Clinical Investigations and Precision Therapeutics Program, CINJ

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2020

(3E,5E)-3,5-Bis(pyridin-3-methylene)-tetrahydrothiopyran-4-one enhances the inhibitory effect of gemcitabine on pancreatic cancer cells

Wu, P., Wang, X., Ma, Y., Xu, X., Liu, W., Sheng, Z., Chen, M., Zhou, R., Zhang, K., Goodin, S., Zheng, X. & Li, D., Aug 2020, In : Bioorganic Chemistry. 101, 104022.

Research output: Contribution to journalArticle

2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors

2019 ASCCP Risk-Based Management Consensus Guidelines Committee, Apr 1 2020, In : Journal of lower genital tract disease. 24, 2, p. 102-131 30 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

5-Year Update of a Multi-Institution, Prospective Phase 2 Hypofractionated Postmastectomy Radiation Therapy Trial

Poppe, M. M., Yehia, Z. A., Baker, C., Goyal, S., Toppmeyer, D., Kirstein, L., Chen, C., Moore, D. F., Haffty, B. G. & Khan, A. J., 2020, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

A demonstration of automated visual evaluation of cervical images taken with a smartphone camera

Xue, Z., Novetsky, A. P., Einstein, M. H., Marcus, J., Befano, B., Guo, P., Demarco, M., Wentzensen, N., Long, L. R., Schiffman, M. & Antani, S., 2020, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Aggressive mammary cancers lacking lymphocytic infiltration arise in irradiated mice and can be prevented by dietary intervention

Omene, C., Ma, L., Moore, J., Ouyang, H., Illa-Bochaca, I., Chou, W., Patel, M. S., Sebastiano, C., Demaria, S., Mao, J. H., Karagoz, K., Gatza, M. L. & Barcellos-Hoff, M. H., Jan 1 2020, In : Cancer Immunology Research. 8, 2, p. 217-229 13 p.

Research output: Contribution to journalArticle

An edge-aware autonomic runtime for data streaming and in-transit processing

Zamani, A. R., Balouek-Thomert, D., Villalobos, J. J., Rodero, I. & Parashar, M., Sep 2020, In : Future Generation Computer Systems. 110, p. 107-118 12 p.

Research output: Contribution to journalArticle

An Experimental Review of Optical Coherence Tomography Systems for Noninvasive Assessment of Hard Dental Tissues

Sahyoun, C. C., Subhash, H. M., Peru, D., Ellwood, R. P. & Pierce, M. C., Jan 1 2020, In : Caries Research. 54, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

An On-Board Spectral-CT/CBCT/SPECT Imaging Configuration for Small-Animal Radiation Therapy Platform: A Monte Carlo Study

Wang, H., Nie, K. & Kuang, Y., Mar 2020, In : IEEE Transactions on Medical Imaging. 39, 3, p. 588-600 13 p., 8784231.

Research output: Contribution to journalArticle

A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer

Piao, X. M., Jeong, P., Yan, C., Kim, Y. H., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J. Y., Kim, I. Y., Moon, S. K., Choi, Y. H., Cha, E. J., Yun, S. J. & Kim, W. J., Jan 1 2020, In : Oncology Letters. 19, 1, p. 476-486 11 p.

Research output: Contribution to journalArticle

Open Access

Antiaging effect of Curcuma longa L. essential oil on ultraviolet-irradiated skin

Zheng, Y., Pan, C., Zhang, Z., Luo, W., Liang, X., Shi, Y., Liang, L., Zheng, X., Zhang, L. & Du, Z., May 2020, In : Microchemical Journal. 154, 104608.

Research output: Contribution to journalArticle

A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors

Stein, M. N., Goodin, S., Gounder, M., Gibbon, D., Moss, R., Portal, D., Lindquist, D., Zhao, Y., Takebe, N., Tan, A., Aisner, J., Lin, H., Ready, N. & Mehnert, J. M., Jun 1 2020, In : Investigational New Drugs. 38, 3, p. 855-865 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Systematic Review of Tests for Postcolposcopy and Posttreatment Surveillance

Clarke, M. A., Unger, E. R., Zuna, R., Nelson, E., Darragh, T. M., Cremer, M., Stockdale, C. K., Einstein, M. H. & Wentzensen, N., Apr 1 2020, In : Journal of lower genital tract disease. 24, 2, p. 148-156 9 p.

