• 4209 Citations
  • 33 h-Index
1979 …2023

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Article
2019

The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening

Capuccino, J. M. V., Chatterjee, P., García, I. E., Botello-Smith, W. M., Zhang, H., Harris, A. L., Luo, Y. & Contreras, J. E., Mar 1 2019, In : Journal of General Physiology. 151, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Electrical coupling and its channels

Harris, A. L., Dec 1 2018, In : Journal of General Physiology. 150, 12, p. 1606-1639 34 p.

Research output: Contribution to journalArticle

2017

Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms

Korayem, A. H., Mujica, P. E., Aramoto, H., Durán, R. G., Nepali, P. R., Kim, D. D., Harris, A. L., Sánchez, F. A. & Durán, W. N., Jan 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 1, p. H179-H189

Research output: Contribution to journalArticle

5 Scopus citations

Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells

De Toledo, S. M., Buonanno, M., Harris, A. L. & Azzam, E. I., Jan 1 2017, In : International Journal of Radiation Biology. 93, 10, p. 1182-1194 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization

Trease, A. J., Capuccino, J. M. V., Contreras, J., Harris, A. L. & Sorgen, P. L., Oct 2017, In : Journal of Molecular and Cellular Cardiology. 111, p. 69-80 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells

Zhao, Y., Lai, Y., Ge, H., Guo, Y., Feng, X., Song, J., Wang, Q., Fan, L., Peng, Y., Cao, M., Harris, A. L., Wang, X. & Tao, L., May 11 2017, In : Cell Death and Disease. 8, 5, e2773.

Research output: Contribution to journalArticle

9 Scopus citations
2016

An electrostatic mechanism for Ca 2+ -mediated regulation of gap junction channels

Bennett, B. C., Purdy, M. D., Baker, K. A., Acharya, C., Mcintire, W. E., Stevens, R. C., Zhang, Q., Harris, A. L., Abagyan, R. & Yeager, M., Jan 12 2016, In : Nature communications. 7, 9770.

Research output: Contribution to journalArticle

54 Scopus citations

Computational Studies of Molecular Permeation through Connexin26 Channels

Luo, Y., Rossi, A. R. & Harris, A. L., Feb 2 2016, In : Biophysical Journal. 110, 3, p. 584-599 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mechanism of gating by calcium in connexin hemichannels

Lopez, W., Ramachandran, J., Alsamarah, A., Luo, Y., Harris, A. L. & Contreras, J. E., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. E7986-E7995

Research output: Contribution to journalArticle

27 Scopus citations
2015

Gap junctions modulate glioma invasion by direct transfer of microRNA

Hong, X., Sin, W. C., Harris, A. L. & Naus, C. C., Jan 1 2015, In : Oncotarget. 6, 17, p. 15566-15577 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules

Tong, X., Lopez, W., Ramachandran, J., Ayad, W. A., Liu, Y., Lopez-Rodriguez, A., Harris, A. L. & Contreras, J. E., Sep 1 2015, In : Journal of General Physiology. 146, 3, p. 245-254 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Connexin 43 is involved in the generation of human-induced pluripotent stem cells

Ke, Q., Li, L., Cai, B., Liu, C., Yang, Y., Gao, Y., Huang, W., Yuan, X., Wang, T., Zhang, Q., Harris, A. L., Tao, L. & Xiang, A. P., Jun 1 2013, In : Human molecular genetics. 22, 11, p. 2221-2233 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Human cell responses to ionizing radiation are differentially affected by the expressed connexins

Autsavapromporn, N., De Toledo, S. M., Jay-Gerin, J. P., Harris, A. L. & Azzam, E. I., Mar 1 2013, In : Journal of Radiation Research. 54, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Insights on the mechanisms of Ca2+ regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y)

Lopez, W., Gonzalez, J., Liu, Y., Harris, A. L. & Contreras, J. E., Jul 1 2013, In : Journal of General Physiology. 142, 1, p. 23-45 23 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin

Hong, X., Wang, Q., Yang, Y., Zheng, S., Tong, X., Zhang, S., Tao, L. & Harris, A., Apr 28 2012, In : Cancer Letters. 317, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Molecular dynamics simulations of the Cx26 hemichannel: Insights into voltage-dependent loop-gating

Kwon, T., Roux, B., Jo, S., Klauda, J. B., Harris, A. L. & Bargiello, T. A., Mar 21 2012, In : Biophysical Journal. 102, 6, p. 1341-1351 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Monocyte-endothelial adhesion is modulated by Cx43-stimulated ATP release from monocytes

