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Research Output

2020

Modeling inter-sex and inter-individual variability in response to chronopharmacological administration of synthetic glucocorticoids

Scherholz, M. L., Rao, R. T. & Androulakis, I. P., Feb 1 2020, In : Chronobiology International. 37, 2, p. 281-296 16 p.

Research output: Contribution to journalArticle

2019
Open Access

At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications

Bae, S. A., Fang, M. Z., Rustgi, V., Zarbl, H. & Androulakis, I. P., Aug 28 2019, In : Frontiers in Nutrition. 6, 132.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Chronopharmacology of glucocorticoids

Scherholz, M. L., Schlesinger, N. & Androulakis, I. P., Nov 1 2019, In : Advanced Drug Delivery Reviews. 151-152, p. 245-261 17 p.

Research output: Contribution to journalReview article

2 Scopus citations

Editorial overview: Systems biology approaches in biomedicine and human therapy

Klapa, M. I. & Androulakis, I. P., Aug 2019, In : Current Opinion in Biotechnology. 58, p. iii-iv

Research output: Contribution to journalEditorial

Fluorescence Imaging of Actin Turnover Parses Early Stem Cell Lineage Divergence and Senescence

Mishra, P., Martin, D. C., Androulakis, I. P. & Moghe, P. V., Dec 1 2019, In : Scientific reports. 9, 1, 10377.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations
5 Scopus citations

The quest for digital health: From diseases to patients

Androulakis, I. P., Aug 4 2019, In : Computers and Chemical Engineering. 127, p. 247-253 7 p.

Research output: Contribution to journalArticle

2018

A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models

Scherholz, M. L., Forder, J. & Androulakis, I. P., Apr 1 2018, In : Journal of Pharmacokinetics and Pharmacodynamics. 45, 2, p. 309-327 19 p.

Research output: Contribution to journalArticle

5 Scopus citations
6 Scopus citations

Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis

Rao, R. T., Scherholz, M. L. & Androulakis, I. P., Dec 2 2018, In : Chronobiology International. 35, 12, p. 1619-1636 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle

Pierre, K., Rao, R. T., Hartmanshenn, C. & Androulakis, I. P., Apr 1 2018, In : Endocrinology. 159, 4, p. 1808-1826 19 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pharmacokinetics and Pharmacodynamics of Curcumin in regulating anti-inflammatory and epigenetic gene expression

Boyanapalli, S. S. S., Huang, Y., Su, Z., Cheng, D., Zhang, C., Guo, Y., Rao, R., Androulakis, I. P. & Kong, A. N., Jun 2018, In : Biopharmaceutics and Drug Disposition. 39, 6, p. 289-297 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Quantitative systems pharmacology: Extending the envelope through systems engineering

Hartmanshenn, C., Rao, R. T., Bae, S. A., Scherholz, M. L., Acevedo, A., Pierre, K. K. & Androulakis, I. P., Jan 1 2018, Computer Aided Chemical Engineering. Manca, D. (ed.). Elsevier B.V., p. 3-34 32 p. (Computer Aided Chemical Engineering; vol. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2017

Allostatic breakdown of cascading homeostat systems: A computational approach

Acevedo, A. & Androulakis, I. P., Jul 2017, In : Heliyon. 3, 7, e00355.

Research output: Contribution to journalArticle

3 Scopus citations

Asymmetry in signal oscillations contributes to efficiency of periodic systems

Bae, S. A., Acevedo, A. & Androulakis, I. P., Jan 1 2017, In : Critical reviews in biomedical engineering. 44, 3, p. 193-211 19 p.

Research output: Contribution to journalArticle

Modeling the sex differences and interindividual variability in the activity of the hypothalamic-pituitary-adrenal axis

Rao, R. T. & Androulakis, I. P., Nov 1 2017, In : Endocrinology. 158, 11, p. 4017-4037 21 p.