Research output: Contribution to journalArticle

Open Access

Atorvastatin and Caffeine in Combination Regulates Apoptosis, Migration, Invasion and Tumorspheres of Prostate Cancer Cells

Wang, Z., Zhang, L., Wan, Z., He, Y., Huang, H., Xiang, H., Wu, X., Zhang, K., Liu, Y., Goodin, S., Du, Z. & Zheng, X., Jan 1 2020, In : Pathology and Oncology Research. 26, 1, p. 209-216 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Avelumab in patients with previously treated metastatic Merkel cell carcinoma: Long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial

D'Angelo, S. P., Bhatia, S., Brohl, A. S., Hamid, O., Mehnert, J. M., Terheyden, P., Shih, K. C., Brownell, I., Lebbé, C., Lewis, K. D., Linette, G. P., Milella, M., Georges, S., Shah, P., Ellers-Lenz, B., Bajars, M., Güzel, G. & Nghiem, P. T., May 15 2020, In : Journal for ImmunoTherapy of Cancer. 8, 1, e000674.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

BRAINSTORM: A Multi-Institutional Phase 1/2 Study of RRx-001 in Combination With Whole Brain Radiation Therapy for Patients With Brain Metastases

Kim, M. M., Parmar, H. A., Schipper, M., Devasia, T., Aryal, M. P., Kesari, S., O'Day, S., Morikawa, A., Spratt, D. E., Junck, L., Mammoser, A., Hayman, J. A., Lawrence, T. S., Tsien, C. I., Aiken, R., Goyal, S., Abrouk, N., Trimble, M., Cao, Y. & Lao, C. D., Jul 1 2020, In : International Journal of Radiation Oncology Biology Physics. 107, 3, p. 478-486 9 p.

Research output: Contribution to journalArticle

Open Access

Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy

Canals, D., Salamone, S., Santacreu, B. J., Nemeth, E., Aguilar, D., Hernandez-Corbacho, M. J., Adada, M., Staquicini, D. I., Arap, W., Pasqualini, R., Haley, J., Obeid, L. M. & Hannun, Y. A., Jun 1 2020, In : FASEB Journal. 34, 6, p. 7610-7630 21 p.

Research output: Contribution to journalArticle

Open Access

Challenges and opportunities in the management of metastatic renal cell carcinoma: combination therapy and the role of cytoreductive surgery

Patel, H. V., Shinder, B., Srinivasan, R. & Singer, E. A., May 1 2020, In : Current opinion in oncology. 32, 3, p. 240-249 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chemical profiling and bioactivity of essential oils from Alpinia officinarum Hance from ten localities in China

Zhang, L., Pan, C., Ou, Z., Liang, X., Shi, Y., Chi, L., Zhang, Z., Zheng, X., Li, C. & Xiang, H., Oct 1 2020, In : Industrial Crops and Products. 153, 112583.

Research output: Contribution to journalArticle

Christine (Cooky) O. Menias, MD, Named RSNA RadioGraphics Editor

Haffty, B. G. & Mauro, M. A., Mar 1 2020, In : Radiology. 294, 3, 1 p.

Research output: Contribution to journalArticle

Clinical codes combined with procedure codes increase diagnostic accuracy of Crohn's disease in a US Military health record

Singla, M., Hutfless, S., Al Kazzi, E., Rodriguez, B., Betteridge, J. & Brant, S., Feb 26 2020, In : BMJ Open Gastroenterology. 7, 1, e000378.

Research output: Contribution to journalArticle

Open Access

Clinical Outcomes in Early Breast Cancer with a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial

Sparano, J. A., Gray, R. J., Makower, D. F., Albain, K. S., Saphner, T. J., Badve, S. S., Wagner, L. I., Kaklamani, V. G., Keane, M. M., Gomez, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Toppmeyer, D. L., Brufsky, A. M., Goetz, M. P., Berenberg, J. L., Mahalcioiu, C., Desbiens, C., Hayes, D. F. & 9 others, Dees, E. C., Geyer, C. E., Olson, J. A., Wood, W. C., Lively, T., Paik, S., Ellis, M. J., Abrams, J. & Sledge, G. W., Mar 2020, In : JAMA Oncology. 6, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Clinical Trials for the Surgical Oncologist: Opportunities and Hurdles

Park, K. U., Mamounas, E. P., Katz, M. H. G., Unzeitig, G., Carpizo, D., You, Y. N., Francescatti, A., Hunt, K. K. & Boughey, J. C., Jul 1 2020, In : Annals of Surgical Oncology. 27, 7, p. 2269-2275 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma

Passero, F. C., Ravi, D., McDonald, J. T., Beheshti, A., David, K. A. & Evens, A. M., Jan 1 2020, In : British Journal of Haematology. 188, 2, p. 295-308 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Conditional survival analysis of hepatocellular carcinoma

Shah, M. M., Meyer, B. I., Rhee, K., NeMoyer, R. E., Lin, Y., Tzeng, C. W. D., Jabbour, S. K., Kennedy, T. J., Nosher, J. L., Kooby, D. A., Maithel, S. K. & Carpizo, D., Jan 1 2020, (Accepted/In press) In : Journal of Surgical Oncology.

