Robert Wood Johnson Medical School (RWJMS), Neuroscience & Cell Biology

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2020

Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment

Norton, S. A., Gifford, J. J., Pawlak, A. P., Derbaly, A., Sherman, S. L., Zhang, H., Wagner, G. C. & Kusnecov, A. W., May 10 2020, In : Neuroscience. 434, p. 8-21 14 p.

Research output: Contribution to journalArticle

Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability

Chi, O., Mellender, S. J., Kiss, G. K., Chiricolo, A., Liu, X., Patel, N., Jacinto, E. & Weiss, H. R., Oct 2020, In : Journal of Stroke and Cerebrovascular Diseases. 29, 10, 105029.

Research output: Contribution to journalArticle

Lysophosphatidic Acid Reduces Microregional Oxygen Supply/Consumption Balance after Cerebral Ischemia-Reperfusion

Weiss, H. R., Mellender, S. J., Kiss, G. K., Chiricolo, A., Liu, X. & Chi, O., Jan 1 2020, (Accepted/In press) In : Journal of Vascular Research.

Research output: Contribution to journalArticle

PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

Chen, Y. C., Mains, R. E., Eipper, B. A., Hoffman, B. G., Czyzyk, T. A., Pintar, J. E. & Verchere, C. B., Mar 1 2020, In : Diabetologia. 63, 3, p. 561-576 16 p.

Research output: Contribution to journalArticle

Reactive Astrocytes as Therapeutic Targets for Brain Degenerative Diseases: Roles Played by Metabotropic Glutamate Receptors

Planas-Fontánez, T. M., Dreyfus, C. F. & Saitta, K. S., Mar 1 2020, In : Neurochemical Research. 45, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

Open Access

Reduced reelin expression in the hippocampus after traumatic brain injury

Dal Pozzo, V., Crowell, B., Briski, N., Crockett, D. P. & D’arcangelo, G., Jul 2020, In : Biomolecules. 10, 7, p. 1-14 14 p., 975.

Research output: Contribution to journalArticle

Open Access

Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development

Popovitchenko, T., Park, Y., Page, N. F., Luo, X., Krsnik, Z., Liu, Y., Salamon, I., Stephenson, J. D., Kraushar, M. L., Volk, N. L., Patel, S. M., Wijeratne, H. R. S., Li, D., Suthar, K. S., Wach, A., Sun, M., Arnold, S. J., Akamatsu, W., Okano, H., Paillard, L. & 6 others, Zhang, H., Buyske, S., Kostovic, I., De Rubeis, S., Hart, R. P. & Rasin, M. R., Dec 1 2020, In : Nature communications. 11, 1, 1674.

Research output: Contribution to journalArticle

Open Access
2019

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

Kruegel, A. C., Uprety, R., Grinnell, S. G., Langreck, C., Pekarskaya, E. A., Le Rouzic, V., Ansonoff, M., Gassaway, M. M., Pintar, J. E., Pasternak, G. W., Javitch, J. A., Majumdar, S. & Sames, D., Jun 26 2019, In : ACS Central Science. 5, 6, p. 992-1001 10 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes

Giarratana, A. O., Teng, S., Reddi, S., Zheng, C., Adler, D., Thakker-Varia, S. & Alder, J., Nov 7 2019, In : Frontiers in Neurology. 10, 1175.

Research output: Contribution to journalArticle

Open Access

Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment

Scully, T., Scott, C. D., Firth, S. M., Pintar, J. E., Twigg, S. M. & Baxter, R. C., Jan 1 2019, In : Experimental cell research. 374, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Inhibition of EphA/Ephrin-A signaling using genetic and pharmacologic approaches improves recovery following traumatic brain injury in mice

Teng, S., Palmieri, A., Maita, I., Zheng, C., Das, G., Park, J., Zhou, R., Suss, J. A. & Varia, S., Aug 24 2019, In : Brain injury. 33, 10, p. 1385-1401 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of p70 ribosomal S6 kinase 1 (S6K1)by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability

Chi, O. Z., Kiss, G. K., Mellender, S. J., Liu, X., Liu, S., Jacinto, E. & Weiss, H. R., Jul 15 2019, In : European Journal of Pharmacology. 855, p. 202-207 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Learning science communication skills using improvisation, video recordings, and practice, practice, practice

Ponzio, N. M., Alder, J., Nucci, M., Dannenfelser, D., Hilton, H., Linardopoulos, N. & Lutz, C., Jan 1 2019, In : Journal of Microbiology and Biology Education. 19, 1, 1433.

Research output: Contribution to journalArticle

Open Access

Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA

Kopp, Z. & Park, Y., Jan 1 2019, In : Aging. 11, 1, p. 230-239 10 p.

Research output: Contribution to journalArticle

Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury 11 Medical and Health Sciences 1109 Neurosciences

Dibona, V. L., Zhu, W., Shah, M. K., Rafalia, A., Ben Cheikh, H., Crockett, D. P. & Zhang, H., Jan 17 2019, In : Journal of Neuroinflammation. 16, 1, 11.

