New Jersey Medical School (NJMS), Pediatrics, Center for Human Development & Aging

2024

Effect of polygenic scores of telomere length alleles on telomere length in newborns and parents

Lee, Y., Jugessur, A., Gjessing, H. K., Harris, J. R., Susser, E., Magnus, P. & Aviv, A., Sep 2024, In: Aging cell. 23, 9, e14241.

Research output: Contribution to journal › Article › peer-review

Open Access

T-cell count and T-cell telomere length in patients with severe COVID-19

Kraft, B. D., Verhulst, S., Lai, T. P., Sullenger, B. A., Wang, Y., Rountree, W., Chen, L., Woods, C. W., Denny, T. N. & Aviv, A., 2024, In: Frontiers in immunology. 15, 1356638.

Research output: Contribution to journal › Article › peer-review

Open Access

Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian Mother, Father, and Child Cohort Study

Skåra, K. H., Lee, Y., Jugessur, A., Gjessing, H. K., Aviv, A., Brumpton, B., Næss, Ø., Hernáez, Á., Hanevik, H. I., Magnus, P. & Magnus, M. C., Dec 2024, In: BMC Medicine. 22, 1, 580.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Buildup from birth onward of short telomeres in human hematopoietic cells

Lai, T. P., Verhulst, S., Savage, S. A., Gadalla, S. M., Benetos, A., Toupance, S., Factor-Litvak, P., Susser, E. & Aviv, A., Jun 2023, In: Aging cell. 22, 6, e13844.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2022

Decoupling blood telomere length from age in recipients of allogeneic hematopoietic cell transplant in the BMT-CTN 1202

Lai, T. P., Verhulst, S., Dagnall, C. L., Hutchinson, A., Spellman, S. R., Howard, A., Katki, H. A., Levine, J. E., Saber, W., Aviv, A. & Gadalla, S. M., Oct 3 2022, In: Frontiers in immunology. 13, 966301.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Fernando D. Martinez on behalf of the NHLBI CARE Network, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group & TOPMed Structural Variation Working Group, Jan 12 2022, In: Cell Genomics. 2, 1, 100084.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality

Anderson, J. J., Susser, E., Arbeev, K. G., Yashin, A. I., Levy, D., Verhulst, S. & Aviv, A., Apr 2022, In: EBioMedicine. 78, 103978.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2021

Measurement of Telomere Length for Longitudinal Analysis: Implications of Assay Precision

Nettle, D., Gadalla, S. M., Lai, T. P., Susser, E., Bateson, M. & Aviv, A., Jul 1 2021, In: American journal of epidemiology. 190, 7, p. 1406-1413 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Number and replating capacity of endothelial colony-forming cells are telomere length dependent: Implication for human atherogenesis

TELARTA consortium, 2021, In: Journal of the American Heart Association. 10, 10, e020606.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes

Lai, T. P., Simpson, M., Patel, K., Verhulst, S., Noh, J., Roche, N., Heller, D., Guirguis, G., Shay, J. W., Herbig, U. & Aviv, A., Dec 2021, In: Scientific reports. 11, 1, 5115.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population

Nimgaonkar, I., Valeri, L., Susser, E., Hussain, S., Sunderram, J. & Aviv, A., Feb 15 2021, In: Aging. 13, 3, p. 3190-3201 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

The Nexus between Telomere Length and Lymphocyte Count in Seniors Hospitalized with COVID-19

Benetos, A., Lai, T. P., Toupance, S., Labat, C., Verhulst, S., Gautier, S., Ungeheuer, M. N., Perret-Guillaume, C., Levy, D., Susser, E. & Aviv, A., Aug 1 2021, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 76, 8, p. E97-E101

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2020

Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies

Arbeev, K. G., Verhulst, S., Steenstrup, T., Kark, J. D., Bagley, O., Kooperberg, C., Reiner, A. P., Hwang, S. J., Levy, D., Fitzpatrick, A. L., Christensen, K., Yashin, A. I. & Aviv, A., Feb 5 2020, In: JAMA Network Open. 3, 2, p. e200023

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

Determinants of telomere length across human tissues

Demanelis, K., Jasmine, F., Chen, L. S., Chernoff, M., Tong, L., Delgado, D., Zhang, C., Shinkle, J., Sabarinathan, M., Lin, H., Ramirez, E., Oliva, M., Kim-Hellmuth, S., Stranger, B. E., Lai, T. P., Aviv, A., Ardlie, K. G., Aguet, F., Ahsan, H. & Doherty, J. A. & 2 others, Kibriya, M. G. & Pierce, B. L., Sep 2020, In: Science. 369, 6509, A69.

