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Research Output 1989 2019

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Article
2019
Open Access
Physiological Adaptation
Glucocorticoids
Allostasis
Circadian Clocks
Periodicity
2 Citations (Scopus)

Chronopharmacology of glucocorticoids

Scherholz, M. L., Schlesinger, N. & Androulakis, I., Jan 1 2019, In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Glucocorticoids
Hydrocortisone
Immunosuppressive Agents
Anti-Inflammatory Agents
Pharmacology
Compartment Model
Pharmacokinetics
Sex Characteristics
sexual dimorphism
pharmacokinetics

Fluorescence Imaging of Actin Turnover Parses Early Stem Cell Lineage Divergence and Senescence

Mishra, P., Martin, D. C., Androulakis, I. & Moghe, P., Dec 1 2019, In : Scientific reports. 9, 1, 10377.

Research output: Contribution to journalArticle

Open Access
Cell Aging
Optical Imaging
Cell Lineage
Actins
Stem Cells
1 Citation (Scopus)
Circadian Rhythm
Meals
Insulin
Glucose
Gene Knockout Techniques

The quest for digital health: From diseases to patients

Androulakis, I., Aug 4 2019, In : Computers and Chemical Engineering. 127, p. 247-253 7 p.

Research output: Contribution to journalArticle

Health
Physiology
Genetics
2018
5 Citations (Scopus)

A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models

Scherholz, M. L., Forder, J. & Androulakis, I., Apr 1 2018, In : Journal of Pharmacokinetics and Pharmacodynamics. 45, 2, p. 309-327 19 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Atenolol
Risperidone
Furosemide
Acetaminophen
6 Citations (Scopus)
Gluconeogenesis
Circadian Rhythm
Light
Liver
Fasting
5 Citations (Scopus)

Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis

Rao, R. T., Scherholz, M. L. & Androulakis, I., Dec 2 2018, In : Chronobiology International. 35, 12, p. 1619-1636 18 p.

Research output: Contribution to journalArticle

Glucocorticoids
Hydrocortisone
Periodicity
Immunosuppressive Agents
Anti-Inflammatory Agents
5 Citations (Scopus)

Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle

Pierre, K., Rao, R. T., Hartmanshenn, C. & Androulakis, I., Apr 1 2018, In : Endocrinology. 159, 4, p. 1808-1826 19 p.

Research output: Contribution to journalArticle

Circadian Clocks
Hydrocortisone
Cell Cycle
Periodicity
Photoperiod
5 Citations (Scopus)

Pharmacokinetics and Pharmacodynamics of Curcumin in regulating anti-inflammatory and epigenetic gene expression

Boyanapalli, S. S. S., Huang, Y., Su, Z., Cheng, D., Zhang, C., Guo, Y., Rao, R., Androulakis, I. & Kong, A-N., Jun 1 2018, In : Biopharmaceutics and Drug Disposition. 39, 6, p. 289-297 9 p.

Research output: Contribution to journalArticle

Curcumin
Epigenomics
Anti-Inflammatory Agents
Pharmacokinetics
Gene Expression
2017
2 Citations (Scopus)

Allostatic breakdown of cascading homeostat systems: A computational approach

Acevedo, A. & Androulakis, I., Jul 1 2017, In : Heliyon. 3, 7, e00355.

Research output: Contribution to journalArticle

Allostasis
Causality
Homeostasis
Tears
Health

Asymmetry in signal oscillations contributes to efficiency of periodic systems

Bae, S. A., Acevedo, A. & Androulakis, I., Jan 1 2017, In : Critical reviews in biomedical engineering. 44, 3, p. 193-211 19 p.

Research output: Contribution to journalArticle

Time varying systems
Feedback
Cell signaling
Decoding
Molecules
8 Citations (Scopus)

Modeling the sex differences and interindividual variability in the activity of the hypothalamic-pituitary-adrenal axis

Rao, R. T. & Androulakis, I., Nov 1 2017, In : Endocrinology. 158, 11, p. 4017-4037 21 p.

Research output: Contribution to journalArticle

Sex Characteristics
Physiological Feedback
Gonadal Hormones
Physiological Adaptation
Corticosterone
2 Citations (Scopus)

On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology

Rao, R. T., Scherholz, M. L., Hartmanshenn, C., Bae, S. A. & Androulakis, I., Dec 5 2017, In : Computers and Chemical Engineering. 107, p. 100-110 11 p.

