Robert Wood Johnson Medical School (RWJMS), Center for Advanced Biotechnology and Medicine

Projects 1975 2024

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Endonucleases
Drug Delivery Systems
Human Influenza
Antiviral Agents
Fluorescence
Influenza B virus
RNA
Innate Immunity
Fluorescence Polarization
Nucleic Acids
Neurobiology
Protein Interaction Maps
Synapses
Brain
Proteins
Mass spectrometry
Neurodegenerative diseases
Liquid chromatography
Mass spectrometers
Pathogens
Nuclear magnetic resonance
Medicine
Biotechnology
Proteins
Cytology
Helicobacter pylori
Stomach
Obesity
Anti-Bacterial Agents
Microbiota

HUMAN TRANSCRIPTION FACTOR IMMUNOGENS: GENERATION OF A COMPLETE SET

Anderson, S., Montelione, G., Arrowsmith, C. & Marcotrigiano, J.

National Institutes of Health

9/23/108/31/15

Project: Research project

Transcription Factors
Proteins
Human Genome Project
Technology
Chromatin Immunoprecipitation
Peptides
Computer-Aided Design
Proteins
Poisons
Therapeutics

Structural Genomics of Eukaryotic Domain Families

Montelione, G., Szyperski, T. A., Rost, B., Hendrickson, W. A., Detitta, G., Arrowsmith, C., Kennedy, M. A., Murray, D., Marcotrigiano, J., Honig, B., Prestegard, J. & Hunt, J. F.

National Institutes of Health

9/1/106/30/16

Project: Research project

Genomics
Proteins
protein structure
genomics
Biological Sciences
Cell Differentiation
Genes
Transcription Factors
Winged-Helix Transcription Factors
Intrinsic Factor
allergenicity
allergens
engineering
digestibility
food allergies
Extracellular Matrix
Collagen
Cell Polarity
Software Design
Neoplasms
Microbiota
Psoriasis
Skin
Microbial Genes
Research
Neurodegenerative diseases
Mass spectrometers
Mass spectrometry
Liquid chromatography
Crosslinking
Antitoxins
Escherichia coli
Bacterial Physiological Phenomena
Cell Death
Bacteria
Membrane Proteins
Proteins
Technology
Biomedical Technology
Molecular Biology
Autistic Disorder
Haplotypes
Alleles
Recombinases
Single Nucleotide Polymorphism

HIV RNase H Natural Product Inhibitors: Isolation and Optimization

Arnold, E., Baroudy, B. M., Jochmans, D. & Parniak, M.

National Institutes of Health

1/1/078/31/12

Project: Research project

Human Immunodeficiency Virus Ribonuclease H
Ribonuclease H
Biological Products
HIV Reverse Transcriptase
Binding Sites
Signal Transduction
Transducers
Protein Kinases
Cytoplasmic Structures
Chemotaxis
Autistic Disorder
Chromosome Mapping
Linkage Disequilibrium
Genes
Haplotypes
Bacillus anthracis
Anthrax
Quorum Sensing
Lethal Dose 50
Macrophages

Structural Genomics of Eukaryotic Domain Families

Inouye, M., Montelione, G., Szyperski, T. A., Detitta, G., Gerstein, M. B., Hendrickson, W. A., Arrowsmith, C., Kennedy, M., Murray, D. & Prestegard, J.

National Institutes of Health

7/1/053/30/11

Project: Research project

Genomics
protein structure
genomics
Proteins
proteome

Structural Genomics of Membrane Proteins

Inouye, M., Gouaux, J., Szyperski, T. A., Girvin, M. E., Mcdermott, A., Gerstein, M. B., Gouaux, J. E., MacKinnon, R., Rost, B., Wang, D. N., Hunt, J. F., Hendrickson, W. A., Shapiro, L. & Zhou, M.

National Institutes of Health

7/1/056/30/11

Project: Research project

Mass spectrometers
Mass spectrometry
Cytology
Deuterium
Chemical modification
Amacrine Cells
Genes
Winged-Helix Transcription Factors
Cell Differentiation
Stem Cells
Magnetic Resonance Spectroscopy
Proteomics
Financial Management
Biotechnology
Medical Schools

Tandem mass spectrometer

Lobel, P.

