Human Genetics Institute of New Jersey - RUCDR

Research Output

2020

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

BIOS Consortium, Feb 1 2020, In : European Journal of Human Genetics. 28, 2, p. 253-263 11 p.

Research output: Contribution to journalArticle

A novel mouse model for the study of endogenous neural stem and progenitor cells after traumatic brain injury

Anderson, J., Patel, M., Forenzo, D., Ai, X., Cai, C., Wade, Q., Risman, R. & Cai, L., Mar 2020, In : Experimental Neurology. 325, 113119.

Research output: Contribution to journalArticle

Author Correction: Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells (Nature Communications, (2014), 5, 1, (4430), 10.1038/ncomms5430)

Chen, C., Jiang, P., Xue, H., Peterson, S. E., Tran, H. T., McCann, A. E., Parast, M. M., Li, S., Pleasure, D. E., Laurent, L. C., Loring, J. F., Liu, Y. & Deng, W., Dec 1 2020, In : Nature communications. 11, 1, 1070.

Research output: Contribution to journalComment/debate

Open Access

Authors’ response

Fine, D. H., Armitage, G. C., Griffen, A. L. & Diehl, S. R., Mar 2020, In : Journal of the American Dental Association. 151, 3, 1 p.

Research output: Contribution to journalLetter

Calming Neurons with a Microglial Touch

Sharma, K., Wu, L. J. & Eyo, U. B., Apr 2020, In : Trends in Neurosciences. 43, 4, p. 197-199 3 p.

Research output: Contribution to journalShort survey

Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry

Liu, J. J., Mirabella, V. R. & Pang, Z. P., Mar 15 2020, In : Brain research. 1731, 145974.

Research output: Contribution to journalArticle

1 Scopus citations

Developmental regulation of the gut–liver (FGF19-CYP7A1) axis in neonates

Memon, N., Griffin, I. J., Lee, C. W., Herdt, A., Weinberger, B. I., Hegyi, T., Carayannopoulos, M. O., Aleksunes, L. M. & Guo, G. L., Mar 18 2020, In : Journal of Maternal-Fetal and Neonatal Medicine. 33, 6, p. 987-992 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development

Schumacher, J. D., Kong, B., Wu, J., Rizzolo, D., Armstrong, L. E., Chow, M. D., Goedken, M., Lee, Y. H. & Guo, G. L., Feb 1 2020, In : Hepatology. 71, 2, p. 670-685 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of total parenteral nutrition on drug metabolism gene expression in mice

Ferrucci-Da Silva, C., Zhan, L., Shen, J., Kong, B., Campbell, M. J., Memon, N., Hegyi, T., Lu, L. & Guo, G. L., Jan 2020, In : Acta Pharmaceutica Sinica B. 10, 1, p. 153-158 6 p.

Research output: Contribution to journalArticle

Open Access

Elevated choline kinase α–mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes

Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D. & Xie, P., Jan 1 2020, In : Journal of Immunology. 204, 2, p. 459-471 13 p.

Research output: Contribution to journalArticle

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer

Wu, R., Wang, L., Yin, R., Hudlikar, R., Li, S., Kuo, H. C. D., Peter, R., Sargsyan, D., Guo, Y., Liu, X. & Kong, A. N. T., Feb 1 2020, In : Molecular Carcinogenesis. 59, 2, p. 227-236 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization

Shang, K., He, J., Zou, J., Qin, C., Lin, L., Zhou, L. Q., Yang, L. L., Wu, L. J., Wang, W., Zhan, K. B. & Tian, D. S., Jan 1 2020, In : Brain research. 1726, 146509.

Research output: Contribution to journalArticle

Open Access

Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle

Yohn, C. N., Shifman, S., Garino, A., Diethorn, E., Bokka, L., Ashamalla, S. A. & Samuels, B. A., Jan 1 2020, (Accepted/In press) In : Psychopharmacology.

