Genomic Instability and Cancer Genetics Program, CINJ

Research Output 1973 2020

Filter
Review article
2020

Vitamin D and the intestine: Review and update

Christakos, S., Li, S., De La Cruz, J., Shroyer, N. F., Criss, Z. K., Verzi, M. P. & Fleet, J. C., Feb 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 196, 105501.

Research output: Contribution to journalReview article

Vitamin D
Intestines
Calcium
Carrier Proteins
Homeostasis
2019

Activation of ATR-related protein kinase upon DNA damage recognition

Ma, M., Rodriguez, A. & Sugimoto, K., Jan 1 2019, (Accepted/In press) In : Current Genetics.

Research output: Contribution to journalReview article

Protein Kinases
DNA Damage
Replication Protein A
Phosphatidylinositol 3-Kinase
Single-Stranded DNA

At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications

Bae, S. A., Fang, M. Z., Rustgi, V., Zarbl, H. & Androulakis, I. P., Aug 28 2019, In : Frontiers in Nutrition. 6, 132.

Research output: Contribution to journalReview article

Open Access
Circadian Rhythm
circadian rhythm
lifestyle
Life Style
Circadian Clocks
5 Citations (Scopus)

Cystinuria: genetic aspects, mouse models, and a new approach to therapy

Sahota, A., Tischfield, J. A., Goldfarb, D. S., Ward, M. D. & Hu, L., Feb 5 2019, In : Urolithiasis. 47, 1, p. 57-66 10 p.

Research output: Contribution to journalReview article

Cystinuria
Cystine
Therapeutics
Crystallization
Diamide

Leukemia’s Clonal Evolution in Development, Progression, and Relapse

Loh, J. W. & Khiabanian, H., Jun 15 2019, In : Current Stem Cell Reports. 5, 2, p. 73-81 9 p.

Research output: Contribution to journalReview article

Clonal Evolution
Leukemia
Hematopoietic Stem Cells
Recurrence
Theoretical Models

Predicting Functional Effects of Synonymous Variants: A Systematic Review and Perspectives

Zeng, Z. & Bromberg, Y., Oct 7 2019, In : Frontiers in Genetics. 10, 914.

Research output: Contribution to journalReview article

Open Access
Genome
Precision Medicine
Codon
Nucleotides
Amino Acids

The Importance and Clinical Implications of FLASH Ultra-High Dose-Rate Studies for Proton and Heavy Ion Radiotherapy

Colangelo, N. W. & Azzam, E. I., Jan 1 2019, In : Radiation Research. 193, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

Heavy Ion Radiotherapy
Protons
Heavy Ions
radiation therapy
heavy ions
2 Citations (Scopus)

The protracted maturation of associative layer IIIC pyramidal neurons in the human prefrontal cortex during childhood: A major role in cognitive development and selective alteration in autism

Petanjek, Z., Sedmak, D., Džaja, D., Hladnik, A., Rašin, M. R. & Jovanov-Milosevic, N., Jan 1 2019, In : Frontiers in Psychiatry. 10, MAR, 122.

Research output: Contribution to journalReview article

Open Access
Pyramidal Cells
Autistic Disorder
Prefrontal Cortex
Neurons
Gene-Environment Interaction
6 Citations (Scopus)

Tumor suppressor p53 and metabolism

Liu, J., Zhang, C., Hu, W. & Feng, Z., Jan 1 2019, In : Journal of molecular cell biology. 11, 4, p. 284-292 9 p.

Research output: Contribution to journalReview article

Open Access
Neoplasms
Cell Aging
Mutant Proteins
Metabolic Networks and Pathways
Cell Cycle Checkpoints
2018
12 Citations (Scopus)

Biomanufacturing for clinically advanced cell therapies

Aijaz, A., Li, M., Smith, D., Khong, D., Leblon, C., Fenton, O. S., Olabisi, R. M., Libutti, S., Tischfield, J., Maus, M. V., Deans, R., Barcia, R. N., Anderson, D. G., Ritz, J., Preti, R. & Parekkadan, B., Jun 1 2018, In : Nature biomedical engineering. 2, 6, p. 362-376 15 p.

