Clinical Investigations and Precision Therapeutics Program, CINJ

Research Output 1976 2019

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Review article
2019
1 Citation (Scopus)

Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review

Chohan, M. O., Marchiò, S., Morrison, L. A., Sidman, R. L., Cavenee, W. K., Dejana, E., Yonas, H., Pasqualini, R. & Arap, W., Apr 1 2019, In : JAMA Neurology. 76, 4, p. 492-500 9 p.

Research output: Contribution to journalReview article

Central Nervous System Cavernous Hemangioma
Drug Repositioning
Penetrance
Germ-Line Mutation
Radiosurgery

Gastrointestinal Cancers: Fine-Tuning the Management of Rectal, Esophageal, and Pancreas Cancers

Olsen, J. R., Apisarnthanarax, S., Murphy, J. D., Tait, D., Huguet, F., Hallemeier, C. L. & Jabbour, S., Sep 1 2019, In : International Journal of Radiation Oncology Biology Physics. 105, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

pancreas
Gastrointestinal Neoplasms
Esophageal Neoplasms
Rectal Neoplasms
Pancreatic Neoplasms

Gut Microbiota, Dietary Phytochemicals, and Benefits to Human Health

Yin, R., Kuo, H. C., Hudlikar, R., Sargsyan, D., Li, S., Wang, L., Wu, R. & Kong, A-N., Jan 1 2019, (Accepted/In press) In : Current Pharmacology Reports.

Research output: Contribution to journalReview article

Microbiota
Phytochemicals
Chronic Disease
Health
Carotenoids

Hybrid Capture-Based Genomic Profiling Identifies BRAF V600 and Non-V600 Alterations in Melanoma Samples Negative by Prior Testing

Boussemart, L., Nelson, A., Wong, M., Ross, J. S., Sosman, J., Mehnert, J., Daniels, G., Kendra, K., Ali, S. M., Miller, V. A. & Schrock, A. B., May 1 2019, In : Oncologist. 24, 5, p. 657-663 7 p.

Research output: Contribution to journalReview article

Melanoma
Mitogen-Activated Protein Kinase Kinases
Mutation
Practice Guidelines
Patient Selection

NCTN Assessment on Current Applications of Radiomics in Oncology

Nie, K., Al-Hallaq, H., Li, X. A., Benedict, S. H., Sohn, J. W., Moran, J. M., Fan, Y., Huang, M., Knopp, M. V., Michalski, J. M., Monroe, J., Obcemea, C., Tsien, C. I., Solberg, T., Wu, J., Xia, P., Xiao, Y. & El Naqa, I., Jun 1 2019, In : International Journal of Radiation Oncology Biology Physics. 104, 2, p. 302-315 14 p.

Research output: Contribution to journalReview article

biomarkers
Standard of Care
recommendations
Biomarkers
Clinical Trials

Rethinking the role of radiation therapy in the treatment of unresectable hepatocellular carcinoma: A data driven treatment algorithm for optimizing outcomes

Sayan, M., Yegya-Raman, N., Greco, S. H., Gui, B., Zhang, A., Chundury, A., Grandhi, M. S., Hochster, H. S., Kennedy, T., Langan, R. C., Malhotra, U., Rustgi, V., Shah, M. M., Spencer, K. R., Carpizo, D., Nosher, J. L. & Jabbour, S., Jan 1 2019, In : Frontiers in Oncology. 9, JUN

Research output: Contribution to journalReview article

Open Access
Hepatocellular Carcinoma
Radiotherapy
Therapeutics
Liver Neoplasms
Venous Thrombosis
2018
4 Citations (Scopus)

Biomanufacturing for clinically advanced cell therapies

Aijaz, A., Li, M., Smith, D., Khong, D., Leblon, C., Fenton, O. S., Olabisi, R., Libutti, S., Tischfield, J., Maus, M. V., Deans, R., Barcia, R. N., Anderson, D. G., Ritz, J., Preti, R. & Parekkadan, B., Jun 1 2018, In : Nature Biomedical Engineering. 2, 6, p. 362-376 15 p.