Research output: Contribution to journalArticle

Gap Junctions and Breast Cancer Dormancy

Sinha, G., Ferrer, A. I., Moore, C. A., Naaldijk, Y. & Rameshwar, P., Apr 2020, In : Trends in Cancer. 6, 4, p. 348-357 10 p.

Research output: Contribution to journalReview article

Genome-wide association studies of the self-rating of effects of ethanol (SRE)

Lai, D., Wetherill, L., Kapoor, M., Johnson, E. C., Schwandt, M., Ramchandani, V. A., Goldman, D., Joslyn, G., Rao, X., Liu, Y., Farris, S., Mayfield, R. D., Dick, D., Hesselbrock, V., Kramer, J., McCutcheon, V. V., Nurnberger, J., Tischfield, J., Goate, A., Edenberg, H. J. & 4 others, Porjesz, B., Agrawal, A., Foroud, T. & Schuckit, M., Mar 1 2020, In : Addiction Biology. 25, 2, e12800.

Research output: Contribution to journalArticle

GNM: GridCell navigational model

Naghizadeh, A., Berenjian, S., Margolis, D. J. & Metaxas, D. N., Jun 15 2020, In : Expert Systems With Applications. 148, 113217.

Research output: Contribution to journalArticle

Integrated Mobile Element Scanning (ME-Scan) method for identifying multiple types of polymorphic mobile element insertions

Loh, J. W., Ha, H., Lin, T., Sun, N., Burns, K. H. & Xing, J., Feb 22 2020, In : Mobile DNA. 11, 1, 12.

Research output: Contribution to journalArticle

Open Access

Investigating learning-related neural circuitry with chronic in vivo optical imaging

Lee, C. R., Najafizadeh, L. & Margolis, D. J., Mar 1 2020, In : Brain Structure and Function. 225, 2, p. 467-480 14 p.

Research output: Contribution to journalReview article

KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells

Cordover, E., Wei, J., Patel, C., Shan, N. L., Gionco, J., Sargsyan, D., Wu, R., Cai, L., Kong, A. N., Jacinto, E. & Minden, A., Feb 17 2020, In : Chemical Research in Toxicology. 33, 2, p. 482-491 10 p.

Research output: Contribution to journalArticle

Loss of Setd4 delays radiation-induced thymic lymphoma in mice

Feng, X., Lu, H., Yue, J., Schneider, N., Liu, J., Denzin, L. K., Chan, C. S., De, S. & Shen, Z., Feb 2020, In : DNA Repair. 86, 102754.

Research output: Contribution to journalArticle

Open Access

Neuroimmune/hematopoietic axis with distinct regulation by the high-mobility group box 1 in association with tachykinin peptides

Gergues, M., Nagula, V., Bliss, S. A., Eljarrah, A., Ayer, S., Gnanavel, N., Sinha, G., Wu, Q., Yehia, G., Greco, S. J., Qian, J. & Rameshwar, P., Feb 15 2020, In : Journal of Immunology. 204, 4, p. 879-891 13 p.

Research output: Contribution to journalArticle

Open Access

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., Jan 1 2020, In : PloS one. 15, 1, e0227501.

Research output: Contribution to journalArticle

Open Access

Peptide-Based Scaffolds for the Culture and Transplantation of Human Dopaminergic Neurons

Francis, N. L., Zhao, N., Calvelli, H. R., Saini, A., Gifford, J. J., Wagner, G. C., Cohen, R. I., Pang, Z. P. & Moghe, P. V., Feb 2020, In : Tissue Engineering - Part A. 26, 3-4, p. 193-205 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats

Wang, L., Li, W., Cheng, D., Guo, Y., Wu, R., Yin, R., Li, S., Kuo, H. C., Hudlikar, R., Yang, H., Buckley, B. & Kong, A. N., Jan 1 2020, (Accepted/In press) In : Journal of Pharmacokinetics and Pharmacodynamics.