Research output: Contribution to journalReview article

Transplants
T-cells
Antigens
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
40 Citations (Scopus)

How cells ensure correct repair of DNA double-strand breaks

Her, J. & Bunting, S. F., Jan 1 2018, In : Journal of Biological Chemistry. 293, 27, p. 10502-10511 10 p.

Research output: Contribution to journalReview article

Double-Stranded DNA Breaks
Repair
Homologous Recombination
Joining
DNA
5 Citations (Scopus)

Parkinson's disease-associated protein Parkin: An unusual player in cancer

Liu, J., Zhang, C., Hu, W. & Feng, Z., Jun 26 2018, In : Cancer Communications. 38, 1, 40.

Research output: Contribution to journalReview article

Mitochondrial Degradation
Ubiquitin-Protein Ligases
Parkinson Disease
Neoplasms
Cell Cycle
39 Citations (Scopus)

Why are there hotspot mutations in the TP53 gene in human cancers?

Baugh, E. H., Ke, H., Levine, A. J., Bonneau, R. A. & Chan, C. S., Jan 1 2018, In : Cell Death and Differentiation. 25, 1, p. 154-160 7 p.

Research output: Contribution to journalReview article

p53 Genes
Mutation
Mutant Proteins
Alleles
Neoplasms
2017
5 Citations (Scopus)

Cross-regulation between transposable elements and host DNA replication

Zaratiegui, M., Mar 21 2017, In : Viruses. 9, 3, 57.

Research output: Contribution to journalReview article

DNA Transposable Elements
DNA Replication
8 Citations (Scopus)
Genome
Neoplasms
Mutation
Cataloging
Precision Medicine
62 Citations (Scopus)

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

Yue, X., Zhao, Y., Xu, Y., Zheng, M., Feng, Z. & Hu, W., Jun 2 2017, In : Journal of molecular biology. 429, 11, p. 1595-1606 12 p.

Research output: Contribution to journalReview article

Mutant Proteins
Neoplasms
Therapeutics
Mutation
Missense Mutation

Prevalence and penetrance of Li-Fraumeni cancer predisposition syndrome

Chan, C. S., Feb 2017, In : Current Opinion in Systems Biology. 1, p. 48-53 6 p.

Research output: Contribution to journalReview article

Penetrance
Li-Fraumeni Syndrome
Cancer
Germ-Line Mutation
Genes
99 Citations (Scopus)

RNA-Seq methods for transcriptome analysis

Hrdlickova, R., Toloue, M. & Tian, B., Jan 1 2017, In : Wiley Interdisciplinary Reviews: RNA. 8, 1, e1364.

Research output: Contribution to journalReview article

Gene Expression Profiling
RNA
Gene expression
Single-Cell Analysis
RNA Sequence Analysis
9 Citations (Scopus)

Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation

Nguyen, A. L. & Schindler, K., May 1 2017, In : Trends in Genetics. 33, 5, p. 349-363 15 p.

Research output: Contribution to journalReview article

Aurora Kinases
Meiosis
Oocytes
Protein Isoforms
Mitosis
11 Citations (Scopus)

The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes

Radford, S. J., Nguyen, A. L., Schindler, K. & McKim, K. S., Jun 1 2017, In : Chromosoma. 126, 3, p. 351-364 14 p.

Research output: Contribution to journalReview article

Spindle Apparatus
Oocytes
Centrosome
Chromosomes
Meiosis
11 Citations (Scopus)

Transcriptional and post-transcriptional mechanisms of the development of neocortical lamination

Popovitchenko, T. & Rasin, M. R., Nov 9 2017, In : Frontiers in Neuroanatomy. 11, 102.

