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2020

Modeling inter-sex and inter-individual variability in response to chronopharmacological administration of synthetic glucocorticoids

Scherholz, M. L., Rao, R. T. & Androulakis, I. P., Feb 1 2020, In : Chronobiology International. 37, 2, p. 281-296 16 p.

Research output: Contribution to journalArticle

2019
Open Access

Fluorescence Imaging of Actin Turnover Parses Early Stem Cell Lineage Divergence and Senescence

Mishra, P., Martin, D. C., Androulakis, I. P. & Moghe, P. V., Dec 1 2019, In : Scientific reports. 9, 1, 10377.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations

The quest for digital health: From diseases to patients

Androulakis, I. P., Aug 4 2019, In : Computers and Chemical Engineering. 127, p. 247-253 7 p.

Research output: Contribution to journalArticle

2018

A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models

Scherholz, M. L., Forder, J. & Androulakis, I. P., Apr 1 2018, In : Journal of Pharmacokinetics and Pharmacodynamics. 45, 2, p. 309-327 19 p.

Research output: Contribution to journalArticle

5 Scopus citations
6 Scopus citations

Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis

Rao, R. T., Scherholz, M. L. & Androulakis, I. P., Dec 2 2018, In : Chronobiology International. 35, 12, p. 1619-1636 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle

Pierre, K., Rao, R. T., Hartmanshenn, C. & Androulakis, I. P., Apr 1 2018, In : Endocrinology. 159, 4, p. 1808-1826 19 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pharmacokinetics and Pharmacodynamics of Curcumin in regulating anti-inflammatory and epigenetic gene expression

Boyanapalli, S. S. S., Huang, Y., Su, Z., Cheng, D., Zhang, C., Guo, Y., Rao, R., Androulakis, I. P. & Kong, A. N., Jun 2018, In : Biopharmaceutics and Drug Disposition. 39, 6, p. 289-297 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Allostatic breakdown of cascading homeostat systems: A computational approach

Acevedo, A. & Androulakis, I. P., Jul 2017, In : Heliyon. 3, 7, e00355.

Research output: Contribution to journalArticle

3 Scopus citations

Asymmetry in signal oscillations contributes to efficiency of periodic systems

Bae, S. A., Acevedo, A. & Androulakis, I. P., Jan 1 2017, In : Critical reviews in biomedical engineering. 44, 3, p. 193-211 19 p.

Research output: Contribution to journalArticle

Modeling the sex differences and interindividual variability in the activity of the hypothalamic-pituitary-adrenal axis

Rao, R. T. & Androulakis, I. P., Nov 1 2017, In : Endocrinology. 158, 11, p. 4017-4037 21 p.

Research output: Contribution to journalArticle

14 Scopus citations

On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology

Rao, R. T., Scherholz, M. L., Hartmanshenn, C., Bae, S. A. & Androulakis, I. P., Dec 5 2017, In : Computers and Chemical Engineering. 107, p. 100-110 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

Zhang, C., Wang, C., Li, W., Wu, R., Guo, Y., Cheng, D., Yang, Y., Androulakis, I. P. & Kong, A. N., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3709-3717 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
5 Scopus citations

The potential of circadian realignment in rheumatoid arthritis

Rao, R. T., Pierre, K. K., Schlesinger, N. & Androulakis, I., Jan 1 2017, In : Critical reviews in biomedical engineering. 44, 3, p. 177-191 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations

Understanding physiology in the continuum: Integration of information from multiple -omics levels

Kamisoglu, K., Acevedo, A., Almon, R. R., Coyle, S., Corbett, S., Dubois, D. C., Nguyen, T. T., Jusko, W. J. & Androulakis, I. P., Feb 27 2017, In : Frontiers in Pharmacology. 8, FEB, 91.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Mathematical modeling of the circadian dynamics of the neuroendocrine-immune network in experimentally induced arthritis

Rao, R., Dubois, D., Almon, R., Jusko, W. J. & Androulakis, I. P., Aug 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 311, 2, p. E310-E324

