. S., Li, J., Schenkel, J. M., Sadimin, E., Kane, M., Lin, H., Shih, W. J., Zloza, A., Chen, S. & Goydos, J. S., Jul 2018, In : Pigment Cell and Melanoma Research. 31, 4, p. 534-540 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment

Wagner, J., Leah Kline, C., Zhou, L., Campbell, K. S., MacFarlane, A. W., Olszanski, A. J., Cai, K. Q., Hensley, H. H., Ross, E. A., Ralff, M. D., Zloza, A., Chesson, C. B., Newman, J. H., Kaufman, H., Bertino, J., Stein, M. & El-Deiry, W. S., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2325-2338 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation

Bommareddy, P. K., Aspromonte, S., Zloza, A., Rabkin, S. D. & Kaufman, H. L., Dec 12 2018, In : Science translational medicine. 10, 471, eaau0417.

Research output: Contribution to journalArticle

31 Scopus citations

Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer

Newman, J. H., Augeri, D. J., Nemoyer, R., Malhotra, J., Langenfeld, E., Chesson, C. B., Dobias, N. S., Lee, M. J., Tarabichi, S., Jhawar, S. R., Bommareddy, P. K., Marshall, SR., Sadimin, E. T., Kerrigan, J. E., Goedken, M., Minerowicz, C., Jabbour, S. K., Li, S., Carayannopolous, M. O., Zloza, A. & 1 others, Langenfeld, J., Jul 5 2018, In : Oncogene. 37, 27, p. 3672-3685 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
5 Scopus citations
2017

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease

Hahm, E., Wei, C., Fernandez, I., Li, J., Tardi, N. J., Tracy, M., Wadhwani, S., Cao, Y., Peev, V., Zloza, A., Lusciks, J., Hayek, S. S., O'Connor, C., Bitzer, M., Gupta, V., Sever, S., Sykes, D. B., Scadden, D. T. & Reiser, J., Jan 1 2017, In : Nature medicine. 23, 1, p. 100-106 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus

Faridi, M. H., Khan, S. Q., Zhao, W., Lee, H. W., Altintas, M. M., Zhang, K., Kumar, V., Armstrong, A. R., Carmona-Rivera, C., Dorschner, J. M., Schnaith, A. M., Li, X., Ghodke-Puranik, Y., Moore, E., Purmalek, M., Irizarry-Caro, J., Zhang, T., Day, R., Stoub, D., Hoffmann, V. & 24 others, Khaliqdina, S. J., Bhargava, P., Santander, A. M., Torroella-Kouri, M., Issac, B., Cimbaluk, D. J., Zloza, A., Prabhakar, R., Deep, S., Jolly, M., Koh, K. H., Reichner, J. S., Bradshaw, E. M., Chen, J., Moita, L. F., Yuen, P. S., Tsai, W. L., Singh, B., Reiser, J., Nath, S. K., Niewold, T. B., Vazquez-Padron, R. I., Kaplan, M. J. & Gupta, V., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

CD4+ T Cells

Kohlhapp, F. J. & Zloza, A., Jan 1 2017, Cancer Therapeutic Targets. Springer New York, Vol. 1-2. p. 117-129 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Choline-magnesium trisalicylate modulates acute myelogenous leukemia gene expression during induction chemotherapy

Medina, D., David, K., Lin, Y., Schaar, D., Patel, V., Gharibo, M., Bannerji, R., Walton, K., Aisner, J., Rabson, A. & Strair, R., May 4 2017, In : Leukemia and Lymphoma. 58, 5, p. 1227-1230 4 p.

Research output: Contribution to journalEditorial

2 Scopus citations

First-in-human clinical trial of oral ONC201 in patients with refractory solid tumors

Stein, M., Bertino, J., Kaufman, H. L., Mayer, T., Moss, R., Silk, A., Chan, N., Malhotra, J., Rodriguez-Rust, L., Aisner, J., Aiken, R., Haffty, B., DiPaola, R. S., Saunders, T., Zloza, A., Damare, S., Beckett, Y., Yu, B., Najmi, S., Gabel, C. & 7 others, Dickerson, S., Zheng, L., El-Deiry, W. S., Allen, J. E., Stogniew, M., Oster, W. & Mehnert, J., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4163-4169 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Infection: a Cause of and Cure for Cancer

Newman, J. H. & Zloza, A., Dec 1 2017, In : Current Pharmacology Reports. 3, 6, p. 315-320 6 p.

