Robert Wood Johnson Medical School (RWJMS), Center for Advanced Biotechnology and Medicine

Research Output

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Review article
2020

Non-nucleoside reverse transcriptase inhibitors join forces with integrase inhibitors to combat HIV

Himmel, D. M. & Arnold, E., Jun 2020, In : Pharmaceuticals. 13, 6, p. 1-26 26 p., 122.

Research output: Contribution to journalReview article

Open Access
2019

Alpha-carboxynucleoside phosphonates: Direct-acting inhibitors of viral DNA polymerases

Balzarini, J., Ford, A., Maguire, N. M., John, J., Das, K., Arnold, E., Dehaen, W. & Maguire, A., Jan 2019, In : Future Medicinal Chemistry. 11, 2, p. 137-154 18 p.

Research output: Contribution to journalReview article

1 Scopus citations

Structural basis of response regulator function

Gao, R., Bouillet, S. & Stock, A. M., Jan 1 2019, In : Annual Review of Microbiology. 73, p. 175-197 23 p.

Research output: Contribution to journalReview article

15 Scopus citations

The role of the changing human microbiome in the asthma pandemic

Borbet, T. C., Zhang, X., Müller, A. & Blaser, M. J., Dec 2019, In : Journal of Allergy and Clinical Immunology. 144, 6, p. 1457-1466 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

What do archaeal and eukaryotic histidine kinases sense?

Papon, N. & Stock, A. M., Jan 1 2019, In : F1000Research. 8

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2018
3 Scopus citations

Using Human Induced Neural Precursor Cells to Define Early Neurodevelopmental Defects in Syndromic and Idiopathic Autism

Connacher, R. J., Dicicco-Bloom, E. & Millonig, J., Dec 1 2018, In : Current Pharmacology Reports. 4, 6, p. 422-435 14 p.

Research output: Contribution to journalReview article

1 Scopus citations
2017

Hypoxia-inducible factor-1α target genes contribute to retinal neuroprotection

Cheng, L., Yu, H., Yan, N., Lai, K. & Xiang, M., Feb 27 2017, In : Frontiers in Cellular Neuroscience. 11, 20.

Research output: Contribution to journalReview article

21 Scopus citations

Searching for the Pareto frontier in multi-objective protein design

Nanda, V., Belure, S. V. & Shir, O. M., Aug 1 2017, In : Biophysical Reviews. 9, 4, p. 339-344 6 p.

Research output: Contribution to journalReview article

2 Scopus citations

Toxins of prokaryotic toxin-antitoxin systems with sequence-specific endoribonuclease activity

Masuda, H. & Inouye, M., Apr 14 2017, In : Toxins. 9, 4, 140.

Research output: Contribution to journalReview article

27 Scopus citations
2016

A community resource of experimental data for NMR / X-ray crystal structure pairs

Everett, J. K., Tejero, R., Murthy, S. B. K., Acton, T. B., Aramini, J. M., Baran, M. C., Benach, J., Cort, J. R., Eletsky, A., Forouhar, F., Guan, R., Kuzin, A. P., Lee, H. W., Liu, G., Mani, R., Mao, B., Mills, J. L., Montelione, A. F., Pederson, K., Powers, R. & 16 others, Ramelot, T., Rossi, P., Seetharaman, J., Snyder, D., Swapna, G. V. T., Vorobiev, S. M., Wu, Y., Xiao, R., Yang, Y., Arrowsmith, C. H., Hunt, J. F., Kennedy, M. A., Prestegard, J. H., Szyperski, T., Tong, L. & Montelione, G. T., Jan 1 2016, In : Protein Science. 25, 1, p. 30-45 16 p.

Research output: Contribution to journalReview article

7 Scopus citations

Antibiotic use and its consequences for the normal microbiome

Blaser, M. J., Apr 29 2016, In : Science. 352, 6285, p. 544-545 2 p.

Research output: Contribution to journalReview article

249 Scopus citations

Rab1 in cell signaling, cancer and other diseases

Yang, X. Z., Li, X. X., Zhang, Y. J., Rodriguez-Rodriguez, L., Xiang, M., Wang, H. Y. & Zheng, X. F. S., Nov 3 2016, In : Oncogene. 35, 44, p. 5699-5704 6 p.

Research output: Contribution to journalReview article

26 Scopus citations
2015

Antibiotics in early life and obesity

Cox, L. M. & Blaser, M. J., Mar 26 2015, In : Nature Reviews Endocrinology. 11, 3, p. 182-190 9 p.

