New Jersey Medical School (NJMS), Biochemistry

Projects

Projects per year 1990 1990 2009 2010 2012 2022

• 56 Finished

Projects per year

Search results

• Finished

  Mitochondrial metabolism and the Lon-PDH axis

  Suzuki, C.

  National Institute of General Medical Sciences

  4/1/21 → 3/31/22

  Project: Research project

  • Pyruvic Acid 100%
  • Oxidoreductases 85%
  • Induced Pluripotent Stem Cells 30%
  • Pyruvate Dehydrogenase Complex Deficiency Disease 30%
  • Fibroblasts 26%

• Regulation and Functions of 3'UTRs in Cellular Stress

  Tian, B. & TIAN, B.

  9/1/18 → 8/31/22

  Project: Research project

  • arsenic 100%
  • shortenings 94%
  • stress response 50%
  • nervous system diseases 42%
  • endoplasmic reticulum stress 40%

• Gene Regulatory Mechanisms that Repress BMP2 in Pathological Calcification

  Rogers, M.

  National Heart, Lung, and Blood Institute

  8/15/17 → 7/31/21

  Project: Research project

  • Bone Morphogenetic Protein 2 100%
  • Regulator Genes 71%
  • MicroRNAs 44%
  • Premature Aging 35%
  • Heart Valves 35%

• Nutrigenomics of Intestinal Vitamin D Action

  Christakos, S., Verzi, M. & FLEET, J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  7/5/17 → 3/31/20

  Project: Research project

  • nutrigenomics 100%
  • vitamin D 86%
  • intestines 69%
  • bone metabolism 27%
  • calcium 17%

• Post-transcriptional gene regulation in normal and diseased neurons

  Pang, Z. & Tian, B.

  National Institute of Neurological Disorders and Stroke

  2/1/17 → 1/31/20

  Project: Research project

  • 3' Untranslated Regions 100%
  • Neurons 49%
  • Polyadenylation 40%
  • RNA-Binding Proteins 37%
  • Neurogenesis 34%

• Regulation of BMP2 in CKD Induced Calcification in the Klotho Aging Model

  Rogers, M.

  National Institute on Aging

  9/15/16 → 8/31/18

  Project: Research project

  • Bone Morphogenetic Protein 2 100%
  • Chronic Renal Insufficiency 67%
  • MicroRNAs 57%
  • Premature Aging 45%
  • Heart Valves 38%

• The in vivo effect of vitamin D on Mycobacterium tuberculosis infection

  Christakos, S., Salgame, P. & Salgame, P.

  National Institute of Allergy and Infectious Diseases

  1/1/16 → 12/31/18

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Vitamin D 91%
  • Tuberculosis 65%
  • CAP18 lipopolysaccharide-binding protein 49%
  • Immunity 37%

• Regulating mtDNA and mtRNA dynamics by the mitochondrial AAA+ Lon protease

  Suzuki, C.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  12/1/15 → 11/30/18

  Project: Research project

  • CODAS syndrome 100%
  • Protease La 55%
  • ATPases Associated with Diverse Cellular Activities 50%
  • Mitochondrial RNA 50%
  • Mitochondrial Dynamics 43%

• Alternative Cleavage and Polyadenylation in Trophoblast Differentiation

  Tian, B., Tian, B. & LU, C.

  8/15/15 → 7/31/18

  Project: Research project

  • Polyadenylation 100%
  • Trophoblasts 57%
  • Placenta 36%
  • Messenger RNA 22%
  • 3' Untranslated Regions 13%

• NO signaling by a Soluble Guanylyl Cyclase -Thioredoxin transnitrosation complex

  Beuve, A., Li, H. & Li, H.

  National Institute of General Medical Sciences

  4/1/15 → 8/31/22

  Project: Research project

  • Soluble Guanylyl Cyclase 100%
  • Thioredoxins 97%
  • Nitrosation 81%
  • Nitric Oxide 71%
  • Cysteine 31%

• Osteoporosis and Molecular Targets of Vitamin D

  Christakos, S.

  National Institute on Aging

  12/1/14 → 12/31/17

  Project: Research project

  • Vitamin D 100%
  • Calcium 91%
  • Osteoporosis 89%
  • Calcitriol Receptors 56%
  • Calbindins 54%

• NUTRIENT BIOAVAILABILITY--PHYTONUTRIENTS AND BEYOND

  Rogers, M.

  National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))

  4/1/14 → 9/30/18

  Project: Research project

  • phytonutrients 100%
  • bioavailability 66%
  • lipids 64%
  • free fatty acids 62%
  • nutrients 40%

• Implication of RNase H domain on dimer stability and drug sensitivity of HIV-1 RT

  Pandey, V.

  National Institute of Allergy and Infectious Diseases

  8/1/13 → 7/31/16

  Project: Research project

  • Drug Stability 74%
  • HIV-1 60%
  • Mutation 24%
  • Pharmaceutical Preparations 18%
  • Dimerization 12%

• Development of IFN-lambda3 for the Prevention and Treatment of Virus Infection

  Durbin, J., Kotenko, S. & Kotenko, S.

  National Institute of Allergy and Infectious Diseases

  1/18/13 → 12/31/18

  Project: Research project

  • Interferons 100%
  • Antiviral Agents 85%
  • Viruses 73%
  • Virus Diseases 73%
  • Interferon Type I 39%

• Structured RNAs Binding to Proteins Containing the dsRBD

  Mathews, M. & Tian, B.

  National Human Genome Research Institute

  8/25/12 → 6/30/15

  Project: Research project

  • Double-Stranded RNA Binding Motif 100%
  • RNA-Binding Proteins 61%
  • RNA 48%
  • Ligands 40%
  • High-Throughput Nucleotide Sequencing 16%

• BMP2 Gene Regulation in Calcific Aortic Valve Disease

  Rogers, M. & Mortlock, D.

  National Heart, Lung, and Blood Institute

  8/23/12 → 6/30/17

  Project: Research project

  • Bone Morphogenetic Protein 2 100%
  • Aortic Diseases 95%
  • Aortic Valve 82%
  • Genes 27%
  • Bone and Bones 9%

• Non-canonical signal pathway for Crk in breast cancer

  Birge, R.

  National Cancer Institute

  7/12/12 → 4/30/18

  Project: Research project

  • src Homology Domains 100%
  • Signal Transduction 58%
  • Breast Neoplasms 49%
  • Tyrosine 38%
  • Phosphorylation 36%

• NOVEL STRUCTURING STRATEGIES FOR UNSATURATED OILS

  Rogers, M.

  National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))

  7/1/12 → 6/30/17

  Project: Research project

  • Fat 100%
  • Lipoprotein 83%
  • Cardioprotective 76%
  • Saturated Fatty Acid 61%
  • Low-Density Lipoprotein 59%

• Vitamin D and Innate Immunity in Respiratory Infections

  Christakos, S., Diamond, G., Christakos, S., Diamond, G. & Diamond, G.

  National Institute of Allergy and Infectious Diseases

  2/15/12 → 1/31/15

  Project: Research project

  • Vitamin D 100%
  • Innate Immunity 86%
  • Respiratory Tract Infections 70%
  • CAP18 lipopolysaccharide-binding protein 40%
  • Epithelial Cells 40%

• Long Non-coding RNAs in Adipogenesis

  Tian, B.

  12/5/11 → 11/30/13

  Project: Research project

  • Adipogenesis 100%
  • Long Noncoding RNA 89%
  • Adipocytes 26%
  • Organized Financing 16%
  • Chromatin Assembly and Disassembly 16%

• Mitochondrial chaperones mortalin and Tid1 in protein degradation

  Suzuki, C.

  National Institute on Aging

  8/15/11 → 7/31/14

  Project: Research project

  • mortalin 100%
  • Proteolysis 50%
  • ATP-Dependent Proteases 32%
  • Mitochondrial Proteins 26%
  • Proteins 25%

• Vitamin D and the Immune System

  Christakos, S., Steinman, L. & Steinman, L.

  National Institute of Allergy and Infectious Diseases

  3/1/11 → 2/28/14

  Project: Research project

  • Interleukin-17 100%
  • Vitamin D 83%
  • Immune System 60%
  • Multiple Sclerosis 60%
  • Paralysis 37%

• FUSE Binding Protein As a Cellular Effector of HCV Replication

  Pandey, V.

  National Institute of Diabetes and Digestive and Kidney Diseases

  7/1/10 → 6/30/13

  Project: Research project

  • Hepacivirus 100%
  • Virus Replication 78%
  • Carrier Proteins 70%
  • Hepatocellular Carcinoma 33%
  • Chronic Hepatitis C 32%

• High throughput screening assays to identify small molecules that target the ClpX

  Suzuki, C.

  National Institute of Neurological Disorders and Stroke

  6/1/10 → 5/31/13

  Project: Research project

  • High-Throughput Screening Assays 100%
  • ATP-Dependent Proteases 95%
  • Peptide Hydrolases 78%
  • Protease La 57%
  • Protein Unfolding 47%

• An Integrated System for Deep Sequencing Experiment and Analysis

  Tian, B.

  4/8/10 → 4/7/11

  Project: Research project

  • dentistry 100%
  • medicine 62%
  • teeth 31%
  • high-throughput nucleotide sequencing 27%
  • Biological Sciences 17%

• Alternative mRNA processing in cardiac hypertrophy

  Tian, B.

  1/1/10 → 11/30/12

  Project: Research project

  • Cardiomegaly 100%
  • Messenger RNA 26%
  • Heart Failure 16%
  • Hypertrophy 14%
  • Polyadenylation 9%

• High throughput screens for modulators of mitochondrial ATP-dependent proteolysis

  Suzuki, C.

  National Institute of General Medical Sciences

  8/15/09 → 7/31/12

  Project: Research project

  • Proteolysis 100%
  • Adenosine Triphosphate 95%
  • ATP-Dependent Proteases 93%
  • Protease La 46%
  • Aconitate Hydratase 42%

• Computational and Experimental Analysis of RNA structures in mRNA polyadenylation

  Lutz, C. & Tian, B.

  National Human Genome Research Institute

  7/22/09 → 6/30/12

  Project: Research project

  • Polyadenylation 100%
  • Messenger RNA 45%
  • RNA 43%
  • Poly A 22%
  • RNA Stability 9%

• Evasion of antiviral protection by poxvirus-encoded interferon antagonists

  Kotenko, S.

  National Institute of Allergy and Infectious Diseases

  6/5/09 → 5/31/12

  Project: Research project

  • Poxviridae 100%
  • Antiviral Agents 78%
  • Interferons 58%
  • Variola virus 21%
  • Vaccinia virus 16%

• Proteomics of HCV Replication Complex

  Pandey, V.

  National Institute of Allergy and Infectious Diseases

  5/7/09 → 4/30/12

  Project: Research project

  • Hepacivirus 100%
  • Virus Replication 78%
  • Proteomics 60%
  • 1-methyl-3-nitro-1,2,4-triazole 26%
  • Hepatovirus 20%

• Structure-Based Development of nonnucleoside anti-HIV-1 RT Drugs

  Pandey, V.

  National Institute of Allergy and Infectious Diseases

  4/10/09 → 3/31/12

  Project: Research project

  • HIV-1 100%
  • Pharmaceutical Preparations 43%
  • Lead 28%
  • HIV Infections 27%
  • Drug Residues 25%

• Regulation of alternative cleavage and polyadenylation

  Tian, B.

  5/1/08 → 5/31/22

  Project: Research project

  • Polyadenylation 100%
  • mRNA Cleavage and Polyadenylation Factors 13%
  • RNA Isoforms 10%
  • Untranslated Regions 10%
  • Genes 9%

• Mechanisms of MeCP2 gene expression regulation

  Lutz, C.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/15/07 → 2/28/10

  Project: Research project

  • Polyadenylation 100%
  • RNA Stability 86%
  • Gene Expression Regulation 70%
  • Research Personnel 55%
  • Rett Syndrome 53%

• Targeting FKBP52 and Copper in Alzheimer's Disease

  Birge, R.

  National Institute on Aging

  8/1/06 → 7/31/09

  Project: Research project

  • Beta-Amyloid 100%
  • Peptide 30%
  • Silencing RNA 23%
  • Neurotoxicity 11%
  • Mammalian Cell 9%

• Studies of DNA Pol I and Pol E2 of M. tuberculosis

  Modak, M.

  National Institute of Allergy and Infectious Diseases

  1/15/06 → 12/31/08

  Project: Research project

  • DNA Polymerase I 100%
  • DNA-Directed DNA Polymerase 98%
  • spleen exonuclease 73%
  • Tuberculosis 60%
  • Preliminary Data 47%

• 3' end formation of human type I and II collagen mRNAs

  Lutz, C.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/15/05 → 11/30/08

  Project: Research project

  • collagen 100%
  • gene expression regulation 45%
  • transactivators 16%
  • site-directed mutagenesis 14%
  • 3' untranslated regions 14%

• Role of Interferon-lambda in Antiviral Response

  Kotenko, S.