Research output: Contribution to journalReview article

5 Scopus citations

Low-dose interleukin-2 impairs host anti-tumor immunity and inhibits therapeutic responses in a mouse model of melanoma

Zloza, A., Dharmadhikari, N. D., Huelsmann, E. J., Broucek, J. R., Hughes, T., Kohlhapp, F. J. & Kaufman, H. L., Jan 1 2017, In : Cancer Immunology, Immunotherapy. 66, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nanoparticles: Augmenting tumor antigen presentation for vaccine and immunotherapy treatments of cancer

Chesson, C. B. & Zloza, A., Dec 2017, In : Nanomedicine. 12, 23, p. 2693-2706 14 p.

Research output: Contribution to journalReview article

10 Scopus citations

Oncolytic viruses-natural and genetically engineered cancer immunotherapies

Jhawar, S. R., Thandoni, A., Bommareddy, P. K., Hassan, S., Kohlhapp, F. J., Goyal, S., Schenkel, J. M., Silk, A. W. & Zloza, A., Sep 11 2017, In : Frontiers in Oncology. 7, SEP, 202.

Research output: Contribution to journalReview article

42 Scopus citations

Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells

Dolfi, S. C., Medina, D. J., Kareddula, A., Paratala, B., Rose, A., Dhami, J., Chen, S., Ganesan, S., Mackay, G., Vazquez, A. & Hirshfield, K. M., 2017, In : Oncotarget. 8, 27, p. 44639-44653 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Supramolecular Peptide Nanofibers Engage Mechanisms of Autophagy in Antigen-Presenting Cells

Rudra, J. S., Khan, A., Clover, T. M., Endsley, J. J., Zloza, A., Wang, J. & Jagannath, C., 2017, In : ACS Omega. 2, 12, p. 9136-9143 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: A report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer

Zloza, A., Karolina Palucka, A., Coussens, L. M., Gotwals, P. J., Headley, M. B., Jaffee, E. M., Lund, A. W., Sharpe, A. H., Sznol, M., Wainwright, D. A., Wong, K. K. & Bosenberg, M. W., Sep 19 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 77.

Research output: Contribution to journalArticle

3 Scopus citations
2016

BMI-1 targeting interferes with patient-derived tumor-initiating cell survival and tumor growth in prostate cancer

Bansal, N., Bartucci, M., Yusuff, S., Davis, S., Flaherty, K., Huselid, E., Patrizii, M., Jones, D., Cao, L., Sydorenko, N., Moon, Y. C., Zhong, H., Medina, D., Kerrigan, J., Stein, M., Kim, I., Davis, T. W., DiPaola, R. S., Bertino, J. & Sabaawy, H., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6176-6191 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

Concerted action of IFN-α and IFN-γ induces local NK cell immunity and halts cancer growth

Lasfar, A., de la Torre, A., Abushahba, W., Cohen-Solal, K. A., Castaneda, I., Yuan, Y., Reuhl, K., Zloza, A., Raveche, E., Laskin, D. L. & Kotenko, S. V., 2016, In : Oncotarget. 7, 31, p. 49259-49267 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Erratum: Oncolytic viruses: A new class of immunotherapy drugs (Nature Reviews Drug Discovery (2015)14, (642-662))

Kaufman, H. L., Kohlhapp, F. J. & Zloza, A., Feb 3 2016, In : Nature Reviews Drug Discovery. 15, 2, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

IFN-lambda therapy: Current status and future perspectives

Lasfar, A., Zloza, A. & Cohen-Solal, K. A., Jan 1 2016, In : Drug Discovery Today. 21, 1, p. 167-171 5 p.

Research output: Contribution to journalReview article

12 Scopus citations

IFN-λ: A new inducer of local immunity against cancer and infections

Lasfar, A., Zloza, A., de la Torre, A. & Cohen-Solal, K. A., 2016, In : Frontiers in immunology. 7, DEC, 598.

Research output: Contribution to journalReview article

13 Scopus citations

IFN-λ cancer immunotherapy: New kid on the block

Lasfar, A., Gogas, H., Zloza, A., Kaufman, H. L. & Kirkwood, J. M., Jul 2016, In : Immunotherapy. 8, 8, p. 877-888 12 p.

Research output: Contribution to journalReview article

11 Scopus citations

Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death

Kohlhapp, F. J., Huelsmann, E. J., Lacek, A. T., Schenkel, J. M., Lusciks, J., Broucek, J. R., Goldufsky, J. W., Hughes, T., Zayas, J. P., Dolubizno, H., Sowell, R. T., Kühner, R., Burd, S., Kubasiak, J. C., Nabatiyan, A., Marshall, SR., Bommareddy, P. K., Li, S., Newman, J. H., Monken, C. E. & 8 others, Shafikhani, S. H., Marzo, A. L., Guevara-Patino, J. A., Lasfar, A., Thomas, P. G., Lattime, E. C., Kaufman, H. L. & Zloza, A., Oct 18 2016, In : Cell Reports. 17, 4, p. 957-965 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Systemic versus local responses in melanoma patients treated with talimogene laherparepvec from a multi-institutional phase II study

Kaufman, H. L., Amatruda, T., Reid, T., Gonzalez, R., Glaspy, J., Whitman, E., Harrington, K., Nemunaitis, J., Zloza, A., Wolf, M. & Senzer, N. N., Mar 15 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 12.

Research output: Contribution to journalArticle

50 Scopus citations

The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma

Boregowda, R. K., Medina, D. J., Markert, E., Bryan, M. A., Chen, W., Chen, S., Rabkin, A., Vido, M. J., Gunderson, S. I., Chekmareva, M., Foran, D. J., Lasfar, A., Goydos, J. S. & Cohen-Solal, K. A., May 17 2016, In : Oncotarget. 7, 20, p. 29689-29707 19 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Enhancing the Magnitude of Antibody Responses through Biomaterial Stereochemistry

Appavu, R., Chesson, C. B., Koyfman, A. Y., Snook, J. D., Kohlhapp, F. J., Zloza, A. & Rudra, J. S., Dec 14 2015, In : ACS Biomaterials Science and Engineering. 1, 7, p. 601-609 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R-/- Hu-PBMC Mice

Zhang, Y. G., Wu, S., Lu, R., Richards, M. H., Huelsmann, E. J., Lacek, A. T., Nabatiyan, A., Chen, D., Al-Harthi, L., Zloza, A. & Sun, J., Aug 1 2015, In : AIDS research and human retroviruses. 31, 8, p. 774-775 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade

Kohlhapp, F. J., Broucek, J. R., Hughes, T., Huelsmann, E. J., Lusciks, J., Zayas, J. P., Dolubizno, H., Fleetwood, V. A., Grin, A., Hill, G. E., Poshepny, J. L., Nabatiyan, A., Ruby, C. E., Snook, J. D., Rudra, J. S., Schenkel, J. M., Masopust, D., Zloza, A. & Kaufman, H. L., May 19 2015, In : Journal for ImmunoTherapy of Cancer. 3, 1, 18.

Research output: Contribution to journalArticle

22 Scopus citations

Oncolytic viruses: A new class of immunotherapy drugs

Kaufman, H. L., Kohlhapp, F. J. & Zloza, A., Sep 1 2015, In : Nature Reviews Drug Discovery. 14, 9, p. 642-662 21 p.

Research output: Contribution to journalReview article

397 Scopus citations

Talimogene laherparepvec (T-VEC) as cancer immunotherapy

Kohlhapp, F. J., Zloza, A. & Kaufman, H. L., Sep 2015, In : Drugs of Today. 51, 9, p. 549-558 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Antigenic peptide nanofibers elicit adjuvant-free CD8+ T cell responses

Chesson, C. B., Huelsmann, E. J., Lacek, A. T., Kohlhapp, F. J., Webb, M. F., Nabatiyan, A., Zloza, A. & Rudra, J. S., Feb 26 2014, In : Vaccine. 32, 10, p. 1174-1180 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells

Medina, D., Abass-Shereef, J., Walton, K., Goodell, L., Aviv, H., Strair, R. & Budak-Alpdogan, T., Apr 10 2014, In : PloS one. 9, 4, e91042.

