• 12279 Citations
  • 65 h-Index
1982 …2024

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2020

Breakthrough bloodstream infections caused by echinocandin-resistant candida tropicalis: An emerging threat to immunocompromised patients with hematological malignancies

Sfeir, M. M., Jiménez-ortigosa, C., Gamaletsou, M. N., Schuetz, A. N., Soave, R., Van Besien, K., Small, C. B., Perlin, D. S. & Walsh, T. J., Mar 2020, In : Journal of Fungi. 6, 1, 20.

Research output: Contribution to journalArticle

Open Access

Isavuconazole prophylaxis in patients with hematologic malignancies and hematopoietic cell transplant recipients

Fontana, L., Perlin, D. S., Zhao, Y., Noble, B. N., Lewis, J. S., Strasfeld, L. & Hakki, M., Mar 1 2020, In : Clinical Infectious Diseases. 70, 5, p. 723-730 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Penetration of ibrexafungerp (formerly SCY-078) at the site of infection in an intra-abdominal candidiasis mouse model

Lee, A., Prideaux, B., Zimmerman, M., Carter, C., Barat, S., Angulo, D., Dartois, V., Perlin, D. S. & Zhao, Y., Jan 1 2020, In : Antimicrobial agents and chemotherapy. 64, 3, e02268.

Research output: Contribution to journalArticle

2019

Adipose tissue regulates pulmonary pathology during TB infection

Ayyappan, J. P., Ganapathi, U., Lizardo, K., Vinnard, C., Subbian, S., Perlin, D. & Nagajyothi, J. F., Mar 1 2019, In : mBio. 10, 2, e02771-18.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A novel, drug resistance-independent, fluorescence-based approach to measure mutation rates in microbial pathogens

Shor, E., Schuyler, J. & Perlin, D. S., Jan 1 2019, In : mBio. 10, 1, e00120-19.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Applying host disease status biomarkers to therapeutic response monitoring in invasive aspergillosis patients

Zhao, Y., Nagasaki, Y., Paderu, P., Sugrue, M. W., Leather, H. L., Wingard, J. R. & Perlin, D. S., Jan 1 2019, In : Medical mycology. 57, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa

Papp-Wallace, K. M., Zeiser, E. T., Becka, S. A., Park, S., Wilson, B. M., Winkler, M. L., D'Souza, R., Singh, I., Sutton, G., Fouts, D. E., Chen, L., Kreiswirth, B. N., Ellis-Grosse, E. J., Drusano, G. L., Perlin, D. S. & Bonomo, R. A., Jul 19 2019, In : The Journal of infectious diseases. 220, 4, p. 666-676 11 p.

Research output: Contribution to journalArticle

Open Access

Detection of Candida auris Antifungal Drug Resistance Markers Directly from Clinical Skin Swabs

Kordalewska, M., Lee, A., Zhao, Y. & Perlin, D. S., Jan 1 2019, In : Antimicrobial agents and chemotherapy. 63, 12, e01754-19.

Research output: Contribution to journalArticle

1 Scopus citations

Development and multicentre validation of an agar-based screening method for echinocandin susceptibility testing of Aspergillus species

Meletiadis, J., Siopi, M., Kanioura, L., Jørgensen, K. M., Perlin, D. S., Mouton, J. W. & Arendrup, M. C., Aug 1 2019, In : The Journal of antimicrobial chemotherapy. 74, 8, p. 2247-2254 8 p.