Research output: Contribution to journalReview article

Neurons
Stem Cells
RNA-Binding Proteins
Long-Term Memory
Pyramidal Cells
2016
194 Citations (Scopus)

Alternative polyadenylation of mRNA precursors

Tian, B. & Manley, J. L., Dec 19 2016, In : Nature Reviews Molecular Cell Biology. 18, 1, p. 18-30 13 p.

Research output: Contribution to journalReview article

Polyadenylation
RNA Precursors
Messenger RNA
Organ Specificity
RNA-Binding Proteins
28 Citations (Scopus)

Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease

Keutgen, X. M., Hammel, P., Choyke, P. L., Libutti, S. K., Jonasch, E. & Kebebew, E., Sep 1 2016, In : Nature Reviews Clinical Oncology. 13, 9, p. 537-549 13 p.

Research output: Contribution to journalReview article

von Hippel-Lindau Disease
Neuroendocrine Tumors
Natural History
Disease Progression
Neoplasms
6 Citations (Scopus)

Functional evaluations of genes disrupted in patients with Tourette's disorder

Sun, N., Tischfield, J. A., King, R. A. & Heiman, G. A., Feb 9 2016, In : Frontiers in Psychiatry. 7, FEB, 11.

Research output: Contribution to journalReview article

Tourette Syndrome
Genes
Animal Models
Inborn Genetic Diseases
Genetically Modified Animals
2 Citations (Scopus)

Methods to study the coupling between replicative helicase and leading-strand DNA polymerase at the replication fork

Nandakumar, D. & Patel, S. S., Oct 1 2016, In : Methods. 108, p. 65-78 14 p.

Research output: Contribution to journalReview article

DNA-Directed DNA Polymerase
DNA
Enzymes
2-Aminopurine
Mitochondria
24 Citations (Scopus)

Minimally Invasive Parathyroidectomy Versus Bilateral Neck Exploration for Primary Hyperparathyroidism

Laird, A. M. & Libutti, S. K., Jan 1 2016, In : Surgical Oncology Clinics of North America. 25, 1, p. 103-118 16 p.

Research output: Contribution to journalReview article

Parathyroidectomy
Neck Dissection
Minimally Invasive Surgical Procedures
Primary Hyperparathyroidism
Diagnostic Imaging
17 Citations (Scopus)

Protein function in precision medicine: deep understanding with machine learning

Rost, B., Radivojac, P. & Bromberg, Y., Aug 1 2016, In : FEBS Letters. p. 2327-2341 15 p.

Research output: Contribution to journalReview article

Precision Medicine
Medicine
Learning systems
Medical History Taking
Protein Interaction Maps
6 Citations (Scopus)

The frontier of RNA metamorphosis and ribosome signature in neocortical development

Kraushar, M. L., Popovitchenko, T., Volk, N. L. & Rasin, M. R., Dec 1 2016, In : International Journal of Developmental Neuroscience. 55, p. 131-139 9 p.

Research output: Contribution to journalReview article

Protein Biosynthesis
Ribosomes
RNA
Neocortex
Messenger RNA
6 Citations (Scopus)

The value of FDG-PET in the staging of gastric adenocarcinoma: A single institution retrospective review

Serrano, O. K., Love, C., Goldman, I., Huang, K., Ng, N., Abraham, T., Da Silva, R., Friedmann, P., Libutti, S. K. & Kennedy, T. J., May 1 2016, In : Journal of Surgical Oncology. 113, 6, p. 640-646 7 p.

Research output: Contribution to journalReview article

Stomach
Adenocarcinoma
Lymph Nodes
Neoplasms
Neoplasm Metastasis
2015
200 Citations (Scopus)

Autophagy, Metabolism, and Cancer

White, E., Mehnert, J. M. & Chan, C. S., Nov 15 2015, In : Clinical Cancer Research. 21, 22, p. 5037-5046 10 p.

Research output: Contribution to journalReview article

Autophagy
Neoplasms
Starvation
Organelles
Recycling
2014
26 Citations (Scopus)

Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis

Shim, G., Ricoul, M., Hempel, W. M., Azzam, E. I. & Sabatier, L., Apr 2014, In : Mutation Research - Reviews in Mutation Research. 760, p. 1-17 17 p.

Research output: Contribution to journalReview article

Radiation Effects
Telomere
Carcinogenesis
Maintenance
Radiation
1 Citation (Scopus)

Fluorescent methods to study transcription initiation and transition into elongation.

Deshpande, A. P., Sultana, S. & Patel, S. S., 2014, In : EXS. 105, p. 105-130 26 p.

Research output: Contribution to journalReview article

Bacteriophage T7
DNA
Fluorescence Spectrometry
DNA-Directed RNA Polymerases
Transcription Factors
17 Citations (Scopus)

Health risks of space exploration: Targeted and nontargeted oxidative injury by high-charge and high-energy particles

Li, M., Gonon, G., Buonanno, M., Autsavapromporn, N., De Toledo, S. M., Pain, D. & Azzam, E., Mar 20 2014, In : Antioxidants and Redox Signaling. 20, 9, p. 1501-1523 23 p.

Research output: Contribution to journalReview article

Cosmic Radiation
Space Flight
Health risks
Radiation
Health
57 Citations (Scopus)

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

Rossiello, F., Herbig, U., Longhese, M. P., Fumagalli, M. & d'Adda di Fagagna, F., Jun 2014, In : Current Opinion in Genetics and Development. 26, p. 89-95 7 p.

Research output: Contribution to journalReview article

Cell Aging
DNA Damage
Telomere
Mammals
DNA Replication
57 Citations (Scopus)

The regulation of MDM2 oncogene and its impact on human cancers

Zhao, Y., Yu, H. & Hu, W., Mar 1 2014, In : Acta Biochimica et Biophysica Sinica. 46, 3, p. 180-189 10 p.

Research output: Contribution to journalReview article

Oncogenes
Tumors
Neoplasms
Ubiquitin-Protein Ligases
Genes
31 Citations (Scopus)

The replicometer is broken: Telomeres activate cellular senescence in response to genotoxic stresses

Suram, A. & Herbig, U., Oct 1 2014, In : Aging cell. 13, 5, p. 780-786 7 p.

Research output: Contribution to journalReview article

Cell Aging
Telomere
DNA Damage
Cell Cycle
Cell Division
2013
190 Citations (Scopus)

Alternative cleavage and polyadenylation: The long and short of it

Tian, B. & Manley, J. L., Jun 1 2013, In : Trends in Biochemical Sciences. 38, 6, p. 312-320 9 p.

Research output: Contribution to journalReview article

Polyadenylation
Messenger RNA
3' Untranslated Regions
Metabolism
Gene expression
21 Citations (Scopus)

Building a genome analysis pipeline to predict disease risk and prevent disease

Bromberg, Y., Nov 1 2013, In : Journal of molecular biology. 425, 21, p. 3993-4005 13 p.

Research output: Contribution to journalReview article

Genome
Medicine
Phenotype
Costs and Cost Analysis
Mutation
25 Citations (Scopus)

Chromatin structure, pluripotency and differentiation

Serrano, L., Vazquez, B. N. & Tischfield, J., Mar 1 2013, In : Experimental Biology and Medicine. 238, 3, p. 259-270 12 p.

Research output: Contribution to journalReview article

Stem cells
Chromatin
Gene expression
Genes
Induced Pluripotent Stem Cells
31 Citations (Scopus)

Complex roles of filamin-A mediated cytoskeleton network in cancer progression

Yue, J., Huhn, S. & Shen, Z., Feb 6 2013, In : Cell and Bioscience. 3, 1, 7.