Research output: Contribution to journalArticle

13 Scopus citations

On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology

Rao, R. T., Scherholz, M. L., Hartmanshenn, C., Bae, S. A. & Androulakis, I. P., Dec 5 2017, In : Computers and Chemical Engineering. 107, p. 100-110 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

Zhang, C., Wang, C., Li, W., Wu, R., Guo, Y., Cheng, D., Yang, Y., Androulakis, I. P. & Kong, A. N., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3709-3717 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
5 Scopus citations

The potential of circadian realignment in rheumatoid arthritis

Rao, R. T., Pierre, K. K., Schlesinger, N. & Androulakis, I., Jan 1 2017, In : Critical reviews in biomedical engineering. 44, 3, p. 177-191 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations

Understanding physiology in the continuum: Integration of information from multiple -omics levels

Kamisoglu, K., Acevedo, A., Almon, R. R., Coyle, S., Corbett, S., Dubois, D. C., Nguyen, T. T., Jusko, W. J. & Androulakis, I. P., Feb 27 2017, In : Frontiers in Pharmacology. 8, FEB, 91.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Mathematical modeling of the circadian dynamics of the neuroendocrine-immune network in experimentally induced arthritis

Rao, R., Dubois, D., Almon, R., Jusko, W. J. & Androulakis, I. P., Aug 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 311, 2, p. E310-E324

Research output: Contribution to journalArticle

10 Scopus citations

Mechanistic modeling of inflammation

Scheff, J. D., Kamisoglu, K. & Androulakis, I. P., Jan 1 2016, AAPS Advances in the Pharmaceutical Sciences Series. Springer Verlag, p. 325-352 28 p. (AAPS Advances in the Pharmaceutical Sciences Series; vol. 23).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Modeling convergence of circadian clocks and metabolism

Bae, S. A. & Androulakis, I. P., Jan 1 2016, Computing and Systems Technology Division 2016 - Core Programming Area at the 2016 AIChE Annual Meeting. AIChE, p. 108-110 3 p. (Computing and Systems Technology Division 2016 - Core Programming Area at the 2016 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine

Hartmanshenn, C., Scherholz, M. & Androulakis, I. P., Oct 1 2016, In : Journal of Pharmacokinetics and Pharmacodynamics. 43, 5, p. 481-504 24 p.

Research output: Contribution to journalReview article

29 Scopus citations

Quantitative Systems Pharmacology: A Framework for Context

Androulakis, I. P., Jun 1 2016, In : Current Pharmacology Reports. 2, 3, p. 152-160 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity

Pierre, K., Schlesinger, N. & Androulakis, I. P., Oct 2016, In : Physiological genomics. 48, 10, p. 719-738 20 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Asymmetry in signal oscillations contributes to efficiency of periodic systems

Bae, S. A., Acevedo, A. & Androulakis, I. P., Jan 1 2015, Food, Pharmaceutical and Bioengineering Division 2015 - Core Programming Area at the 2015 AIChE Meeting. AIChE, p. 88-89 2 p. (Food, Pharmaceutical and Bioengineering Division 2015 - Core Programming Area at the 2015 AIChE Meeting; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response

Mavroudis, P. D., Corbett, S., Calvano, S. E. & Androulakis, I., Feb 1 2015, In : Mathematical Biosciences. 260, p. 54-64 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models

Rao, R., Orman, M. A., Berthiaume, F. & Androulakis, I. P., Jan 1 2015, In : Data in Brief. 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS

Kamisoglu, K., Haimovich, B., Calvano, S. E., Coyle, S. M., Corbett, S. A., Langley, R. J., Kingsmore, S. F. & Androulakis, I. P., Mar 3 2015, In : Critical Care. 19, 1, 71.