Research output: Contribution to journal › Article › peer-review

Open Access

313 Scopus citations

Genetics and geography of leukocyte telomere length in sub-Saharan Africans

Hunt, S. C., Hansen, M. E. B., Verhulst, S., McQuillan, M. A., Beggs, W., Lai, T. P., Mokone, G. G., Mpoloka, S. W., Meskel, D. W., Belay, G., Nyambo, T. B., Abnet, C. C., Yeager, M., Chanock, S. J., Province, M. A., Williams, S. M., Aviv, A. & Tishkoff, S. A., Sep 15 2020, In: Human molecular genetics. 29, 18, p. 3014-3020 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Telomeres and COVID-19

Aviv, A., Jun 1 2020, In: FASEB Journal. 34, 6, p. 7247-7252 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2019

DNA methylation-based estimator of telomere length

Lu, A. T., Seeboth, A., Tsai, P. C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., Li, Y., Harris, S. E., Corley, J., Taylor, A., Deary, I. J., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Chen, W. & Li, S. & 7 others, Mangino, M., Bell, J. T., Wilson, J. G., Aviv, A., Marioni, R. E., Raj, K. & Horvath, S., 2019, In: Aging. 11, 16, p. 5895-5923 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

218 Scopus citations

DNA methylation GrimAge strongly predicts lifespan and healthspan

Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Ferrucci, L. & Horvath, S., Jan 1 2019, In: Aging. 11, 2, p. 303-327 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1254 Scopus citations

Epigenome-wide association study of leukocyte telomere length

Lee, Y., Sun, D., Ori, A. P. S., Lu, A. T., Seeboth, A., Harris, S. E., Deary, I. J., Marioni, R. E., Soerensen, M., Mengel-From, J., Hjelmborg, J., Christensen, K., Wilson, J. G., Levy, D., Reiner, A. P., Chen, W., Li, S., Harris, J. R., Magnus, P. & Aviv, A. & 2 others, Jugessur, A. & Horvath, S., 2019, In: Aging. 11, 16, p. 5876-5894 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Paternal Age and Transgenerational Telomere Length Maintenance: A Simulation Model

Horvath, K., Eisenberg, D., Stone, R., Anderson, J., Kark, J. & Aviv, A., Dec 1 2019, In: Scientific reports. 9, 1, 20.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Shortened leukocyte telomere length is associated with reduced pulmonary function and greater subsequent decline in function in a sample of World Trade Center responders

Clouston, S. A. P., Edelman, N. H., Aviv, A., Stewart, C. & Luft, B. J., Dec 1 2019, In: Scientific reports. 9, 1, 8148.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Smoking does not accelerate leucocyte telomere attrition: A meta-analysis of 18 longitudinal cohorts

Bateson, M., Aviv, A., Bendix, L., Benetos, A., Ben-Shlomo, Y., Bojesen, S. E., Cooper, C., Cooper, R., Deary, I. J., Hägg, S., Harris, S. E., Kark, J. D., Kronenberg, F., Kuh, D., Labat, C., Martin-Ruiz, C. M., Meyer, C., Nordestgaard, B. G., Penninx, B. W. J. H. & Pepper, G. V. & 11 others, Révész, D., Said, M. A., Starr, J. M., Syddall, H., Thomson, W. M., Van Der Harst, P., Whooley, M., Von Zglinicki, T., Willeit, P., Zhan, Y. & Nettle, D., Jun 1 2019, In: Royal Society Open Science. 6, 6, 190420.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Telomere length tracking in children and their parents: implications for adult onset diseases

Benetos, A., Verhulst, S., Labat, C., Lai, T. P., Girerd, N., Toupance, S., Zannad, F., Rossignol, P. & Aviv, A., Dec 1 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 14248-14253 6 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2018

An epigenetic biomarker of aging for lifespan and healthspan

Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner1, A. P., Aviv1, A., Lohman, K., Liu, Y., Ferrucci, L. & Horvath, S., Apr 1 2018, In: Aging. 10, 4, p. 573-591 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1755 Scopus citations

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

Horvath, S., Oshima, J., Martin, G. M., Lu, A. T., Quach, A., Cohen, H., Felton, S., Matsuyama, M., Lowe, D., Kabacik, S., Wilson, J. G., Reiner, A. P., Maierhofer, A., Flunkert, J., Aviv, A., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D. & Whitsel, E. A. & 3 others, Ferrucci, L., Matsuyama, S. & Raj, K., Jul 1 2018, In: Aging. 10, 7, p. 1758-1775 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