Research output: Contribution to journalReview article

Filamins
Cytoskeleton
Microfilament Proteins
Neoplasms
Actins
194 Citations (Scopus)

End-joining, translocations and cancer

Bunting, S. F. & Nussenzweig, A., Jul 1 2013, In : Nature Reviews Cancer. 13, 7, p. 443-454 12 p.

Research output: Contribution to journalReview article

Gene Fusion
Neoplasms
Chromosomes
Growth
5 Citations (Scopus)

Library screening and receptor-directed targeting of gammaretroviral vectors

Mazari, P. M. & Roth, M. J., Jan 1 2013, In : Future Microbiology. 8, 1, p. 107-121 15 p.

Research output: Contribution to journalReview article

Hope
Precision Medicine
Cell- and Tissue-Based Therapy
Genetic Therapy
Libraries
44 Citations (Scopus)

News from the protein mutability landscape

Hecht, M., Bromberg, Y. & Rost, B., Nov 1 2013, In : Journal of molecular biology. 425, 21, p. 3937-3948 12 p.

Research output: Contribution to journalReview article

Mutation
Proteins
High-Throughput Nucleotide Sequencing
Explosions
Protein Stability
32 Citations (Scopus)

Toward a genome-wide landscape of translational control

Larsson, O., Tian, B. & Sonenberg, N., Jan 1 2013, In : Cold Spring Harbor Perspectives in Biology. 5, 1

Research output: Contribution to journalReview article

Genes
Genome
High-Throughput Nucleotide Sequencing
Protein Biosynthesis
Proteome
2012

[The primary intestinal granulocytic sarcoma patient: two case reports and literature review].

Xia, B., Guo, Q. & Zhao, W. P., Oct 1 2012, In : Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 33, 10, p. 869-871 3 p.

Research output: Contribution to journalReview article

Myeloid Sarcoma
Intestinal Neoplasms
Primary granulocytic sarcoma
20 Citations (Scopus)

Mechanism of transcription initiation by the yeast mitochondrial RNA polymerase

Deshpande, A. P. & Patel, S., Sep 1 2012, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1819, 9-10, p. 930-938 9 p.

Research output: Contribution to journalReview article

DNA-Directed RNA Polymerases
Transcription
Yeast
Transcription Factors
Yeasts
105 Citations (Scopus)

Signals for pre-mRNA cleavage and polyadenylation

Tian, B. & Graber, J. H., May 1 2012, In : Wiley Interdisciplinary Reviews: RNA. 3, 3, p. 385-396 12 p.

Research output: Contribution to journalReview article

Polyadenylation
RNA Precursors
Eukaryota
Messenger RNA
Bioinformatics
69 Citations (Scopus)

The Regulation of Multiple p53 Stress Responses is Mediated through MDM2

Hu, W., Feng, Z. & Levine, A. J., Dec 1 2012, In : Genes and Cancer. 3, 3-4, p. 199-208 10 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
Tumor Suppressor Protein p53
MicroRNAs
Oncogenes
DNA Damage
28 Citations (Scopus)

What is the best criterion for the interpretation of adrenal vein sample results in patients with primary hyperaldosteronism?

Webb, R., Mathur, A., Chang, R., Baid, S., Nilubol, N., Libutti, S. K., Stratakis, C. A. & Kebebew, E., Jun 1 2012, In : Annals of Surgical Oncology. 19, 6, p. 1881-1886 6 p.

Research output: Contribution to journalReview article

Hyperaldosteronism
Veins
Hydrocortisone
Aldosterone
Adrenalectomy
2011
65 Citations (Scopus)

Acrolein induced DNA damage, mutagenicity and effect on DNA repair

Tang, M. S., Wang, H. T., Hu, Y., Chen, W. S., Akao, M., Feng, Z. & Hu, W., Sep 1 2011, In : Molecular Nutrition and Food Research. 55, 9, p. 1291-1300 10 p.

Research output: Contribution to journalReview article

acrolein
Acrolein
mutagenicity
DNA repair
DNA Repair