Research output: Contribution to journalArticle

3 Scopus citations

Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment

Yu, W., Zhang, H., Shin, M. R. & Sesti, F., May 14 2019, In : Biochemical and Biophysical Research Communications. 512, 4, p. 665-669 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons

Sun, M., Huang, C., Wang, H. & Zhang, H., May 2019, In : Neurobiology of Aging. 77, p. 87-93 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins

Kim, H., Xu, R., Padmashri, R., Dunaevsky, A., Liu, Y., Dreyfus, C. F. & Jiang, P., May 14 2019, In : Stem Cell Reports. 12, 5, p. 890-905 16 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2018

Activation of Akt by SC79 decreased cerebral infarct in early cerebral ischemia-reperfusion despite increased BBB disruption

Liu, X., Kiss, G. K., Mellender, S. J., Weiss, H. & Chi, O., Aug 10 2018, In : Neuroscience Letters. 681, p. 78-82 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Akt activation improves microregional oxygen supply/consumption balance after cerebral ischemia-reperfusion

Weiss, H., Chi, O., Kiss, G. K., Liu, X., Damito, S. & Jacinto, E., Mar 15 2018, In : Brain research. 1683, p. 48-54 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Altered salt taste response and increased tongue epithelium Scnna1 expression in adult Engrailed-2 null mice

Gupta, A., Li, X., DiCicco-Bloom, E. & Bello, N. T., Oct 1 2018, In : Physiology and Behavior. 194, p. 410-419 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation

Scully, T., Scott, C. D., Firth, S. M., Sedger, L. M., Pintar, J. E., Twigg, S. M. & Baxter, R. C., Feb 2018, In : Endocrine-Related Cancer. 25, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer’s disease

Wei, Y., Shin, M. R. & Sesti, F., Aug 1 2018, In : Cell Death and Disease. 9, 8, 820.

Research output: Contribution to journalArticle

4 Scopus citations

Rapid detection of neurodevelopmental phenotypes in human neural precursor cells (NPCs)

Williams, M., Prem, S., Zhou, X., Matteson, P., Yeung, P. L., Lu, C-W., Pang, Z., Brzustowicz, L., Millonig, J. & Dicicco-Bloom, E., Mar 2 2018, In : Journal of Visualized Experiments. 2018, 133, e56628.

Research output: Contribution to journalArticle

6 Scopus citations

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains

Zhang, L., Zhang, P., Wang, G., Zhang, H., Zhang, Y., Yu, Y., Zhang, M., Xiao, J., Crespo, P., Hell, J. W., Lin, L., Huganir, R. L. & Zhu, J. J., May 16 2018, In : Neuron. 98, 4, p. 783-800.e4

Research output: Contribution to journalArticle

17 Scopus citations

Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M. E., Xie, M., Kicheva, A., Annusver, K., Kasper, M., Symmons, O., Pan, L., Spitz, F., Kaiser, J., Hovorakova, M., Zikmund, T., Sunadome, K., Matise, M. P., Wang, H., Marklund, U., Abdo, H. & 6 others, Ernfors, P., Maire, P., Wurmser, M., Chagin, A. S., Fried, K. & Adameyko, I., Jun 13 2018, In : eLife. 7, e34465.

Research output: Contribution to journalArticle

8 Scopus citations

The endolysosomal system and proteostasis: From development to degeneration

Winckler, B., Faundez, V., Maday, S., Cai, Q., Almeida, C. G. & Zhang, H., Oct 31 2018, In : Journal of Neuroscience. 38, 44, p. 9364-9374 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions

Eyo, U. B., Bispo, A., Liu, J., Sabu, S., Wu, R., Dibona, V. L., Zheng, J., Murugan, M., Zhang, H., Tang, Y. & Wu, L-J., Dec 1 2018, In : Scientific reports. 8, 1, 828.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Atrophin protein RERE positively regulates Notch targets in the developing vertebrate spinal cord

Wang, H., Gui, H., Rallo, M. S., Xu, Z. & Matise, M. P., May 1 2017, In : Journal of neurochemistry. 141, 3, p. 347-357 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Blood -brain barrier disruption was less under isoflurane than pentobarbital anesthesia via a PI3K/Akt pathway in early cerebral ischemia

Chi, O., Mellender, S. J., Kiss, G. K., Liu, X. & Weiss, H., May 1 2017, In : Brain Research Bulletin. 131, p. 1-6 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

Lim, C. S., Kang, X., Mirabella, V., Zhang, H., Bu, Q., Araki, Y., Hoang, E. T., Wang, S., Shen, Y., Choi, S., Kaang, B. K., Chang, Q., Pang, Z. P., Huganir, R. L. & Zhu, J. J., Mar 15 2017, In : Genes & development. 31, 6, p. 537-552 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Control of species-dependent cortico-motoneuronal connections underlying manual dexterity

Gu, Z., Kalamboglas, J., Yoshioka, S., Han, W., Li, Z., Kawasawa, Y. I., Pochareddy, S., Li, Z., Liu, F., Xu, X., Wijeratne, S., Ueno, M., Blatz, E., Salomone, J., Kumanogoh, A., Rasin, M. R., Gebelein, B., Weirauch, M. T., Sestan, N., Martin, J. H. & 1 others, Yoshida, Y., Jul 28 2017, In : Science. 357, 6349, p. 400-404 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cytoskeletal remodeling via Rho GTPases during oxidative and thermal stress in Caenorhabditis elegans

Patel, R., Sriramoji, S., Marucci, M., Aziz, I., Shah, S. & Sesti, F., Oct 21 2017, In : Biochemical and Biophysical Research Communications. 492, 3, p. 338-342 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hypoxic preconditioning increases blood-brain barrier disruption in the early stages of cerebral ischemia

Chi, O. Z., Mellender, S. J., Barsoum, S., Liu, X. & Weiss, H. R., Feb 1 2017, In : Current Neurovascular Research. 14, 1, p. 26-31 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Neuropeptide VGF promotes maturation of hippocampal dendrites that is reduced by single nucleotide polymorphisms

Behnke, J., Cheedalla, A., Bhatt, V., Bhat, M., Teng, S., Palmieri, A., Windon, C. C., Thakker-Varia, S. & Alder, J., Mar 11 2017, In : International journal of molecular sciences. 18, 3, 612.

Research output: Contribution to journalArticle

11 Scopus citations

Opioids and opioid receptors orchestrate wound repair

Wang, Y., Gupta, M., Poonawala, T., Farooqui, M., Li, Y., Peng, F., Rao, S., Ansonoff, M., Pintar, J. E. & Gupta, K., Jul 2017, In : Translational Research. 185, p. 13-23 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain

Yu, W., Gowda, M., Sharad, Y., Singh, S. A. & Sesti, F., Jan 1 2017, In : Cell Death and Disease. 8, 4, e2737.

Research output: Contribution to journalArticle

9 Scopus citations

Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1

Sun, M. & Zhang, H., Dec 1 2017, In : Neurobiology of Aging. 60, p. 129-140 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy

Lim, C. S., Wen, C., Sheng, Y., Wang, G., Zhou, Z., Wang, S., Zhang, H., Ye, A. & Zhu, J. J., Oct 25 2017, In : Small. 13, 40, 1701972.

Research output: Contribution to journalArticle

1 Scopus citations

Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity

Wu, Q., Sun, M., Bernard, L. P. & Zhang, H., Jan 1 2017, In : Journal of Biological Chemistry. 292, 39, p. 16150-16160 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine

Berezniuk, I., Rodriguiz, R. M., Zee, M. L., Marcus, D. J., Pintar, J., Morgan, D. J., Wetsel, W. C. & Fricker, L. D., Nov 2017, In : Journal of neurochemistry. 143, 3, p. 268-281 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rapamycin decreased blood-brain barrier permeability in control but not in diabetic rats in early cerebral ischemia

Chi, O. Z., Kiss, G. K., Mellender, S. J., Liu, X. & Weiss, H. R., Jul 27 2017, In : Neuroscience Letters. 654, p. 17-22 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Spatial gene expression analysis of neuroanatomical differences in mouse models

Fernandes, D. J., Ellegood, J., Askalan, R., Blakely, R. D., Dicicco-Bloom, E., Egan, S. E., Osborne, L. R., Powell, C. M., Raznahan, A., Robins, D. M., Salter, M. W., Sengar, A. S., Veenstra-VanderWeele, J. & Lerch, J. P., Dec 2017, In : NeuroImage. 163, p. 220-230 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Strain differences in cuprizone induced demyelination

Yu, Q., Hui, R., Park, J., Huang, Y., Kusnecov, A. W., Dreyfus, C. F. & Zhou, R., Nov 3 2017, In : Cell and Bioscience. 7, 1, 59.

Research output: Contribution to journalArticle

11 Scopus citations

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor

Samuels, B. A., Nautiyal, K. M., Kruegel, A. C., Levinstein, M. R., Magalong, V. M., Gassaway, M. M., Grinnell, S. G., Han, J., Ansonoff, M. A., Pintar, J. E., Javitch, J. A., Sames, D. & Hen, R., Apr 19 2017, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

27 Scopus citations
2016

A novel nociceptin receptor antagonist LY2940094 inhibits excessive feeding behavior in rodents: A possible mechanism for the treatment of binge eating disorder

Statnick, M. A., Chen, Y., Ansonoff, M., Witkin, J. M., Rorick-Kehn, L., Suter, T. M., Song, M., Hu, C., Lafuente, C., Jiménez, A., Benito, A., Diaz, N., Martínez-Grau, M. A., Toledo, M. A. & Pintar, J. E., Feb 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 2, p. 493-502 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis

Dever, D. P., Adham, Z. O., Thompson, B., Genestine, M., Cherry, J., Olschowka, J. A., DiCicco-Bloom, E. & Opanashuk, L. A., May 1 2016, In : Developmental Neurobiology. 76, 5, p. 533-550 18 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effects of rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia

Chi, O., Barsoum, S., Vega-Cotto, N. M., Jacinto, E., Liu, X., Mellender, S. J. & Weiss, H., Mar 1 2016, In : Neuroscience. 316, p. 321-327 7 p.

Research output: Contribution to journalArticle

13 Scopus citations