Research output: Contribution to journalArticle

Efficacy of humanized single large doses of caspofungin on the lethality and fungal tissue burden in a deeply neutropenic murine model against candida albicans and candida dubliniensis

Prépost, E., Tóth, Z., Perlin, D. S., Gesztelyi, R., Kardos, G., Kovács, R., Nagy, F., Forgács, L. & Majoros, L., Jan 1 2019, In : Infection and Drug Resistance. 12, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

Open Access

Membrane-Disrupting Nanofibrous Peptide Hydrogels

Sarkar, B., Siddiqui, Z., Nguyen, P. K., Dube, N., Fu, W., Park, S., Jaisinghani, S., Paul, R., Kozuch, S. D., Deng, D., Iglesias-Montoro, P., Li, M., Sabatino, D., Perlin, D. S., Zhang, W., Mondal, J. & Kumar, V. A., Sep 9 2019, In : ACS Biomaterials Science and Engineering. 5, 9, p. 4657-4670 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

Hou, X., Healey, K. R., Shor, E., Kordalewska, M., Ortigosa, C. J., Paderu, P., Xiao, M., Wang, H., Zhao, Y., Lin, L. Y., Zhang, Y. H., Li, Y. Z., Xu, Y. C., Perlin, D. S. & Zhao, Y., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1619-1625 7 p.

Research output: Contribution to journalArticle

Open Access

Rapid detection of ERG11-associated azole resistance and FKS-associated echinocandin resistance in Candida auris

Hou, X., Lee, A., Jiménez-Ortigosa, C., Kordalewska, M., Perlin, D. S. & Zhao, Y., Jan 2019, In : Antimicrobial agents and chemotherapy. 63, 1, e01811-18.

Research output: Contribution to journalArticle

12 Scopus citations

Spontaneous mutational frequency and fks mutation rates vary by echinocandin agent against Candida Glabrata

Shields, R. K., Kline, E. G., Healey, K. R., Kordalewska, M., Perlin, D. S., Hong Nguyen, M. & Clancy, C. J., Jan 2019, In : Antimicrobial agents and chemotherapy. 63, 1, e01692-18.

Research output: Contribution to journalArticle

6 Scopus citations

Stress-induced changes in the lipid microenvironment of β- (1,3)-d-glucan synthase cause clinically important echinocandin resistance in Aspergillus fumigatus

Satish, S., Jiménez-Ortigosa, C., Zhao, Y., Lee, M. H., Dolgov, E., Krüger, T., Park, S., Denning, D. W., Kniemeyer, O., Brakhage, A. A. & Perlin, D. S., May 1 2019, In : mBio. 10, 3, e00779-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tissue distribution and penetration of isavuconazole at the site of infection in experimental invasive aspergillosis in mice with underlying chronic granulomatous disease

Lee, A., Prideaux, B., Lee, M. H., Zimmerman, M., Dolgov, E., Perlin, D. S. & Zhao, Y., Jun 2019, In : Antimicrobial agents and chemotherapy. 63, 6, e00524-19.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Absence of azole or echinocandin resistance in candida glabrata isolates in India despite background prevalence of strains with defects in the dna mismatch repair pathway

Singh, A., Healey, K. R., Yadav, P., Upadhyaya, G., Sachdeva, N., Sarma, S., Kumar, A., Tarai, B., Perlin, D. S. & Chowdhary, A., Jun 2018, In : Antimicrobial agents and chemotherapy. 62, 6, e00195-18.

Research output: Contribution to journalArticle

16 Scopus citations

A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: Role of the ERG11 and FKS1 genes in azole and echinocandin resistance

Chowdhary, A., Prakash, A., Sharma, C., Kordalewska, M., Kumar, A., Sarma, S., Tarai, B., Singh, A., Upadhyaya, G., Upadhyay, S., Yadav, P., Singh, P. K., Khillan, V., Sachdeva, N., Perlin, D. S. & Meis, J. F., Apr 1 2018, In : Journal of Antimicrobial Chemotherapy. 73, 4, p. 891-899 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

An optimized synthetic-bioinformatic natural product antibiotic sterilizes multidrug-resistant Acinetobacter baumannii-infected wounds

Vila-Farres, X., Chu, J., Ternei, M. A., Lemetre, C., Park, S., Perlin, D. S. & Brady, S. F., Jan 1 2018, In : mSphere. 3, 1, e00528-17.

Research output: Contribution to journalArticle

4 Scopus citations

A novel, rapid, and low-volume assay for therapeutic drug monitoring of posaconazole and other long-chain azole-class antifungal drugs

Wiedman, G. R., Zhao, Y. & Perlin, D. S., Nov 1 2018, In : mSphere. 3, 6, e00623-18.

Research output: Contribution to journalArticle

A novel, tomographic imaging probe for rapid diagnosis of fungal keratitis

Lee, M. H., Wiedman, G., Park, S., Mustaev, A., Zhao, Y. & Perlin, D. S., Oct 1 2018, In : Medical mycology. 56, 7, p. 796-802 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
5 Scopus citations

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

Hover, B. M., Kim, S. H., Katz, M., Charlop-Powers, Z., Owen, J. G., Ternei, M. A., Maniko, J., Estrela, A. B., Molina, H., Park, S., Perlin, D. S. & Brady, S. F., Apr 1 2018, In : Nature Microbiology. 3, 4, p. 415-422 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Direct detection of emergent fungal pathogen Candida auris in clinical skin swabs by SYBR green-based quantitative PCR assay

Sexton, D. J., Kordalewska, M., Bentz, M. L., Welsh, R. M., Perlin, D. S. & Litvintseva, A. P., Dec 2018, In : Journal of clinical microbiology. 56, 12, e01337-18.

Research output: Contribution to journalArticle

17 Scopus citations

FKS2 and FKS3 genes of opportunistic human pathogen Candida albicans influence echinocandin susceptibility

Suwunnakorn, S., Wakabayashi, H., Kordalewska, M., Perlin, D. S. & Rustchenko, E., Apr 2018, In : Antimicrobial agents and chemotherapy. 62, 4, e02299-17.

Research output: Contribution to journalArticle

6 Scopus citations

Limited ERG11 mutations identified in isolates of candida auris directly contribute to reduced azole susceptibility

Healey, K. R., Kordalewska, M., Ortigosa, C. J., Singh, A., Berrío, I., Chowdhary, A. & Perlin, D. S., Oct 2018, In : Antimicrobial agents and chemotherapy. 62, 10, e01427.

Research output: Contribution to journalArticle

26 Scopus citations

Molecular analysis of resistance and detection of non-wild-type strains using etest epidemiological cutoff values for amphotericin B and echinocandins for bloodstream candida infections from a tertiary hospital in Qatar

Taj-Aldeen, S. J., Salah, H., Perez, W. B., Almaslamani, M., Motyl, M., AbdulWahab, A., Healey, K. R. & Perlin, D. S., Sep 2018, In : Antimicrobial agents and chemotherapy. 62, 9, e00214-18.

Research output: Contribution to journalArticle

3 Scopus citations

Multilocus sequence typing (MLST) genotypes of candida glabrata bloodstream isolates in Korea: Association with antifungal resistance, mutations in mismatch repair gene (Msh2), and clinical outcomes

Byun, S. A., Won, E. J., Kim, M. N., Lee, W. G., Lee, K., Lee, H. S., Uh, Y., Healey, K. R., Perlin, D. S., Choi, M. J., Kim, S. H. & Shin, J. H., Jul 13 2018, In : Frontiers in Microbiology. 9, JUL, 1523.

Research output: Contribution to journalArticle

10 Scopus citations

Significantly improved pharmacokinetics enhances in vivo efficacy of APX001 against echinocandin-and multidrug-resistant Candida isolates in a mouse model of invasive candidiasis

Zhao, Y., Lee, M. H., Paderu, P., Lee, A., Jimenez-Ortigosa, C., Park, S., Mansbach, R. S., Shaw, K. J. & Perlin, D. S., Oct 2018, In : Antimicrobial agents and chemotherapy. 62, 10, e00425.