Research output: Contribution to journalArticle

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Neal, M. L., Fleming, S. M., Budge, K. M., Boyle, A. M., Kim, C., Alam, G., Beier, E. E., Wu, L. J. & Richardson, J. R., Jan 1 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 1679-1694 16 p.

Research output: Contribution to journalArticle

Open Access

PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer

Wang, C., Feng, Y., Zhang, C., Cheng, D., Wu, R., Yang, Y., Sargsyan, D., Kumar, D. & Kong, A. N., Jan 1 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 1304-1318 15 p.

Research output: Contribution to journalArticle

Open Access

Reactive Astrocytes as Therapeutic Targets for Brain Degenerative Diseases: Roles Played by Metabotropic Glutamate Receptors

Planas-Fontánez, T. M., Dreyfus, C. F. & Saitta, K. S., Mar 1 2020, In : Neurochemical Research. 45, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

Open Access

Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis

Salvatore, J. E., Barr, P. B., Stephenson, M., Aliev, F., Kuo, S. I. C., Su, J., Agrawal, A., Almasy, L., Bierut, L., Bucholz, K., Chan, G., Edenberg, H. J., Johnson, E. C., McCutcheon, V. V., Meyers, J. L., Schuckit, M., Tischfield, J., Wetherill, L. & Dick, D. M., Feb 1 2020, In : Addiction. 115, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

SLC17a6/7/8 vesicular glutamate transporter homologs in nematodes

Serrano-Saiz, E., Vogt, M. C., Levy, S., Wang, Y., Kaczmarczyk, K. K., Mei, X., Bai, G., Singson, A., Grant, B. D. & Hobert, O., Jan 1 2020, In : Genetics. 214, 1, p. 163-178 16 p.

Research output: Contribution to journalArticle

Spontaneous hyperactivity in Ash1l mutant mice, a new model for Tourette syndrome

Liu, S., Tian, M., He, F., Li, J., Xie, H., Liu, W., Zhang, Y., Zhang, R., Yi, M., Che, F., Ma, X., Zheng, Y., Deng, H., Wang, G., Chen, L., Sun, X., Xu, Y., Wang, J., Zang, Y., Han, M. & 28 others, Wang, X., Guan, H., Ge, Y., Wu, C., Wang, H., Liang, H., Li, H., Ran, N., Yang, Z., Huang, H., Wei, Y., Zheng, X., Sun, X., Feng, X., Zheng, L., Zhu, T., Luo, W., Chen, Q., Yan, Y., Huang, Z., Jing, Z., Guo, Y., Zhang, X., Schaaf, C. P., Xing, J., Wang, C., Yu, F. & Guan, J. S., Feb 1 2020, In : Molecular psychiatry. 25, 2, p. 241-242 2 p.

Research output: Contribution to journalComment/debate

Trends in mesenchymal stem cell clinical trials 2004-2018: Is efficacy optimal in a narrow dose range?

Kabat, M., Bobkov, I., Kumar, S. & Grumet, M., Jan 1 2020, In : Stem Cells Translational Medicine. 9, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Open Access

Understanding the role of phenotypic switching in cancer drug resistance

Gunnarsson, E. B., De, S., Leder, K. & Foo, J., Apr 7 2020, In : Journal of Theoretical Biology. 490, 110162.

Research output: Contribution to journalArticle

Vitamin D and the intestine: Review and update

Christakos, S., Li, S., De La Cruz, J., Shroyer, N. F., Criss, Z. K., Verzi, M. P. & Fleet, J. C., Feb 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 196, 105501.

Research output: Contribution to journalReview article

Whole Genome Sequencing and Assembly of the Asian Honey Bee Apis dorsata

Oppenheim, S., Cao, X., Rueppel, O., Krongdang, S., Phokasem, P., DeSalle, R., Goodwin, S., Xing, J., Chantawannakul, P. & Rosenfeld, J. A., Jan 1 2020, In : Genome biology and evolution. 12, 1, p. 3677-3683 7 p.

