Genomic Instability and Cancer Genetics Program, CINJ

Research Output 1974 2019

Filter
Review article
2019
4 Citations (Scopus)

Cystinuria: genetic aspects, mouse models, and a new approach to therapy

Sahota, A., Tischfield, J., Goldfarb, D. S., Ward, M. D. & Hu, L., Feb 5 2019, In : Urolithiasis. 47, 1, p. 57-66 10 p.

Research output: Contribution to journalReview article

Cystinuria
Cystine
Therapeutics
Crystallization
Diamide

Leukemia’s Clonal Evolution in Development, Progression, and Relapse

Loh, J. W. & Khiabanian, H., Jun 15 2019, In : Current Stem Cell Reports. 5, 2, p. 73-81 9 p.

Research output: Contribution to journalReview article

Clonal Evolution
Leukemia
Hematopoietic Stem Cells
Recurrence
Theoretical Models
2 Citations (Scopus)

Tumor suppressor p53 and metabolism

Liu, J., Zhang, C., Hu, W. & Feng, Z., Jan 1 2019, In : Journal of Molecular Cell Biology. 11, 4, p. 284-292 9 p.

Research output: Contribution to journalReview article

Open Access
Neoplasms
Cell Aging
Mutant Proteins
Metabolic Networks and Pathways
Cell Cycle Checkpoints
2018
4 Citations (Scopus)

Biomanufacturing for clinically advanced cell therapies

Aijaz, A., Li, M., Smith, D., Khong, D., Leblon, C., Fenton, O. S., Olabisi, R., Libutti, S., Tischfield, J., Maus, M. V., Deans, R., Barcia, R. N., Anderson, D. G., Ritz, J., Preti, R. & Parekkadan, B., Jun 1 2018, In : Nature Biomedical Engineering. 2, 6, p. 362-376 15 p.

Research output: Contribution to journalReview article

Transplants
T-cells
Antigens
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
27 Citations (Scopus)

How cells ensure correct repair of DNA double-strand breaks

Her, J. & Bunting, S., Jan 1 2018, In : Journal of Biological Chemistry. 293, 27, p. 10502-10511 10 p.

Research output: Contribution to journalReview article

Double-Stranded DNA Breaks
Repair
Homologous Recombination
Joining
DNA
2 Citations (Scopus)

Parkinson's disease-associated protein Parkin: An unusual player in cancer

Liu, J., Zhang, C., Hu, W. & Feng, Z., Jun 26 2018, In : Cancer Communications. 38, 1, 40.

Research output: Contribution to journalReview article

Mitochondrial Degradation
Ubiquitin-Protein Ligases
Parkinson Disease
Neoplasms
Cell Cycle
2017
52 Citations (Scopus)

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

Yue, X., Zhao, Y., Xu, Y., Zheng, M., Feng, Z. & Hu, W., Jun 2 2017, In : Journal of molecular biology. 429, 11, p. 1595-1606 12 p.

Research output: Contribution to journalReview article

Mutant Proteins
Neoplasms
Therapeutics
Mutation
Missense Mutation

Prevalence and penetrance of Li-Fraumeni cancer predisposition syndrome

Chan, C., Feb 1 2017, In : Current Opinion in Systems Biology. 1, p. 48-53 6 p.

Research output: Contribution to journalReview article

Penetrance
Li-Fraumeni Syndrome
Cancer
Germ-Line Mutation
Genes
75 Citations (Scopus)

RNA-Seq methods for transcriptome analysis

Hrdlickova, R., Toloue, M. & Tian, B., Jan 1 2017, In : Wiley Interdisciplinary Reviews: RNA. 8, 1, e1364.

Research output: Contribution to journalReview article

Gene Expression Profiling
RNA
Gene expression
Single-Cell Analysis
RNA Sequence Analysis
7 Citations (Scopus)

Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation

Nguyen, A. L. & Schindler, K., May 1 2017, In : Trends in Genetics. 33, 5, p. 349-363 15 p.

Research output: Contribution to journalReview article

Aurora Kinases
Meiosis
Oocytes
Protein Isoforms
Mitosis
10 Citations (Scopus)

Transcriptional and post-transcriptional mechanisms of the development of neocortical lamination

Popovitchenko, T. & Rasin, M-R., Nov 9 2017, In : Frontiers in Neuroanatomy. 11, 102.

Research output: Contribution to journalReview article

Neurons
Stem Cells
RNA-Binding Proteins
Long-Term Memory
Pyramidal Cells
2016
158 Citations (Scopus)

Alternative polyadenylation of mRNA precursors

Tian, B. & Manley, J. L., Dec 19 2016, In : Nature Reviews Molecular Cell Biology. 18, 1, p. 18-30 13 p.

Research output: Contribution to journalReview article

Polyadenylation
RNA Precursors
Messenger RNA
Organ Specificity
RNA-Binding Proteins
5 Citations (Scopus)

Functional evaluations of genes disrupted in patients with Tourette's disorder

Sun, N., Tischfield, J., King, R. A. & Heiman, G., Feb 9 2016, In : Frontiers in Psychiatry. 7, FEB, 11.

Research output: Contribution to journalReview article

Tourette Syndrome
Genes
Animal Models
Inborn Genetic Diseases
Genetically Modified Animals
14 Citations (Scopus)

Protein function in precision medicine: deep understanding with machine learning

Rost, B., Radivojac, P. & Bromberg, Y., Aug 1 2016, In : FEBS Letters. p. 2327-2341 15 p.

Research output: Contribution to journalReview article

Precision Medicine
Medicine
Learning systems
Medical History Taking
Protein Interaction Maps
6 Citations (Scopus)

The value of FDG-PET in the staging of gastric adenocarcinoma: A single institution retrospective review

Serrano, O. K., Love, C., Goldman, I., Huang, K., Ng, N., Abraham, T., Da Silva, R., Friedmann, P., Libutti, S. & Kennedy, T., May 1 2016, In : Journal of Surgical Oncology. 113, 6, p. 640-646 7 p.

Research output: Contribution to journalReview article

Stomach
Adenocarcinoma
Lymph Nodes
Neoplasms
Neoplasm Metastasis
2015
169 Citations (Scopus)

Autophagy, Metabolism, and Cancer

White, E., Mehnert, J. & Chan, C., Nov 15 2015, In : Clinical Cancer Research. 21, 22, p. 5037-5046 10 p.

Research output: Contribution to journalReview article

Autophagy
Neoplasms
Starvation
Organelles
Recycling
2014
9 Citations (Scopus)

Epigenetic diversity in hematopoietic neoplasms

Shaknovich, R., De, S. & Michor, F., Dec 1 2014, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1846, 2, p. 477-484 8 p.

Research output: Contribution to journalReview article

Hematologic Neoplasms
Epigenomics
DNA Methylation
Neoplasms
Histone Code
1 Citation (Scopus)

Fluorescent methods to study transcription initiation and transition into elongation.

Deshpande, A. P., Sultana, S. & Patel, S., Jan 1 2014, In : EXS. 105, p. 105-130 26 p.

Research output: Contribution to journalReview article

Bacteriophage T7
DNA
Fluorescence Spectrometry
DNA-Directed RNA Polymerases
Transcription Factors
17 Citations (Scopus)

Health risks of space exploration: Targeted and nontargeted oxidative injury by high-charge and high-energy particles

Li, M., Gonon, G., Buonanno, M., Autsavapromporn, N., De Toledo, S. M., Pain, D. & Azzam, E., Mar 20 2014, In : Antioxidants and Redox Signaling. 20, 9, p. 1501-1523 23 p.

Research output: Contribution to journalReview article

Cosmic Radiation
Space Flight
Health risks
Radiation
Health
48 Citations (Scopus)

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

Rossiello, F., Herbig, U., Longhese, M. P., Fumagalli, M. & d'Adda di Fagagna, F., Jan 1 2014, In : Current Opinion in Genetics and Development. 26, p. 89-95 7 p.

Research output: Contribution to journalReview article

Cell Aging
DNA Damage
Telomere
Mammals
DNA Replication
30 Citations (Scopus)

The replicometer is broken: Telomeres activate cellular senescence in response to genotoxic stresses

Suram, A. & Herbig, U., Oct 1 2014, In : Aging cell. 13, 5, p. 780-786 7 p.

Research output: Contribution to journalReview article

Cell Aging
Telomere
DNA Damage
Cell Cycle
Cell Division
2013
25 Citations (Scopus)

Chromatin structure, pluripotency and differentiation

Serrano De La Pena, L., Vazquez Prat, B. N. & Tischfield, J., Mar 1 2013, In : Experimental Biology and Medicine. 238, 3, p. 259-270 12 p.

Research output: Contribution to journalReview article

Stem cells
Chromatin
Gene expression
Genes
Induced Pluripotent Stem Cells
185 Citations (Scopus)

End-joining, translocations and cancer

Bunting, S. & Nussenzweig, A., Jul 1 2013, In : Nature Reviews Cancer. 13, 7, p. 443-454 12 p.

Research output: Contribution to journalReview article

Gene Fusion
Neoplasms
Chromosomes
Growth
7 Citations (Scopus)
Watchful Waiting
Neuroendocrine Tumors
Pancreatic Neoplasms
Pancreas
42 Citations (Scopus)

News from the protein mutability landscape

Hecht, M., Bromberg, Y. & Rost, B., Nov 1 2013, In : Journal of molecular biology. 425, 21, p. 3937-3948 12 p.

Research output: Contribution to journalReview article

Mutation
Proteins
High-Throughput Nucleotide Sequencing
Explosions
Protein Stability
2012

[The primary intestinal granulocytic sarcoma patient: two case reports and literature review].

Xia, B., Guo, Q. & Zhao, W. P., Oct 1 2012, In : Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 33, 10, p. 869-871 3 p.

Research output: Contribution to journalReview article

Myeloid Sarcoma
Intestinal Neoplasms
Primary granulocytic sarcoma
19 Citations (Scopus)

Pancreatic neuroendocrine tumors: Entering a new era

Oberstein, P. E., Remotti, H., Saif, M. W. & Libutti, S., Mar 26 2012, In : Journal of the Pancreas. 13, 2, p. 169-173 5 p.

Research output: Contribution to journalReview article

Neuroendocrine Tumors
Neoplasms
Biomarkers
Therapeutics
Gastrointestinal Neoplasms
100 Citations (Scopus)

Signals for pre-mRNA cleavage and polyadenylation

Tian, B. & Graber, J. H., May 1 2012, In : Wiley Interdisciplinary Reviews: RNA. 3, 3, p. 385-396 12 p.

Research output: Contribution to journalReview article

Polyadenylation
RNA Precursors
Eukaryota
Messenger RNA
Bioinformatics
2011
48 Citations (Scopus)

Dynamic coupling between the motors of DNA replication: Hexameric helicase, DNA polymerase, and primase

Patel, S., Pandey, M. & Nandakumar, D., Oct 1 2011, In : Current Opinion in Chemical Biology. 15, 5, p. 595-605 11 p.

Research output: Contribution to journalReview article

Molecular Motor Proteins
Nucleoside-Triphosphatase
DNA Primase
Single-Stranded DNA
DNA-Directed DNA Polymerase
2010
123 Citations (Scopus)

PALB2/FANCN: Recombining cancer and fanconi anemia

Tischkowitz, M. & Xia, B., Oct 1 2010, In : Cancer Research. 70, 19, p. 7353-7359 7 p.

Research output: Contribution to journalReview article

Fanconi Anemia
BRCA2 Protein
Breast Neoplasms
Mutation
Pancreatic Neoplasms
150 Citations (Scopus)

The origins and evolution of the p53 family of genes.

Belyi, V. A., Ak, P., Markert, E., Wang, H., Hu, W., Puzio-Kuter, A. & Levine, A. J., Jan 1 2010, In : Cold Spring Harbor Perspectives in Biology. 2, 6

Research output: Contribution to journalReview article

p53 Genes
Genes
Fishes
Sea Anemones
Genomic Instability
2009

Application of proteomic techniques to human tissues

Richardson, A. M., Rodriguez-Canales, J., Gannot, G., Libutti, S., Chuaqui, R. F. & Tangrea, M. A., Dec 4 2009, In : Journal of Organ Dysfunction. 5, 2, p. 110-118 9 p.

Research output: Contribution to journalReview article

Proteomics
Technology
Mass Spectrometry
Tissue Preservation
Protein Array Analysis
18 Citations (Scopus)

Cytological analysis of meiosis in fixed Drosophila ovaries.

McKim, K., Joyce, E. F. & Jang, J. K., Jan 1 2009, In : Methods in molecular biology (Clifton, N.J.). 558, p. 197-216 20 p.

Research output: Contribution to journalReview article

Meiosis
Drosophila
Ovary
Pachytene Stage
Metaphase
2008
59 Citations (Scopus)

p53: A new player in reproduction

Hu, W., Feng, Z., Atwal, G. S. & Levine, A. J., Apr 1 2008, In : Cell Cycle. 7, 7, p. 848-852 5 p.

Research output: Contribution to journalReview article

Leukemia Inhibitory Factor
Reproduction
p53 Genes
Proteins
Alleles
2007
298 Citations (Scopus)

Noncoding RNAs and Gene Silencing

Zaratiegui Biurrun, M., Irvine, D. V. & Martienssen, R. A., Feb 23 2007, In : Cell. 128, 4, p. 763-776 14 p.

Research output: Contribution to journalReview article

Untranslated RNA
Gene Silencing
RNA Interference
Genes
RNA
2005
157 Citations (Scopus)

A single nucleotide polymorphism in the MDM2 gene: From a molecular and cellular explanation to clinical effect

Bond, G. L., Hu, W. & Levine, A., Jul 1 2005, In : Cancer Research. 65, 13, p. 5481-5484 4 p.

Research output: Contribution to journalReview article

Single Nucleotide Polymorphism
Genes
Neoplasms
Disease Progression
Phenotype
2004
404 Citations (Scopus)

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

Spitz, D. R., Azzam, E., Li, J. J. & Gius, D., Aug 1 2004, In : Cancer and Metastasis Reviews. 23, 3-4, p. 311-322 12 p.

Research output: Contribution to journalReview article

Ionizing Radiation
Oxidation-Reduction
Free Radicals
Bystander Effect
Radiobiology
110 Citations (Scopus)

Stress Signaling from Irradiated to Non-Irradiated Cells

Azzam, E., De Toledo, S. M. & Little, J. B., Feb 1 2004, In : Current Cancer Drug Targets. 4, 1, p. 53-64 12 p.

Research output: Contribution to journalReview article

Ionizing Radiation
Bystander Effect
Gap Junctions
Population
Radiotherapy
169 Citations (Scopus)

The double-stranded-RNA-binding motif: Interference and much more

Tian, B., Bevilacqua, P. C., Diegelman-Parente, A. & Mathews, M., Dec 1 2004, In : Nature Reviews Molecular Cell Biology. 5, 12, p. 1013-1023 11 p.

Research output: Contribution to journalReview article

RNA
RNA Interference
Antiviral Agents
Double-Stranded RNA Binding Motif
Proteins
182 Citations (Scopus)

The Mus81 solution to resolution: Generating meiotic crossovers without Holliday junctions

Hollingsworth, N. M. & Brill, S., Jan 15 2004, In : Genes and Development. 18, 2, p. 117-125 9 p.

Research output: Contribution to journalReview article

Cruciform DNA
Saccharomyces cerevisiae Proteins
Endonucleases
DNA-Binding Proteins
Meiosis
2003
21 Citations (Scopus)

Complex patterns and simple architects: molecular guidance cues for developing axonal pathways in the telencephalon.

Judas, M., Milosević, N. J., Rasin, M-R., Heffer-Lauc, M. & Kostović, I., Jan 1 2003, In : Progress in molecular and subcellular biology. 32, p. 1-32 32 p.

Research output: Contribution to journalReview article

Nerve Tissue Proteins
Developmental Gene Expression Regulation
Eph Family Receptors
Ephrins
Semaphorins
176 Citations (Scopus)

Current Advances in Molecular Imaging: Noninvasive in Vivo Bioluminescent and Fluorescent Optical Imaging in Cancer Research

Choy, G., Choyke, P. & Libutti, S., Oct 1 2003, In : Molecular Imaging. 2, 4, p. 303-312 10 p.

Research output: Contribution to journalReview article

Molecular imaging
Molecular Imaging
Optical Imaging
Imaging techniques
Research
2002
52 Citations (Scopus)

Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and α-difluoromethylornithine on tumorigenesis in a rat surgical model

Chen, X., Li, N., Wang, S., Hong, J., Fang, M., Yousselfson, J., Yang, P., Newman, R. A., Lubet, R. A. & Yang, C., Dec 1 2002, In : Carcinogenesis. 23, 12, p. 2095-2102 8 p.

Research output: Contribution to journalReview article

Masoprocol
Sulindac
Eflornithine
Anatomic Models
Arachidonic Acid
38 Citations (Scopus)

Regulation of repair by the 26S proteasome

Sweder, K. & Madura, K., Dec 1 2002, In : Journal of Biomedicine and Biotechnology. 2002, 2, p. 94-105 12 p.

Research output: Contribution to journalReview article

Repair
DNA Repair
Proteasome Endopeptidase Complex
Proteins
DNA
2000
422 Citations (Scopus)

Structure and function of hexameric helicases

Patel, S. & Picha, K. M., Nov 2 2000, In : Annual review of biochemistry. 69, p. 651-697 47 p.

Research output: Contribution to journalReview article

Nucleoside-Triphosphatase
Nucleotides
Hydrolysis
DNA
Bloom Syndrome
1998
30 Citations (Scopus)

Isolated hepatic perfusion: A potentially effective treatment for patients with metastatic or primary cancers confined to the liver

Alexander, H. R., Bartlett, D. L. & Libutti, S., Mar 2 1998, In : Cancer Journal from Scientific American. 4, 1, p. 2-11 10 p.

Research output: Contribution to journalReview article

Regional Perfusion Cancer Chemotherapy
Intra Arterial Infusions
Liver Neoplasms
Perfusion
Clinical Trials
1997
264 Citations (Scopus)

A reassessment of the low molecular weight phospholipase A2 gene family in mammals

Tischfield, J., Aug 5 1997, In : Journal of Biological Chemistry. 272, 28, p. 17247-17250 4 p.

Research output: Contribution to journalReview article

Molecular Sequence Data
Signal transduction
Mammals
Molecular Evolution
Phospholipases A
1996

DNA checkpoint control in Saccharomyces cerevisae

Sugimoto, K., Ando, S., Simomura, T. & Kondo, T., Jan 1 1996, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 41, 12 Suppl, p. 1807-1812 6 p.

Research output: Contribution to journalReview article

Ataxia Telangiectasia
Saccharomyces
Fungal Proteins
DNA Replication
S Phase
1988
47 Citations (Scopus)

The Metropolis algorithm

Bhanot, G., Dec 1 1988, In : Reports on Progress in Physics. 51, 3, p. 429-457 29 p., 003.

Research output: Contribution to journalReview article

theorems
Markov Chains
Markov processes
Baths
baths
1985

A review of numerical simulation methods

Bhanot, G., Jan 1 1985, In : Progress in Particle and Nuclear Physics. 14, C, p. 105-121 17 p.

Research output: Contribution to journalReview article

simulation