Research output: Contribution to journalArticle

29 Scopus citations

Modeling the dynamics of neuroendocrine-immune interactions in collagen-induced arthritis

Rao, R., Dubois, D., Almon, R., Jusko, W. J. & Androulakis, I., Jan 1 2015, Chemical Engineers in Medicine 2015 - Topical Conference at the 2015 AIChE Annual Meeting. AIChE, p. 122-124 3 p. (Chemical Engineers in Medicine 2015 - Topical Conference at the 2015 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Modeling the dynamics of neuroendocrine-immune interactions in collagen-induced arthritis

Rao, R., Dubois, D., Almon, R., Jusko, W. J. & Androulakis, I., Jan 1 2015, Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting. AIChE, p. 681-683 3 p. (Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pharmacokinetics and pharmacodynamics of 3,3′-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes

Wu, T. Y., Huang, Y., Zhang, C., Su, Z. Y., Boyanapalli, S., Khor, T. O., Wang, H., Lin, H., Gounder, M., Kagan, L., Androulakis, I. P. & Kong, A. N. T., Aug 28 2015, In : Journal of Pharmacokinetics and Pharmacodynamics. 42, 4, p. 401-408 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Special issue on Mathematical Models of Inflammation

Androulakis, I. Y. P., Feb 1 2015, In : Mathematical Biosciences. 260, p. 1 1 p.

Research output: Contribution to journalEditorial

11 Scopus citations

Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: A systems approach to liver function in pharmacogenomics

Kamisoglu, K., Sukumaran, S., Nouri-Nigjeh, E., Tu, C., Li, J., Shen, X., Duan, X., Qu, J., Almon, R. R., Dubois, D. C., Jusko, W. J. & Androulakis, I., Feb 1 2015, In : OMICS A Journal of Integrative Biology. 19, 2, p. 80-91 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

A chemical engineer's perspective on health and disease

Androulakis, I. P., Dec 4 2014, In : Computers and Chemical Engineering. 71, p. 665-671 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver

Nguyen, T. T., Mattick, J. S. A., Yang, Q., Orman, M. A., Ierapetritou, M. G., Berthiaume, F. & Androulakis, I. P., Mar 25 2014, In : BMC Bioinformatics. 15, 1, 83.

Research output: Contribution to journalArticle

10 Scopus citations

Biosystems modeling and engineering

Linninger, A. A. & Androulakis, I. P., Dec 4 2014, In : Computers and Chemical Engineering. 71, p. 663-664 2 p.

Research output: Contribution to journalEditorial

Circadian signatures in rat liver: From gene expression to pathways

Ovacik, M. A., Sukumaran, S., Almon, R. R., Dubois, D. C., Jusko, W. J. & Androulakis, I. P., Jan 1 2014, Sleep, Circadian Rhythms, and Metabolism: The Rhythm of Life. Apple Academic Press, p. 23-52 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dynamic Models of Disease Progression: Toward a Multiscale Model of Systemic Inflammation in Humans

Scheff, J. D., Foteinou, P. T., Calvano, S. E., Lowry, S. F. & Androulakis, I. P., Jun 13 2014, Dynamic Process Modeling. wiley, Vol. 7-7. p. 319-368 50 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Effects of corticosteroids on liver function: Inter-relationships between transcription and translation

Kamisoglu, K., Sukumaran, S., Nouri-Nigjeh, E., Tu, C., Li, J., Zhang, M., Wopperer, S., Yu, H., Qu, J., Almon, R. R., Dubois, D., Jusko, W. J. & Androulakis, I. P., Jan 1 2014, Systems Biology 2014 - Topical Conference at the 2014 AIChE Annual Meeting. AIChE, p. 125-127 3 p. (Systems Biology 2014 - Topical Conference at the 2014 AIChE Annual Meeting).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Effects of coupled dose and rhythm manipulation of plasma cortisol levels on leukocyte transcriptional response to endotoxin challenge in humans

Kamisoglu, K., Sleight, K., Nguyen, T. T., Calvano, S. E., Coyle, S. M., Corbett, S. & Androulakis, I., Oct 12 2014, In : Innate Immunity. 20, 7, p. 774-784 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Human metabolic response to systemic inflammation: Concordance between the experimental endotoxemia and clinical cases

Kamisoglu, K., Calvano, S. E., Coyle, S. M., Corbett, S. A. & Androulakis, I. P., Jan 1 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. AIChE, Vol. 1. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Integrated analysis of transcriptional and metabolic profiling in human endotoxemia

Kamisoglu, K., Calvano, S. E., Coyle, S. M., Corbett, S. A. & Androulakis, I. P., Jan 1 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. AIChE, p. 1077-1078 2 p. (Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution