Rutgers Office of Research Commercialization

Research Output 1979 2019

  • 9107 Citations
  • 41 h-Index
  • 121 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Letter
2019

Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model

Rizzolo, D., Buckley, K., Kong, B., Zhan, L., Shen, J., Stofan, M., Brinker, A., Goedken, M., Buckley, B. & Guo, G. L., Jul 2019, In : Hepatology. 70, 1, p. 389-402 14 p.

Research output: Contribution to journalArticle

Cholestanetriol 26-Monooxygenase
Cholesterol 7-alpha-Hydroxylase
Bile Acids and Salts
Knockout Mice
Homeostasis

Bioengineered adipose-derived stem cells for targeted enzyme-prodrug therapy of ovarian cancer intraperitoneal metastasis

Malekshah, O. M., Sarkar, S., Nomani, A., Patel, N., Javidian, P., Goedken, M., Polunas, M., Louro, P. & Hatefi, A., Oct 2019, In : Journal of Controlled Release. 311-312, p. 273-287 15 p.

Research output: Contribution to journalArticle

Enzyme Therapy
Prodrugs
Ovarian Neoplasms
Stem Cells
Neoplasm Metastasis

Coencapsulation of ISCs and MSCs Enhances Viability and Function of both Cell Types for Improved Wound Healing

Aijaz, A., Teryek, M., Goedken, M., Polunas, M. & Olabisi, R. M., Oct 1 2019, In : Cellular and Molecular Bioengineering. 12, 5, p. 481-493 13 p.

Research output: Contribution to journalArticle

Open Access
Wound Healing
Stem Cells
Insulin
Insulin-Secreting Cells
Stem cells
1 Citation (Scopus)

Combinatorial therapy of zinc metallochaperones with mutant p53 reactivation and diminished copper binding

Zaman, S., Yu, X., Bencivenga, A. F., Blanden, A. R., Liu, Y., Withers, T., Na, B., Blayney, A. J., Gilleran, J., Boothman, D. A., Loh, S. N., Kimball, S. D. & Carpizo, D. R., Jan 1 2019, In : Molecular Cancer Therapeutics. 18, 8, p. 1355-1365 11 p.

Research output: Contribution to journalArticle

Metallochaperones
Zinc
Copper
Drug Therapy
Radiation

Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development

Schumacher, J. D., Kong, B., Wu, J., Rizzolo, D., Armstrong, L. E., Chow, M. D., Goedken, M., Lee, Y. H. & Guo, G. L., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Fibroblast Growth Factors
Liver Cirrhosis
Bile Acids and Salts
Cholestyramine Resin

Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion

D'Errico, J. N., Doherty, C., Fournier, S. B., Renkel, N., Kallontzi, S., Goedken, M., Fabris, L., Buckley, B. & Stapleton, P. A., Sep 2019, In : Biomedicine and Pharmacotherapy. 117, 109148.

Research output: Contribution to journalArticle

Open Access
Nanostructures
Gold
Placenta
Uterine Artery
Perfusion
1 Citation (Scopus)

Inhibition of ER stress by 2-aminopurine treatment modulates cardiomyopathy in a murine chronic chagas disease model

Ayyappan, J. P., Lizardo, K., Wang, S., Yurkow, E. & Nagajyothi, J. F., Jan 1 2019, In : Biomolecules and Therapeutics. 27, 4, p. 386-394 9 p.

Research output: Contribution to journalArticle

2-Aminopurine
Endoplasmic Reticulum Stress
Chagas Disease
Cardiomyopathies
Chronic Disease

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Donepudi, A. C., Goedken, M. J., Schuetz, J. D. & E Manautou, J., 2019, In : Toxicology Reports. 6, p. 841-849 9 p.

Research output: Contribution to journalArticle

Open Access
Multidrug Resistance-Associated Proteins
Acetaminophen
Toxicity
Kinetics
Liver
2018

Effect of World Trade Center Dust Exposure and Chronic Intermittent Hypoxia on Macrophage Matrix Metalloproteinase-12 Expression in Mice

Radbel, J., Le-Hoang, O., Vayas, K. N., Patel, K., Goedken, M., Sunil, V. R., Laskin, D. & Sunderram, J., Apr 1 2018, In : Annals of the American Thoracic Society. 15, 2, p. S125-S126

Research output: Contribution to journalArticle

Open Access
Matrix Metalloproteinase 12
Dust
Macrophages
Alveolar Macrophages
Phosphates
2 Citations (Scopus)

Gene-by-environment interaction of Bcrp-/- and methionine-and choline-deficient diet-induced nonalcoholic steatohepatitis alters SN-38 disposition

Toth, E. L., Li, H., Dzierlenga, A. L., Clarke, J. D., Vildhede, A., Goedken, M. & Cherrington, N. J., Nov 2018, In : Drug Metabolism and Disposition. 46, 11, p. 1478-1486 9 p.

Research output: Contribution to journalArticle

Open Access
irinotecan
Gene-Environment Interaction
Choline
Methionine
Diet
6 Citations (Scopus)

Improved freeze drying efficiency by ice nucleation proteins with ice morphology modification

Jin, J., Yurkow, E., Adler, D. & Lee, T. C., Apr 1 2018, In : Food Research International. 106, p. 90-97 8 p.

Research output: Contribution to journalArticle

ice nucleation
Freeze Drying
Ice
freeze drying
ice
1 Citation (Scopus)

Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer

Newman, J. H., Augeri, D. J., Nemoyer, R., Malhotra, J., Langenfeld, E., Chesson, C. B., Dobias, N. S., Lee, M. J., Tarabichi, S., Jhawar, S. R., Bommareddy, P. K., Marshall, SR., Sadimin, E. T., Kerrigan, J. E., Goedken, M., Minerowicz, C., Jabbour, S. K., Li, S., Carayannopolous, M. O., Zloza, A. & 1 others, Langenfeld, J., Jul 5 2018, In : Oncogene. 37, 27, p. 3672-3685 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein Receptors
Lung Neoplasms
Cell Survival
Neoplasms
Heterografts
7 Citations (Scopus)

Zinc metallochaperones reactivate mutant p53 using an on/off switch mechanism: A new paradigm in cancer therapeutics

Yu, X., Kogan, S., Chen, Y., Tsang, A. T., Withers, T., Lin, H., Gilleran, J., Buckley, B., Moore, D., Bertino, J., Chan, C., Kimball, S., Loh, S. N. & Carpizo, D., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4505-4517 13 p.

Research output: Contribution to journalArticle

Metallochaperones
Zinc
Neoplasms
Therapeutics
Pharmacokinetics
2017
6 Citations (Scopus)

A Novel Approach To Improve the Efficiency of Block Freeze Concentration Using Ice Nucleation Proteins with Altered Ice Morphology

Jin, J., Yurkow, E. J., Adler, D. & Lee, T. C., Mar 22 2017, In : Journal of agricultural and food chemistry. 65, 11, p. 2373-2382 10 p.

Research output: Contribution to journalArticle

ice nucleation
Ice
ice
desalination
Desalination
15 Citations (Scopus)

Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)

Garbuzenko, O. B., Ivanova, V., Kholodovych, V., Reimer, D. C., Reuhl, K. R., Yurkow, E., Adler, D. & Minko, T., Aug 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 6, p. 1983-1992 10 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Prostaglandins E
Dinoprostone
Nanoparticles
Lipids
7 Citations (Scopus)

In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice

Li, H., Clarke, J. D., Dzierlenga, A. L., Bear, J., Goedken, M. J. & Cherrington, N. J., Feb 1 2017, In : Journal of Biochemical and Molecular Toxicology. 31, 2, e21840.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Metabolism
Pharmacokinetics
Losartan
Omeprazole
2 Citations (Scopus)

Synthesis and Characterization of Novel BMI1 Inhibitors Targeting Cellular Self-Renewal in Hepatocellular Carcinoma

Bartucci, M., Hussein, M. S., Huselid, E., Flaherty, K., Patrizii, M., Laddha, S. V., Kui, C., Bigos, R. A., Gilleran, J. A., El Ansary, M. M. S., Awad, M. A. M., Kimball, S., Augeri, D. & Sabaawy, H., Aug 1 2017, In : Targeted Oncology. 12, 4, p. 449-462 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Hepatocellular Carcinoma
Neoplasms
Stem Cells
Recurrence
9 Citations (Scopus)

The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis

Schumacher, J. D., Kong, B., Pan, Y., Zhan, L., Sun, R., Aa, J., Rizzolo, D., Richardson, J. R., Chen, A., Goedken, M., Aleksunes, L. M., Laskin, D. L. & Guo, G. L., Sep 1 2017, In : Toxicology and Applied Pharmacology. 330, p. 1-8 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
High Fat Diet
Fatty Liver
Nutrition
Liver
16 Citations (Scopus)

Thiosemicarbazones functioning as zinc metallochaperones to reactivate mutant p53

Yu, X., Blanden, A., Tsang, A. T., Zaman, S., Liu, Y., Gilleran, J., Bencivenga, A. F., Kimball, S. D., Loh, S. N. & Carpizo, D. R., Jun 2017, In : Molecular Pharmacology. 91, 6, p. 567-575 9 p.

Research output: Contribution to journalArticle

Metallochaperones
Thiosemicarbazones
Zinc
Chelating Agents
Reactive Oxygen Species
2016
3 Citations (Scopus)

Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir

Laho, T., Clarke, J. D., Dzierlenga, A. L., Li, H., Klein, D. M., Goedken, M., Micuda, S. & Cherrington, N. J., Sep 1 2016, In : Biochemical Pharmacology. 115, p. 144-151 8 p.

Research output: Contribution to journalArticle

Kidney
Glomerular Filtration Rate
Pharmacokinetics
Nutrition
Choline
12 Citations (Scopus)

Enhanced hepatotoxicity by acetaminophen in Vanin-knockout mice is associated with deficient proliferative and immune responses

Ferreira, D. W., Goedken, M. J., Rommelaere, S., Chasson, L., Galland, F., Naquet, P. & Manautou, J. E., Apr 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 4, p. 662-669 8 p.

Research output: Contribution to journalArticle

Open Access
Acetaminophen
Knockout Mice
PPAR alpha
Clofibrate
Liver
19 Citations (Scopus)

Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death

Augeri, D. J., Langenfeld, E., Castle, M., Gilleran, J. A. & Langenfeld, J., Apr 6 2016, In : Molecular Cancer. 15, 1, 27.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
Bone Morphogenetic Proteins
Growth Factor Receptors
Transforming Growth Factors
Lung Neoplasms
2015

Erratum: Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore (Molecular Pharmacology (2015) 87 (825-831))

Blanden, R., Yu, X., Aaron, J. W., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N., Dec 1 2015, In : Molecular Pharmacology. 88, 6, 1 p.

Research output: Contribution to journalComment/debate

Erratum:N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent(Journal of Medicinal Chemistry (2004) 47 (1719-1728) DOI: 10.1021/jm0305568)

Misra, R. N., Xiao, H. Y., Kim, K. S., Lu, S., Han, W. C., Barbosa, S. A., Hunt, J. T., Rawlins, D. B., Shan, W., Ahmed, S. Z., Qian, L., Chen, B. C., Zhao, R., Bednarz, M. S., Kellar, K. A., Mulheron, J. G., Batorsky, R., Roongta, U., Kamath, A., Marathe, P. & 7 others, Ranadive, S. A., Sack, J. S., Tokarski, J. S., Pavletich, N. P., Lee, F. Y. F., Webster, K. R. & Kimball, S. D., Sep 24 2015, In : Journal of medicinal chemistry. 58, 18, 1 p.

Research output: Contribution to journalComment/debate

29 Citations (Scopus)

Interactions between nuclear receptor SHP and FOXA1 maintain oscillatory homocysteine homeostasis in mice

Tsuchiya, H., Da Costa, K. A., Lee, S., Renga, B., Jaeschke, H., Yang, Z., Orena, S. J., Goedken, M. J., Zhang, Y., Kong, B., Lebofsky, M., Rudraiah, S., Smalling, R., Guo, G., Fiorucci, S., Zeisel, S. H. & Wang, L., May 1 2015, In : Gastroenterology. 148, 5, p. 1012-1023.e14

Research output: Contribution to journalArticle

Homocysteine
Cytoplasmic and Nuclear Receptors
Homeostasis
Betaine-Homocysteine S-Methyltransferase
Cystathionine
19 Citations (Scopus)

Mechanism of altered metformin distribution in nonalcoholic steatohepatitis

Clarke, J. D., Dzierlenga, A. L., Nelson, N. R., Li, H., Werts, S., Goedken, M. J. & Cherrington, N. J., Sep 2015, In : Diabetes. 64, 9, p. 3305-3313 9 p.