Research output: Contribution to journalArticle

Process engineering
Systems engineering
Supply chains
Pharmacodynamics
Pharmacokinetics
11 Citations (Scopus)

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

Zhang, C., Wang, C., Li, W., Wu, R., Guo, Y., Cheng, D., Yang, Y., Androulakis, I. & Kong, A-N., Nov 6 2017, In : Molecular pharmaceutics. 14, 11, p. 3709-3717 9 p.

Research output: Contribution to journalArticle

Epigenomics
Leukocytes
Anti-Inflammatory Agents
Pharmacokinetics
Antioxidants
4 Citations (Scopus)
Hydrocortisone
Kidney
Photoperiod
Suprachiasmatic Nucleus
Neurosecretory Systems
3 Citations (Scopus)

The potential of circadian realignment in rheumatoid arthritis

Rao, R. T., Pierre, K. K., Schlesinger, N. & Androulakis, I., Jan 1 2017, In : Critical reviews in biomedical engineering. 44, 3, p. 177-191 15 p.

Research output: Contribution to journalArticle

Clocks
Oxidative stress
Machinery
Modulation
12 Citations (Scopus)
circadian rhythm
Circadian Rhythm
Photoperiod
Light
photoperiod
7 Citations (Scopus)

Understanding physiology in the continuum: Integration of information from multiple -omics levels

Kamisoglu, K., Acevedo, A., Almon, R. R., Coyle, S., Corbett, S., Dubois, D. C., Nguyen, T. T., Jusko, W. J. & Androulakis, I., Feb 27 2017, In : Frontiers in Pharmacology. 8, FEB, 91.

Research output: Contribution to journalArticle

Endotoxemia
Metabolomics
Methylprednisolone
Statistical Models
Proteomics
2016
10 Citations (Scopus)

Mathematical modeling of the circadian dynamics of the neuroendocrine-immune network in experimentally induced arthritis

Rao, R., Dubois, D., Almon, R., Jusko, W. J. & Androulakis, I. P., Aug 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 311, 2, p. E310-E324

Research output: Contribution to journalArticle

Arthritis
Cytokines
Corticosterone
Rheumatoid Arthritis
Edema
17 Citations (Scopus)

The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity

Pierre, K., Schlesinger, N. & Androulakis, I. P., Oct 2016, In : Physiological genomics. 48, 10, p. 719-738 20 p.

Research output: Contribution to journalArticle

Photoperiod
Immunity
Circadian Rhythm
Biological Phenomena
Social Adjustment
2015
22 Citations (Scopus)

Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response

Mavroudis, P. D., Corbett, S., Calvano, S. E. & Androulakis, I., Feb 1 2015, In : Mathematical Biosciences. 260, p. 54-64 11 p.

Research output: Contribution to journalArticle

Cortisol
Homeostasis
Cytokines
Acute
cortisol
2 Citations (Scopus)

Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models

Rao, R., Orman, M. A., Berthiaume, F. & Androulakis, I., Jan 1 2015, In : Data in Brief. 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

animal
trauma
regulation
23 Citations (Scopus)

Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS

Kamisoglu, K., Haimovich, B., Calvano, S. E., Coyle, S. M., Corbett, S., Langley, R. J., Kingsmore, S. F. & Androulakis, I., Mar 3 2015, In : Critical Care. 19, 1, 71.

Research output: Contribution to journalArticle

Systemic Inflammatory Response Syndrome
Endotoxemia
Sepsis
Inflammation
Lipopolysaccharides
5 Citations (Scopus)

Pharmacokinetics and pharmacodynamics of 3,3′-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes

Wu, T. Y., Huang, Y., Zhang, C., Su, Z. Y., Boyanapalli, S., Khor, T. O., Wang, H., Lin, H., Gounder, M., Kagan, L., Androulakis, I. & Kong, A-N., Aug 28 2015, In : Journal of Pharmacokinetics and Pharmacodynamics. 42, 4, p. 401-408 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Gene Expression
Enzymes
Pharmaceutical Preparations
diindolylmethane
10 Citations (Scopus)
Systems engineering
Pharmacology
Precision Medicine
Pharmaceutical Preparations
Medicine
8 Citations (Scopus)

Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: A systems approach to liver function in pharmacogenomics

Kamisoglu, K., Sukumaran, S., Nouri-Nigjeh, E., Tu, C., Li, J., Shen, X., Duan, X., Qu, J., Almon, R. R., Dubois, D. C., Jusko, W. J. & Androulakis, I., Feb 1 2015, In : OMICS A Journal of Integrative Biology. 19, 2, p. 80-91 12 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Methylprednisolone
Gene Expression Profiling
Proteome
Systems Analysis
2014
12 Citations (Scopus)

A chemical engineer's perspective on health and disease

Androulakis, I., Dec 4 2014, In : Computers and Chemical Engineering. 71, p. 665-671 7 p.

