Edward Arnold

Balzarini, J., Ford, A., Maguire, N. M., John, J., Das, K., Arnold, E., Dehaen, W. & Maguire, A., Jan 1 2019, In : Future Medicinal Chemistry. 11, 2, p. 137-154 18 p.

Research output: Contribution to journal › Review article

Nucleic Acid Synthesis Inhibitors

Organophosphonates

Viral DNA

DNA-Directed DNA Polymerase

Nucleosides

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease

Sagong, H. Y., Bauman, J. D., Nogales, A., Martínez-Sobrido, L., Arnold, E. & Lavoie, E., Jan 1 2019, In : ChemMedChem.

Research output: Contribution to journal › Article

Endonucleases

Human Influenza

Antiviral Agents

Influenza A virus

Structure-Activity Relationship

1 Citation (Scopus)

Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes

Martinez, S. E., Bauman, J. D., Das, K. & Arnold, E., Mar 1 2019, In : Protein Science. 28, 3, p. 587-597 11 p.

Research output: Contribution to journal › Article

Nucleosides

Fingers

Stavudine

DNA

Chemical modification

Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

Das, K., Martinez, S. E., DeStefano, J. J. & Arnold, E., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7308-7313 6 p.

Research output: Contribution to journal › Article

Open Access

Reverse Transcription

HIV-1

Nucleotides

Thumb

Catalytic Domain

2 Citations (Scopus)

Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase

Boyer, P. L., Smith, S. J., Zhao, X. Z., Das, K., Gruber, K., Arnold, E., Burke, T. R. & Hughes, S. H., Jul 1 2018, In : Journal of virology. 92, 13, e02203-17.

Research output: Contribution to journal › Article

Ribonuclease H

RNA-directed DNA polymerase

Human immunodeficiency virus 1

active sites

Catalytic Domain