Research output: Contribution to journalArticle

11 Scopus citations

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

Vickers, C. F., Silva, A. P. G., Chakraborty, A., Fernandez, P., Kurepina, N., Saville, C., Naranjo, Y., Pons, M., Schnettger, L. S., Gutierrez, M. G., Park, S., Kreiswith, B. N., Perlin, D. S., Thomas, E. J., Cavet, J. S. & Tabernero, L., Sep 27 2018, In : Journal of medicinal chemistry. 61, 18, p. 8337-8352 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Understanding echinocandin resistance in the emerging pathogen candida auris

Kordalewska, M., Lee, A., Park, S., Berrio, I., Chowdhary, A., Zhao, Y. & Perlin, D. S., Jun 2018, In : Antimicrobial agents and chemotherapy. 62, 6, e00238-18.

Research output: Contribution to journalArticle

33 Scopus citations

VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice

Break, T. J., Desai, J. V., Healey, K. R., Natarajan, M., Ferre, E. M. N., Henderson, C., Zelazny, A., Siebenlist, U., Yates, C. M., Cohen, O. J., Schotzinger, R. J., Perlin, D. S., Garvey, E. P. & Lionakis, M. S., Jan 1 2018, In : Journal of Antimicrobial Chemotherapy. 73, 8, p. 2089-2094 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

An aptamer-based biosensor for the azole class of antifungal drugs

Wiedman, G. R., Zhao, Y., Mustaev, A., Ping, J., Vishnubhotla, R., Johnson, A. T. C. & Perlin, D. S., Jul 1 2017, In : mSphere. 2, 4, e00274-17.

Research output: Contribution to journalArticle

4 Scopus citations

Antimicrobials inspired by nonribosomal peptide synthetase gene clusters

Vila-Farres, X., Chu, J., Inoyama, D., Ternei, M. A., Lemetre, C., Cohen, L. J., Cho, W., Reddy, B. V. B., Zebroski, H. A., Freundlich, J. S., Perlin, D. S. & Brady, S. F., Feb 1 2017, In : Journal of the American Chemical Society. 139, 4, p. 1404-1407 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation with Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015

Heo, S. T., Tatara, A. M., Jiménez-Ortigosa, C., Jiang, Y., Lewis, R. E., Tarrand, J., Tverdek, F., Albert, N. D., Verweij, P. E., Meis, J. F., Mikos, A. G., Perlin, D. S. & Kontoyiannis, D. P., Jul 15 2017, In : Clinical Infectious Diseases. 65, 2, p. 216-225 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Culture-independent molecular methods for detection of antifungal resistance mechanisms and fungal identification

Perlin, D. S. & Wiederhold, N. P., Jan 15 2017, In : Journal of Infectious Diseases. 216, p. S458-S465

Research output: Contribution to journalArticle

14 Scopus citations

Delivering on antimicrobial resistance agenda not possible without improving fungal diagnostic capabilities

Denning, D. W., Perlin, D. S., Muldoon, E. G., Colombo, A. L., Chakrabarti, A., Richardson, M. D. & Sorrell, T. C., Feb 2017, In : Emerging Infectious Diseases. 23, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

De novo acquisition of resistance to SCY-078 in Candida glabrata involves FKS mutations that both overlap and are distinct from those conferring echinocandin resistance

Jiménez-Ortigosa, C., Perez, W. B., Angulo, D., Borroto-Esoda, K. & Perlin, D. S., Sep 2017, In : Antimicrobial agents and chemotherapy. 61, 9, e00833-17.

Research output: Contribution to journalArticle

10 Scopus citations

Emergence of echinocandin resistance due to a point mutation in the fks1 gene of Aspergillus fumigatus in a patient with chronic pulmonary aspergillosis

Jiménez-Ortigosa, C., Moore, C., Denning, D. W. & Perlin, D. S., Dec 2017, In : Antimicrobial agents and chemotherapy. 61, 12, e01277.

Research output: Contribution to journalArticle

12 Scopus citations

Expression dynamics of innate immunity in influenza virus-infected swine

Montoya, M., Foni, E., Solórzano, A., Razzuoli, E., Baratelli, M., Bilato, D., Córdoba, L., del Burgo, M. A. M., Martinez, J., Martinez-Orellana, P., Chiapponi, C., Perlin, D. S., del Real, G. & Amadori, M., Apr 21 2017, In : Frontiers in Veterinary Science. 4, APR, 48.

Research output: Contribution to journalArticle

Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata

Vella, A., De Carolis, E., Mello, E., Perlin, D. S., Sanglard, D., Sanguinetti, M. & Posteraro, B., Dec 1 2017, In : Scientific reports. 7, 1, 9099.

Research output: Contribution to journalArticle

17 Scopus citations

Rapid and accurate molecular identification of the emerging multidrug-resistant pathogen Candida auris

Kordalewska, M., Zhao, Y., Lockhart, S. R., Chowdhary, A., Berrio, I. & Perlin, D. S., Aug 2017, In : Journal of clinical microbiology. 55, 8, p. 2445-2452 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

The gastrointestinal tract is a major source of echinocandin drug resistance in a murine model of Candida glabrata colonization and systemic dissemination

Healey, K. R., Nagasaki, Y., Zimmerman, M., Kordalewska, M., Park, S., Zhao, Y. & Perlin, D. S., Dec 2017, In : Antimicrobial agents and chemotherapy. 61, 12, e01412.

Research output: Contribution to journalArticle

9 Scopus citations

Tolerance to caspofungin in Candida albicans is associated with at least three distinctive mechanisms that govern expression of FKS genes and cell wall remodeling

Yang, F., Zhang, L., Wakabayashi, H., Myers, J., Jiang, Y., Cao, Y., Jimenez-Ortigosa, C., Perlin, D. S. & Rustchenko, E., May 2017, In : Antimicrobial agents and chemotherapy. 61, 5, e00071.

Research output: Contribution to journalArticle

16 Scopus citations

Unraveling drug penetration of echinocandin antifungals at the site of infection in an intra-abdominal abscess model

Zhao, Y., Prideaux, B., Nagasaki, Y., Lee, M. H., Chen, P. Y., Blanc, L., Ho, H., Clancy, C. J., Nguyen, M. H., Dartois, V. & Perlin, D. S., Jan 1 2017, In : Antimicrobial agents and chemotherapy. 61, 10

Research output: Contribution to journalArticle

22 Scopus citations
2016

Albumin enhances caspofungin activity against Aspergillus species by facilitating drug delivery to germinating hyphae

Ioannou, P., Andrianaki, A., Akoumianaki, T., Kyrmizi, I., Albert, N., Perlin, D., Samonis, G., Kontoyiannis, D. P. & Chamilos, G., Mar 2016, In : Antimicrobial agents and chemotherapy. 60, 3, p. 1226-1233 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus

Henry, C., Fontaine, T., Heddergott, C., Robinet, P., Aimanianda, V., Beau, R., Beauvais, A., Mouyna, I., Prevost, M. C., Fekkar, A., Zhao, Y., Perlin, D. & Latgé, J. P., Dec 1 2016, In : Cellular Microbiology. 18, 12, p. 1881-1891 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Blood Aspergillus RNA is a promising alternative biomarker for invasive aspergillosis

Zhao, Y., Paderu, P., Railkar, R., Douglas, C., Iannone, R., Shire, N. & Perlin, D. S., Nov 1 2016, In : Medical mycology. 54, 8, p. 801-807 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

CD101: a novel long-acting echinocandin

Zhao, Y., Perez, W. B., Jiménez-Ortigosa, C., Hough, G., Locke, J. B., Ong, V., Bartizal, K. & Perlin, D. S., Sep 1 2016, In : Cellular Microbiology. 18, 9, p. 1308-1316 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Direct molecular diagnosis of aspergillosis and CYP51A profiling from respiratory samples of french patients

Grenoble Aspergillus Committee, Jul 29 2016, In : Frontiers in Microbiology. 7, JUL, 1164.

Research output: Contribution to journalArticle

16 Scopus citations