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Research Output

2020

Cytokinin sensing in bacteria

Kabbara, S., Bidon, B., Kilani, J., Osman, M., Hamze, M., Stock, A. M. & Papon, N., Feb 2020, In : Biomolecules. 10, 2, 186.

Research output: Contribution to journalComment/debate

Open Access
2019

Drug-like Fragments Inhibit agr-Mediated Virulence Expression in Staphylococcus aureus

Bezar, I. F., Mashruwala, A. A., Boyd, J. M. & Stock, A. M., Dec 1 2019, In : Scientific reports. 9, 1, 6786.

Research output: Contribution to journalArticle

Open Access

Structural basis of response regulator function

Gao, R., Bouillet, S. & Stock, A. M., Jan 1 2019, In : Annual Review of Microbiology. 73, p. 175-197 23 p.

Research output: Contribution to journalReview article

4 Scopus citations

The plos biology xv collection: 15 years of exceptional science highlighted across 12 months

Richardson, L. A., Schmid, S. L., Bhandoola, A., Harly, C., Hedenström, A., Laub, M. T., Mace, G. M., Sengupta, P., Stock, A. M., Read, A. F., Malik, H. S., Estelle, M., Lowell, S. & Kimmelman, J., Feb 2019, In : PLoS biology. 17, 2, e3000180.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Two-component systems

Papon, N. & Stock, A., Aug 5 2019, In : Current Biology. 29, 15, p. R724-R725

Research output: Contribution to journalShort survey

1 Scopus citations

What do archaeal and eukaryotic histidine kinases sense?

Papon, N. & Stock, A. M., Jan 1 2019, In : F1000Research. 8

Research output: Contribution to journalReview article

Open Access
2018

Overcoming the Cost of Positive Autoregulation by Accelerating the Response with a Coupled Negative Feedback

Gao, R. & Stock, A. M., Sep 11 2018, In : Cell Reports. 24, 11, p. 3061-3071.e6

Research output: Contribution to journalArticle

1 Scopus citations

Quantitative Analysis of Intracellular Response Regulator Phosphatase Activity of Histidine Kinases

Gao, R. & Stock, A., Jan 1 2018, Methods in Enzymology. Allen, K. N. (ed.). Academic Press Inc., p. 301-319 19 p. (Methods in Enzymology; vol. 607).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2017

Call for original research papers for a special collection in Journal of Bacteriology: Two-component signal transduction

Stock, A. & Zhulin, I. B., Jan 1 2017, In : Journal of bacteriology. 199, 2, e00748-16.

Research output: Contribution to journalEditorial

Classic Spotlights: Selected highlights from the first 100 years of the Journal of Bacteriology

Armitage, J. P., Becker, A., Christie, P. J., de Boer, P. A. J., DiRita, V. J., Gourse, R. L., Henkin, T. M., Margolin, W., Metcalf, W. W., Mullineaux, C. W., O'Toole, G. A., Parkinson, J. S., Schneewind, O., Silhavy, T. J., Stock, A. & Zhulin, I. B., Jul 1 2017, In : Journal of bacteriology. 199, 13, e00062-17.

Research output: Contribution to journalEditorial

Counterbalancing regulation in response memory of a positively autoregulated two-component system

Gao, R., Godfrey, K. A., Sufian, M. A. & Stock, A., Sep 1 2017, In : Journal of bacteriology. 199, 18, e00390-17.

Research output: Contribution to journalArticle

3 Scopus citations

Quantitative kinetic analyses of shutting off a two-component system

Gao, R. & Stock, A., May 1 2017, In : mBio. 8, 3, e00412-17.

Research output: Contribution to journalArticle

13 Scopus citations

Two-component signal transduction: A special issue in the Journal of Bacteriology

Stock, A. & Zhulin, I. B., Sep 1 2017, In : Journal of bacteriology. 199, 18, e00443-17.

Research output: Contribution to journalEditorial

1 Scopus citations
2016

Classic spotlight: Managing stress

Stock, A., Jan 1 2016, In : Journal of bacteriology. 198, 19, 1 p.

Research output: Contribution to journalEditorial

Classic spotlight: A window on multicellular development

Stock, A., Jan 1 2016, In : Journal of bacteriology. 198, 4, 1 p.

Research output: Contribution to journalEditorial

Classic spotlight: Crowd sourcing provided Penicillium strains for the war effort

Forest, K. T. & Stock, A., Jan 1 2016, In : Journal of bacteriology. 198, 6, 1 p.

Research output: Contribution to journalEditorial

2015

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

Winkelmann, D., Forgacs, E., Miller, M. T. & Stock, A., Aug 6 2015, In : Nature communications. 6, 7974.

Research output: Contribution to journalArticle

34 Scopus citations

Temporal hierarchy of gene expression mediated by transcription factor binding affinity and activation dynamics

Gao, R. & Stock, A., May 26 2015, In : mBio. 6, 3

Research output: Contribution to journalArticle

17 Scopus citations
2013

Comprehensive analysis of OmpR phosphorylation, dimerization, and DNA binding supports a canonical model for activation

Barbieri, C. M., Wu, T. & Stock, A., May 27 2013, In : Journal of molecular biology. 425, 10, p. 1612-1626 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Evolutionary Tuning of Protein Expression Levels of a Positively Autoregulated Two-Component System

Gao, R. & Stock, A., Oct 1 2013, In : PLoS genetics. 9, 10, e1003927.

Research output: Contribution to journalArticle

18 Scopus citations
40 Scopus citations
49 Scopus citations
2012

Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding

Leonard, P. G., Bezar, I. F., Sidote, D. J. & Stock, A., Dec 18 2012, In : Biochemistry. 51, 50, p. 10035-10043 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inhibition of Bacterial Virulence: Drug-Like Molecules Targeting the Salmonella enterica PhoP Response Regulator

Tang, Y. T., Gao, R., Havranek, J. J., Groisman, E. A., Stock, A. & Marshall, G. R., Jun 1 2012, In : Chemical Biology and Drug Design. 79, 6, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2011

Loss of niemann-pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway

Dixit, S. S., Jadot, M., Sohar, I., Sleat, D. E., Stock, A. & Lobel, P., Aug 24 2011, In : PloS one. 6, 8, e23677.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Molecular strategies for phosphorylation-mediated regulation of response regulator activity

Gao, R. & Stock, A., Apr 1 2010, In : Current Opinion in Microbiology. 13, 2, p. 160-167 8 p.

Research output: Contribution to journalReview article

107 Scopus citations

Regulation of response regulator autophosphorylation through interdomain contacts

Barbieri, C. M., Mack, T. R., Robinson, V. L., Miller, M. T. & Stock, A., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32325-32335 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Biological insights from structures of two-component proteins

Gao, R. & Stock, A., Oct 1 2009, In : Annual Review of Microbiology. 63, p. 133-154 22 p.

Research output: Contribution to journalReview article

423 Scopus citations

Catalytically Incompetent by Design

Gao, R. & Stock, A., Aug 12 2009, In : Structure. 17, 8, p. 1038-1040 3 p.

Research output: Contribution to journalShort survey

4 Scopus citations
35 Scopus citations

Probing the Roles of the Two Different Dimers Mediated by the Receiver Domain of the Response Regulator PhoB

Mack, T. R., Gao, R. & Stock, A., Jun 5 2009, In : Journal of molecular biology. 389, 2, p. 349-364 16 p.

Research output: Contribution to journalArticle

33 Scopus citations
2008

Interaction of CheY with the C-terminal peptide of CheZ

Guhaniyogi, J., Wu, T., Patel, S. & Stock, A., Feb 1 2008, In : Journal of bacteriology. 190, 4, p. 1419-1428 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with an Unusual Mode of Binding

Sidote, D. J., Barbieri, C. M., Wu, T. & Stock, A., May 7 2008, In : Structure. 16, 5, p. 727-735 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids

Gao, R., Tao, Y. & Stock, A., Sep 1 2008, In : Molecular microbiology. 69, 6, p. 1358-1372 15 p.

Research output: Contribution to journalArticle

41 Scopus citations
86 Scopus citations
2007

Bacterial response regulators: versatile regulatory strategies from common domains

Gao, R., Mack, T. R. & Stock, A., May 1 2007, In : Trends in Biochemical Sciences. 32, 5, p. 225-234 10 p.

Research output: Contribution to journalReview article

196 Scopus citations
11 Scopus citations
53 Scopus citations

Diguanylate Cyclase Activation: It Takes Two

Stock, A., Aug 14 2007, In : Structure. 15, 8, p. 887-888 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation

Friedland, N., Mack, T. R., Yu, M., Hung, L. W., Terwilliger, T. C., Waldo, G. S. & Stock, A., Jun 12 2007, In : Biochemistry. 46, 23, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?

Dixit, S. S., Sleat, D. E., Stock, A. & Lobel, P., Nov 15 2007, In : Biochemical Journal. 408, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease

Xu, S., Benoff, B., Liou, H. L., Lobel, P. & Stock, A., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23525-23531 7 p.

Research output: Contribution to journalArticle

138 Scopus citations
2006

A new perspective on response regulator activation

Stock, A. & Guhaniyogi, J., Nov 1 2006, In : Journal of bacteriology. 188, 21, p. 7328-7330 3 p.

Research output: Contribution to journalComment/debate

47 Scopus citations
33 Scopus citations

Identification of methylation sites in Thermotoga maritima chemotaxis receptors

Perez, E., Zheng, H. & Stock, A., Jun 1 2006, In : Journal of bacteriology. 188, 11, p. 4093-4100 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

Liou, H. L., Dixit, S. S., Xu, S., Tint, G. S., Stock, A. & Lobel, P., Dec 1 2006, In : Journal of Biological Chemistry. 281, 48, p. 36710-36723 14 p.

Research output: Contribution to journalArticle

81 Scopus citations

Transmembrane signaling by asymmetry

Stock, A., Oct 1 2006, In : Nature Structural and Molecular Biology. 13, 10, p. 861-862 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations
2005

A common dimerization interface in bacterial response regulators KdpE and TorR

Toro-Roman, A., Wu, T. & Stock, A., Dec 1 2005, In : Protein Science. 14, 12, p. 3077-3088 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Mechanism of activation for transcription factor PhoB suggested by different modes of dimerization in the inactive and active states

Bachhawat, P., Swapna, G. V. T., Montelione, G. & Stock, A., Sep 1 2005, In : Structure. 13, 9, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

97 Scopus citations
96 Scopus citations