Research output: Contribution to journalArticle

10 Scopus citations

The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity

Pierre, K., Schlesinger, N. & Androulakis, I. P., Oct 2016, In : Physiological genomics. 48, 10, p. 719-738 20 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response

Mavroudis, P. D., Corbett, S., Calvano, S. E. & Androulakis, I., Feb 1 2015, In : Mathematical Biosciences. 260, p. 54-64 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models

Rao, R., Orman, M. A., Berthiaume, F. & Androulakis, I. P., Jan 1 2015, In : Data in Brief. 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS

Kamisoglu, K., Haimovich, B., Calvano, S. E., Coyle, S. M., Corbett, S. A., Langley, R. J., Kingsmore, S. F. & Androulakis, I. P., Mar 3 2015, In : Critical Care. 19, 1, 71.

Research output: Contribution to journalArticle

33 Scopus citations

Pharmacokinetics and pharmacodynamics of 3,3′-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes

Wu, T. Y., Huang, Y., Zhang, C., Su, Z. Y., Boyanapalli, S., Khor, T. O., Wang, H., Lin, H., Gounder, M., Kagan, L., Androulakis, I. P. & Kong, A. N. T., Aug 28 2015, In : Journal of Pharmacokinetics and Pharmacodynamics. 42, 4, p. 401-408 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
11 Scopus citations

Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: A systems approach to liver function in pharmacogenomics

Kamisoglu, K., Sukumaran, S., Nouri-Nigjeh, E., Tu, C., Li, J., Shen, X., Duan, X., Qu, J., Almon, R. R., Dubois, D. C., Jusko, W. J. & Androulakis, I., Feb 1 2015, In : OMICS A Journal of Integrative Biology. 19, 2, p. 80-91 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

A chemical engineer's perspective on health and disease

Androulakis, I. P., Dec 4 2014, In : Computers and Chemical Engineering. 71, p. 665-671 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver

Nguyen, T. T., Mattick, J. S. A., Yang, Q., Orman, M. A., Ierapetritou, M. G., Berthiaume, F. & Androulakis, I. P., Mar 25 2014, In : BMC Bioinformatics. 15, 1, 83.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of coupled dose and rhythm manipulation of plasma cortisol levels on leukocyte transcriptional response to endotoxin challenge in humans

Kamisoglu, K., Sleight, K., Nguyen, T. T., Calvano, S. E., Coyle, S. M., Corbett, S. & Androulakis, I., Oct 12 2014, In : Innate Immunity. 20, 7, p. 774-784 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Integrated transcriptional and metabolic profiling in human endotoxemia

Kamisoglu, K., Calvano, S. E., Coyle, S. M., Corbett, S. & Androulakis, I., Dec 12 2014, In : Shock. 42, 6, p. 499-508 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mathematical modeling of light-mediated hpa axis activity and downstream implications on the entrainment of peripheral clock genes

Mavroudis, P. D., Corbett, S. A., Calvano, S. E. & Androulakis, I. P., Oct 15 2014, In : Physiological genomics. 46, 20, p. 766-778 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

On heart rate variability and autonomic activity in homeostasis and in systemic inflammation

Scheff, J. D., Griffel, B., Corbett, S. A., Calvano, S. E. & Androulakis, I. P., Jan 1 2014, In : Mathematical Biosciences. 252, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Reactive flow simulation based on the integration of automated mechanism generation and on-the-fly reduction

Zhang, S., Broadbelt, L. J., Androulakis, I. & Ierapetritou, M., Jul 17 2014, In : Energy and Fuels. 28, 7, p. 4801-4811 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

A hybrid kinetic mechanism reduction scheme based on the on-the-fly reduction and quasi-steady-state approximation

Zhang, S., Androulakis, I. P. & Ierapetritou, M. G., Apr 9 2013, In : Chemical Engineering Science. 93, p. 150-162 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

A multiscale modeling approach to inflammation: A case study in human endotoxemia