Research output: Contribution to journalArticle

10 Scopus citations

Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs

Dolfi, S. C., Jäger, A. V., Medina, D., Haffty, B., Yang, J. M. & Hirshfield, K., Aug 1 2014, In : Cancer Letters. 350, 1-2, p. 52-60 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

High-dose IL-2 induces rapid albumin uptake by endothelial cells through Src-dependent caveolae-mediated endocytosis

Zloza, A., Kim, D. W. O., Broucek, J., Schenkel, J. M. & Kaufman, H. L., Nov 1 2014, In : Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 34, 11, p. 915-919 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice

Lu, R., Wu, S., Zhang, Y., Xia, Y., Huelsmann, E. J., Lacek, A. T., Nabatiyan, A., Richards, M. H., Narasipura, S. D., Lutgen, V., Chen, H., Kaufman, H. L., Chen, D., Al-Harthi, L., Zloza, A. & Sun, J., 2014, In : AIDS research and human retroviruses. 30, 7, p. 677-684 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Immunoglobulin-like transcript 2 (ILT2) is a biomarker of therapeutic response to oncolytic immunotherapy with vaccinia viruses

Zloza, A., Kim, D. W., Kim-Schulze, S., Jagoda, M. C., Monsurro, V., Marincola, F. M. & Kaufman, H. L., Jan 27 2014, In : Journal for ImmunoTherapy of Cancer. 2, 1, 1.

Research output: Contribution to journalArticle

11 Scopus citations

Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells

Kim, D. W., Zloza, A., Broucek, J., Schenkel, J. M., Ruby, C., Samaha, G. & Kaufman, H. L., May 6 2014, In : Journal of translational medicine. 12, 1, 113.

Research output: Contribution to journalArticle

6 Scopus citations

Malignancies in HIV/AIDS: From epidemiology to therapeutic challenges

Rubinstein, P. G., Aboulafia, D. M. & Zloza, A., Feb 20 2014, In : AIDS. 28, 4, p. 453-465 13 p.

Research output: Contribution to journalReview article

112 Scopus citations

Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response

Wood, S., Jayaraman, V., Huelsmann, E. J., Bonish, B., Burgad, D., Sivaramakrishnan, G., Qin, S., DiPietro, L. A., Zloza, A., Zhang, C. & Shafikhani, S. H., Mar 11 2014, In : PloS one. 9, 3, e91574.

Research output: Contribution to journalArticle

80 Scopus citations

Results of a randomized phase i gene therapy clinical trial of nononcolytic fowlpox viruses encoding T cell costimulatory molecules

Kaufman, H. L., Kim, D. W., Kim-Schulze, S., DeRaffele, G., Jagoda, M. C., Broucek, J. R. & Zloza, A., May 1 2014, In : Human gene therapy. 25, 5, p. 452-460 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Metabotropic Glutamate Receptor 1 Expression and Its Polymorphic Variants Associate with Breast Cancer Phenotypes

Mehta, M. S., Dolfi, S. C., Bronfenbrener, R., Bilal, E., Chen, C., Moore, D., Lin, Y., Rahim, H., Aisner, S., Kersellius, R. D., Teh, J., Chen, S., Toppmeyer, D. L., Medina, D. J., Ganesan, S., Vazquez, A. & Hirshfield, K. M., Jul 26 2013, In : PloS one. 8, 7, e69851.

Research output: Contribution to journalArticle

16 Scopus citations

Mutant HSP70 reverses autoimmune depigmentation in vitiligo

Mosenson, J. A., Zloza, A., Nieland, J. D., Garrett-Mayer, E., Eby, J. M., Huelsmann, E. J., Kumar, P., Denman, C. J., Lacek, A. T., Kohlhapp, F. J., Alamiri, A., Hughes, T., Bines, S. D., Kaufman, H. L., Overbeck, A., Mehrotra, S., Hernandez, C., Nishimura, M. I., Guevara-Patino, J. A. & Le Poole, I. C., Feb 27 2013, In : Science translational medicine. 5, 174, 174ra28.

Research output: Contribution to journalArticle

54 Scopus citations