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Edward Arnold

  • 19108 Citations
  • 75 h-Index
1979 …2019
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  • 6 Similar Profiles
HIV-1 Medicine & Life Sciences
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Nucleosides Medicine & Life Sciences
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Projects 1988 2019

Drug Development Targeting Influenza A Cap-Snatching Endonuclease

Arnold, E.

National Institutes of Health (NIH)

7/1/15 → 6/30/17

Project: Research project

Endonucleases
Assays
Pharmaceutical Preparations
Cytotoxicity
Molecules

Hiv-1 Reverse Transcriptase Structure: Function, Inhibition, And Resistance

Arnold, E.

National Institutes of Health (NIH)

11/1/88 → 1/31/19

Project: Research project

Research Output 1979 2019

Alpha-carboxynucleoside phosphonates: Direct-acting inhibitors of viral DNA polymerases

Balzarini, J., Ford, A., Maguire, N. M., John, J., Das, K., Arnold, E., Dehaen, W. & Maguire, A., Jan 1 2019, In : Future Medicinal Chemistry. 11, 2, p. 137-154 18 p.

Research output: Contribution to journal › Review article

Nucleic Acid Synthesis Inhibitors
Organophosphonates
Viral DNA
DNA-Directed DNA Polymerase
Nucleosides

Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes

Martinez, S. E., Bauman, J. D., Das, K. & Arnold, E., Mar 1 2019, In : Protein Science. 28, 3, p. 587-597 11 p.

Research output: Contribution to journal › Article

Nucleosides
Fingers
Stavudine
DNA
Chemical modification
2 Citations (Scopus)

Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase

Boyer, P. L., Smith, S. J., Zhao, X. Z., Das, K., Gruber, K., Arnold, E., Burke, T. R. & Hughes, S. H., Jul 1 2018, In : Journal of virology. 92, 13, e02203-17.

Research output: Contribution to journal › Article

Ribonuclease H
RNA-directed DNA polymerase
Human immunodeficiency virus 1
active sites
Catalytic Domain

Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae (Scientific Reports (2018) DOI: 10.1038/s41598-018-23423-1)

Vedithi, S. C., Malhotra, S., Das, M., Daniel, S., Kishore, N., George, A., Arumugam, S., Rajan, L., Ebenezer, M., Ascher, D. B., Arnold, E. & Blundell, T. L., Dec 1 2018, In : Scientific reports. 8, 1, 8250.

Research output: Contribution to journal › Comment/debate

Mycobacterium leprae
Rifampin
Mutation
Lepromatous Leprosy
Ribonucleotides
1 Citation (Scopus)

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

Vedithi, S. C., Malhotra, S., Das, M., Daniel, S., Kishore, N., George, A., Arumugam, S., Rajan, L., Ebenezer, M., Ascher, D. B., Arnold, E. & Blundell, T. L., Dec 1 2018, In : Scientific reports. 8, 1, 5016.

Research output: Contribution to journal › Article

Mycobacterium leprae
Rifampin
Leprosy
Holoenzymes
DNA-Directed RNA Polymerases