National Institutes of Health

4/1/043/31/05

Project: Research project

Mass spectrometry
Mass spectrometers
Proteins
HIV Reverse Transcriptase
Gene therapy
cold stress
proteins
Escherichia coli
protein synthesis
host strains

Enabling Anti-AIDS drug design against novel targets

Jones, R., Arnold, E., Parniak, M. & Hughes, S.

National Institutes of Health

7/1/027/31/08

Project: Research project

Anti-HIV Agents
Drug Design
Ribonuclease H
AIDS Vaccines
Vaccines
Transcription Factors
Central Nervous System
Neurogenesis
Inner Ear
Knockout Mice
circadian rhythm
Melanogaster
introns
photoperiod
Drosophila
Bacteria

STRUCTURAL GENOMICS OF EUKARYOTIC MODEL ORGANISMS

Montelione, G., Hendrickson, W. A., Anderson, S. & Honig, B.

National Institutes of Health

9/30/008/31/06

Project: Research project

Proteins
Nuclear magnetic resonance spectroscopy
Genes
Nuclear magnetic resonance
Screening
Pylorus
Helicobacter pylori
Stomach
Theoretical Models
pylorus
Inborn Genetic Diseases
Medical Genetics
Enzymes
Genes
Glycoproteins

MASS SPECTROMETER

Lobel, P.

National Institutes of Health

5/1/9910/31/00

Project: Research project

spectrometers
desorption
ionization
lasers
principal investigators

PRINCIPAL NIH RESEARCH RESOURCE X RAY BEAMLINE AT NSLS: WIGGLER BEAMLINE X25

Arnold, E., Flanagan, J., Phillips, W., Berendzen, J., Moore, P. B., Berman, L., Ealick, S., Capel, M., Ruiming, X., Reinherz, E., Terwilliger, T. O. M., Ellenberger, T. E., Sweet, R., Lewis, H. A. L., Sanghani, P., Ohlendorf, D., Chen, L. I. N., Mariuzza, R., Bahnson, B., Beese, L., Hill, C. P., Churchill, M., Doublié, S., van Roey, P., Brown, B. A., Patel, D., Crane, B., Lu, Y. I., Wolberger, C., Ha, Y. A., Honglin, L., Kantrowitz, E., Lambright, D., Kull, F., Becker, M., Amzel, L. M., Reinisch, K., Steitz, T. A., Crane, A., Gouaux, J. E., MacKinnon, R., Schneider, D. K., Swaminathan, S., Robinson, H., Gehring, K., Marcotrigiano, J., Quan, H., Leahy, D., Agbandje-McKenna, M., Stock, A. M., Bohm, A. A., Sondek, J., Muniz, J. R. C., Lawson, C., Marmorstein, R., Varughese, K., Wang, J. H., Wucherpfennig, K., Richter-Addo, G. B., Dashuang, S., Izard, T., Parry, C., Jiang, J., Pollard, T. D., Boriack-Sjodin, A., Kong, X., Silvaggi, N., Kissinger, C., Schulman, B., Neiditch, M., Coulombe, R., Lolis, E., Ferguson, K., Clarke, T., Birrane, G., Verdine, G., Cygler, M., Murakami, K., Bruner, S., Hengming, K., Parris, K. D., Strobel, S., Sygusch, J., Ippolito, J., Zhao, Y., Mallett, T. C., Williams, L. D., Cordes, M., Jianhua, F., Soares, A. S., Braddock, D., Colman, P., Zhaohui, X., McDonough, M., Kobe, B., Yili, L., Serganov, A., Gallagher, T., Morstein, R., Delbaere, L., Paetzel, M. W., Loll, P., Samanta, U., Mariuzza, R., Moore, P. B., Cohen, C., Rould, M., Van Den Akker, F., Huang, Z., Merithew, E., Heroux, A., Goldberg, J., Miller, C., Schlessinger, J., Berman, L. E., Jayaraman, S., Yigong, S., Hill, C. P., Birktoft, J., Hong, L., Junop, M., Almo, S. C., Martucci, W. E., Howell, P. L., Song, J., Quan, H., Zhao, R. U. I., Royer, W., Fu, D. A. X., Wang, Z., Hunt, J. F., Schroeder, S., Kielkopf, C., Vivien, Y., Kissinger, C., Bohm, A. A., Vicens, C. N., Wucherpfennig, K., Morais Cabral, J., Ha, Y. A., Smith, P., Blaber, M., Pata, J., Radisky, E., Bussiere, D., Reinisch, K., Hart, P. J., Allen, K. N., Vedula, L. S., Blobel, G., Schindelin, H., Buchanan, S. K., Wang, Q. I., Eckenroth, B., Zhou, Z., Lowther, W. T., Gallagher, D., Simmons, C. R., Zhaohui, X., Krasilnikov, A. S., Robinson, V., Silvaggi, N., Park, R., Huang, M., Hughson, F., McMillan, M., Agbandje-McKenna, M., Lawson, C., Allen, C., Hollis, T., vandenberg, L. N., Anderson, A. C., Stern, L., Zongchao, J., Tang, L., Joseph, L., Parsons, J., Christopher Charles, L., Tremblay, L., Serganov, A., Neiditch, M., Xiong, Y., Acharya, R., Modis, Y., Jiang-Yong, M., Furukawa, H., Aggarwal, A. K., Orville, A., Khangulov, S., Morrison, J., Eathiraj, S., Z Helen, W., Boudker, O., Jiang, J., Yuan, Y. U., Sanghani, P., Almo, S. C., Czyzewski, B. K., Soares, A. S., Quan, H., Pavletich, N., Beglova, N., Jogl, G., Akey, C., Stock, A. M., Long, S. B., Boriack-Sjodin, P., Riedl, S., Richter-Addo, G. B., Pata, J., Oldfield, E., Wuxian, S., Lolis, E., Heldwein, E., Schiffer, C. A., Joshua, L., Howell, P. L., Garcia-Diaz, M., MacKinnon, R., McKeever, B. M., Huang, Z., Blaber, M., Radisky, E., Pascal, J., Page, R., Sliz, P., vandemark, A. P., Smith, P. B., Reinisch, K., Christensen, H. E., Jian, H., Schlessinger, J., Mariuzza, R., Allen, K., Mangel, W. F., Hardy, J., Vedula, L. S., Feklistov, A., Bowman, G. D., Bing, H., Seeliger, M. A., Armache, K. J., Steitz, T. A., Bruner, S., Everse, S., Huang, M., Sherman, D., Bohm, A. A., Hubbard, S. R., Blobel, G., Nimigean, C., Hang, S., Lawson, C., Lu, Y. I., Simanshu, D., Fromme, J. C., Gerratana, B., Blacklow, S. C., Liu, C., Zhou, M. & Liu, C.

National Institutes of Health

9/30/986/30/13

Project: Research project

Anti-HIV Agents
Organized Financing
Macromolecular Substances
HIV-1
available personnel
Subtilisin
Protein Folding
Mutation
Proteins
Serine Proteases
Neuronal Ceroid-Lipofuscinoses
Enzymes
Mutation
Genes
Proteins
Retinal Ganglion Cells
POU Domain Factors
Transcription Factors
Retina
Genes
Pylorus
Genetic Recombination
Stomach
Genotype
Horizontal Gene Transfer

STRUCTURE/FUNCTION OF HIV REVERSE TRANSCRIPTASE

Arnold, E., Kollman, P., Johnson, K. & Hughes, S.

National Institutes of Health

8/1/977/31/02

Project: Research project

Detectors
X rays
X ray laboratories
Medicine
Dentistry
Biophysics
Serine Proteases
Nuclear magnetic resonance
Amyloid beta-Protein Precursor
Calorimetry
Pylorus
Helicobacter pylori
Carcinogenesis
Stomach Neoplasms
Biomarkers
Drosophila
Phosphorylation
Circadian Clocks
Proteins
Circadian Rhythm
HIV Reverse Transcriptase
DNA-Directed DNA Polymerase
Nucleic Acids
Holoenzymes
DNA
HIV Reverse Transcriptase
HIV-1
Nucleosides
Mutation
Drug Resistance
biotechnology
molecular dynamics
autoradiography
sequencing
biology