• 9825 Citations
  • 51 h-Index
1976 …2024
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Research Output 1976 2020

2020

Long-term Respiratory Effects of Mustard Vesicants

Malaviya, R., Laskin, J. D. & Laskin, D. L., Feb 1 2020, In : Toxicology Letters. 319, p. 168-174 7 p.

Research output: Contribution to journalArticle

Mustard Gas
Mustard Plant
Irritants
Respiratory System
Gas Poisoning

Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard

Sunil, V. R., Vayas, K. N., Abramova, E. V., Rancourt, R., Cervelli, J. A., Malaviya, R., Goedken, M., Venosa, A., Gow, A. J., Laskin, J. D. & Laskin, D. L., Jan 15 2020, In : Toxicology and Applied Pharmacology. 387, 114798.

Research output: Contribution to journalArticle

Mechlorethamine
Oxidative stress
Lung Injury
Oxidative Stress
Fibrosis
2019
1 Citation (Scopus)

Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis

Szilagyi, J. T., Composto-Wahler, G. M., Joseph, L. B., Wang, B., Rosen, T., Laskin, J. D. & Aleksunes, L. M., Mar 2019, In : Pharmacological Research. 141, p. 331-342 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Trophoblasts
Down-Regulation
Cyclic AMP Response Element-Binding Protein
Messenger RNA
2 Citations (Scopus)

Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns

Son, Y., Mishin, V., Laskin, J. D., Mainelis, G., Wackowski, O. A., Delnevo, C., Schwander, S., Khlystov, A., Samburova, V. & Meng, Q., Jun 17 2019, In : Chemical Research in Toxicology. 32, 6, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

Tobacco Products
Hydroxyl Radical
Vapors
Vegetables
Glycerol

Phototoxicity of 7-oxycoumarins with keratinocytes in culture

Guillon, C., Jan, Y. H., Heck, D. E., Mariano, T. M., Rapp, R. D., Jetter, M., Kardos, K., Whittemore, M., Akyea, E., Jabin, I., Laskin, J. D. & Heindel, N. D., Aug 2019, In : Bioorganic Chemistry. 89, 103014.

Research output: Contribution to journalArticle

Phototoxic Dermatitis
Keratinocytes
Coumarins
Light
Growth
4 Citations (Scopus)

Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone

Szilagyi, J. T., Gorczyca, L., Brinker, A., Buckley, B., Laskin, J. D. & Aleksunes, L. M., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 394-404 11 p.

Research output: Contribution to journalArticle

Zearalenone
Mycotoxins
Breast Neoplasms
Placenta
Proteins

Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids

Venosa, A., Smith, L. C., Murray, A., Banota, T., Gow, A. J., Laskin, J. D. & Laskin, D. L., Dec 1 2019, In : Toxicological Sciences. 172, 2, p. 344-358 15 p.

Research output: Contribution to journalArticle

Mechlorethamine
Foam Cells
Pulmonary Fibrosis
Macrophages
Foams
2 Citations (Scopus)

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants

Laskin, D. L., Malaviya, R. & Laskin, J. D., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 287-301 15 p.

Research output: Contribution to journalReview article

Pulmonary Fibrosis
Acute Lung Injury
Macrophages
Pulmonary diseases
Wounds and Injuries
1 Citation (Scopus)
Open Access
Dust
Lymph Nodes
Histones
Lung
Keratin-17
2 Citations (Scopus)
Mustard Gas
Mechlorethamine
Ataxia Telangiectasia
DNA Damage
Cell Cycle
2 Citations (Scopus)

Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions

Guillon, C. D., Jan, Y. H., Foster, N., Ressner, J., Heck, D. E., Laskin, J. D. & Heindel, N. D., Feb 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 4, p. 619-622 4 p.

Research output: Contribution to journalArticle

Methoxsalen
Cytotoxicity
Light
Keratinocytes
Skin Diseases
2018

Expression of cytokines and chemokines in mouse skin treated with sulfur mustard

Chang, Y. C., Soriano, M., Hahn, R. A., Casillas, R. P., Gordon, M. K., Laskin, J. D. & Gerecke, D. R., Sep 15 2018, In : Toxicology and Applied Pharmacology. 355, p. 52-59 8 p.