Yuan, D., Wang, Q., Wu, D., Yu, M., Zhang, S., Li, L., Tao, L. & Harris, A. L., Apr 13 2012, In : Biochemical and Biophysical Research Communications. 420, 3, p. 536-541 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells

Autsavapromporn, N., de Toledo, S. M., Buonanno, M., Jay-Gerin, J. P., Harris, A. L. & Azzam, E. I., Aug 2 2011, In : Journal of Radiation Research. 52, 4, p. 408-414 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mechanism for modulation of gating of connexin26-containing channels by taurine

Locke, D., Kieken, F., Tao, L., Sorgen, P. L. & Harris, A. L., Sep 1 2011, In : Journal of General Physiology. 138, 3, p. 321-339 19 p.

Research output: Contribution to journalArticle

20 Scopus citations

Molecular dynamics simulations of the Cx26 hemichannel: Evaluation of structural models with Brownian dynamics

Kwon, T., Harris, A. L., Rossi, A. & Bargiello, T. A., Nov 1 2011, In : Journal of General Physiology. 138, 5, p. 475-493 19 p.

Research output: Contribution to journalArticle

58 Scopus citations

The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells

Autsavapromporn, N., De Toledo, S. M., Little, J. B., Jay-Gerin, J. P., Harris, A. L. & Azzam, E. I., Mar 1 2011, In : Radiation Research. 175, 3, p. 347-357 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2010

Cisplatin and oxaliplatin inhibit gap junctional communication by direct action and by reduction of connexin expression, thereby counteracting cytotoxic efficacy

Wang, Q., You, T., Yuan, D., Han, X., Hong, X., He, B., Wang, L., Tong, X., Tao, L. & Harris, A. L., Jun 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 333, 3, p. 903-911 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2009

Connexin channels and phospholipids: Association and modulation

Locke, D. & Harris, A. L., Aug 17 2009, In : BMC Biology. 7, 52.

Research output: Contribution to journalArticle

27 Scopus citations

Post-translational modifications of connexin26 revealed by mass spectrometry

Locke, D., Bian, S., Li, H. & Harris, A. L., Dec 15 2009, In : Biochemical Journal. 424, 3, p. 385-398 14 p.

Research output: Contribution to journalArticle

43 Scopus citations

Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions

He, B., Tong, X., Wang, L., Wang, Q., Ye, H., Liu, B., Hong, X., Tao, L. & Harris, A. L., Sep 15 2009, In : Clinical Cancer Research. 15, 18, p. 5803-5810 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2007

2-Aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32

Tao, L. & Harris, A. L., Feb 1 2007, In : Molecular Pharmacology. 71, 2, p. 570-579 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Ca2+-dependent inactivation of CaV1.2 channels prevents Gd3+ block: Does Ca2+ block the pore of inactivated channels?

Babich, O., Matveev, V., Harris, A. L. & Shirokov, R., Jun 1 2007, In : Journal of General Physiology. 129, 6, p. 477-483 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Nature of Cx30-containing channels in the adult mouse mammary gland

Locke, D., Jamieson, S., Stein, T., Liu, J., Hodgins, M. B., Harris, A. L. & Gusterson, B., Apr 1 2007, In : Cell And Tissue Research. 328, 1, p. 97-107 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2006

Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates

Ayad, W. A., Locke, D., Koreen, I. V. & Harris, A. L., Jun 16 2006, In : Journal of Biological Chemistry. 281, 24, p. 16727-16739 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Isoelectric points and post-translational modifications of connexin26 and connexin32

Locke, D., Koreen, I. V. & Harris, A. L., Jun 1 2006, In : FASEB Journal. 20, 8, p. E426-E438

Research output: Contribution to journalArticle

36 Scopus citations
2005

Lipid rafts prepared by different methods contain different connexin channels, but gap junctions are not lipid rafts

Locke, D., Liu, J. & Harris, A. L., Oct 4 2005, In : Biochemistry. 44, 39, p. 13027-13042 16 p.

Research output: Contribution to journalArticle

62 Scopus citations
2004

Altered permeability and modulatory character of connexin channels during mammary gland development

Locke, D., Stein, T., Davies, C., Morris, J., Harris, A. L., Evans, W. H., Monaghan, P. & Gusterson, B., Aug 15 2004, In : Experimental cell research. 298, 2, p. 643-660 18 p.