Research output: Contribution to journalArticle

Open Access
Metformin
Choline
Methionine
Diet
Kidney
11 Citations (Scopus)

Multidrug resistance-associated protein 3 plays an important role in protection against acute toxicity of diclofenac

Scialis, R. J., Csanaky, I. L., Goedken, M. J. & Manautou, J. E., Jul 1 2015, In : Drug Metabolism and Disposition. 43, 7, p. 944-950 7 p.

Research output: Contribution to journalArticle

Open Access
Diclofenac
Wounds and Injuries
multidrug resistance-associated protein 3
Small Intestine
Multidrug Resistance-Associated Proteins
6 Citations (Scopus)

Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis

Canet, M. J., Hardwick, R. N., Lake, A. D., Dzierlenga, A. L., Clarke, J. D., Goedken, M. J. & Cherrington, N. J., Jan 1 2015, In : Drug Metabolism and Disposition. 43, 2, p. 266-272 7 p.

Research output: Contribution to journalArticle

Open Access
Xenobiotics
Theoretical Models
Kidney
Drug and Narcotic Control
Choline
19 Citations (Scopus)

Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice

Ghanem, C. I., Rudraiah, S., Bataille, A. M., Vigo, M. B., Goedken, M. J. & Manautou, J. E., Apr 1 2015, In : Biochemical Pharmacology. 94, 3, p. 203-211 9 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Acetaminophen
Brain
Messenger RNA
Proteins
33 Citations (Scopus)

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore

Blanden, A. R., Yu, X., Wolfe, A. J., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N., May 1 2015, In : Molecular Pharmacology. 87, 5, p. 825-831 7 p.

Research output: Contribution to journalArticle

Metallochaperones
Ionophores
Zinc
Neoplasms
Metals
2014
27 Citations (Scopus)

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity

Salojin, K. V., Hamman, B. D., Chang, W. C., Jhaver, K. G., Al-Shami, A., Crisostomo, J., Wilkins, C., Digeorge-Foushee, A. M., Allen, J., Patel, N., Gopinathan, S., Zhou, J., Nouraldeen, A., Jessop, T. C., Bagdanoff, J. T., Augeri, D. J., Read, R., Vogel, P., Swaffield, J., Wilson, A. & 5 others, Platt, K. A., Carson, K. G., Main, A., Zambrowicz, B. P. & Oravecz, T., May 22 2014, In : PloS one. 9, 5, e98151.

Research output: Contribution to journalArticle

autoimmunity
T-cells
Autoimmunity
T-lymphocytes
T-Lymphocytes
36 Citations (Scopus)

Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis

Hardwick, R. N., Clarke, J. D., Lake, A. D., Canet, M. J., Anumol, T., Street, S. M., Merrell, M. D., Goedken, M. J., Snyder, S. A. & Cherrington, N. J., Nov 1 2014, In : Toxicological Sciences. 142, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

Open Access
Methotrexate
Toxicity
Pharmaceutical Preparations
Liver
Rodentia
15 Citations (Scopus)

Is nuclear factor erythroid 2-Related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in Mice?

Rohrer, P. R., Rudraiah, S., Goedken, M. J. & Manautou, J. E., Oct 1 2014, In : Drug Metabolism and Disposition. 42, 10, p. 1663-1674 12 p.

Research output: Contribution to journalArticle

Safe Sex
Acetaminophen
Sex Characteristics
Alanine Transaminase
Messenger RNA
18 Citations (Scopus)

MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule Cells

Wen, X., Gibson, C. J., Yang, I., Buckley, B., Goedken, M. J., Richardson, J. R. & Aleksunes, L. M., Oct 1 2014, In : Toxicological Sciences. 141, 2, p. 475-483 9 p.