Research output: Contribution to journalArticle

Process engineering
Systems engineering
Supply chains
Health
Engineers
10 Citations (Scopus)

Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver

Nguyen, T. T., Mattick, J. S. A., Yang, Q., Orman, M. A., Ierapetritou, M., Berthiaume, F. & Androulakis, I., Mar 25 2014, In : BMC Bioinformatics. 15, 1, 83.

Research output: Contribution to journalArticle

Transcriptional Regulation
Transcription factors
Bioinformatics
Transcription Factor
Computational Biology
3 Citations (Scopus)

Effects of coupled dose and rhythm manipulation of plasma cortisol levels on leukocyte transcriptional response to endotoxin challenge in humans

Kamisoglu, K., Sleight, K., Nguyen, T. T., Calvano, S. E., Coyle, S. M., Corbett, S. & Androulakis, I., Oct 12 2014, In : Innate Immunity. 20, 7, p. 774-784 11 p.

Research output: Contribution to journalArticle

Endotoxins
Hydrocortisone
Leukocytes
Protein Biosynthesis
Sepsis
9 Citations (Scopus)

Integrated transcriptional and metabolic profiling in human endotoxemia

Kamisoglu, K., Calvano, S. E., Coyle, S. M., Corbett, S. & Androulakis, I., Dec 12 2014, In : Shock. 42, 6, p. 499-508 10 p.

Research output: Contribution to journalArticle

Endotoxemia
Leukocytes
Metabolomics
Metabolic Networks and Pathways
Energy Metabolism
23 Citations (Scopus)

Mathematical modeling of light-mediated hpa axis activity and downstream implications on the entrainment of peripheral clock genes

Mavroudis, P. D., Corbett, S., Calvano, S. E. & Androulakis, I., Oct 15 2014, In : Physiological genomics. 46, 20, p. 766-778 13 p.

Research output: Contribution to journalArticle

Hydrocortisone
Light
Genes
Appointments and Schedules
Photophobia
12 Citations (Scopus)

On heart rate variability and autonomic activity in homeostasis and in systemic inflammation

Scheff, J. D., Griffel, B., Corbett, S., Calvano, S. E. & Androulakis, I., Jan 1 2014, In : Mathematical Biosciences. 252, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Heart Rate Variability
Homeostasis
Inflammation
heart rate
homeostasis
1 Citation (Scopus)

Reactive flow simulation based on the integration of automated mechanism generation and on-the-fly reduction

Zhang, S., Broadbelt, L. J., Androulakis, I. & Ierapetritou, M., Jul 17 2014, In : Energy and Fuels. 28, 7, p. 4801-4811 11 p.

Research output: Contribution to journalArticle

Flow simulation
Fluxes
Methane
Oxidation
Air
2013
8 Citations (Scopus)

A hybrid kinetic mechanism reduction scheme based on the on-the-fly reduction and quasi-steady-state approximation

Zhang, S., Androulakis, I. & Ierapetritou, M., Apr 9 2013, In : Chemical Engineering Science. 93, p. 150-162 13 p.

Research output: Contribution to journalArticle

Kinetics
Approximation
Combustion
Fluxes
Nonlinear Algebraic Equations
6 Citations (Scopus)

A multiscale modeling approach to inflammation: A case study in human endotoxemia

Scheff, J. D., Mavroudis, P. D., Foteinou, P. T., An, G., Calvano, S. E., Doyle, J., Dick, T. E., Lowry, S. F., Vodovotz, Y. & Androulakis, I., Jul 1 2013, In : Journal of Computational Physics. 244, p. 279-289 11 p.

Research output: Contribution to journalArticle

Differential equations
heart rate
biology
differential equations
nonlinearity
10 Citations (Scopus)

An Agent-Based Model of Cellular Dynamics and Circadian Variability in Human Endotoxemia

Nguyen, T. T., Calvano, S. E., Lowry, S. F. & Androulakis, I. P., Jan 30 2013, In : PloS one. 8, 1, e55550.

Research output: Contribution to journalArticle

endotoxemia
Endotoxemia
Endotoxins
Cytokines
cytokines
7 Citations (Scopus)

A semi-mechanistic integrated toxicokinetic-toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes

Stamatelos, S. K., Androulakis, I., Kong, A-N. & Georgopoulos, P., Jan 1 2013, In : Journal of Theoretical Biology. 317, p. 244-256 13 p.