Research output: Contribution to journalReview article

Transplants
T-cells
Antigens
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor

Decision-Making Strategy for Rectal Cancer Management Using Radiation Therapy for Elderly or Comorbid Patients

Wang, S. J., Hathout, L., Malhotra, U., Maloney Patel, N., Kilic, S., Poplin, E. & Jabbour, S., Mar 15 2018, In : International Journal of Radiation Oncology Biology Physics. 100, 4, p. 926-944 19 p.

Research output: Contribution to journalReview article

decision making
Rectal Neoplasms
radiation therapy
Decision Making
Radiotherapy
1 Citation (Scopus)

Empiric radiotherapy for lung cancer collaborative group multi-institutional evidence-based guidelines for the use of empiric stereotactic body radiation therapy for non-small cell lung cancer without pathologic confirmation

Berman, A. T., Jabbour, S., Vachani, A., Robinson, C., Isabelle Choi, J., Mohindra, P., Rengan, R., Bradley, J. & Simone, C. B., Feb 1 2018, In : Translational Lung Cancer Research. 8, 1, p. 5-14 10 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Radiotherapy
Guidelines
Lung

Examining EML4-ALK variants in the clinical setting: The next frontier?

Patel, M., Malhotra, J. & Jabbour, S., Nov 1 2018, In : Journal of Thoracic Disease. 10, p. S4104-S4107

Research output: Contribution to journalReview article

8 Citations (Scopus)

In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

Ramirez, C. N., Li, W., Zhang, C., Wu, R., Su, S., Wang, C., Gao, L., Yin, R. & Kong, A-N., Jan 1 2018, In : AAPS Journal. 20, 1, 19.

Research output: Contribution to journalReview article

Curcumin
Phytochemicals
Isothiocyanates
Neoplasms
Animal Models
3 Citations (Scopus)

Management of locally advanced rectal cancer in the elderly: A critical review and algorithm

Hathout, L., Maloney Patel, N., Malhotra, U., Wang, S. J., Chokhavatia, S., Dalal, I., Poplin, E. & Jabbour, S., Apr 1 2018, In : Journal of Gastrointestinal Oncology. 9, 2, p. 363-376 14 p.

Research output: Contribution to journalReview article

Rectal Neoplasms
Cause of Death
Complementary Therapies
Colorectal Neoplasms
Consensus
4 Citations (Scopus)

Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds

Bao, C., Kramata, P., Lee, H. J. & Suh, N., Jan 1 2018, In : Molecular Nutrition and Food Research. 62, 1, 1700621.

Research output: Contribution to journalReview article

Erinaceidae
neoplasms
Neoplasms
Biological Products
HhAntag691

Serum microRNA guiding personalized radiation therapy in nonsmall cell lung cancer

Amin, N. P., Mohindra, P. & Jabbour, S., Nov 1 2018, In : Journal of Thoracic Disease. 10, p. S4108-S4112

Research output: Contribution to journalReview article

MicroRNAs
Non-Small Cell Lung Carcinoma
Radiotherapy
Serum
4 Citations (Scopus)

The Pathology of Acute Liver Failure

Fyfe, B., Zaldana, F. & Liu, C., May 1 2018, In : Clinics in Liver Disease. 22, 2, p. 257-268 12 p.

Research output: Contribution to journalReview article

Acute Liver Failure
Pathology
Necrosis
Patient Care Team
Wounds and Injuries
17 Citations (Scopus)

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

Chen, M., Du, Z. Y., Zheng, X., Li, D. L., Zhou, R. & Zhang, K., Apr 1 2018, In : Neural Regeneration Research. 13, 4, p. 742-752 11 p.

Research output: Contribution to journalReview article

Curcumin
Alzheimer Disease
Amyloid
Chronic Disease
Cerebrovascular Disorders
2 Citations (Scopus)

Zinc metallochaperones as Mutant p53 reactivators: A new paradigm in cancer therapeutics

Kogan, S. & Carpizo, D., Jun 1 2018, In : Cancers. 10, 6, 166.

Research output: Contribution to journalReview article

Metallochaperones
Zinc
Neoplasms
Therapeutics
Ions
2017
4 Citations (Scopus)

ACR Appropriateness Criteria ® Resectable Pancreatic Cancer

Jones, W. E., Suh, W. W., Abdel-Wahab, M., Abrams, R. A., Azad, N., Das, P., Dragovic, J., Goodman, K. A., Jabbour, S., Konski, A. A., Koong, A. C., Kumar, R., Lee, P., Pawlik, T. M., Small, W. & Herman, J. M., Jan 1 2017, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 40, 2, p. 109-117 9 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Adenocarcinoma
Guidelines
Expert Testimony
Adjuvant Chemotherapy
9 Citations (Scopus)

Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology

Chastain, L. G. & Sarkar, D., May 1 2017, In : Alcohol. 60, p. 53-66 14 p.

