Clinical Investigations and Precision Therapeutics Program, CINJ

Research Output 1976 2019

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Review article
2015
14 Citations (Scopus)

Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals

Guo, Y., Su, Z. Y. & Kong, A-N., Aug 1 2015, In : Current Pharmacology Reports. 1, 4, p. 245-257 13 p.

Research output: Contribution to journalReview article

Diet Therapy
Phytochemicals
Epigenomics
Untranslated RNA
Tumor Biomarkers
61 Citations (Scopus)
Glucosinolates
Brassica
Epigenomics
Inflammation
Carcinogenesis
1 Citation (Scopus)

Does genetic susceptibility increase risk for neurocognitive decline among patients with acute lymphoblastic leukemia?

Cole, P., Jul 1 2015, In : Future Oncology. 11, 13, p. 1855-1858 4 p.

Research output: Contribution to journalReview article

Pharmaceutical Economics
Pharmacogenetics
Genetic Predisposition to Disease
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
84 Citations (Scopus)

Epigenetic regulation of Keap1-Nrf2 signaling

Guo, Y., Yu, S., Zhang, C. & Kong, A-N., Jan 1 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 337-349 13 p.

Research output: Contribution to journalReview article

Epigenomics
Proteins
Oxidative stress
GATA1 Transcription Factor
Oxidative Stress
70 Citations (Scopus)

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Brouwer, K. L. R., Aleksunes, L., Brandys, B., Giacoia, G. P., Knipp, G., Lukacova, V., Meibohm, B., Nigam, S., M Rieder, M. & Wildt, S. D., Sep 1 2015, In : Clinical pharmacology and therapeutics. 98, 3, p. 266-287 22 p.

Research output: Contribution to journalReview article

Membrane Transport Proteins
Pediatrics
Pharmaceutical Preparations
Drug Therapy
Intestines
13 Citations (Scopus)

Interaction of isoflavones with the BCRP/ABCG2 drug transporter

Bircsak, K. M. & Aleksunes, L., Jul 1 2015, In : Current Drug Metabolism. 16, 2, p. 124-140 17 p.

Research output: Contribution to journalReview article

Isoflavones
Breast Neoplasms
Pharmaceutical Preparations
Proteins
Cell membranes
22 Citations (Scopus)

MicroRNAs: new Players in Cancer Prevention Targeting Nrf2, Oxidative Stress and Inflammatory Pathways

Zhang, C., Shu, L. & Kong, A-N., Feb 1 2015, In : Current Pharmacology Reports. 1, 1, p. 21-30 10 p.

Research output: Contribution to journalReview article

Oxidative stress
MicroRNAs
Oxidative Stress
Neoplasms
Chemoprevention
20 Citations (Scopus)

Oncolytic Virus Immunotherapy for Melanoma

Dharmadhikari, N., Mehnert, J. & Kaufman, H. L., Jan 1 2015, In : Current treatment options in oncology. 16, 3

Research output: Contribution to journalReview article

Oncolytic Viruses
Immunotherapy
Melanoma
Granulocyte-Macrophage Colony-Stimulating Factor
Viruses
6 Citations (Scopus)

Optimal timing of sipuleucel-T treatment in metastatic castration-resistant prostate cancer

David Crawford, E., Petrylak, D. P., Higano, C. S., Kibel, A. S., Kantoff, P. W., Small, E. J., Shore, N. D. & Ferrari, A., Jan 1 2015, In : Canadian Journal of Urology. 22, 6, p. 8048-8055 8 p.

Research output: Contribution to journalReview article

Castration
Prostatic Neoplasms
Therapeutics
Immunotherapy
sipuleucel-T
30 Citations (Scopus)

Reactivating mutant p53 using small molecules as zinc metallochaperones: Awakening a sleeping giant in cancer

Blanden, A. R., Yu, X., Loh, S. N., Levine, A. J. & Carpizo, D., Nov 1 2015, In : Drug Discovery Today. 20, 11, p. 1391-1397 7 p.

Research output: Contribution to journalReview article

Metallochaperones
Zinc
Neoplasms
Missense Mutation
Protein Binding

Sub-centimeter HER2-Positive Breast Cancer: How Small Is Too Small to Treat?

Morris, G. J., Dawood, S., Cortes, J., Ward, J. H., Vaklavas, C., Forero, A., Ward, S. & Toppmeyer, D., Aug 1 2015, In : Seminars in oncology. 42, 4, p. e67-e79

Research output: Contribution to journalReview article

21 Citations (Scopus)

Targeting cancer stem cells in solid tumors by vitamin D

So, J. Y. & Suh, N., Jan 1 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 148, p. 79-85 7 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Stem cells
Vitamin D
Tumors
Neoplasms
8 Citations (Scopus)

Targeting HER2 Positive Breast Cancer with Chemopreventive Agents

Wahler, J. & Suh, N., Oct 1 2015, In : Current Pharmacology Reports. 1, 5, p. 324-335 12 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Pharmaceutical Preparations
Tumors
Animals
Therapeutics
114 Citations (Scopus)

The complexity of the Nrf2 pathway: Beyond the antioxidant response

Huang, Y., Li, W., Su, Z. Y. & Kong, A-N., Dec 1 2015, In : Journal of Nutritional Biochemistry. 26, 12, p. 1401-1413 13 p.

Research output: Contribution to journalReview article

NF-E2-Related Factor 2
Antioxidants
Phase II Metabolic Detoxication
Neurodegenerative diseases
Detoxification
9 Citations (Scopus)

The relationship of perioperative fluid administration to outcomes in colorectal and pancreatic surgery: A review of the literature

Eng, O. S., Melstrom, L. G. & Carpizo, D., Mar 1 2015, In : Journal of Surgical Oncology. 111, 4, p. 472-477 6 p.

Research output: Contribution to journalReview article

Colorectal Surgery
Hypovolemia
Perfusion
89 Citations (Scopus)

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance

Huh, W. K., Ault, K. A., Chelmow, D., Davey, D. D., Goulart, R. A., Garcia, F. A. R., Kinney, W. K., Massad, L. S., Mayeaux, E. J., Saslow, D., Schiffman, M., Wentzensen, N., Lawson, H. W. & Einstein, M., Feb 6 2015, In : Obstetrics and gynecology. 125, 2, p. 330-337 8 p.

Research output: Contribution to journalReview article

Early Detection of Cancer
Uterine Cervical Neoplasms
Colposcopy
United States Food and Drug Administration
Cell Biology
64 Citations (Scopus)

“Curcumin, the King of Spices”: Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases

Boyanapalli, S. S. S. & Kong, A-N., Apr 1 2015, In : Current Pharmacology Reports. 1, 2, p. 129-139 11 p.

Research output: Contribution to journalReview article

Spices
Curcumin
Epigenomics
Histone Acetyltransferases
Histone Deacetylases
2014
13 Citations (Scopus)

Defining the Role of Adjuvant Therapy: Ampullary and Duodenal Adenocarcinoma

Jabbour, S. & Mulvihill, D., Jan 1 2014, In : Seminars in Radiation Oncology. 24, 2, p. 85-93 9 p.

Research output: Contribution to journalReview article

Adenocarcinoma
Ampulla of Vater
Adjuvant Chemotherapy
Pancreatic Neoplasms
Duodenum
6 Citations (Scopus)
Squamous Cell Carcinoma
Skin
Radiation
Therapeutics
Sentinel Lymph Node Biopsy
13 Citations (Scopus)

Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress

Bekdash, R., Zhang, C. & Sarkar, D., Jan 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 9, p. 2323-2330 8 p.

Research output: Contribution to journalReview article

Pro-Opiomelanocortin
Fetal Development
Epigenomics
Alcohols
Neurons
4 Citations (Scopus)

Molecular and genetic epidemiology of cancer in low- and medium-income countries

Malhotra, J., Sep 1 2014, In : Annals of Global Health. 80, 5, p. 418-425 8 p.

Research output: Contribution to journalReview article

Molecular Epidemiology
Molecular Biology
Neoplasms
Carcinogens
Genetic Polymorphisms
3 Citations (Scopus)
Estrogen Receptors
Breast Neoplasms
Tamoxifen
Drug Therapy
Aromatase Inhibitors

Special issue on computational finance

Thulasiram, R. K. & Parashar, M., Jun 25 2014, In : Concurrency Computation Practice and Experience. 26, 9, p. 1607-1608 2 p.

Research output: Contribution to journalReview article

Computational Finance
Finance
Pricing
Currency
Parallel processing systems
19 Citations (Scopus)

Stratification of treatment intensity in relapsed pediatric Hodgkin lymphoma

Harker-Murray, P. D., Drachtman, R., Hodgson, D. C., Chauvenet, A. R., Kelly, K. M. & Cole, P., Apr 1 2014, In : Pediatric Blood and Cancer. 61, 4, p. 579-586 8 p.

Research output: Contribution to journalReview article

Hodgkin Disease
Hematopoietic Stem Cell Transplantation
Pediatrics
Drug Therapy
Radiotherapy
10 Citations (Scopus)

Technical aspects of radiation therapy for anal cancer

Scher, E. D., Ahmed, I., Yue, N. J. & Jabbour, S., Jan 1 2014, In : Journal of Gastrointestinal Oncology. 5, 3, p. 198-211 14 p.

Research output: Contribution to journalReview article

Anus Neoplasms
Radiotherapy
Combination Drug Therapy
Positron-Emission Tomography
Anatomy
2013
406 Citations (Scopus)

2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors

Massad, L. S., Einstein, M., Huh, W. K., Katki, H. A., Kinney, W. K., Schiffman, M., Solomon, D., Wentzensen, N. & Lawson, H. W., Apr 1 2013, In : Obstetrics and gynecology. 121, 4, p. 829-846 18 p.

Research output: Contribution to journalReview article

Early Detection of Cancer
Cervical Intraepithelial Neoplasia
Uterine Cervical Neoplasms
Guidelines
Neoplasms
30 Citations (Scopus)

Children's Oncology Group's 2013 blueprint for research: Hodgkin lymphoma

Kelly, K. M., Hodgson, D., Appel, B., Chen, L., Cole, P., Horton, T. & Keller, F. G., Jun 1 2013, In : Pediatric Blood and Cancer. 60, 6, p. 972-978 7 p.

Research output: Contribution to journalReview article

gemcitabine
Hodgkin Disease
Radiotherapy
Drug Therapy
Research
70 Citations (Scopus)

Comprehensive Control of Human Papillomavirus Infections and Related Diseases

Bosch, F. X., Broker, T. R., Forman, D., Moscicki, A. B., Gillison, M. L., Doorbar, J., Stern, P. L., Stanley, M., Arbyn, M., Poljak, M., Cuzick, J., Castle, P. E., Schiller, J. T., Markowitz, L. E., Fisher, W. A., Canfell, K., Denny, L. A., Franco, E. L., Steben, M., Kane, M. A. & 80 others, Schiffman, M., Meijer, C. J. L. M., Sankaranarayanan, R., Castellsagué, X., Kim, J. J., Brotons, M., Alemany, L., Albero, G., Diaz, M., Sanjosé, S. D., Anttila, A., Banks, L., Bergeron, C., Belinson, J. L., Berkhof, J., Bravo, I. G., Bray, F., Brotherton, J. M. L., Bruni, L., Burchell, A., Chaturvedi, A., Chesson, H., Chevarie-Davis, M., Cubie, H., Deeks, S. L., de Martel, C., de Sanjosé, S., Dillner, J., Einstein, M., Ferlay, J., Fiander, A., Franceschi, S., Garland, S. M., Giuliano, A. R., Goodman, M. T., Gravitt, P., Hampson, I. N., Heard, I., Iftner, T., Isidean, S. D., Jensen, C., Jeronimo, J., Kinney, W., Kitchener, H. C., Kjaer, S. K., Kocjan, B. J., Koliopoulos, G., Kulasingam, S. L., Lacey, C. J., Scott LaMontagne, D., Lazcano-Ponce, E., Lorincz, A. T., Lortet-Tieulent, J., Naucler, P., Ogilvie, G., Palefsky, J., Peto, J., Pinto, L. A., Plummer, M., Qiao, Y. L., Quint, W., Ronco, G., Schwartz, S., Serrano, B., Smith, J., Snijders, P. J. F., Soerjomataram, I., Steinberg, B. M., Stoler, M., Szarewski, A., Trimble, C., Tsu, V., van Damme, P., van der Burg, S. H., Vicari, A. S., Vignat, J., von Knebel Doeberitz, M., Vorsters, A., Wang, S. A. & Wittet, S., Nov 22 2013, In : Vaccine. 31, SUPPL.8, p. 11-131 121 p.

Research output: Contribution to journalReview article

Papillomavirus Infections
Papillomaviridae
infection
neoplasms
Uterine Cervical Neoplasms
137 Citations (Scopus)

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

Lee, J. H., Khor, T. O., Shu, L., Su, Z. Y., Fuentes, F. & Kong, A-N., Feb 1 2013, In : Pharmacology and Therapeutics. 137, 2, p. 153-171 19 p.

Research output: Contribution to journalReview article

Phytochemicals
Epigenomics
Cell Death
Chemoprevention
Neoplasms
29 Citations (Scopus)

Effects of Alcohol on the Endocrine System

Rachdaoui, N. & Sarkar, D., Sep 1 2013, In : Endocrinology and Metabolism Clinics of North America. 42, 3, p. 593-615 23 p.

Research output: Contribution to journalReview article

Endocrine System
Alcohols
Bone Neoplasms
Bone Diseases
Nervous System
18 Citations (Scopus)

Establishment of metabolism and transport pathways in the rodent and human fetal liver

Moscovitz, J. E. & Aleksunes, L., Dec 6 2013, In : International journal of molecular sciences. 14, 12, p. 23801-23827 27 p.

Research output: Contribution to journalReview article

rodents
metabolism
liver
Metabolism
Liver
7 Citations (Scopus)
Watchful Waiting
Neuroendocrine Tumors
Pancreatic Neoplasms
Pancreas
1 Citation (Scopus)

Gastric cancer: Past accomplishments, present approaches and future aspirations

Tunceroglu, A. & Jabbour, S., Jan 1 2013, In : Clinical Practice. 10, 1, p. 47-77 31 p.

Research output: Contribution to journalReview article

Stomach Neoplasms
Stomach
Epidemiology
Radiotherapy
Therapeutics
13 Citations (Scopus)

How can outcomes be improved for older patients with hodgkin lymphoma?

Evens, A. & Hong, F., Apr 20 2013, In : Journal of Clinical Oncology. 31, 12, p. 1502-1505 4 p.

Research output: Contribution to journalReview article

Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Vinblastine
Bleomycin
Hodgkin Disease
235 Citations (Scopus)

Human papillomavirus and cervical cancer

Crosbie, E. J., Einstein, M., Franceschi, S. & Kitchener, H. C., Jan 1 2013, In : The Lancet. 382, 9895, p. 889-899 11 p.

Research output: Contribution to journalReview article

Uterine Cervical Neoplasms
Human papillomavirus 16
Human papillomavirus 18
Papillomavirus Infections
Virion
16 Citations (Scopus)

Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma

Puszyk, W. M., Trinh, T. L., Chapple, S. J. & Liu, C., Sep 1 2013, In : Laboratory Investigation. 93, 9, p. 983-990 8 p.

Research output: Contribution to journalReview article

Epigenomics
Hepatocellular Carcinoma
Genetic Epigenesis
Liver
Biochemical Phenomena
82 Citations (Scopus)

Nanotechnology approaches for personalized treatment of multidrug resistant cancers

Minko, T., Rodriguez-Rust, L. & Pozharov, V., Nov 15 2013, In : Advanced Drug Delivery Reviews. 65, 13-14, p. 1880-1895 16 p.

Research output: Contribution to journalReview article

Nanotechnology
Pharmaceutical Preparations
Neoplasms
Precision Medicine
Multiple Drug Resistance
11 Citations (Scopus)

Targeting epigenetics for cancer prevention by dietary cancer preventive compounds-the case of miRNA

Kong, A-N., Zhang, C. & Su, Z. Y., Jan 1 2013, In : Cancer Prevention Research. 6, 7, p. 622-624 3 p.

Research output: Contribution to journalReview article

MicroRNAs
Epigenomics
Neoplasms
Phytochemicals
Grape Seed Extract
2012
20 Citations (Scopus)

ACR Appropriateness Criteria® Resectable Rectal Cancer

Jones, W. E., Thomas, C. R., Herman, J. M., Abdel-Wahab, M., Azad, N., Blackstock, W., Das, P., Goodman, K. A., Hong, T. S., Jabbour, S., Konski, A. A., Koong, A. C., Rodriguez-Bigas, M., Small, W., Zook, J. & Suh, W. W., Sep 24 2012, In : Radiation Oncology. 7, 1, 161.

Research output: Contribution to journalReview article

Rectal Neoplasms
Clinical Trials
oxaliplatin
Fluorouracil
Consensus
32 Citations (Scopus)

Active surveillance for prostate cancer: Past, present and future

Singer, E., Kaushal, A., Turkbey, B., Couvillon, A., Pinto, P. A. & Parnes, H. L., May 1 2012, In : Current opinion in oncology. 24, 3, p. 243-250 8 p.

Research output: Contribution to journalReview article

Prostatic Neoplasms
Therapeutics
Urinary Incontinence
Erectile Dysfunction
Prostate-Specific Antigen
9 Citations (Scopus)

Adjuvant therapy of gastrointestinal stromal tumors

Koshenkov, V. & Rodgers, S. E., Jul 1 2012, In : Current opinion in oncology. 24, 4, p. 414-418 5 p.

Research output: Contribution to journalReview article

Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
Recurrence
Mutation
Survival
94 Citations (Scopus)

Circadian nature of immune function

Logan, R. W. & Sarkar, D., Feb 5 2012, In : Molecular and Cellular Endocrinology. 349, 1, p. 82-90 9 p.

Research output: Contribution to journalReview article

Immune system
Clocks
Immune System
Autonomic Pathways
Pacemakers
75 Citations (Scopus)

MTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy

Gomez-Pinillos, A. & Ferrari, A., Jun 1 2012, In : Hematology/Oncology Clinics of North America. 26, 3, p. 483-505 23 p.

Research output: Contribution to journalReview article

Sirolimus
Neoplasms
Phosphatidylinositol 3-Kinases
Therapeutics
Protein-Serine-Threonine Kinases
19 Citations (Scopus)

Pancreatic neuroendocrine tumors: Entering a new era

Oberstein, P. E., Remotti, H., Saif, M. W. & Libutti, S., Mar 26 2012, In : Journal of the Pancreas. 13, 2, p. 169-173 5 p.

Research output: Contribution to journalReview article

Neuroendocrine Tumors
Neoplasms
Biomarkers
Therapeutics
Gastrointestinal Neoplasms
27 Citations (Scopus)

Regulation of cancer progression by β-endorphin neuron

Sarkar, D., Murugan, S., Zhang, C. & Boyadjieva, N., Feb 15 2012, In : Cancer Research. 72, 4, p. 836-840 5 p.

Research output: Contribution to journalReview article

Endorphins
Neurons
Neoplasms
Cytokines
Endocrine System
8 Citations (Scopus)

Special section on autonomic cloud computing: Technologies, services, and applications

Ranjan, R., Buyya, R. & Parashar, M., Jun 25 2012, In : Concurrency Computation Practice and Experience. 24, 9, p. 935-937 3 p.

Research output: Contribution to journalReview article

Autonomic Computing
Cloud computing
Cloud Computing
Quality of service
Decomposition
7 Citations (Scopus)

Strawberry fields forever?

Suh, N. & Pezzuto, J. M., Jan 1 2012, In : Cancer Prevention Research. 5, 1, p. 30-33 4 p.

Research output: Contribution to journalReview article

Fragaria
Powders
Fruit
Vitis
Esophageal Neoplasms
544 Citations (Scopus)

The prevention and treatment of missing data in clinical trials

Little, R. J., D'Agostino, R., Cohen, M. L., Dickersin, K., Emerson, S. S., Farrar, J. T., Frangakis, C., Hogan, J. W., Molenberghs, G., Murphy, S. A., Neaton, J. D., Rotnitzky, A., Scharfstein, D., Shih, W., Siegel, J. P. & Stern, H., Oct 4 2012, In : New England Journal of Medicine. 367, 14, p. 1355-1360 6 p.

Research output: Contribution to journalReview article

90 Citations (Scopus)

Therapy of human papillomavirus-related disease

Stern, P. L., van der Burg, S. H., Hampson, I. N., Broker, T. R., Fiander, A., Lacey, C. J., Kitchener, H. C. & Einstein, M., Jan 1 2012, In : Vaccine. 30, SUPPL.5

Research output: Contribution to journalReview article

Papillomaviridae
therapeutics
neoplasms
uterine cervical neoplasms
Neoplasms
23 Citations (Scopus)

What is the best criterion for the interpretation of adrenal vein sample results in patients with primary hyperaldosteronism?

Webb, R., Mathur, A., Chang, R., Baid, S., Nilubol, N., Libutti, S., Stratakis, C. A. & Kebebew, E., Jun 1 2012, In : Annals of Surgical Oncology. 19, 6, p. 1881-1886 6 p.

Research output: Contribution to journalReview article

Hyperaldosteronism
Veins
Hydrocortisone
Aldosterone
Adrenalectomy