424 Scopus citations

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Lu, A. T., Xue, L., Salfati, E. L., Chen, B. H., Ferrucci, L., Levy, D., Joehanes, R., Murabito, J. M., Kiel, D. P., Tsai, P. C., Yet, I., Bell, J. T., Mangino, M., Tanaka, T., McRae, A. F., Marioni, R. E., Visscher, P. M., Wray, N. R., Deary, I. J. & Levine, M. E. & 19 others, Quach, A., Assimes, T., Tsao, P. S., Absher, D., Stewart, J. D., Li, Y., Reiner, A. P., Hou, L., Baccarelli, A. A., Whitsel, E. A., Aviv, A., Cardona, A., Day, F. R., Wareham, N. J., Perry, J. R. B., Ong, K. K., Raj, K., Lunetta, K. L. & Horvath, S., Dec 1 2018, In: Nature communications. 9, 1, 387.

Research output: Contribution to journal › Article › peer-review

Open Access

141 Scopus citations

Rapid shortening of leukocyte telomeres is associated with poorer pulmonary function among healthy adults

Desai, K., Berkman, N., Cohen-Manheim, I., Sinnreich, R., Aviv, A. & Kark, J. D., Dec 2018, In: Respiratory Medicine. 145, p. 73-79 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Reflections on telomere dynamics and ageing-related diseases in humans

Aviv, A. & Shay, J. W., Mar 5 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1741, 20160436.

Research output: Contribution to journal › Article › peer-review

Open Access

124 Scopus citations

The mitochondrial genome, paternal age and telomere length in humans

Aviv, A., Mar 5 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1741, 20170210.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2017

Acne and Telomere Length: A New Spectrum between Senescence and Apoptosis Pathways

Ribero, S., Sanna, M., Visconti, A., Navarini, A., Aviv, A., Glass, D., Spector, T. D., Smith, C., Simpson, M., Barker, J., Mangino, M., Falchi, M. & Bataille, V., Feb 1 2017, In: Journal of Investigative Dermatology. 137, 2, p. 513-515 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Ancestry, Telomere Length, and Atherosclerosis Risk

Benetos, A. & Aviv, A., Jun 1 2017, In: Circulation: Cardiovascular Genetics. 10, 3, e001718.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

A null mutation in SERPINE1 protects against biological aging in humans

Khan, S. S., Shah, S. J., Klyachko, E., Baldridge, A. S., Eren, M., Place, A. T., Aviv, A., Puterman, E., Lloyd-Jones, D. M., Heiman, M., Miyata, T., Gupta, S., Shapiro, A. D. & Vaughan, D. E., 2017, In: Science Advances. 3, 11, eaao1617.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

Telomeres Mendelian Randomization Collaboration, May 1 2017, In: JAMA Oncology. 3, 5, p. 636-651 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

399 Scopus citations

Correlation of leukocyte telomere length measurement methods in patients with dyskeratosis congenita and in their unaffected relatives

Khincha, P. P., Dagnall, C. L., Hicks, B., Jones, K., Aviv, A., Kimura, M., Katki, H., Aubert, G., Giri, N., Alter, B. P., Savage, S. A. & Gadalla, S. M., Aug 13 2017, In: International journal of molecular sciences. 18, 8, 1765.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Leukocyte telomere length, T cell composition and DNA methylation age

Chen, B. H., Carty, C. L., Kimura, M., Kark, J. D., Chen, W., Li, S., Zhang, T., Kooperberg, C., Levy, D., Assimes, T., Absher, D., Horvath, S., Reiner, A. P. & Aviv, A., Sep 1 2017, In: Aging. 9, 9, p. 1983-1995 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Leukocyte telomere length and cardiovascular disease in African Americans: The Jackson Heart Study

Mwasongwe, S., Gao, Y., Griswold, M., Wilson, J. G., Aviv, A., Reiner, A. P. & Raffield, L. M., Nov 2017, In: Atherosclerosis. 266, p. 41-47 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Positive association between vitamin D serum levels and naevus counts

Ribero, S., Glass, D., Mangino, M., Aviv, A., Spector, T. & Bataille, V., 2017, In: Acta Dermato-Venereologica. 97, 3, p. 321-324 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Short Telomeres, but Not Telomere Attrition Rates, Are Associated with Carotid Atherosclerosis

Toupance, S., Labat, C., Temmar, M., Rossignol, P., Kimura, M., Aviv, A. & Benetos, A., Aug 1 2017, In: Hypertension. 70, 2, p. 420-425 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Telomeres and the natural lifespan limit in humans

