Research Output

2020

A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus

Chen, G., Ma, L. C., Wang, S., Woltz, R. L., Grasso, E. M., Montelione, G. T. & Krug, R. M., Jan 10 2020, In : Nucleic acids research. 48, 1, p. 304-315 12 p.

Research output: Contribution to journalArticle

Open Access

Architectured helically coiled scaffolds from elastomeric poly(butylene succinate) (PBS) copolyester via wet electrospinning

Sonseca, A., Sahay, R., Stepien, K., Bukala, J., Wcislek, A., McClain, A., Sobolewski, P., Sui, X. M., Puskas, J. E., Kohn, J., Wagner, H. D. & El Fray, M., Mar 2020, In : Materials Science and Engineering C. 108, 110505.

Research output: Contribution to journalArticle

Open Access

A step toward engineering thick tissues: Distributing microfibers within 3D printed frames

Molde, J., Steele, J. A. M., Pastino, A. K., Mahat, A., Murthy, N. S. & Kohn, J., Mar 1 2020, In : Journal of Biomedical Materials Research - Part A. 108, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

Open Access

Automated Synthesis of Polymers

Gormley, A., Feb 2020

Research output: Innovation

Biodegradable PEG Hydrogels and Methods of Use

Sinko, P., Deshmukh, M., Stein, S., Gunaseelan, S. & Singh, Y., Jan 2020

Research output: Innovation

Calcium phosphate enriched synthetic tyrosine-derived polycarbonate – dicalcium phosphate dihydrate polymer scaffolds for enhanced bone regeneration

Saxena, S., Chang, W., Fakhrzadeh, A., Murthy, N. S., Zhang, W., Kohn, J. & Yelick, P. C., Mar 2020, In : Materialia. 9, 100616.

Research output: Contribution to journalArticle

Open Access

Cav-1 participates in the development of diabetic neuropathy pain through the TLR4 signaling pathway

Jia, G. L., Huang, Q., Cao, Y. N., Xie, C. S., Shen, Y. J., Chen, J. L., Lu, J. H., Zhang, M. B., Li, J., Tao, Y. X. & Cao, H., Mar 1 2020, In : Journal of Cellular Physiology. 235, 3, p. 2060-2070 11 p.

Research output: Contribution to journalArticle

Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis

Rios, F. J., Zou, Z. G., Harvey, A. P., Harvey, K. Y., Nosalski, R., Anyfanti, P., Camargo, L. L., Lacchini, S., Ryazanov, A. G., Ryazanova, L., McGrath, S., Guzik, T. J., Goodyear, C. S., Montezano, A. C. & Touyz, R. M., Mar 1 2020, In : Cardiovascular research. 116, 3, p. 721-735 15 p.

Research output: Contribution to journalArticle

Open Access

Cytokinin sensing in bacteria

Kabbara, S., Bidon, B., Kilani, J., Osman, M., Hamze, M., Stock, A. M. & Papon, N., Feb 2020, In : Biomolecules. 10, 2, 186.

Research output: Contribution to journalComment/debate

Open Access

D3R grand challenge 4: blind prediction of protein–ligand poses, affinity rankings, and relative binding free energies

Parks, C. D., Gaieb, Z., Chiu, M., Yang, H., Shao, C., Walters, W. P., Jansen, J. M., McGaughey, G., Lewis, R. A., Bembenek, S. D., Ameriks, M. K., Mirzadegan, T., Burley, S. K., Amaro, R. E. & Gilson, M. K., Feb 1 2020, In : Journal of Computer-Aided Molecular Design. 34, 2, p. 99-119 21 p.

Research output: Contribution to journalArticle

Detection of Extracellular Vesicle RNA Using Molecular Beacons

Oliveira, G. P. D., Zigon, E., Rogers, G., Davodian, D., Lu, S., Jovanovic-Talisman, T., Jones, J., Tigges, J., Tyagi, S. & Ghiran, I. C., Jan 24 2020, In : iScience. 23, 1, 100782.

Research output: Contribution to journalArticle

Open Access

Disassembly of Nanospheres with a PEG Shell upon Adsorption onto PEGylated Substrates

Patel, A., Lima, M. R. N., Cho, H. Y., Lee, K. B., Murthy, N. S. & Kohn, J., Jan 14 2020, In : Langmuir. 36, 1, p. 232-241 10 p.

Research output: Contribution to journalArticle

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

Kang, D., Ruiz, F. X., Feng, D., Pilch, A., Zhao, T., Wei, F., Wang, Z., Sun, Y., Fang, Z., De Clercq, E., Pannecouque, C., Arnold, E., Liu, X. & Zhan, P., Feb 13 2020, In : Journal of medicinal chemistry. 63, 3, p. 1298-1312 15 p.

Research output: Contribution to journalArticle

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer

Wu, R., Wang, L., Yin, R., Hudlikar, R., Li, S., Kuo, H. C. D., Peter, R., Sargsyan, D., Guo, Y., Liu, X. & Kong, A. N. T., Feb 1 2020, In : Molecular Carcinogenesis. 59, 2, p. 227-236 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Evolutionary coupling saturation mutagenesis: Coevolution-guided identification of distant sites influencing Bacillus naganoensis pullulanase activity

Wang, X., Jing, X., Deng, Y., Nie, Y., Xu, F., Xu, Y., Zhao, Y. L., Hunt, J. F., Montelione, G. T. & Szyperski, T., Mar 1 2020, In : FEBS Letters. 594, 5, p. 799-812 14 p.

Research output: Contribution to journalArticle

Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance

Xavier RUIZ, F. & Arnold, E., Apr 2020, In : Current Opinion in Structural Biology. 61, p. 113-123 11 p.

Research output: Contribution to journalReview article

High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application

Grime, G. W., Zeldin, O. B., Snell, M. E., Lowe, E. D., Hunt, J. F., Montelione, G. T., Tong, L., Snell, E. H. & Garman, E. F., Jan 8 2020, In : Journal of the American Chemical Society. 142, 1, p. 185-197 13 p.

Research output: Contribution to journalArticle

Impact of the Protein Data Bank on antineoplastic approvals

Westbrook, J. D., Soskind, R., Hudson, B. P. & Burley, S. K., Jan 1 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalReview article

Open Access
Open Access
1 Scopus citations

Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site

Rudolph, M. J., Czajka, T. F., Davis, S. A., Thi Nguyen, C. M., Li, X. P., Tumer, N. E., Vance, D. J. & Mantis, N. J., Feb 14 2020, In : Journal of molecular biology. 432, 4, p. 1109-1125 17 p.

Research output: Contribution to journalArticle

KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells

Cordover, E., Wei, J., Patel, C., Shan, N. L., Gionco, J., Sargsyan, D., Wu, R., Cai, L., Kong, A. N., Jacinto, E. & Minden, A., Feb 17 2020, In : Chemical Research in Toxicology. 33, 2, p. 482-491 10 p.

Research output: Contribution to journalArticle

Mathematical Models of Protease-Based Enzymatic Biosensors

Agrawal, D. K., Dolan, E. M., Hernandez, N. E., Blacklock, K. M., Khare, S. D. & Sontag, E. D., Feb 21 2020, In : ACS Synthetic Biology. 9, 2, p. 198-208 11 p.

Research output: Contribution to journalArticle

Message from the new Editor-in-Chief

Hu, L. L., Feb 1 2020, In : Medicinal Chemistry Research. 29, 2, 1 p.

Research output: Contribution to journalEditorial

Open Access

NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview

Pramono, A. A., Rather, G. M., Herman, H., Lestari, K. & Bertino, J. R., Feb 26 2020, In : Biomolecules. 10, 3

Research output: Contribution to journalReview article

Open Access

Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats

Wang, L., Li, W., Cheng, D., Guo, Y., Wu, R., Yin, R., Li, S., Kuo, H. C., Hudlikar, R., Yang, H., Buckley, B. & Kong, A. N., Jan 1 2020, (Accepted/In press) In : Journal of Pharmacokinetics and Pharmacodynamics.

Research output: Contribution to journalArticle

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

Sharma, G., Hu, C., Staquicini, D. I., Brigman, J. L., Liu, M., Mauvais-Jarvis, F., Pasqualini, R., Arap, W., Arterburn, J. B., Hathaway, H. J. & Prossnitz, E. R., Jan 29 2020, In : Science translational medicine. 12, 528, eaau5956.

Research output: Contribution to journalArticle

PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer

Wang, C., Feng, Y., Zhang, C., Cheng, D., Wu, R., Yang, Y., Sargsyan, D., Kumar, D. & Kong, A. N., Jan 1 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 1304-1318 15 p.

Research output: Contribution to journalArticle

Open Access

RCSB Protein Data Bank: Enabling biomedical research and drug discovery

Goodsell, D. S., Zardecki, C., Di Costanzo, L., Duarte, J. M., Hudson, B. P., Persikova, I., Segura, J., Shao, C., Voigt, M., Westbrook, J. D., Young, J. Y. & Burley, S. K., Jan 1 2020, In : Protein Science. 29, 1, p. 52-65 14 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate

Tang, H., Venkatesh, S., Lin, Z., Lu, X., Saeidi, H., Rather, G. M., Bertino, J. R., Lin, C. Y., Javanmard, M. & Sengupta, K., Apr 2019, 2019 IEEE Custom Integrated Circuits Conference, CICC 2019. Institute of Electrical and Electronics Engineers Inc., 8780363. (Proceedings of the Custom Integrated Circuits Conference; vol. 2019-April).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

Chen, G., Xie, W., Nah, J., Sauvat, A., Liu, P., Pietrocola, F., Sica, V., Carmona-Gutierrez, D., Zimmermann, A., Pendl, T., Tadic, J., Bergmann, M., Hofer, S. J., Domuz, L., Lachkar, S., Markaki, M., Tavernarakis, N., Sadoshima, J., Madeo, F., Kepp, O. & 1 others, Kroemer, G., Nov 7 2019, In : EMBO Molecular Medicine. 11, 11, e10469.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Aberrant arc between the common hepatic artery and a replaced right hepatic artery resulting in misperfusion in a patient with a hepatic arterial infusion pump

Hasan, O., Greco, S., Kennedy, T., Carpizo, D., Kempf, J. & Nosher, J., Mar 1 2019, In : Surgical and Radiologic Anatomy. 41, 3, p. 355-358 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Achieving molecular orientation in thermally extruded 3D printed objects

Ghodbane, S. A., Murthy, N. S., Dunn, M. G. & Kohn, J., Jul 3 2019, In : Biofabrication. 11, 4, 045004.

Research output: Contribution to journalArticle

Open Access

Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3

Wang, H., Zhang, J. & You, G., Mar 1 2019, In : AAPS Journal. 21, 2, 30.

Research output: Contribution to journalArticle

2 Scopus citations

Adaptation of liquid handling robotics for high throughput customizable raft-polymerization

Tamasi, M., Kosuri, S., Upadhya, R. & Gormley, A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Adsorption of Fibrinogen and Fibronectin on Elastomeric Poly(butylene succinate) Copolyesters

Sobolewski, P., Murthy, N. S., Kohn, J. & El Fray, M., Jul 2 2019, In : Langmuir. 35, 26, p. 8850-8859 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

A Dual Wavelength Polymerization and Bioconjugation Strategy for High Throughput Synthesis of Multivalent Ligands

Li, Z., Kosuri, S., Foster, H., Cohen, J., Jumeaux, C., Stevens, M. M., Chapman, R. & Gormley, A. J., Jan 1 2019, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Advances in the structural studies of antibiotic potentiators against Escherichia coli

Blankson, G. A., Parhi, A. K., Kaul, M., Pilch, D. S. & LaVoie, E. J., Aug 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 15, p. 3254-3278 25 p.

Research output: Contribution to journalArticle

A ligand motif enables differential vascular targeting of endothelial junctions between brain and retina

Tang, F. H. F., Staquicini, F. I., Teixeira, A. A. R., Michaloski, J. S., Namiyama, G. M., Taniwaki, N. N., Setubal, J. C., Da Silva, A. M., Sidman, R. L., Pasqualini, R., Arap, W. & Giordano, R. J., Feb 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 6, p. 2300-2305 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Alpha-carboxynucleoside phosphonates: Direct-acting inhibitors of viral DNA polymerases

Balzarini, J., Ford, A., Maguire, N. M., John, J., Das, K., Arnold, E., Dehaen, W. & Maguire, A., Jan 2019, In : Future Medicinal Chemistry. 11, 2, p. 137-154 18 p.

Research output: Contribution to journalReview article

1 Scopus citations

A method to deliver patterned electrical impulses to Schwann cells cultured on an artificial axon

Merolli, A., Mao, Y., Voronin, G., Steele, J., Murthy, N. & Kohn, J., Jun 1 2019, In : Neural Regeneration Research. 14, 6, p. 1052-1059 8 p.

Research output: Contribution to journalArticle

Open Access

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

Saito, T., Nah, J., Oka, S. I., Mukai, R., Monden, Y., Maejima, Y., Ikeda, Y., Sciarretta, S., Liu, T., Li, H., Baljinnyam, E., Fraidenraich, D., Fritzky, L., Zhai, P., Ichinose, S., Isobe, M., Hsu, C. P., Kundu, M. & Sadoshima, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 802-819 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury

Yang, L., Cerqueira, S. R., Lee, J. K. & Lee, K. B., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

An ELISA-Based Screening Platform for Ligand–Receptor Discovery

Ozgul, S., von Daake, S., Kakehi, S., Sereni, D., Denissova, N., Hanlon, C., Huang, Y. J., Everett, J. K., Yin, C., Montelione, G. T. & Comoletti, D., Jan 1 2019, Methods in Enzymology. Wand, A. J. (ed.). Academic Press Inc., p. 453-475 23 p. (Methods in Enzymology; vol. 615).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

An Injectable and Long-Acting Local Anesthetics

Tao, Y. & Xu, X., Apr 2019

Research output: Innovation

Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the protein data bank (PDB)

Adams, P. D., Afonine, P. V., Baskaran, K., Berman, H. M., Berrisford, J., Bricogne, G., Brown, D. G., Burley, S. K., Chen, M., Feng, Z., Flensburg, C., Gutmanas, A., Hoch, J. C., Ikegawa, Y., Kengaku, Y., Krissinel, E., Kurisu, G., Liang, Y., Liebschner, D., Mak, L. & 15 others, Markley, J. L., Moriarty, N. W., Murshudov, G. N., Noble, M., Peisach, E., Persikova, I., Poon, B. K., Sobolev, O. V., Ulrich, E. L., Velankar, S., Vonrhein, C., Westbrook, J., Wojdyr, M., Yokochi, M. & Young, J. Y., Apr 1 2019, In : Acta Crystallographica Section D: Structural Biology. 75, p. 451-454 4 p.

Research output: Contribution to journalLetter

Open Access
3 Scopus citations