Research output: Contribution to journalArticle

58 Scopus citations

Biochemical requirements for inhibition of connexin26-containing channels by natural and synthetic taurine analogs

Tao, L. & Harris, A. L., Sep 10 2004, In : Journal of Biological Chemistry. 279, 37, p. 38544-38554 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Neutral, acidic, and basic derivatives of anthranilamide that confer different formal charge to reducing oligosaccharides

Locke, D., Bevans, C. G., Wang, L. X., Zhang, Y., Harris, A. L. & Lee, Y. C., Jan 22 2004, In : Carbohydrate Research. 339, 2, p. 221-231 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Reversible pore block of connexin channels by cyclodextrins

Locke, D., Koreen, I. V., Liu, J. Y. & Harris, A. L., May 28 2004, In : Journal of Biological Chemistry. 279, 22, p. 22883-22892 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tetracycline-regulated enables purification and functional analysis of recombinant connexin channels from mammalian cells

Koreen, I. V., Elsayed, W. A., Liu, Y. J. & Harris, A. L., Oct 1 2004, In : Biochemical Journal. 383, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2003

Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates

Locke, D., Wang, L. X., Bevans, C. G., Lee, Y. C. & Harris, A. L., Jul 1 2003, In : Cell Communication and Adhesion. 10, 4-6, p. 239-244 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2001

Exploring hemichannel permeability in vitro.

Harris, A. L. & Bevans, C. G., 2001, In : Methods in molecular biology (Clifton, N.J.). 154, p. 357-377 21 p.

Research output: Contribution to journalArticle

30 Scopus citations
1999

Different ionic selectivities for connexins 26 and 32 produce rectifying gap junction channels

Suchyna, T. M., Nitsche, J. M., Chilton, M., Harris, A. L., Veenstra, R. D. & Nicholson, B. J., Dec 1999, In : Biophysical Journal. 77, 6, p. 2968-2987 20 p.

Research output: Contribution to journalArticle

78 Scopus citations

Direct high affinity modulation of connexin channel activity by cyclic nucleotides

Bevans, C. G. & Harris, A. L., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3720-3725 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Regulation of connexin channels by pH: Direct action of the protonated form of taurine and other aminosulfonates

Bevans, C. G. & Harris, A. L., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3711-3719 9 p.

Research output: Contribution to journalArticle

76 Scopus citations
1998

Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules

Bevans, C. G., Kordel, M., Rhee, S. K. & Harris, A. L., Jan 30 1998, In : Journal of Biological Chemistry. 273, 5, p. 2808-2816 9 p.

Research output: Contribution to journalArticle

262 Scopus citations
1996

Channel-forming activity of immunoaffinity-purified connexin32 in single phospholipid membranes

Rhee, S. K., Bevans, C. G. & Harris, A. L., Aug 10 1996, In : Biochemistry. 35, 28, p. 9212-9223 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
1995

Horizontal 'solvent-free' lipid bimolecular membranes with two-sided access can be formed and facilitate ion channel reconstitution

Brutyan, R. A., DeMaria, C. & Harris, A. L., Jun 14 1995, In : BBA - Biomembranes. 1236, 2, p. 339-344 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Selectivity of connexin-specific gap junctions does not correlate with channel conductance

Veenstra, R. D., Wang, H. Z., Beblo, D. A., Chilton, M. G., Harris, A. L., Beyer, E. C. & Brink, P. R., Dec 1995, In : Circulation research. 77, 6, p. 1156-1165 10 p.

Research output: Contribution to journalArticle

208 Scopus citations
1992

Ion channels in single bilayers induced by rat connexin32

Harris, A. L., Walter, A., Paul, D., Goodenough, D. A. & Zimmerberg, J., Oct 1992, In : Molecular Brain Research. 15, 3-4, p. 269-280 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
1989

Transport-Specific isolation of large channels reconstituted into lipid vesicles

Harris, A. L., Walter, A. & Zimmerberg, J., Aug 1 1989, In : The Journal of Membrane Biology. 109, 3, p. 243-250 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
1984

Gating of gap junction channels

Spray, D. C., White, R. L., de Carvalho, A. C., Harris, A. L. & Bennett, M. V., Jan 1 1984, In : Biophysical Journal. 45, 1, p. 219-230 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Substituted benzyl acetates: A new class of compounds that reduce gap junctional conductance by cytoplasmic acidification

Spray, D. C., Nerbonne, J., Campos De Carvalho, A., Harris, A. L. & Bennett, M. V., Jan 1 1984, In : Journal of Cell Biology. 99, 1 I, p. 174-179 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
1983

Control of intercellular communication by voltage dependence of gap junctional conductance

Harris, A. L., Spray, D. C. & Bennett, M. V. L., Jan 1 1983, In : Journal of Neuroscience. 3, 1, p. 79-100 22 p.

Research output: Contribution to journalArticle

36 Scopus citations