Research output: Contribution to journalArticle

CoREC: Scalable and Resilient In-memory Data Staging for In-situWorkflows

Duan, S., Subedi, P., Davis, P., Teranishi, K., Kolla, H., Gamell, M. & Parashar, M., May 16 2020, In : ACM Transactions on Parallel Computing. 7, 2, 12.

Research output: Contribution to journalArticle

Open Access

Deadline Constrained Video Analysis via In-Transit Computational Environments

Zamani, A. R., Zou, M., Diaz-Montes, J., Petri, I., Rana, O., Anjum, A. & Parashar, M., Jan 1 2020, In : IEEE Transactions on Services Computing. 13, 1, p. 59-72 14 p., 7817858.

Research output: Contribution to journalArticle

1 Scopus citations

Disparities in utilization of services for racial and ethnic minorities with hepatocellular carcinoma associated with hepatitis C

Kangas-Dick, A., Gall, V., Hilden, P., Turner, A., Greenbaum, A., Sesti, J., Paul, S., Carpizo, D., Kennedy, T., Sadaria Grandhi, M., Alexander, H. R., Wang, S., Geffner, S., August, D. & Langan, R. C., 2020, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

Dose-dependent growth delay of breast cancer xenografts in the bone marrow of mice treated with 223Ra: The role of bystander effects and their potential for therapy

Leung, C. N., Canter, B. S., Rajon, D., Bäck, T. A., Christopher Fritton, J., Azzam, E. I. & Howell, R. W., Jan 2020, In : Journal of Nuclear Medicine. 61, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dosimetric comparisons of different hypofractionated stereotactic radiotherapy techniques in treating intracranial tumors > 3 cm in longest diameter

Cao, H., Xiao, Z., Zhang, Y., Kwong, T., Danish, S. F., Weiner, J., Wang, X., Yue, N., Dai, Z., Kuang, Y., Bai, Y. & Nie, K., 2020, In : Journal of neurosurgery. 132, 4, p. 1024-1032 9 p.

Research output: Contribution to journalArticle

Effectiveness of Breast-Conserving Surgery and 3-Dimensional Conformal Partial Breast Reirradiation for Recurrence of Breast Cancer in the Ipsilateral Breast: The NRG Oncology/RTOG 1014 Phase 2 Clinical Trial

Arthur, D. W., Winter, K. A., Kuerer, H. M., Haffty, B., Cuttino, L., Todor, D. A., Anne, P. R., Anderson, P., Woodward, W. A., McCormick, B., Cheston, S., Sahijdak, W. M., Canaday, D., Brown, D. R., Currey, A., Fisher, C. M., Jagsi, R., Moughan, J. & White, J. R., Jan 2020, In : JAMA Oncology. 6, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Enhancement of sorafenib-mediated death of Hepatocellular carcinoma cells by Carnosic acid and Vitamin D2 analog combination

Wu, Q., Wang, X., Pham, K., Luna, A., Studzinski, G. P. & Liu, C., Mar 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 197, 105524.

Research output: Contribution to journalArticle

Epigenome, Transcriptome, and Protection by Sulforaphane at Different Stages of UVB-Induced Skin Carcinogenesis

Li, S., Yang, Y., Sargsyan, D., Wu, R., Yin, R., Kuo, H. C. D., Yang, I., Wang, L., Cheng, D., Ramirez, C. N., Hudlikar, R., Lu, Y. & Kong, A. N., Jun 1 2020, In : Cancer Prevention Research. 13, 6, p. 551-561 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Evaluating unplanned readmission and prolonged length of stay following minimally invasive surgery for endometrial cancer

Kohut, A., Earnhardt, M. C., Cuccolo, N. G., Kim, C. S., Song, M., Girda, E., De Meritens, A. B., Stephenson, R., Balica, A., Leiser, A., Demissie, K. & Rodriguez-Rodriguez, L., Jan 2020, In : Gynecologic Oncology. 156, 1, p. 162-168 7 p.

Research output: Contribution to journalArticle

Open Access

Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer

Babiker, H. M., Milhem, M., Aisner, J., Edenfield, W., Shepard, D., Savona, M., Iyer, S., Abdelrahim, M., Beach, C. L., Skikne, B., Laille, E., Tsai, K. T. & Ho, T., Mar 1 2020, In : Cancer chemotherapy and pharmacology. 85, 3, p. 621-626 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Factors Associated With Receipt of Partial Nephrectomy or Minimally Invasive Surgery for Patients With Clinical T1a and T1b Renal Masses: Implications for Regionalization of Care

Sterling, J., Rivera-Núñez, Z., Patel, H. V., Farber, N. J., Kim, S., Radadia, K. D., Modi, P. K., Goyal, S., Parikh, R., Weiss, R. E., Kim, I. Y., Elsamra, S. E., Jang, T. L. & Singer, E. A., Jan 1 2020, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

1 Scopus citations

Genomic and immunologic correlates of LAG-3 expression in cancer

Panda, A., Rosenfeld, J. A., Singer, E. A., Bhanot, G. & Ganesan, S., Jan 1 2020, In : OncoImmunology. 9, 1, 1756116.

Research output: Contribution to journalArticle

Open Access

GNM: GridCell navigational model

Naghizadeh, A., Berenjian, S., Margolis, D. J. & Metaxas, D. N., Jun 15 2020, In : Expert Systems With Applications. 148, 113217.

Research output: Contribution to journalArticle

Greater survival improvement in African American vs. Caucasian women with hormone negative breast cancer

Wieder, R., Shafiq, B. & Adam, N., Jan 1 2020, In : Journal of Cancer. 11, 10, p. 2808-2820 13 p.

Research output: Contribution to journalArticle

Open Access

High-Dose Ipilimumab and High-Dose Interleukin-2 for Patients With Advanced Melanoma

Silk, A. W., Kaufman, H. L., Curti, B., Mehnert, J. M., Margolin, K., McDermott, D., Clark, J., Newman, J., Bommareddy, P. K., Denzin, L., Najmi, S., Haider, A., Shih, W., Kane, M. P. & Zloza, A., Jan 10 2020, In : Frontiers in Oncology. 9, 1483.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

How I treat advanced Hodgkin lymphoma — a global view

Hokland, P., Shah, M., David, K., Evens, A., Auer, R., Ledieu, R., Kreissl, S., Bröckelmann, P. J., Borchmann, P., Korula, A., Mathews, V., Owattanapanich, W. & Trotman, J., 2020, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Open Access

Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency

Zhang, X., Santos, R., Debevec, G., Li, D., Schutte, R., Pham, K., Liu, C., Ostrov, D. A. & Giulianotti, M., Jun 18 2020, In : Biochemical and Biophysical Research Communications. 527, 1, p. 317-323 7 p.

Research output: Contribution to journalArticle

IGF2 drives formation of ileal neuroendocrine tumors in patients and mice

Contractor, T., Clausen, R., Harris, G. R., Rosenfeld, J. A., Carpizo, D. R., Tang, L. & Harris, C. R., Jan 1 2020, In : Endocrine-Related Cancer. 27, 3, p. 175-186 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: Associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype

Llanos, A. A. M., Lin, Y., Chen, W., Yao, S., Norin, J., Chekmareva, M. A., Omene, C., Cong, L., Omilian, A. R., Khoury, T., Hong, C. C., Ganesan, S., Foran, D. J., Higgins, M., Ambrosone, C. B., Bandera, E. V. & Demissie, K., Feb 11 2020, In : Breast Cancer Research. 22, 1, 18.

Research output: Contribution to journalArticle

Open Access

Impact of pathologic lymph node-positive renal cell carcinoma on survival in patients without metastasis: Evidence in support of expanding the definition of stage IV kidney cancer

Srivastava, A., Rivera-Núñez, Z., Kim, S., Sterling, J., Farber, N. J., Radadia, K. D., Patel, H. V., Modi, P. K., Goyal, S., Parikh, R., Mayer, T. M., Saraiya, B., Sadimin, E. T., Weiss, R. E., Kim, I. Y., Elsamra, S. E., Jang, T. L. & Singer, E. A., Jul 1 2020, In : Cancer. 126, 13, p. 2991-3001 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Individual and joint effects of metformin and statins on mortality among patients with high-risk prostate cancer

Tan, X. L., Jian-Yu, E., Lin, Y., Rebbeck, T. R., Lu, S. E., Shang, M., Kelly, W. K., D'Amico, A., Stein, M. N., Zhang, L., Jang, T. L., Kim, I. Y., Demissie, K., Ferrari, A. & Lu-Yao, G., Apr 1 2020, In : Cancer Medicine. 9, 7, p. 2379-2389 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients

Ashktorab, H., Brim, H., Hassan, S., Nouraie, M., Gebreselassie, A., Laiyemo, A. O., Kibreab, A., Aduli, F., Latella, G., Brant, S. R., Sherif, Z. & Habtezion, A., Jun 5 2020, In : BMC Gastroenterology. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Insertional oncogenesis by HPV70 revealed by multiple genomic analyses in a clinically HPV-negative cervical cancer

Van Arsdale, A., Patterson, N. E., Maggi, E. C., Agoni, L., Van Doorslaer, K., Harmon, B., Nevadunsky, N., Kuo, D. Y. S., Einstein, M. H., Lenz, J. & Montagna, C., Feb 1 2020, In : Genes Chromosomes and Cancer. 59, 2, p. 84-95 12 p.

Research output: Contribution to journalArticle

1 Scopus citations