Research output: Contribution to journalReview article

Pathology
pathology
alcohol
Alcohols
Epigenomics
4 Citations (Scopus)

An Assessment of Imaging Informatics for Precision Medicine in Cancer

Chennubhotla, C., Clarke, L. P., Fedorov, A., Foran, D., Harris, G., Helton, E., Nordstrom, R., Prior, F., Rubin, D., Saltz, J. H., Shalley, E. & Sharma, A., Aug 1 2017, In : Yearbook of medical informatics. 26, 1, p. 110-119 10 p.

Research output: Contribution to journalReview article

Precision Medicine
Informatics
Neoplasms
Cataloging
Education
43 Citations (Scopus)

Eurogin 2016 Roadmap: how HPV knowledge is changing screening practice

Wentzensen, N., Arbyn, M., Berkhof, J., Bower, M., Canfell, K., Einstein, M., Farley, C., Monsonego, J. & Franceschi, S., May 15 2017, In : International Journal of Cancer. 140, 10, p. 2192-2200 9 p.

Research output: Contribution to journalReview article

Anus Neoplasms
Uterine Cervical Neoplasms
Papillomavirus Vaccines
Papillomavirus Infections
Vaccination
15 Citations (Scopus)

Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

Yue, Q., Gao, G., Zou, G., Yu, H. & Zheng, X., Jan 1 2017, In : BioMed Research International. 2017, 8412508.

Research output: Contribution to journalReview article

Biological Products
Pancreatic Neoplasms
Herbal Medicine
Chemotherapy
Radiotherapy
5 Citations (Scopus)

Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System

Rachdaoui, N. & Sarkar, D., Jan 1 2017, In : Alcohol research : current reviews. 38, 2, p. 255-276 22 p.

Research output: Contribution to journalReview article

Endocrine System
Alcoholism
Thyroid Gland
Alcohols
Somatomedins
7 Citations (Scopus)

Pharmacogenetic Predictors of Treatment-Related Toxicity Among Children With Acute Lymphoblastic Leukemia

Maxwell, R. R. & Cole, P., Jun 1 2017, In : Current Hematologic Malignancy Reports. 12, 3, p. 176-186 11 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Guidelines
Therapeutics
Clinical Protocols
6 Citations (Scopus)

Phytochemicals in Traditional Chinese Herbal Medicine: Cancer Prevention and Epigenetics Mechanisms

Zhou, Z. H., Yang, J. & Kong, A-N., Apr 1 2017, In : Current Pharmacology Reports. 3, 2, p. 77-91 15 p.

Research output: Contribution to journalReview article

Herbal Medicine
Phytochemicals
Epigenomics
Bioelectric potentials
Genetic Epigenesis
2 Citations (Scopus)

Systematic Review of International Colposcopy Quality Improvement Guidelines

Mayeaux, E. J., Novetsky, A. P., Chelmow, D., Choma, K., Garcia, F., Liu, A. H., Papasozomenos, T. & Einstein, M., Oct 1 2017, In : Journal of Lower Genital Tract Disease. 21, 4, p. 249-257 9 p.

Research output: Contribution to journalReview article

Colposcopy
Quality Improvement
Guidelines
Communication Aids for Disabled
Pathology
2 Citations (Scopus)

The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer

Hathout, L., Williams, T. & Jabbour, S., Feb 1 2017, In : Current Colorectal Cancer Reports. 13, 1, p. 61-72 12 p.

Research output: Contribution to journalReview article

Rectal Neoplasms
Radiotherapy
Radiation
Proton Therapy
Brachytherapy
19 Citations (Scopus)

Xenobiotic transporters and kidney injury

George, B., You, D., Joy, M. S. & Aleksunes, L., Jul 1 2017, In : Advanced Drug Delivery Reviews. 116, p. 73-91 19 p.