Research output: Contribution to journalArticle

Mustard Gas
Chemokines
Macrophages
Skin
Cytokines
2 Citations (Scopus)

Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth

Laskin, J. D., Jan, Y. H., Jetter, M. M., Guillon, C. D., Mariano, T. M., Heck, D. E. & Heindel, N. D., May 1 2018, In : Photochemistry and photobiology. 94, 3, p. 577-582 6 p.

Research output: Contribution to journalArticle

Pyranocoumarins
Growth Inhibitors
Photosensitizing Agents
Keratinocytes
inhibitors

Monocytes

Malaviya, R., Laskin, J. D. & Laskin, D. L., Jan 1 2018, Hematopoietic System Toxicology. Elsevier Inc., Vol. 12-15. p. 183-191 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Monocytes
Dendritic Cells
Plastics
Immune System
Rodentia
2 Citations (Scopus)

Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard

Sunil, V. R., Vayas, K. N., Cervelli, J. A., Ebramova, E. V., Gow, A. J., Goedken, M., Malaviya, R., Laskin, J. D. & Laskin, D. L., Nov 1 2018, In : Toxicological sciences : an official journal of the Society of Toxicology. 166, 1, p. 108-122 15 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Mechlorethamine
Oxidative stress
Lung Injury
Macrophages
2 Citations (Scopus)

Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase

Szilagyi, J. T., Fussell, K. C., Wang, Y., Jan, Y. H., Mishin, V., Richardson, J. R., Heck, D. E., Yang, S., Aleksunes, L. M., Laskin, D. L. & Laskin, J. D., Nov 15 2018, In : Toxicology and Applied Pharmacology. 359, p. 102-107 6 p.

Research output: Contribution to journalArticle

Cytochrome Reductases
Nitrofurantoin
Cytochromes b5
Oxidation-Reduction
Oxidoreductases
1 Citation (Scopus)

Role of psoralen receptors in cell growth regulation

Laskin, J. D. & Laskin, D. L., Jan 1 2018, Psoralen DNA Photobiology. CRC Press, Vol. 2. p. 135-148 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell growth
Intercellular Signaling Peptides and Proteins
Steroid hormones
Fibroblast Growth Factors
Platelet-Derived Growth Factor
3 Citations (Scopus)

Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug

Joseph, L. B., Composto, G. M., Perez, R. M., Kim, H. D., Casillas, R. P., Heindel, N. D., Young, S. C., Lacey, C. J., Saxena, J., Guillon, C. D., Croutch, C. R., Laskin, J. D. & Heck, D. E., Sep 1 2018, In : Toxicology Letters. 293, p. 77-81 5 p.

Research output: Contribution to journalArticle

Mustard Gas
Cell Degranulation
Prodrugs
Cholinergic Antagonists
Mast Cells
2017
32 Citations (Scopus)

Anti-TNFα therapy in inflammatory lung diseases

Malaviya, R., Laskin, J. D. & Laskin, D. L., Dec 2017, In : Pharmacology and Therapeutics. 180, p. 90-98 9 p.

Research output: Contribution to journalReview article

Lung Diseases
Tumor Necrosis Factor-alpha
Pathology
Therapeutics
Pulmonary Fibrosis
5 Citations (Scopus)

CCR2 regulates inflammatory cell accumulation in the lung and tissue injury following ozone exposure

Francis, M., Groves, A. M., Sun, R., Cervelli, J. A., Choi, H., Laskin, J. D. & Laskin, D. L., Feb 1 2017, In : Toxicological Sciences. 155, 2, p. 474-484 11 p.

Research output: Contribution to journalArticle

Macrophages
Ozone
Lung Injury
Tissue
Lung
4 Citations (Scopus)

Diacetyl/ l -Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells

Yang, S., Jan, Y. H., Mishin, V., Heck, D. E., Laskin, D. L. & Laskin, J. D., Jul 17 2017, In : Chemical Research in Toxicology. 30, 7, p. 1406-1418 13 p.

Research output: Contribution to journalArticle

Xylulose
Diacetyl
Oxidation-Reduction
Oxidoreductases
Epithelial Cells
14 Citations (Scopus)

Localization of the placental BCRP/ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity

Szilagyi, J. T., Vetrano, A. M., Laskin, J. & Aleksunes, L., Jul 1 2017, In : Placenta. 55, p. 29-36 8 p.

Research output: Contribution to journalArticle

Cholesterol
Lipids
Pravastatin
Placenta
Anticholesteremic Agents
6 Citations (Scopus)

Regulation of nitrogen mustard-induced lung macrophage activation by valproic acid, a histone deacetylase inhibitor

Venosa, A., Gow, J. G., Hall, L. R., Malaviya, R., Gow, A. J., Laskin, J. D. & Laskin, D. L., May 1 2017, In : Toxicological Sciences. 157, 1, p. 222-234 13 p.

Research output: Contribution to journalArticle

Mechlorethamine
Histone Deacetylase Inhibitors
Macrophage Activation
Macrophages
Valproic Acid
8 Citations (Scopus)

Role of spleen-derived macrophages in ozone-induced lung inflammation and injury

Francis, M., Sun, R., Cervelli, J. A., Choi, H., Mandal, M., Abramova, E. V., Gow, A. J., Laskin, J. D. & Laskin, D. L., Jan 1 2017, In : Toxicological Sciences. 155, 1, p. 182-195 14 p.

Research output: Contribution to journalArticle

Macrophages
Ozone
Lung Injury
Pneumonia
Spleen
6 Citations (Scopus)

World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung

Sunil, V. R., Vayas, K. N., Fang, M., Zarbl, H., Massa, C., Gow, A. J., Cervelli, J. A., Kipen, H., Laumbach, R. J., Lioy, P. J., Laskin, J. D. & Laskin, D. L., Feb 1 2017, In : Experimental and Molecular Pathology. 102, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Dust
Epigenomics
Oxidative Stress
Inflammation
2016
4 Citations (Scopus)

ADAM17 inhibitors attenuate corneal epithelial detachment induced by mustard exposure

DeSantis-Rodrigues, A., Chang, Y. C., Hahn, R. A., Po, I. P., Zhou, P., Lacey, C. J., Pillai, A., Young, S. C., Flowers, R. A., Gallo, M. A., Laskin, J. D., Gerecke, D. R., Svoboda, K. K. H., Heinde, N. D. & Gordon, M. K., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 1687-1698 12 p.

Research output: Contribution to journalArticle

Mustard Plant
Mechlorethamine
Cornea
Irritants
Wound Healing
26 Citations (Scopus)
Mechlorethamine
Macrophages
Lung Injury
Fibrosis
Lung
11 Citations (Scopus)

Inflammatory mechanisms of pulmonary injury induced by mustards

Malaviya, R., Sunil, V. R., Venosa, A., Vayas, K. N., Heck, D. E., Laskin, J. D. & Laskin, D. L., Feb 26 2016, In : Toxicology Letters. 244, p. 2-7 6 p.

Research output: Contribution to journalArticle

Mustard Gas
Mechlorethamine
Mustard Plant
Irritants
Macrophages
5 Citations (Scopus)

Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants

Malaviya, R., Sunil, V. R., Venosa, A., Vayas, K. N., Businaro, R., Heck, D. E., Laskin, J. D. & Laskin, D. L., Jan 1 2016, In : Annals of the New York Academy of Sciences. 1374, 1, p. 168-175 8 p.

Research output: Contribution to journalReview article

Mustard Gas
Mechlorethamine
Mustard Plant
Irritants
Macrophages
6 Citations (Scopus)

Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug

Composto, G. M., Laskin, J. D., Laskin, D. L., Gerecke, D. R., Casillas, R. P., Heindel, N. D., Joseph, L. B. & Heck, D. E., Jun 1 2016, In : Experimental and Molecular Pathology. 100, 3, p. 522-531 10 p.

Research output: Contribution to journalArticle

Mechlorethamine
Prodrugs
Indomethacin
Skin
Wounds and Injuries
3 Citations (Scopus)

Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury

Lacey, C. J., Wohlman, I., Guillon, C., Saxena, J., Fianu-Velgus, C., Aponte, E., Young, S. C., Heck, D. E., Joseph, L. B., Laskin, J. D. & Heindel, N. D., Aug 1 2016, In : Annals of the New York Academy of Sciences. 1378, 1, p. 174-179 6 p.

Research output: Contribution to journalArticle

Mustard Gas
Mustard Plant
Molecular Pathology
Prodrugs
Pathology
14 Citations (Scopus)

Mustard vesicant-induced lung injury: Advances in therapy

Weinberger, B., Malaviya, R., Sunil, V. R., Venosa, A., Heck, D. E., Laskin, J. D. & Laskin, D. L., Aug 15 2016, In : Toxicology and Applied Pharmacology. 305, p. 1-11 11 p.

Research output: Contribution to journalReview article

Mustard Plant
Irritants
Lung Injury
Toxicity
Acetylcysteine
6 Citations (Scopus)

Mustard vesicants alter expression of the endocannabinoid system in mouse skin

Wohlman, I. M., Composto, G. M., Heck, D. E., Heindel, N. D., Lacey, C. J., Guillon, C. D., Casillas, R. P., Croutch, C. R., Gerecke, D. R., Laskin, D. L., Joseph, L. B. & Laskin, J. D., Jul 15 2016, In : Toxicology and Applied Pharmacology. 303, p. 30-44 15 p.

Research output: Contribution to journalArticle

Endocannabinoids
Mustard Plant
Irritants
Skin
PPAR alpha
3 Citations (Scopus)

Novel approaches to mitigating parathion toxicity: targeting cytochrome P450–mediated metabolism with menadione

Jan, Y. H., Richardson, J. R., Baker, A. A., Mishin, V., Heck, D. E., Laskin, D. L. & Laskin, J. D., Aug 1 2016, In : Annals of the New York Academy of Sciences. 1378, 1, p. 80-86 7 p.

Research output: Contribution to journalArticle

Parathion
Vitamin K 3
Cytochromes
Metabolism
Toxicity
9 Citations (Scopus)

Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1)

Udasin, R. G., Wen, X., Bircsak, K. M., Aleksunes, L. M., Shakarjian, M. P., Kong, A. N. T., Heck, D. E., Laskin, D. L. & Laskin, J. D., Jan 1 2016, In : Toxicological Sciences. 149, 1, p. 202-212 11 p.

Research output: Contribution to journalArticle

Mechlorethamine
Keratinocytes
Irritants
verlukast
Glutathione
3 Citations (Scopus)

Preparedness and response to chemical and biological threats: the role of exposure science

Lioy, P. J., Laskin, J. D. & Georgopoulos, P. G., Aug 1 2016, In : Annals of the New York Academy of Sciences. 1378, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

Biological Factors
Reentry
Emergencies
Risk analysis
Civil Defense
5 Citations (Scopus)

Selective targeting of heme protein in cytochrome P450 and nitric oxide synthase by diphenyleneiodonium

Szilagyi, J. T., Mishin, V., Heck, D. E., Jan, Y. H., Aleksunes, L. M., Richardson, J. R., Heindel, N. D., Laskin, D. L. & Laskin, J. D., May 1 2016, In : Toxicological Sciences. 151, 1, p. 150-159 10 p.

Research output: Contribution to journalArticle

Hemeproteins
Nitric Oxide Synthase
Cytochrome P-450 Enzyme System
Nitric Oxide Synthase Type II
Heme
5 Citations (Scopus)

The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury

Mandal, M., Gardner, C. R., Sun, R., Choi, H., Lad, S., Mishin, V., Laskin, J. D. & Laskin, D. L., Aug 1 2016, In : Toxicology and Applied Pharmacology. 304, p. 110-120 11 p.

Research output: Contribution to journalArticle

Macrophages
Acetaminophen
Liver
Spleen
Wounds and Injuries
2015
13 Citations (Scopus)
Particulate Matter
Hydroxyl Radical
Molecular Probes
Oxidative Stress
Fluorescence
19 Citations (Scopus)

Attenuation of nitrogen mustard-induced pulmonary injury and fibrosis by anti-tumor necrosis factor-α antibody

Malaviya, R., Sunil, V. R., Venosa, A., Verissimo, V. L., Cervelli, J. A., Vayas, K. N., Hall, L. R., Laskin, J. & Laskin, D., Nov 1 2015, In : Toxicological Sciences. 148, 1, p. 71-88 18 p., kfv161.

Research output: Contribution to journalArticle

Mechlorethamine
Pulmonary Fibrosis
Lung Injury
Tumor Necrosis Factor-alpha
Macrophages
4 Citations (Scopus)

Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents

Saxena, J., Meloni, D., Huang, M. T., Heck, D. E., Laskin, J. D., Heindel, N. D. & Young, S. C., Dec 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5609-5612 4 p.

Research output: Contribution to journalArticle

Carbamates
Carbonates
Cholinesterase Inhibitors
Anti-Inflammatory Agents
Inflammation
13 Citations (Scopus)
Mechlorethamine
Lung Injury
Pneumonia
Fibrosis
Spleen
4 Citations (Scopus)

Pulmonary Macrophages

Laskin, D. L., Malaviya, R. & Laskin, J. D., Mar 18 2015, Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., p. 629-649 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Macrophage Activation
Alveolar Macrophages
Macrophages
Homeostasis
Phenotype
27 Citations (Scopus)

Radiation-induced lung injury and inflammation in mice: Role of inducible nitric oxide synthase and surfactant protein D

Malaviya, R., Gow, A. J., Francis, M., Abramova, E. V., Laskin, J. D. & Laskin, D. L., Mar 1 2015, In : Toxicological Sciences. 144, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Lung Injury
Nitric Oxide Synthase Type II
Pneumonia
Radiation
16 Citations (Scopus)

Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galectin-3

Sunil, V. R., Francis, M., Vayas, K. N., Cervelli, J. A., Choi, H., Laskin, J. & Laskin, D., Apr 5 2015, In : Toxicology and Applied Pharmacology. 284, 2, p. 236-245 10 p.

Research output: Contribution to journalArticle

Galectin 3
Galactosides
Macrophages
Ozone
Lung Injury
9 Citations (Scopus)

Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase

Yang, S., Jan, Y. H., Mishin, V., Richardson, J. R., Hossain, M. M., Heindel, N. D., Heck, D. E., Laskin, D. L. & Laskin, J. D., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 529-540 12 p.

Research output: Contribution to journalArticle

sepiapterin reductase
Oxidation-Reduction
Pharmaceutical Preparations
Neurotransmitter Agents
Reactive Oxygen Species
7 Citations (Scopus)
Thioredoxin-Disulfide Reductase
Mechlorethamine
Thioredoxins
Disulfides
Epithelial Cells
12 Citations (Scopus)

Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication

Jan, Y. H., Richardson, J. R., Baker, A. A., Mishin, V., Heck, D. E., Laskin, D. & Laskin, J., Oct 1 2015, In : Toxicology and Applied Pharmacology. 288, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

Parathion
Vitamin K 3
Metabolism
Cytochrome P-450 Enzyme System
Oxidation-Reduction
2014
36 Citations (Scopus)

Acetaminophen reactive intermediates target hepatic thioredoxin reductase

Jan, Y. H., Heck, D. E., Dragomir, A. C., Gardner, C. R., Laskin, D. L. & Laskin, J. D., May 19 2014, In : Chemical Research in Toxicology. 27, 5, p. 882-894 13 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Acetaminophen
Imines
Liver
Oxidation-Reduction
13 Citations (Scopus)
Mustard Gas
Thioredoxin-Disulfide Reductase
Disulfides
Oxidation-Reduction
Rats