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Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
HIV-1 Medicine & Life Sciences
RNA-Directed DNA Polymerase Medicine & Life Sciences
Reverse Transcriptase Inhibitors Medicine & Life Sciences
Rhinovirus Medicine & Life Sciences
Ribonuclease H Medicine & Life Sciences
Mutation Medicine & Life Sciences
Nucleosides Medicine & Life Sciences
Rilpivirine Medicine & Life Sciences

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Projects 1988 2019

Pharmaceutical Preparations

Research Output 1979 2019

Alpha-carboxynucleoside phosphonates: Direct-acting inhibitors of viral DNA polymerases

Balzarini, J., Ford, A., Maguire, N. M., John, J., Das, K., Arnold, E., Dehaen, W. & Maguire, A., Jan 1 2019, In : Future Medicinal Chemistry. 11, 2, p. 137-154 18 p.

Research output: Contribution to journalReview article

Nucleic Acid Synthesis Inhibitors
Viral DNA
DNA-Directed DNA Polymerase

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease

Sagong, H. Y., Bauman, J. D., Nogales, A., Martínez-Sobrido, L., Arnold, E. & Lavoie, E., Jan 1 2019, In : ChemMedChem.

Research output: Contribution to journalArticle

Human Influenza
Antiviral Agents
Influenza A virus
Structure-Activity Relationship
1 Citation (Scopus)

Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes

Martinez, S. E., Bauman, J. D., Das, K. & Arnold, E., Mar 1 2019, In : Protein Science. 28, 3, p. 587-597 11 p.

Research output: Contribution to journalArticle

Chemical modification

Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

Das, K., Martinez, S. E., DeStefano, J. J. & Arnold, E., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7308-7313 6 p.

Research output: Contribution to journalArticle

Open Access
Reverse Transcription
Catalytic Domain
2 Citations (Scopus)

Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase

Boyer, P. L., Smith, S. J., Zhao, X. Z., Das, K., Gruber, K., Arnold, E., Burke, T. R. & Hughes, S. H., Jul 1 2018, In : Journal of virology. 92, 13, e02203-17.

Research output: Contribution to journalArticle

Ribonuclease H
RNA-directed DNA polymerase
Human immunodeficiency virus 1
active sites
Catalytic Domain