Research output: Contribution to journalArticle

Open Access
2019

Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barrett's Cells

Zhang, Q., Agoston, A. T., Pham, T. H., Zhang, W., Zhang, X., Huo, X., Peng, S., Bajpai, M., Das, K., Odze, R. D., Spechler, S. J. & Souza, R. F., Jan 2019, In : Gastroenterology. 156, 1, p. 130-144.e10

Research output: Contribution to journalArticle

5 Scopus citations
Open Access
2 Scopus citations

Activation of S6 signaling is associated with cell survival and multinucleation in hyperplastic skin after epidermal loss of AURORA-A Kinase

Ryan, W. K., Fernandez, J., Peterson, M. K., Sheneman, D. W., Podell, B. K., De, S. & Torchia, E. C., Mar 1 2019, In : Cell Death and Differentiation. 26, 3, p. 548-564 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P. & Pang, Z. P., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Age modulates liver responses to asparaginase-induced amino acid stress in mice

Nikonorova, I. A., Zhu, Q., Signore, C. C., Mirek, E. T., Jonsson, W. O., Kong, B., Guo, G. L., Belden, W. J. & Anthony, T. X. G., Jan 1 2019, In : Journal of Biological Chemistry. 294, 38, p. 12864-13875 1012 p.

Research output: Contribution to journalReview article

Open Access

Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

Rao, X., Thapa, K. S., Chen, A. B., Lin, H., Gao, H., Reiter, J. L., Hargreaves, K. A., Ipe, J., Lai, D., Xuei, X., Wang, Y., Gu, H., Kapoor, M., Farris, S. P., Tischfield, J., Foroud, T., Goate, A. M., Skaar, T. C., Mayfield, R. D., Edenberg, H. J. & 1 others, Liu, Y., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Altered gut-liver axis in liver diseases

Zhou, H., Bajaj, J. S. & Guo, G. L., Mar 2019, In : Liver Research. 3, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Open Access

ALYREF links 3′-end processing to nuclear export of non-polyadenylated mRNAs

Fan, J., Wang, K., Du, X., Wang, J., Chen, S., Wang, Y., Shi, M., Zhang, L., Wu, X., Zheng, D., Wang, C., Wang, L., Tian, B., Li, G., Zhou, Y. & Cheng, H., May 2 2019, In : EMBO Journal. 38, 9, e99910.

Research output: Contribution to journalArticle

2 Scopus citations

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

Saito, T., Nah, J., Oka, S. I., Mukai, R., Monden, Y., Maejima, Y., Ikeda, Y., Sciarretta, S., Liu, T., Li, H., Baljinnyam, E., Fraidenraich, D., Fritzky, L., Zhai, P., Ichinose, S., Isobe, M., Hsu, C. P., Kundu, M. & Sadoshima, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 802-819 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Kapoor, M., Wang, J. C., Farris, S. P., Liu, Y., McClintick, J., Gupta, I., Meyers, J. L., Bertelsen, S., Chao, M., Nurnberger, J., Tischfield, J., Harari, O., Zeran, L., Hesselbrock, V., Bauer, L., Raj, T., Porjesz, B., Agrawal, A., Foroud, T., Edenberg, H. J. & 2 others, Mayfield, R. D. & Goate, A., Dec 1 2019, In : Translational psychiatry. 9, 1, 89.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

An Enzyme-free Method for Isolation and Expansion of Human Adipose-derived Mesenchymal Stem Cells

Sherman, L. S., Condé-Green, A., Naaldijk, Y., Lee, E. S. & Rameshwar, P., Dec 16 2019, In : Journal of visualized experiments : JoVE. 154

Research output: Contribution to journalArticle

Open Access

An Optical Exposé of Cortical Function

Shvedov, N. & Margolis, D. J., Aug 1 2019, In : Trends in Neurosciences. 42, 8, p. 511-513 3 p.

Research output: Contribution to journalShort survey