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Grace Guo

  • 4925 Citations
  • 34 h-Index
20002019
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  • 13 Similar Profiles
Bile Acids and Salts Medicine & Life Sciences
Liver Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Homeostasis Medicine & Life Sciences
Fibroblast Growth Factors Medicine & Life Sciences
Knockout Mice Medicine & Life Sciences
Fatty Liver Medicine & Life Sciences
Hepatocytes Medicine & Life Sciences

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Projects 2008 2018

Gut Bile Acids, Fxr, & Fgf15 In Total Parenteral Nutrition-Associated Cholestasis

Guo, G.

National Institutes of Health (NIH)

7/5/13 → 5/31/18

Project: Research project

Fibroblast Growth Factor Receptors
Total Parenteral Nutrition
Cholestasis
Bile Acids and Salts

Tissue Specific Mechanism Of Fxr In Suppressing Bile-Acid Synthesis

Guo, G.

National Institutes of Health (NIH)

6/10/08 → 5/31/13

Project: Research project

Bile Acids and Salts
Homeostasis
Liver
Gene Expression
Liver Diseases

Research Output 2000 2019

Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR

Dong, B., Singh, A. B., Guo, G. L., Young, M. & Liu, J., May 2019, In : International journal of molecular medicine. 43, 5, p. 1927-1938 12 p.

Research output: Contribution to journal › Article

Open Access
Cytoplasmic and Nuclear Receptors
Cricetinae
Response Elements
Gene Expression
Liver

Age modulates liver responses to asparaginase-induced amino acid stress in mice

Nikonorova, I. A., Zhu, Q., Signore, C. C., Mirek, E. T., Jonsson, W. O., Kong, B., Guo, G. L., Belden, W. J. & Anthony, T. X. G., Jan 1 2019, In : Journal of Biological Chemistry. 294, 38, p. 12864-13875 1012 p.

Research output: Contribution to journal › Review article

Open Access
Asparaginase
Liver
Amino Acids
Genes
Transcriptome

Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model

Rizzolo, D., Buckley, K., Kong, B., Zhan, L., Shen, J., Stofan, M., Brinker, A., Goedken, M., Buckley, B. & Guo, G., Jul 1 2019, In : Hepatology. 70, 1, p. 389-402 14 p.

Research output: Contribution to journal › Article

Cholestanetriol 26-Monooxygenase
Cholesterol 7-alpha-Hydroxylase
Bile Acids and Salts
Knockout Mice
Homeostasis

Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development

Schumacher, J. D., Kong, B., Wu, J., Rizzolo, D., Armstrong, L. E., Chow, M. D., Goedken, M., Lee, Y-H. & Guo, G., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journal › Article

Hepatic Stellate Cells
Fibroblast Growth Factors
Liver Cirrhosis
Bile Acids and Salts
Cholestyramine Resin
1 Citation (Scopus)

FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury

Kong, B., Zhang, M., Huang, M., Rizzolo, D., Armstrong, L. E., Schumacher, J. D., Chow, M. D., Lee, Y-H. & Guo, G., Apr 1 2019, In : Digestive and Liver Disease. 51, 4, p. 570-576 7 p.

Research output: Contribution to journal › Article

Bile Acids and Salts
Alcohols
Liver
Wounds and Injuries
Ethanol