  National Institute of Allergy and Infectious Diseases

  12/16/04 → 11/30/09

  Project: Research project

  • Antiviral Agents 100%
  • Interferons 90%
  • Viruses 38%
  • maltoporins 21%
  • Dendritic Cells 20%

• Genome Targeted Inhibitors of Retroviruses

  Pandey, V.

  National Institute of Allergy and Infectious Diseases

  8/1/02 → 7/31/03

  Project: Research project

  • Nylons 100%
  • Nucleotides 67%
  • Retroviridae 50%
  • Genome 35%
  • Peptides 33%

• Mechanisms of post-transcriptional regulation of MeCP2

  Lutz, C.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  7/1/02 → 6/30/05

  Project: Research project

  • 3' Untranslated Regions 100%
  • Rett Syndrome 32%
  • Polyadenylation 30%
  • Protein Biosynthesis 26%
  • Genes 19%

• Characterization of the IL-TIF Receptor Complex

  Kotenko, S.

  National Institute of Allergy and Infectious Diseases

  5/3/01 → 4/30/07

  Project: Research project

  • IL-TIF IL-10-related T cell-derived inducible factor 100%
  • Cytokines 22%
  • Interleukin-10 21%
  • Ligands 21%
  • Interleukin-10 Receptors 19%

• STRUCTURE AND FUNCTION OF THE MITOCHONDRIAL LON PROTEASE

  Suzuki, C.

  National Institute of General Medical Sciences

  5/1/00 → 4/30/06

  Project: Research project

  • Protease La 100%
  • ATP-Dependent Proteases 63%
  • Mitochondrial DNA 54%
  • Yeasts 42%
  • Mitochondrial Genome 32%

• RETINOIC ACID REGULATED GENES AND EMBRYOS

  Rogers, M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  2/1/00 → 1/31/06

  Project: Research project

  • Tretinoin 100%
  • Embryonic Structures 57%
  • Retinoids 53%
  • Response Elements 34%
  • Genes 32%

• Genome Targeted Inhibitors of Retroviruses

  Pandey, V.

  National Institute of Allergy and Infectious Diseases

  4/1/99 → 1/31/09

  Project: Research project

  • Retroviridae 100%
  • Nylons 74%
  • Genome 62%
  • Nucleotides 28%
  • Nucleic Acids 26%

• IDENTIFICATION OF A NOVEL SIGNAL PATHWAY FOR NGF

  Birge, R.

  National Institute of General Medical Sciences

  1/1/99 → 12/31/03

  Project: Research project

  • Nerve Growth Factor 100%
  • Signal Transduction 52%
  • Tyrosine 34%
  • Paxillin 31%
  • Proto-Oncogene Proteins c-crk 30%

• PRESERVATION OF BETA CELL FUNCTION BY CALBINDIN D28K

  Christakos, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/30/98 → 9/29/02

  Project: Research project

  • Calbindin 1 100%
  • Calbindins 81%
  • Insulin 27%
  • Secretagogues 24%
  • Pancreas Transplantation 13%

• STRUCTURE/FUNCTION RELATIONSHIP IN HIV1 RT

  Pandey, V. & PANDEY, V. N.

  National Cancer Institute

  5/15/96 → 8/31/04

  Project: Research project

  • RNA-Directed DNA Polymerase 100%
  • Amino Acids 90%
  • Catalysis 76%
  • HIV-1 74%
  • HIV 59%

• SIGNAL TRANSDUCTION AND DIFFERENTIATION IN PC12 CELLS

  Birge, R.

  National Institute of General Medical Sciences

  9/15/94 → 9/14/96

  Project: Research project

  • Signal transduction 100%

• RETINOIC ACID: REGULATED GENES AND EARLY EMBRYOS

  Rogers, M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  7/15/94 → 6/30/99

  Project: Research project

• OSTEOPOROSIS/DIHYDROXYVITAMIN REGULATED GENE EXPRESSION

  Christakos, S.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  9/30/91 → 8/31/96

  Project: Research project

  • calbindin 100%
  • osteoporosis 89%
  • vitamin D 75%
  • bone mineralization 54%
  • gene expression 49%

• NUCLEOTIDE METABOLISM &PROMOTION OF CARCINOGENESIS

  Lea, M.

  1/1/90 → 1/31/92

  Project: Research project

  • uracil 100%
  • carcinogenesis 87%
  • arginine 70%
  • uracil-DNA glycosylase 66%
  • diet 62%