Research output: Contribution to journalArticle

Arsenic
arsenic
hepatocytes
pharmacokinetics
Hepatocytes
2 Citations (Scopus)

Effect of Fasting on the Metabolic Response of Liver to Experimental Burn Injury

Orman, M. A., Ierapetritou, M., Androulakis, I. & Berthiaume, F., Feb 5 2013, In : PloS one. 8, 2, e54825.

Research output: Contribution to journalArticle

burns (injuries)
Liver
fasting
Fasting
Animals
8 Citations (Scopus)

Enzyme sequence similarity improves the reaction alignment method for cross-species pathway comparison

Ovacik, M. A. & Androulakis, I., Sep 15 2013, In : Toxicology and Applied Pharmacology. 271, 3, p. 363-371 9 p.

Research output: Contribution to journalArticle

Taxonomies
Enzymes
Pharmacologic Actions
Glycolysis
Metabolic Networks and Pathways
37 Citations (Scopus)

Metabolomic fingerprinting: Challenges and opportunities

Kosmides, A. K., Kamisoglu, K., Calvano, S. E., Corbett, S. & Androulakis, I., Dec 1 2013, In : Critical reviews in biomedical engineering. 41, 3, p. 205-221 17 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolites
Proteomics
Tissue
Systems Biology
11 Citations (Scopus)

Pathway modeling of microarray data: A case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP)

Ovacik, M. A., Sen, B., Euling, S. Y., Gaido, K. W., Ierapetritou, M. & Androulakis, I., Sep 15 2013, In : Toxicology and Applied Pharmacology. 271, 3, p. 386-394 9 p.

Research output: Contribution to journalArticle

Dibutyl Phthalate
Microarrays
Testis
Genes
Gene Expression
6 Citations (Scopus)

Predicting critical transitions in a model of systemic inflammation

Scheff, J. D., Calvano, S. E. & Androulakis, I., Sep 19 2013, In : Journal of Theoretical Biology. 338, p. 9-15 7 p.

Research output: Contribution to journalArticle

Inflammation
inflammation
Physiology
Biological systems
physiological state
23 Citations (Scopus)

Temporal metabolic profiling of plasma during endotoxemia in humans

Kamisoglu, K., Sleight, K. E., Calvano, S. E., Coyle, S. M., Corbett, S. & Androulakis, I., Dec 1 2013, In : Shock. 40, 6, p. 519-526 8 p.

Research output: Contribution to journalArticle

Endotoxemia
Lipopolysaccharides
Inflammation
Lipid Metabolism
Endotoxins
6 Citations (Scopus)

Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration

Nguyen, T. T., Almon, R. R., Dubois, D. C., Sukumaran, S., Jusko, W. J. & Androulakis, I., Oct 24 2013, In : Gene Regulation and Systems Biology. 2014, 8, p. 75-87 13 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
adrenal cortex hormones
Gene expression
Liver
gene expression
11 Citations (Scopus)

Translational applications of evaluating physiologic variability in human endotoxemia

Scheff, J. D., Mavroudis, P. D., Calvano, S. E. & Androulakis, I. P., Aug 1 2013, In : Journal of Clinical Monitoring and Computing. 27, 4, p. 405-415 11 p.

Research output: Contribution to journalArticle

Endotoxemia
Inflammation
Biological Phenomena
Systems Biology
Periodicity
30 Citations (Scopus)

Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set

Euling, S. Y., White, L. D., Kim, A. S., Sen, B., Wilson, V. S., Keshava, C., Keshava, N., Hester, S., Ovacik, M. A., Ierapetritou, M., Androulakis, I. & Gaido, K. W., Sep 15 2013, In : Toxicology and Applied Pharmacology. 271, 3, p. 349-362 14 p.

Research output: Contribution to journalArticle

Toxicogenetics
Dibutyl Phthalate
Risk assessment
Testis
Rats
2012
14 Citations (Scopus)

Comparison of biodiesel performance based on HCCI engine simulation using detailed mechanism with on-the-fly reduction

Zhang, S., Broadbelt, L. J., Androulakis, I. & Ierapetritou, M., Feb 16 2012, In : Energy and Fuels. 26, 2, p. 976-983 8 p.

Research output: Contribution to journalArticle

Biofuels
Biodiesel
Engines
Esters
Computational fluid dynamics
10 Citations (Scopus)

Dynamics of hepatic gene expression profile in a rat cecal ligation and puncture model

Yang, Q., Mattick, J. S. A., Orman, M. A., Nguyen, T. T., Ierapetritou, M., Berthiaume, F. & Androulakis, I., Aug 1 2012, In : Journal of Surgical Research. 176, 2, p. 583-600 18 p.

Research output: Contribution to journalArticle

Transcriptome
Punctures
Ligation
Liver
Transcription Factors