Scheff, J. D., Mavroudis, P. D., Foteinou, P. T., An, G., Calvano, S. E., Doyle, J., Dick, T. E., Lowry, S. F., Vodovotz, Y. & Androulakis, I. P., Jul 1 2013, In : Journal of Computational Physics. 244, p. 279-289 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

An Agent-Based Model of Cellular Dynamics and Circadian Variability in Human Endotoxemia

Nguyen, T. T., Calvano, S. E., Lowry, S. F. & Androulakis, I. P., Jan 30 2013, In : PloS one. 8, 1, e55550.

Research output: Contribution to journalArticle

11 Scopus citations
7 Scopus citations

Effect of Fasting on the Metabolic Response of Liver to Experimental Burn Injury

Orman, M. A., Ierapetritou, M. G., Androulakis, I. P. & Berthiaume, F., Feb 5 2013, In : PloS one. 8, 2, e54825.

Research output: Contribution to journalArticle

3 Scopus citations

Enzyme sequence similarity improves the reaction alignment method for cross-species pathway comparison

Ovacik, M. A. & Androulakis, I., Sep 15 2013, In : Toxicology and Applied Pharmacology. 271, 3, p. 363-371 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Metabolomic fingerprinting: Challenges and opportunities

Kosmides, A. K., Kamisoglu, K., Calvano, S. E., Corbett, S. A. & Androulakis, I. P., Dec 1 2013, In : Critical reviews in biomedical engineering. 41, 3, p. 205-221 17 p.

Research output: Contribution to journalArticle

49 Scopus citations

Pathway modeling of microarray data: A case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP)

Ovacik, M. A., Sen, B., Euling, S. Y., Gaido, K. W., Ierapetritou, M. G. & Androulakis, I. P., Sep 15 2013, In : Toxicology and Applied Pharmacology. 271, 3, p. 386-394 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Predicting critical transitions in a model of systemic inflammation

Scheff, J. D., Calvano, S. E. & Androulakis, I. P., Sep 19 2013, In : Journal of Theoretical Biology. 338, p. 9-15 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Temporal metabolic profiling of plasma during endotoxemia in humans

Kamisoglu, K., Sleight, K. E., Calvano, S. E., Coyle, S. M., Corbett, S. A. & Androulakis, I. P., Dec 1 2013, In : Shock. 40, 6, p. 519-526 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration

Nguyen, T. T., Almon, R. R., Dubois, D. C., Sukumaran, S., Jusko, W. J. & Androulakis, I. P., Oct 24 2013, In : Gene Regulation and Systems Biology. 2014, 8, p. 75-87 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Translational applications of evaluating physiologic variability in human endotoxemia

Scheff, J. D., Mavroudis, P. D., Calvano, S. E. & Androulakis, I. P., Aug 1 2013, In : Journal of Clinical Monitoring and Computing. 27, 4, p. 405-415 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set

Euling, S. Y., White, L. D., Kim, A. S., Sen, B., Wilson, V. S., Keshava, C., Keshava, N., Hester, S., Ovacik, M. A., Ierapetritou, M. G., Androulakis, I. P. & Gaido, K. W., Sep 15 2013, In : Toxicology and Applied Pharmacology. 271, 3, p. 349-362 14 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

Comparison of biodiesel performance based on HCCI engine simulation using detailed mechanism with on-the-fly reduction

Zhang, S., Broadbelt, L. J., Androulakis, I. & Ierapetritou, M., Feb 16 2012, In : Energy and Fuels. 26, 2, p. 976-983 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Dynamics of hepatic gene expression profile in a rat cecal ligation and puncture model

Yang, Q., Mattick, J. S. A., Orman, M. A., Nguyen, T. T., Ierapetritou, M., Berthiaume, F. & Androulakis, I., Aug 1 2012, In : Journal of Surgical Research. 176, 2, p. 583-600 18 p.

Research output: Contribution to journalArticle

10 Scopus citations