Research output: Contribution to journalReview article

212 Scopus citations

A unified initiative to harness Earth's microbiomes: Transition from description to causality and engineering

Alivisatos, A. P., Blaser, M. J., Brodie, E. L., Chun, M., Dangl, J. L., Donohue, T. J., Dorrestein, P. C., Gilbert, J. A., Green, J. L., Jansson, J. K., Knight, R., Maxon, M. E., McFall-Ngai, M. J., Miller, J. F., Pollard, K. S., Ruby, E. G. & Taha, S. A., Oct 30 2015, In : Science. 350, 6260, p. 507-508 2 p.

Research output: Contribution to journalReview article

123 Scopus citations
2014

Drug resistance in non-B subtype HIV-1: Impact of HIV-1 reverse transcriptase inhibitors

Singh, K., Flores, J. A., Kirby, K. A., Neogi, U., Sonnerborg, A., Hachiya, A., Das, K., Arnold, E., McArthur, C., Parniak, M. & Sarafianos, S. G., Sep 24 2014, In : Viruses. 6, 9, p. 3535-3562 28 p.

Research output: Contribution to journalReview article

19 Scopus citations

The microbiome revolution

Blaser, M. J., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4162-4165 4 p.

Research output: Contribution to journalReview article

Open Access
125 Scopus citations
2013

Foxn4: A multi-faceted transcriptional regulator of cell fates in vertebrate development

Xiang, M. & Li, S. G., Nov 1 2013, In : Science China Life Sciences. 56, 11, p. 985-993 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

HIV-1 reverse transcriptase and antiviral drug resistance. Part 1

Das, K. & Arnold, E., Apr 2013, In : Current Opinion in Virology. 3, 2, p. 111-118 8 p.

Research output: Contribution to journalReview article

88 Scopus citations

HIV-1 reverse transcriptase and antiviral drug resistance. Part 2

Das, K. & Arnold, E., Apr 2013, In : Current Opinion in Virology. 3, 2, p. 119-128 10 p.

Research output: Contribution to journalReview article

59 Scopus citations

Intrinsic control of mammalian retinogenesis

Xiang, M., Jul 1 2013, In : Cellular and Molecular Life Sciences. 70, 14, p. 2519-2532 14 p.

Research output: Contribution to journalReview article

47 Scopus citations

Quality assessment of protein NMR structures

Rosato, A., Tejero, R. & Montelione, G. T., Oct 2013, In : Current Opinion in Structural Biology. 23, 5, p. 715-724 10 p.

Research output: Contribution to journalReview article

20 Scopus citations
2012

How mesenchymal stem cells interact with tissue immune responses

Shi, Y., Su, J., Roberts, A. I., Shou, P., Rabson, A. B. & Ren, G., Mar 2012, In : Trends in Immunology. 33, 3, p. 136-143 8 p.

Research output: Contribution to journalReview article

333 Scopus citations
2011

Microbiome and malignancy

Plottel, C. S. & Blaser, M. J., Oct 4 2011, In : Cell Host and Microbe. 10, 4, p. 324-335 12 p.

Research output: Contribution to journalReview article

Open Access
192 Scopus citations

Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications

Yilmaz, P., Kottmann, R., Field, D., Knight, R., Cole, J. R., Amaral-Zettler, L., Gilbert, J. A., Karsch-Mizrachi, I., Johnston, A., Cochrane, G., Vaughan, R., Hunter, C., Park, J., Morrison, N., Rocca-Serra, P., Sterk, P., Arumugam, M., Bailey, M., Baumgartner, L., Birren, B. W. & 78 others, Blaser, M. J., Bonazzi, V., Booth, T., Bork, P., Bushman, F. D., Buttigieg, P. L., Chain, P. S. G., Charlson, E., Costello, E. K., Huot-Creasy, H., Dawyndt, P., Desantis, T., Fierer, N., Fuhrman, J. A., Gallery, R. E., Gevers, D., Gibbs, R. A., Gil, I. S., Gonzalez, A., Gordon, J. I., Guralnick, R., Hankeln, W., Highlander, S., Hugenholtz, P., Jansson, J., Kau, A. L., Kelley, S. T., Kennedy, J., Knights, D., Koren, O., Kuczynski, J., Kyrpides, N., Larsen, R., Lauber, C. L., Legg, T., Ley, R. E., Lozupone, C. A., Ludwig, W., Lyons, D., Maguire, E., Methé, B. A., Meyer, F., Muegge, B., Nakielny, S., Nelson, K. E., Nemergut, D., Neufeld, J. D., Newbold, L. K., Oliver, A. E., Pace, N. R., Palanisamy, G., Peplies, J., Petrosino, J., Proctor, L., Pruesse, E., Quast, C., Raes, J., Ratnasingham, S., Ravel, J., Relman, D. A., Assunta-Sansone, S., Schloss, P. D., Schriml, L., Sinha, R., Smith, M. I., Sodergren, E., Spor, A., Stombaugh, J., Tiedje, J. M., Ward, D. V., Weinstock, G. M., Wendel, D., White, O., Whiteley, A., Wilke, A., Wortman, J. R., Yatsunenko, T. & Glöckner, F. O., May 2011, In : Nature biotechnology. 29, 5, p. 415-420 6 p.

Research output: Contribution to journalReview article

324 Scopus citations

Regulation of growth and death in Escherichia coli by toxin-antitoxin systems

Yamaguchi, Y. & Inouye, M., Nov 1 2011, In : Nature Reviews Microbiology. 9, 11, p. 779-790 12 p.

Research output: Contribution to journalReview article

231 Scopus citations

The effects of protein crowding in bacterial photosynthetic membranes on the flow of quinone redox species between the photochemical reaction center and the ubiquinol-cytochrome c 2 oxidoreductase

Woronowicz, K., Sha, D., Frese, R. N., Sturgis, J. N., Nanda, V. & Niederman, R., Aug 1 2011, In : Metallomics. 3, 8, p. 765-774 10 p.

Research output: Contribution to journalReview article

13 Scopus citations
2010

Advances in protein NMR provided by the NIGMS Protein Structure Initiative: Impact on drug discovery

Montelione, G. T. & Szyperski, T., May 1 2010, In : Current Opinion in Drug Discovery and Development. 13, 3, p. 335-349 15 p.

Research output: Contribution to journalReview article

11 Scopus citations

A microscale protein NMR sample screening pipeline

Rossi, P., Swapna, G. V. T., Huang, Y. J., Aramini, J. M., Anklin, C., Conover, K., Hamilton, K., Xiao, R., Acton, T. B., Ertekin, A., Everett, J. K. & Montelione, G. T., Jan 2010, In : Journal of biomolecular NMR. 46, 1, p. 11-22 12 p.

Research output: Contribution to journalReview article

65 Scopus citations

Designing artificial enzymes by intuition and computation

Nanda, V. & Koder, R. L., Jan 2010, In : Nature Chemistry. 2, 1, p. 15-24 10 p.

Research output: Contribution to journalReview article

172 Scopus citations

Molecular strategies for phosphorylation-mediated regulation of response regulator activity

Gao, R. & Stock, A., Apr 1 2010, In : Current Opinion in Microbiology. 13, 2, p. 160-167 8 p.

Research output: Contribution to journalReview article

110 Scopus citations

Structures of influenza A proteins and insights into antiviral drug targets

Das, K., Aramini, J. M., Ma, L. C., Krug, R. M. & Arnold, E., May 2010, In : Nature Structural and Molecular Biology. 17, 5, p. 530-538 9 p.

Research output: Contribution to journalReview article

237 Scopus citations
2009

Biological insights from structures of two-component proteins

Gao, R. & Stock, A., Oct 2009, In : Annual Review of Microbiology. 63, p. 133-154 22 p.

Research output: Contribution to journalReview article

448 Scopus citations

Chapter 12 mRNA Interferases, Sequence-Specific Endoribonucleases from the Toxin-Antitoxin Systems

Yamaguchi, Y. & Inouye, M., Dec 1 2009, In : Progress in Molecular Biology and Translational Science. 85, C, p. 467-500 34 p.

Research output: Contribution to journalReview article

94 Scopus citations

Coadaptation of Helicobacter pylori and humans: Ancient history, modern implications

Atherton, J. C. & Blaser, M. J., Sep 1 2009, In : Journal of Clinical Investigation. 119, 9, p. 2475-2487 13 p.

Research output: Contribution to journalReview article

Open Access
347 Scopus citations

Proteomics of the lysosome

Lübke, T., Lobel, P. & Sleat, D. E., Apr 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 4, p. 625-635 11 p.

Research output: Contribution to journalReview article

157 Scopus citations

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Sarafianos, S. G., Marchand, B., Das, K., Himmel, D. M., Parniak, M. A., Hughes, S. H. & Arnold, E., Jan 23 2009, In : Journal of molecular biology. 385, 3, p. 693-713 21 p.

Research output: Contribution to journalReview article

312 Scopus citations

Structures of RNA polymerase-antibiotic complexes

Ho, M. X., Hudson, B. P., Das, K., Arnold, E. & Ebright, R. H., Dec 2009, In : Current Opinion in Structural Biology. 19, 6, p. 715-723 9 p.

Research output: Contribution to journalReview article

84 Scopus citations

Unique opportunities for NMR methods in structural genomics

Montelione, G. T., Arrowsmith, C., Girvin, M. E., Kennedy, M. A., Markley, J. L., Powers, R., Prestegard, J. H. & Szyperski, T., Apr 2009, In : Journal of Structural and Functional Genomics. 10, 2, p. 101-106 6 p.

Research output: Contribution to journalReview article

17 Scopus citations
2008

Disappearing microbiota: Helicobacter pylori protection against esophageal adenocarcinoma

Blaser, M. J., Oct 2008, In : Cancer Prevention Research. 1, 5, p. 308-311 4 p.

Research output: Contribution to journalReview article

Open Access
78 Scopus citations

PCTA: A new player in TGF-β signaling

Liu, F., Nov 14 2008, In : Science signaling. 1, 46, p. pe49

Research output: Contribution to journalReview article

10 Scopus citations

Protein production and purification

Gräslund, S., Nordlund, P., Weigelt, J., Hallberg, B. M., Bray, J., Gileadi, O., Knapp, S., Oppermann, U., Arrowsmith, C., Hui, R., Ming, J., dhe-Paganon, S., Park, H. W., Savchenko, A., Yee, A., Edwards, A., Vincentelli, R., Cambillau, C., Kim, R., Kim, S. H. & 64 others, Rao, Z., Shi, Y., Terwilliger, T. C., Kim, C. Y., Hung, L. W., Waldo, G. S., Peleg, Y., Albeck, S., Unger, T., Dym, O., Prilusky, J., Sussman, J. L., Stevens, R. C., Lesley, S. A., Wilson, I. A., Joachimiak, A., Collart, F., Dementieva, I., Donnelly, M. I., Eschenfeldt, W. H., Kim, Y., Stols, L., Wu, R., Zhou, M., Burley, S. K., Emtage, J. S., Sauder, J. M., Thompson, D., Bain, K., Luz, J., Gheyi, T., Zhang, F., Atwell, S., Almo, S. C., Bonanno, J. B., Fiser, A., Swaminathan, S., Studier, F. W., Chance, M. R., Sali, A., Acton, T. B., Xiao, R., Zhao, L., Ma, L. C., Hunt, J. F., Tong, L., Cunningham, K., Inouye, M., Anderson, S., Janjua, H., Shastry, R., Ho, C. K., Wang, D., Wang, H., Jiang, M., Montelione, G. T., Stuart, D. I., Owens, R. J., Daenke, S., Schütz, A., Heinemann, U., Yokoyama, S., Büssow, K. & Gunsalus, K. C., Feb 2008, In : Nature Methods. 5, 2, p. 135-146 12 p.

Research output: Contribution to journalReview article

536 Scopus citations

The intramolecular chaperone-mediated protein folding

Chen, Y. J. & Inouye, M., Dec 1 2008, In : Current Opinion in Structural Biology. 18, 6, p. 765-770 6 p.

Research output: Contribution to journalReview article

64 Scopus citations

Understanding microbe-induced cancers

Blaser, M. J., Jun 2008, In : Cancer Prevention Research. 1, 1, p. 15-20 6 p.

Research output: Contribution to journalReview article

Open Access
28 Scopus citations
2007

Bacterial response regulators: versatile regulatory strategies from common domains

Gao, R., Mack, T. R. & Stock, A., May 2007, In : Trends in Biochemical Sciences. 32, 5, p. 225-234 10 p.

Research output: Contribution to journalReview article

202 Scopus citations

Lysosomal proteomics and disease

Sleat, D. E., Jadot, M. & Lobel, P., Sep 1 2007, In : Proteomics - Clinical Applications. 1, 9, p. 1134-1146 13 p.

Research output: Contribution to journalReview article

19 Scopus citations

The Raz mTaz of human mesenchymal stem cells

Banerjee, D., Glod, J. & Rabson, A., Oct 1 2007, In : Stem Cells and Development. 16, 5, p. 691-693 3 p.

Research output: Contribution to journalReview article

1 Scopus citations
2006

Current insights into the regulation of programmed cell death by NF-κB

Dutta, J., Fan, Y., Gupta, N., Fan, G. & Gelinas, C., Oct 30 2006, In : Oncogene. 25, 51, p. 6800-6816 17 p.

Research output: Contribution to journalReview article

320 Scopus citations

Finding one of a kind: advances in single-protein production

Falzon, L., Suzuki, M. & Inouye, M., Aug 1 2006, In : Current Opinion in Biotechnology. 17, 4, p. 347-352 6 p.

Research output: Contribution to journalReview article

7 Scopus citations

Regulating a circadian clock's period, phase and amplitude by phosphorylation: Insights from Drosophila

Bae, K. & Edery, I., Nov 1 2006, In : Journal of Biochemistry. 140, 5, p. 609-617 9 p.

Research output: Contribution to journalReview article

54 Scopus citations