Steenstrup, T., Kark, J. D., Verhulst, S., Thinggaard, M., Hjelmborg, J. V. B., Dalgård, C., Kyvik, K. O., Christiansen, L., Mangino, M., Spector, T. D., Petersen, I., Kimura, M., Benetos, A., Labat, C., Sinnreich, R., Hwang, S. J., Levy, D., Hunt, S. C., Fitzpatrick, A. L. & Chen, W. & 9 others, Berenson, G. S., Barbieri, M., Paolisso, G., Gadalla, S. M., Savage, S. A., Christensen, K., Yashin, A. I., Arbeev, K. G. & Aviv, A., 2017, In: Aging. 9, 4, p. 1130-1142 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

2016

A short leucocyte telomere length is associated with development of insulin resistance

Verhulst, S., Dalgård, C., Labat, C., Kark, J. D., Kimura, M., Christensen, K., Toupance, S., Aviv, A., Kyvik, K. O. & Benetos, A., Jun 1 2016, In: Diabetologia. 59, 6, p. 1258-1265 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

DNA methylation age is associated with mortality in a longitudinal Danish twin study

Christiansen, L., Lenart, A., Tan, Q., Vaupel, J. W., Aviv, A., Mcgue, M. & Christensen, K., Feb 1 2016, In: Aging cell. 15, 1, p. 149-154 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

235 Scopus citations

Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife

Cohen-Manheim, I., Doniger, G. M., Sinnreich, R., Simon, E. S., Pinchas, R., Aviv, A. & Kark, J. D., Feb 1 2016, In: European Journal of Epidemiology. 31, 2, p. 147-157 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Leukocyte telomere length in newborns: Implications for the role of telomeres in human disease

Factor-Litvak, P., Susser, E., Kezios, K., McKeague, I., Kark, J. D., Hoffman, M., Kimura, M., Wapner, R. & Aviv, A., Apr 2016, In: Pediatrics. 137, 4

Research output: Contribution to journal › Article › peer-review

Open Access

182 Scopus citations

Shorter telomere length in Europeans than in Africans due to polygenetic adaptation

Hansen, M. E. B., Hunt, S. C., Stone, R. C., Horvath, K., Herbig, U., Ranciaro, A., Hirbo, J., Beggs, W., Reiner, A. P., Wilson, J. G., Kimura, M., Vivo, I. D., Chen, M. M., Kark, J. D., Levy, D., Nyambo, T., Tishkoff, S. A. & Aviv, A., Jun 1 2016, In: Human molecular genetics. 25, 11, p. 2324-2330 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Telomere length measurement by a novel Luminex-based assay: A blinded comparison to Southern blot

Pierce, B. L., Jasmine, F., Roy, S., Zhang, C., Aviv, A., Hunt, S. C., Ahsan, H. & Kibriya, M. G., 2016, In: International Journal of Molecular Epidemiology and Genetics. 7, 1, p. 18-23 6 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2015

Commentary: The reliability of telomere length measurements

Verhulst, S., Susser, E., Factor-Litvak, P. R., Simons, M. J. P., Benetos, A., Steenstrup, T., Kark, J. D. & Aviv, A., Oct 1 2015, In: International journal of epidemiology. 44, 5, p. 1683-1686 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

DCAF4, a novel gene associated with leucocyte telomere length

Mangino, M., Christiansen, L., Stone, R., Hunt, S. C., Horvath, K., Eisenberg, D. T. A., Kimura, M., Petersen, I., Kark, J. D., Herbig, U., Reiner, A. P., Benetos, A., Codd, V., Nyholt, D. R., Sinnreich, R., Christensen, K., Nassar, H., Hwang, S. J., Levy, D. & Bataille, V. & 11 others, Fitzpatrick, A. L., Chen, W., Berenson, G. S., Samani, N. J., Martin, N. G., Tishkoff, S., Schork, N. J., Kyvik, K. O., Dalgård, C., Spector, T. D. & Aviv, A., 2015, In: Journal of medical genetics. 52, 3, p. 157-162 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Height and bone mineral density are associated with naevus count supporting the importance of growth in melanoma susceptibility

Ribero, S., Glass, D., Aviv, A., Spector, T. D. & Bataille, V., Jan 22 2015, In: PloS one. 10, 1, e0116863.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort

Paul, L., Jacques, P. F., Aviv, A., Vasan, R. S., D’Agostino, R. B., Levy, D. & Selhub, J., Mar 2015, In: European Journal of Nutrition. 54, 2, p. 235-241 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Leukocyte Telomere Length and Coronary Artery Calcium

Hunt, S. C., Kimura, M., Hopkins, P. N., Carr, J. J., Heiss, G., Province, M. A. & Aviv, A., Jul 15 2015, In: American Journal of Cardiology. 116, 2, p. 214-218 5 p., 21114.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

New Jersey Medical School (NJMS), Pediatrics, Center for Human Development & Aging

Research output

Search results