Research output: Contribution to journalArticle

Paraquat
Toxicity
Kidney
Knockout Mice
Proximal Kidney Tubule
43 Citations (Scopus)

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

Yu, X., Blanden, A. R., Narayanan, S., Jayakumar, L., Lubin, D., Augeri, D., David Kimball, S., Loh, S. N. & Carpizo, D. R., Jan 1 2014, In : Oncotarget. 5, 19, p. 8879-8892 14 p.

Research output: Contribution to journalArticle

Metallochaperones
Zinc
Pharmaceutical Preparations
Pharmaceutical Chemistry
Mutant Proteins
29 Citations (Scopus)

Synergistic interaction between genetics and disease on pravastatin disposition

Clarke, J. D., Hardwick, R. N., Lake, A. D., Lickteig, A. J., Goedken, M. J., Klaassen, C. D. & Cherrington, N. J., Jul 2014, In : Journal of Hepatology. 61, 1, p. 139-147 9 p.

Research output: Contribution to journalArticle

Pravastatin
Inborn Genetic Diseases
Fatty Liver
Organic Anion Transporters
Hydroxymethylglutaryl-CoA Reductase Inhibitors
12 Citations (Scopus)

Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat

Kyriakides, M., Hardwick, R. N., Jin, Z., Goedken, M. J., Holmes, E., Cherrington, N. J. & Coen, M., Nov 1 2014, In : Toxicological Sciences. 142, 1, p. 105-116 12 p.

Research output: Contribution to journalArticle

Open Access
Fatty Liver
Methotrexate
Liver
Rats
Phenotype
15 Citations (Scopus)

Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes

Rudraiah, S., Rohrer, P. R., Gurevich, I., Goedken, M. J., Rasmussen, T., Hines, R. N. & Manautou, J. E., Sep 12 2014, In : Toxicological Sciences. 141, 1, p. 263-277 15 p., kfu124.

Research output: Contribution to journalArticle

Open Access
dimethylaniline monooxygenase (N-oxide forming)
Acetaminophen
Hepatocytes
Liver
Messenger RNA
28 Citations (Scopus)

Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-Null mice

Wen, X., Buckley, B., McCandlish, E., Goedken, M. J., Syed, S., Pelis, R., Manautou, J. E. & Aleksunes, L. M., Jan 1 2014, In : American Journal of Pathology. 184, 5, p. 1299-1308 10 p.

Research output: Contribution to journalArticle

Cisplatin
Platinum
Kidney
Wounds and Injuries
multidrug resistance-associated protein 2
2013
6 Citations (Scopus)

Pregnancy represses induction of efflux transporters in livers of type i diabetic mice

Aleksunes, L. M., Xu, J., Lin, E., Wen, X., Goedken, M. J. & Slitt, A. L., Sep 1 2013, In : Pharmaceutical research. 30, 9, p. 2209-2220 12 p.

Research output: Contribution to journalArticle

Streptozocin
Liver
Pregnancy
Medical problems
Transcription Factors
2011
20 Citations (Scopus)

Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N -[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1 H -imidazole-2-carboxamide (JNJ-28312141)

Illig, C. R., Manthey, C. L., Wall, M. J., Meegalla, S. K., Chen, J., Wilson, K. J., Ballentine, S. K., Desjarlais, R. L., Schubert, C., Crysler, C. S., Chen, Y., Molloy, C. J., Chaikin, M. A., Donatelli, R. R., Yurkow, E., Zhou, Z., Player, M. R. & Tomczuk, B. E., Nov 24 2011, In : Journal of medicinal chemistry. 54, 22, p. 7860-7883 24 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Anti-Inflammatory Agents
Clinical Trials, Phase I
Experimental Arthritis
2010
75 Citations (Scopus)

Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: Discovery of (E)-1-(4-((1 R,2 S,3 R)-1,2,3,4-tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone oxime (LX2931) and (1 R,2 S,3 R)-1-(2-(Isoxazol-3-yl)-1 H -imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

Bagdanoff, J. T., Donoviel, M. S., Nouraldeen, A., Carlsen, M., Jessop, T. C., Tarver, J., Aleem, S., Dong, L., Zhang, H., Boteju, L., Hazelwood, J., Yan, J., Bednarz, M., Layek, S., Owusu, I. B., Gopinathan, S., Moran, L., Lai, Z., Kramer, J., Kimball, S. D. & 11 others, Yalamanchili, P., Heydorn, W. E., Frazier, K. S., Brooks, B., Brown, P., Wilson, A., Sonnenburg, W. K., Main, A., Carson, K. G., Oravecz, T. & Augeri, D. J., Dec 23 2010, In : Journal of medicinal chemistry. 53, 24, p. 8650-8662 13 p.

Research output: Contribution to journalArticle

Oximes
Rheumatoid Arthritis
Clinical Trials, Phase I
Inborn Genetic Diseases
Pharmaceutical Chemistry
109 Citations (Scopus)
NF-E2-Related Factor 2
Cisplatin
Kidney
Genes
Glutamate-Cysteine Ligase
2009
77 Citations (Scopus)

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-Null mice

Cui, Y. J., Aleksunes, L. M., Tanaka, Y., Goedken, M. J. & Klaassen, C. D., Jun 29 2009, In : Toxicological Sciences. 110, 1, p. 47-60 14 p.

Research output: Contribution to journalArticle

Liver
Wounds and Injuries
Bile Acids and Salts
Messenger RNA
Genotype
70 Citations (Scopus)

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

Manthey, C. L., Johnson, D. L., Illig, C. R., Tuman, R. W., Zhou, Z., Baker, J. F., Chaikin, M. A., Donatelli, R. R., Franks, C. F., Zeng, L., Crysler, C., Chen, Y., Yurkow, E. J., Boczon, L., Meegalla, S. K., Wilson, K. J., Wall, M. J., Chen, J., Ballentine, S. K., Ott, H. & 4 others, Baumann, C., Lawrence, D., Tomczuk, B. E. & Molloy, C. J., Nov 1 2009, In : Molecular Cancer Therapeutics. 8, 11, p. 3151-3161 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Receptor Protein-Tyrosine Kinases
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
53 Citations (Scopus)

Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma

Harrison, B. A., Whitlock, N. A., Voronkov, M. V., Almstead, Z. Y., Gu, K. J., Mabon, R., Gardyan, M., Hamman, B. D., Allen, J., Gopinathan, S., McKnight, B., Crist, M., Zhang, Y., Liu, Y., Courtney, L. F., Key, B., Zhou, J., Patel, N., Yates, P. W., Liu, Q. & 5 others, Wilson, A. G. E., Kimball, S. D., Crosson, C. E., Rice, D. S. & Rawlins, D. B., Nov 12 2009, In : Journal of medicinal chemistry. 52, 21, p. 6515-6518 4 p.

Research output: Contribution to journalArticle

Lim Kinases
Ocular Hypertension
Glaucoma
Enzyme Assays
Intraocular Pressure
54 Citations (Scopus)

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Goodwin, N. C., Mabon, R., Harrison, B. A., Shadoan, M. K., Almstead, Z. Y., Xie, Y., Healy, J., Buhring, L. M., DaCosta, C. M., Bardenhagen, J., Mseeh, F., Liu, Q., Nouraldeen, A., Wilson, A. G. E., Kimball, S. D., Powell, D. R. & Rawlins, D. B., Oct 22 2009, In : Journal of medicinal chemistry. 52, 20, p. 6201-6204 4 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Xylose
Type 2 Diabetes Mellitus
Glucose
Homeostasis
19 Citations (Scopus)

Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors

Jin, H., Cianchetta, G., Devasagayaraj, A., Gu, K., Marinelli, B., Samala, L., Scott, S., Stouch, T., Tunoori, A., Wang, Y., Zang, Y., Zhang, C., David Kimball, S., Main, A. J., Ding, Z. M., Sun, W., Yang, Q., Yu, X. Q., Powell, D. R., Wilson, A. & 2 others, Liu, Q. & Shi, Z. C., Sep 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5229-5232 4 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Serotonin
Acids
Triazines
Chemotherapy
2008
49 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Acetaminophen
Hepatocytes
Up-Regulation
Liver
42 Citations (Scopus)

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

Campion, S. N., Johnson, R., Aleksunes, L. M., Goedken, M. J., Van Rooijen, N., Scheffer, G. L., Cherrington, N. J. & Manautou, J. E., Aug 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 2, p. G294-G304

Research output: Contribution to journalArticle

Kupffer Cells
Acetaminophen
Liver
Clodronic Acid
Liposomes