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Grace Guo

  • 4649 Citations
  • 33 h-Index
20002019
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Bile Acids and Salts Medicine & Life Sciences
Liver Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Homeostasis Medicine & Life Sciences
Fibroblast Growth Factors Medicine & Life Sciences
Knockout Mice Medicine & Life Sciences
Hepatocytes Medicine & Life Sciences
Fatty Liver Medicine & Life Sciences

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Projects 2008 2018

Gut Bile Acids, Fxr, & Fgf15 In Total Parenteral Nutrition-Associated Cholestasis

Guo, G.

National Institutes of Health (NIH)

7/5/13 → 5/31/18

Project: Research project

Fibroblast Growth Factor Receptors
Total Parenteral Nutrition
Cholestasis
Bile Acids and Salts

Tissue Specific Mechanism Of Fxr In Suppressing Bile-Acid Synthesis

Guo, G.

National Institutes of Health (NIH)

6/10/08 → 5/31/13

Project: Research project

Bile Acids and Salts
Homeostasis
Liver
Gene Expression
Liver Diseases

Research Output 2000 2019

Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR

Dong, B., Singh, A. B., Guo, G., Young, M. & Liu, J., May 1 2019, In : International journal of molecular medicine. 43, 5, p. 1927-1938 12 p.

Research output: Contribution to journal › Article

Open Access
Cytoplasmic and Nuclear Receptors
Cricetinae
Response Elements
Gene Expression
Liver

Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model

Rizzolo, D., Buckley, K., Kong, B., Zhan, L., Shen, J., Stofan, M., Brinker, A., Goedken, M., Buckley, B. & Guo, G., Jul 1 2019, In : Hepatology. 70, 1, p. 389-402 14 p.

Research output: Contribution to journal › Article

Cholestanetriol 26-Monooxygenase
Cholesterol 7-alpha-Hydroxylase
Bile Acids and Salts
Knockout Mice
Homeostasis

FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury

Kong, B., Zhang, M., Huang, M., Rizzolo, D., Armstrong, L. E., Schumacher, J. D., Chow, M. D., Lee, Y-H. & Guo, G., Apr 1 2019, In : Digestive and Liver Disease. 51, 4, p. 570-576 7 p.

Research output: Contribution to journal › Article

Bile Acids and Salts
Alcohols
Liver
Wounds and Injuries
Ethanol
1 Citation (Scopus)

Is This the Time to Reconsider the Names for Xenobiotic Nuclear Receptors?

Kong, B. & Guo, G., Jan 1 2019, In : Hepatology. 69, 1, p. 16-18 3 p.

Research output: Contribution to journal › Editorial

Xenobiotics
Cytoplasmic and Nuclear Receptors
Names

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling–activated Src maintains cholesterol levels and protects from atherosclerosis

Byun, S., Jung, H., Chen, J., Kim, Y. C., Kim, D. H., Kong, B., Guo, G., Kemper, B. & Kemper, J. K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 22, p. 8732-8744 13 p.

Research output: Contribution to journal › Article

Phosphorylation
Atherosclerosis
Cholesterol
Class B Scavenger Receptors
Liver