Clinical Investigations and Precision Therapeutics Program, CINJ

Research Output 1976 2019

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Review article
2006
191 Citations (Scopus)

Display technologies: Application for the discovery of drug and gene delivery agents

Sergeeva, A., Kolonin, M. G., Molldrem, J. J., Pasqualini, R. & Arap, W., Dec 30 2006, In : Advanced Drug Delivery Reviews. 58, 15, p. 1622-1654 33 p.

Research output: Contribution to journalReview article

Genetic Association Studies
Drug Discovery
Technology
Proteome
Bacteriophages
6 Citations (Scopus)

Ethical issues in palliative care

Demme, R. A., Singer, E., Greenlaw, J. & Quill, T. E., Mar 1 2006, In : Anesthesiology Clinics of North America. 24, 1, p. 129-144 16 p.

Research output: Contribution to journalReview article

Palliative Care
Ethics
Double Effect Principle
Perioperative Care
Hypnotics and Sedatives
66 Citations (Scopus)

Modulation of metabolic enzymes by dietary phytochemicals: A review of mechanisms underlying beneficial versus unfavorable effects

Mandlekar, S., Hong, J. L. & Kong, A-N., Aug 1 2006, In : Current Drug Metabolism. 7, 6, p. 661-675 15 p.

Research output: Contribution to journalReview article

Phytochemicals
Modulation
Toxicity
NF-E2 Transcription Factor
Enzymes
271 Citations (Scopus)

Nrf2: A potential molecular target for cancer chemoprevention by natural compounds

Jeong, W. S., Jun, M. & Kong, A-N., Jan 1 2006, In : Antioxidants and Redox Signaling. 8, 1-2, p. 99-106 8 p.

Research output: Contribution to journalReview article

Antioxidant Response Elements
Chemoprevention
Neoplasms
Gene expression
Antioxidants
61 Citations (Scopus)

Reduced-dose rasburicase (recombinant xanthine oxidase) in adult cancer patients with hyperuricemia

Trifilio, S., Gordon, L., Singhal, S., Tallman, M., Evens, A., Rashid, K., Fishman, M., Masino, K., Pi, J. & Mehta, J., Jun 1 2006, In : Bone Marrow Transplantation. 37, 11, p. 997-1001 5 p.

Research output: Contribution to journalReview article

Hyperuricemia
Xanthine Oxidase
Uric Acid
Neoplasms
rasburicase
144 Citations (Scopus)

T-cell non-Hodgkin lymphoma

Rizvi, M. A., Evens, A., Tallman, M. S., Nelson, B. P. & Rosen, S. T., Feb 15 2006, In : Blood. 107, 4, p. 1255-1264 10 p.

Research output: Contribution to journalReview article

T-cells
T-Cell Lymphoma
Non-Hodgkin's Lymphoma
Peripheral T-Cell Lymphoma
Genetic Translocation
26 Citations (Scopus)

Toxicogenomics in drug discovery and drug development: Potential applications and future challenges

Khor, T. O., Ibrahim, S. & Kong, A-N., Aug 1 2006, In : Pharmaceutical research. 23, 8, p. 1659-1664 6 p.

Research output: Contribution to journalReview article

Toxicogenetics
Drug Discovery
Pharmaceutical Preparations
Drug Approval
Poisons
112 Citations (Scopus)

Vascular targeting: Recent advances and therapeutic perspectives

Hajitou, A., Pasqualini, R. & Arap, W., Apr 1 2006, In : Trends in Cardiovascular Medicine. 16, 3, p. 80-88 9 p.

Research output: Contribution to journalReview article

Blood Vessels
Ligands
Bacteriophages
Endothelium
Neoplasms
2005
8 Citations (Scopus)

Antimetabolites: A new perspective

Cole, P., Zebala, J. A. & Kamen, B. A., Jan 1 2005, In : Drug Discovery Today: Therapeutic Strategies. 2, 4, p. 337-342 6 p.

Research output: Contribution to journalReview article

Antimetabolites
Folic Acid Antagonists
Metabolomics
Nucleosides
Biochemistry
68 Citations (Scopus)

Chemopreventive functions of isothiocyanates

Keum, Y. S., Jeong, W. S. & Kong, A-N., Sep 1 2005, In : Drug News and Perspectives. 18, 7, p. 445-451 7 p.

Research output: Contribution to journalReview article

Isothiocyanates
Glucosinolates
Phase II Metabolic Detoxication
Transcription Factor AP-1
Vegetables
11 Citations (Scopus)

Clinical characteristics of erythropoietin-associated pure red cell aplasia

Carson, K. R., Evens, A., Bennett, C. L. & Lumina, S., Jan 1 2005, In : Best Practice and Research: Clinical Haematology. 18, 3 SPEC. ISS., p. 467-472 6 p.

Research output: Contribution to journalReview article

Pure Red-Cell Aplasia
Erythropoietin
Cells
Immunosuppressive Agents
Neutralizing Antibodies
60 Citations (Scopus)

Deception detection through automatic, unobtrusive analysis of nonverbal behavior

Meservy, T. O., Jensen, M. L., Kruse, J., Burgoon, J. K., Nunamaker, J. F., Twitchell, D. P., Tsechpenakis, G. & Metaxas, D., Sep 1 2005, In : IEEE Intelligent Systems. 20, 5, p. 36-43 8 p.

Research output: Contribution to journalReview article

192 Citations (Scopus)

Dietary cancer-chemopreventive compounds: From signaling and gene expression to pharmacological effects

Chen, C. & Kong, A-N., Jun 1 2005, In : Trends in Pharmacological Sciences. 26, 6, p. 318-326 9 p.

Research output: Contribution to journalReview article

Gene expression
Pharmacology
Environmental Carcinogens
Gene Expression
Cell death
17 Citations (Scopus)

Epoetin-induced pure red-cell aplasia (PRCA): Preliminary results from the research on adverse drug events and reports (RADAR) group

Evens, A., Bennett, C. L. & Luminari, S., Jan 1 2005, In : Best Practice and Research: Clinical Haematology. 18, 3 SPEC. ISS., p. 481-489 9 p.

Research output: Contribution to journalReview article

Pure Red-Cell Aplasia
Epoetin Alfa
Erythropoietin
Drug-Related Side Effects and Adverse Reactions
Cells
46 Citations (Scopus)

Ethics guidelines for research with the recently dead

Pentz, R. D., Cohen, C. B., Wicclair, M., DeVita, M. A., Flamm, A. L., Youngner, S. J., Hamric, A. B., McCabe, M. S., Glover, J. J., Kittiko, W. J., Kinlaw, K., Keller, J., Asch, A., Kavanagh, J. J. & Arap, W., Nov 1 2005, In : Nature medicine. 11, 11, p. 1145-1149 5 p.

Research output: Contribution to journalReview article

Research Ethics
Guidelines
Tissue and Organ Procurement
Research
Consensus
742 Citations (Scopus)

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Xu, C., Li, C. Y. T. & Kong, A-N., Mar 31 2005, In : Archives of Pharmacal Research. 28, 3, p. 249-268 20 p.

Research output: Contribution to journalReview article

Xenobiotics
Metabolism
Genes
Cholesterol 7-alpha-Hydroxylase
Orphan Nuclear Receptors
79 Citations (Scopus)

Regulation of Nrf2, NF-κB, and AP-1 signaling pathways by chemopreventive agents

Shen, G., Jeong, W. S., Hu, R. & Kong, A-N., Nov 1 2005, In : Antioxidants and Redox Signaling. 7, 11-12, p. 1648-1663 16 p.

Research output: Contribution to journalReview article

NF-E2-Related Factor 2
Transcription Factor AP-1
Phytochemicals
Chemoprevention
Cell signaling
111 Citations (Scopus)

Spare the rod and spoil the eye

Arden, G. B., Sidman, R. L., Arap, W. & Schlingemann, R. O., Jun 1 2005, In : British Journal of Ophthalmology. 89, 6, p. 764-769 6 p.

Research output: Contribution to journalReview article

Dark Adaptation
Retinal Diseases
Retinopathy of Prematurity
Eye Diseases
Macular Degeneration
29 Citations (Scopus)

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Hochhauser, C. J., Lewis, M., Kamen, B. A. & Cole, P., Dec 1 2005, In : Supportive Care in Cancer. 13, 12, p. 967-974 8 p.

Research output: Contribution to journalReview article

Child Behavior
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Steroids
Folic Acid Antagonists
Leukemia
16 Citations (Scopus)

TGF-β3 increases gap-junctional communication among folliculostellate cells to release bFGF

Kabir, N., Chaturvedi, K., Lian, S. L. & Sarkar, D., Sep 1 2005, In : Endocrinology. 146, 9, p. 4054-4060 7 p.

Research output: Contribution to journalReview article

Fibroblast Growth Factor 2
Transforming Growth Factor beta
Gap Junctions
Coloring Agents
Octanols
16 Citations (Scopus)

Volumetric heart modelling and analysis

Park, K., Montillo, A., Metaxas, D. & Axel, L., Feb 1 2005, In : Communications of the ACM. 48, 2, p. 43-48 6 p.

Research output: Contribution to journalReview article

Image analysis
Muscle
Magnetization
Image processing
Modulation
2004
28 Citations (Scopus)

Analyzing Excessive No Changes in Clinical Trials with Clustered Data

Lu, S-E., Lin, Y. & Shih, W., Mar 1 2004, In : Biometrics. 60, 1, p. 257-267 11 p.

Research output: Contribution to journalReview article

Clustered Data
Clinical Trials
clinical trials
Bone
Medicine
24 Citations (Scopus)

Anogenital neoplasia in AIDS

Einstein, M. & Kadish, A. S., Sep 1 2004, In : Current opinion in oncology. 16, 5, p. 455-462 8 p.

Research output: Contribution to journalReview article

Acquired Immunodeficiency Syndrome
Neoplasms
Human papillomavirus 16
Cellular Immunity
Serology
2 Citations (Scopus)

Application of expression genomics in drug development and genomic medicine

Chin, K. V., Selvanayagam, Z. E., Vittal, R., Kita, T., Kudoh, K., Yang, C., Wong, Y. F., Cheung, T. H., Yeo, W., Chung, T. K. H., Lin, Y., Liao, J., Shih, W., Yap, S. F. & Lin, A. W., Jun 1 2004, In : Drug Development Research. 62, 2, p. 124-133 10 p.

Research output: Contribution to journalReview article

Genomics
Medicine
Genome
Pharmaceutical Preparations
Databases
37 Citations (Scopus)

Biological properties of monomeric and polymeric catechins: Green tea catechins and procyanidins

Jeong, W. S. & Kong, A-N., Dec 1 2004, In : Pharmaceutical Biology. 42, SUPPL., p. 84-93 10 p.

Research output: Contribution to journalReview article

Proanthocyanidins
Catechin
Tea
Wine
Signal Transduction
216 Citations (Scopus)

Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms

Keum, Y. S., Jeong, W. S. & Kong, A-N., Nov 2 2004, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 555, 1-2 SPEC. ISS., p. 191-202 12 p.

Research output: Contribution to journalReview article

Isothiocyanates
Chemoprevention
Vegetables
Carcinogenesis
Glucosinolates
21 Citations (Scopus)

Conservative management of breast cancer in BRCA1/2 mutation carriers

Alpert, T. E. & Haffty, B., Jan 1 2004, In : Clinical Breast Cancer. 5, 1, p. 37-42 6 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Mutation
Second Primary Neoplasms
Germ-Line Mutation
Neoplasm Genes
207 Citations (Scopus)

Dietary chemopreventive compounds and ARE/EpRE signaling

Chen, C. & Kong, A-N., Jun 15 2004, In : Free Radical Biology and Medicine. 36, 12, p. 1505-1516 12 p.

Research output: Contribution to journalReview article

Antioxidant Response Elements
NF-E2-Related Factor 2
Enzymes
Chemoprevention
Carcinogenesis
267 Citations (Scopus)

Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis

Karban, A. S., Okazaki, T., Panhuysen, C. I. M., Gallegos, T., Potter, J. J., Bailey-Wilson, J. E., Silverberg, M. S., Duerr, R. H., Cho, J. H., Gregersen, P. K., Wu, Y., Achkar, J. P., Dassopoulos, T., Mezey, E., Bayless, T. M., Nouvet, F. J. & Brant, S., Jan 1 2004, In : Human molecular genetics. 13, 1, p. 35-45 11 p.

Research output: Contribution to journalReview article

Ulcerative Colitis
Inflammatory Bowel Diseases
Pedigree
Alleles
Exons
7 Citations (Scopus)

Potential of gene therapy for the treatment of pituitary tumors

Goya, R. G., Sarkar, D., Brown, O. A. & Hereñú, C. B., Mar 1 2004, In : Current Gene Therapy. 4, 1, p. 79-87 9 p.

Research output: Contribution to journalReview article

Pituitary Neoplasms
Genetic Therapy
Prolactinoma
Transgenic Suicide Genes
Therapeutics
34 Citations (Scopus)

Treatment of T-cell non-Hodgkin's lymphoma

Evens, A. & Gartenhaus, R. B., Jan 1 2004, In : Current treatment options in oncology. 5, 4, p. 289-303 15 p.

Research output: Contribution to journalReview article

T-Cell Lymphoma
Non-Hodgkin's Lymphoma
Natural Killer T-Cells
Therapeutics
B-Cell Lymphoma
2003
5 Citations (Scopus)

Characterization of time-varying properties and regional strains in myocardial ischemia

Liao, J., Li, J. & Metaxas, D., Sep 1 2003, In : Cardiovascular Engineering. 3, 3, p. 109-116 8 p.

Research output: Contribution to journalReview article

Myocardial Ischemia
Myocardium
Mechanics
Endocardium
Diagnostic Imaging
5 Citations (Scopus)

Controlling type I error rate for fast track drug development programmes

Shih, W., Ouyang, P., Quan, H., Lin, Y., Michiels, B. & Bijnens, L., Mar 15 2003, In : Statistics in Medicine. 22, 5, p. 665-675 11 p.

Research output: Contribution to journalReview article

Type I Error Rate
Drugs
Pharmaceutical Preparations
United States Food and Drug Administration
Type I error
176 Citations (Scopus)

Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research

Choy, G., Choyke, P. & Libutti, S., Oct 1 2003, In : Molecular Imaging. 2, 4, p. 303-312 10 p.

Research output: Contribution to journalReview article

Molecular imaging
Molecular Imaging
Optical Imaging
Imaging techniques
Research
213 Citations (Scopus)

Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells

Chen, C., Shen, G., Hebbar, V., Hu, R., Owuor, E. D. & Kong, A-N., Aug 1 2003, In : Carcinogenesis. 24, 8, p. 1369-1378 10 p.

Research output: Contribution to journalReview article

Colon
Adenocarcinoma
JNK Mitogen-Activated Protein Kinases
HT29 Cells
Cytochromes c
13 Citations (Scopus)

Molecular etiology of mature T-cell non-Hodgkins lymphomas

Evens, A. & Gartenhaus, R. B., Dec 1 2003, In : Frontiers in Bioscience. 8

Research output: Contribution to journalReview article

T-cells
T-Cell Lymphoma
Non-Hodgkin's Lymphoma
Chromosome Aberrations
Cyclin-Dependent Kinase Inhibitor p15
170 Citations (Scopus)

Optical Systems for In Vivo Molecular Imaging of Cancer

Sokolov, K., Aaron, J., Hsu, B., Nida, D., Gillenwater, A., Follen, M., MacAulay, C., Adler-Storthz, K., Korgel, B., Descour, M., Pasqualini, R., Arap, W., Lam, W. & Richards-Kortum, R., Jan 1 2003, In : Technology in Cancer Research and Treatment. 2, 6, p. 491-504 14 p.

Research output: Contribution to journalReview article

Optical Devices
Molecular Imaging
Neoplasms
Contrast Media
Papillomavirus Infections
25 Citations (Scopus)

Revisiting ethical guidelines for research with terminal wean and brain-dead participants

Pentz, R. D., Flamm, A. L., Pasqualini, R., Logothetis, C. J. & Arap, W., Jan 1 2003, In : Hastings Center Report. 33, 1, p. 20-26 7 p.

Research output: Contribution to journalReview article

Brain Death
brain
Guidelines
Research
Ethicists
141 Citations (Scopus)

The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells

Langenfeld, E. M., Calvano, S. E., Abou-Nukta, F., Lowry, S. F., Amenta, P. & Langenfeld, J., Sep 1 2003, In : Carcinogenesis. 24, 9, p. 1445-1454 10 p.

Research output: Contribution to journalReview article

Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 2
Non-Small Cell Lung Carcinoma
Growth
Neoplasms
2002
48 Citations (Scopus)

Algorithmic issues in modeling motion

Agarwal, P. K., Guibas, L. J., Edelsbrunner, H., Erickson, J., Isard, M., Har-Peled, S., Hershberger, J., Jensen, C., Kavraki, L., Koehl, P., Lin, M., Manocha, D., Metaxas, D., Mirtich, B., Mount, D., Muthukrishnan, S., Pai, D., Sacks, E., Snoeyink, J., Suri, S. & 1 others, Wolefson, O., Dec 1 2002, In : ACM Computing Surveys. 34, 4, p. 550-572 23 p.

Research output: Contribution to journalReview article

Data structures
Motion
Modeling
Algorithms and Data Structures
Review
51 Citations (Scopus)

Application of DNA microarrays in pharmacogenomics and toxicogenomics

Chin, K. V. & Kong, A-N., Dec 1 2002, In : Pharmaceutical research. 19, 12, p. 1773-1778 6 p.

Research output: Contribution to journalReview article

Toxicogenetics
Pharmacogenetics
Xenobiotics
Microarrays
Oligonucleotide Array Sequence Analysis
11 Citations (Scopus)
Recombinant Fusion Proteins
Thyroid Hormone Receptors
Trans-Activators
Gene Expression Regulation
Nuclear Proteins
172 Citations (Scopus)

In vivo phage display and vascular heterogeneity: Implications for targeted medicine

Trepel, M., Arap, W. & Pasqualini, R., Jun 1 2002, In : Current Opinion in Chemical Biology. 6, 3, p. 399-404 6 p.

Research output: Contribution to journalReview article

Bacteriophages
Medicine
Blood Vessels
Peptide Library
Display devices
343 Citations (Scopus)

Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes

Rushmore, T. H. & Kong, A-N., Oct 1 2002, In : Current Drug Metabolism. 3, 5, p. 481-490 10 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Xenobiotics
Gene expression
Genes
Enzymes
97 Citations (Scopus)
Clinical Trials
Therapeutics
2001
273 Citations (Scopus)

Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)

Kong, A-N., Owuor, E., Yu, R., Hebbar, V., Chen, C., Hu, R. & Mandlekar, S., Dec 24 2001, In : Drug Metabolism Reviews. 33, 3-4, p. 255-271 17 p.

Research output: Contribution to journalReview article

Antioxidant Response Elements
Enzyme Induction
Butylated Hydroxyanisole
Xenobiotics
Phosphotransferases
7 Citations (Scopus)

Signal transduction events elicited by natural products that function as cancer chemopreventive agents

Primiano, T., Yu, R. & Kong, A-N., Oct 1 2001, In : Pharmaceutical Biology. 39, 2, p. 83-107 25 p.

Research output: Contribution to journalReview article

Biological Products
Signal Transduction
Chemoprevention
Neoplasms
Isothiocyanates
112 Citations (Scopus)

Viscoelasticity of the vessel wall: The role of collagen and elastic fibers

Silver, F., Horvath, I. & Foran, D., Dec 1 2001, In : Critical reviews in biomedical engineering. 29, 3, p. 279-301 23 p.

Research output: Contribution to journalReview article

Viscoelasticity
Collagen
Fibers
Tendons
Tissue
2000
3 Citations (Scopus)

High-dose methotrexate is lethal to rats. Why give it to children?

Cole, P. & Kamen, B. A., Jan 1 2000, In : Pediatric Hematology and Oncology. 17, 8, p. 609-613 5 p.

Research output: Contribution to journalReview article

Chemotherapy
Methotrexate
Rats
Drug Therapy
Rat
113 Citations (Scopus)

Progress in antiangiogenic gene therapy of cancer

Feldman, A. L. & Libutti, S., Sep 15 2000, In : Cancer. 89, 6, p. 1181-1194 14 p.

Research output: Contribution to journalReview article

Genetic Therapy
Angiogenesis Inhibitors
Neoplasms
National Library of Medicine (U.S.)
Proteins