Research output: Contribution to journalReview article

Xenobiotics
Kidney
Wounds and Injuries
Carrier Proteins
Halogenated Hydrocarbons
2016
3 Citations (Scopus)

ACR appropriateness criteria® borderline and unresectable pancreas cancer

Small, W., Hayes, J. P., Suh, W. W., May, A. W., Abrams, R. A., Azad, N., Das, P., Dragovic, J., Goodman, K. A., Jabbour, S., Jones, W. E., Konski, A. A., Koong, A. C., Kumar, R., Lee, P., Pawlik, T. M. & Herman, J. M., Jul 15 2016, In : ONCOLOGY (United States). 30, 7

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Radiation
Guidelines
Drug Therapy
Therapeutics
9 Citations (Scopus)
Pectobacterium chrysanthemi
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypersensitivity
Escherichia coli
61 Citations (Scopus)

Consensus Statement on Proton Therapy in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer

Chang, J. Y., Jabbour, S., De Ruysscher, D., Schild, S. E., Simone, C. B., Rengan, R., Feigenberg, S., Khan, A., Choi, N. C., Bradley, J. D., Zhu, X. R., Lomax, A. J. & Hoppe, B. S., May 1 2016, In : International Journal of Radiation Oncology Biology Physics. 95, 1, p. 505-516 12 p.

Research output: Contribution to journalReview article

Proton Therapy
Non-Small Cell Lung Carcinoma
lungs
therapy
cancer
5 Citations (Scopus)

How I manage patients with grey zone lymphoma

Kritharis, A., Pilichowska, M. & Evens, A., Aug 1 2016, In : British Journal of Haematology. 174, 3, p. 345-350 6 p.

Research output: Contribution to journalReview article

Lymphoma
Lymphoma, Large B-Cell, Diffuse
Hematopoietic Stem Cell Transplantation
Vincristine
Prednisolone
34 Citations (Scopus)

Improving Outcomes for Esophageal Cancer using Proton Beam Therapy

Chuong, M. D., Hallemeier, C. L., Jabbour, S., Yu, J., Badiyan, S., Merrell, K. W., Mishra, M. V., Li, H., Verma, V. & Lin, S. H., May 1 2016, In : International Journal of Radiation Oncology Biology Physics. 95, 1, p. 488-497 10 p.

Research output: Contribution to journalReview article

Proton Therapy
Esophageal Neoplasms
proton beams
radiation therapy
therapy
18 Citations (Scopus)

Male germline transmits fetal alcohol epigenetic marks for multiple generations: A review

Sarkar, D., Jan 1 2016, In : Addiction Biology. 21, 1, p. 23-34 12 p.

Research output: Contribution to journalReview article

Epigenomics
Alcohols
Pro-Opiomelanocortin
Genes
Embryonic Development
33 Citations (Scopus)
Tumors
cancer
tumors
Neoplasms
sequencing
15 Citations (Scopus)

Precision targeted therapy of ovarian cancer

Sapiezynski, J., Taratula, O., Rodriguez-Rust, L. & Minko, T., Dec 10 2016, In : Journal of Controlled Release. 243, p. 250-268 19 p.

Research output: Contribution to journalReview article

Nanotechnology
Ovarian Neoplasms
Therapeutics
Direction compound
8 Citations (Scopus)

Regulation of Keap1–Nrf2 signaling: The role of epigenetics

Cheng, D., Wu, R., Guo, Y. & Kong, A-N., Jan 1 2016, In : Current Opinion in Toxicology. 1, p. 134-138 5 p.

Research output: Contribution to journalReview article

Epigenomics
GATA1 Transcription Factor
DNA sequences
Gene expression
Antioxidants
20 Citations (Scopus)

Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

Bak, M. J., Das Gupta, S., Wahler, J. & Suh, N., Oct 1 2016, In : Seminars in Cancer Biology. 40_41, p. 170-191 22 p.

Research output: Contribution to journalReview article

Biological Products
Estrogen Receptors
Breast Neoplasms
Estrogens
Carcinogenesis
1 Citation (Scopus)

Successes and Failures of Combined Modalities in Upper Gastrointestinal Malignancies: New Directions

Jamorabo, D. S., Lin, S. H. & Jabbour, S., Oct 1 2016, In : Seminars in Radiation Oncology. 26, 4, p. 307-319 13 p.

Research output: Contribution to journalReview article

Immunotherapy
Radiotherapy
Active Immunotherapy
Combined Modality Therapy
Neoplasms
6 Citations (Scopus)

The value of FDG-PET in the staging of gastric adenocarcinoma: A single institution retrospective review

Serrano, O. K., Love, C., Goldman, I., Huang, K., Ng, N., Abraham, T., Da Silva, R., Friedmann, P., Libutti, S. & Kennedy, T., May 1 2016, In : Journal of Surgical Oncology. 113, 6, p. 640-646 7 p.

Research output: Contribution to journalReview article

Stomach
Adenocarcinoma
Lymph Nodes
Neoplasms
Neoplasm Metastasis
17 Citations (Scopus)

Tocopherols in cancer: An update

Das Gupta, S. & Suh, N., Jun 1 2016, In : Molecular nutrition & food research. 60, 6, p. 1354-1363 10 p.

Research output: Contribution to journalReview article

Tocopherols
tocopherols
neoplasms
Neoplasms
clinical trials
19 Citations (Scopus)

Trends in United States prostate cancer incidence rates by age and stage, 1995-2012

Hoffman, R. M., Meisner, A. L. W., Arap, W., Barry, M., Shah, S. K., Zeliadt, S. B. & Wiggins, C. L., Feb 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 2, p. 259-263 5 p.

Research output: Contribution to journalReview article

Prostatic Neoplasms
Incidence
Confidence Intervals
Guidelines
Delayed Diagnosis
2015
2 Citations (Scopus)

Architecture of Signature miRNA Regulatory Networks in Cancer Chemoprevention

Nair, S. & Kong, A-N., Apr 1 2015, In : Current Pharmacology Reports. 1, 2, p. 89-101 13 p.

Research output: Contribution to journalReview article

Chemoprevention
MicroRNAs
Neoplasms
Biomarkers
Long Noncoding RNA
169 Citations (Scopus)

Autophagy, Metabolism, and Cancer

White, E., Mehnert, J. & Chan, C., Nov 15 2015, In : Clinical Cancer Research. 21, 22, p. 5037-5046 10 p.

Research output: Contribution to journalReview article

Autophagy
Neoplasms
Starvation
Organelles
Recycling
6 Citations (Scopus)

Changes in the Trend of Alcohol-Related Cancers: Perspectives on Statistical Trends

Malhotra, J., Praud, D. & Boffetta, P., Sep 21 2015, In : Chemical Research in Toxicology. 28, 9, p. 1661-1665 5 p.

Research output: Contribution to journalReview article

Alcohols
Alcohol Drinking
Pharyngeal Neoplasms
Neoplasms
Laryngeal Neoplasms
25 Citations (Scopus)

Clinical management of multiple melanoma brain metastases a systematic review

Goyal, S., Silk, A., Tian, S., Mehnert, J., Danish, S., Ranjan, S. & Kaufman, H. L., Aug 1 2015, In : JAMA Oncology. 1, 5, p. 668-676 9 p.

Research output: Contribution to journalReview article

Melanoma
Neoplasm Metastasis
Brain
Radiotherapy
Radiosurgery
126 Citations (Scopus)

Curcumin, inflammation, and chronic diseases: How are they linked?

He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S. & Du, Z., Jan 1 2015, In : Molecules. 20, 5, p. 9183-9213 31 p.

Research output: Contribution to journalReview article

Curcumin
Chronic Disease
Inflammation
Oxidative stress
Oxidative Stress
14 Citations (Scopus)

Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals

Guo, Y., Su, Z. Y. & Kong, A-N., Aug 1 2015, In : Current Pharmacology Reports. 1, 4, p. 245-257 13 p.

Research output: Contribution to journalReview article

Diet Therapy
Phytochemicals
Epigenomics
Untranslated RNA
Tumor Biomarkers
60 Citations (Scopus)
Glucosinolates
Brassica
Epigenomics
Inflammation
Carcinogenesis
1 Citation (Scopus)

Does genetic susceptibility increase risk for neurocognitive decline among patients with acute lymphoblastic leukemia?

Cole, P., Jul 1 2015, In : Future Oncology. 11, 13, p. 1855-1858 4 p.

Research output: Contribution to journalReview article

Pharmaceutical Economics
Pharmacogenetics
Genetic Predisposition to Disease
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate