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Fingerprint Dive into the research topics where Joel Freundlich is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Mycobacterium tuberculosis Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
Tuberculosis Medicine & Life Sciences
Triclosan Chemical Compounds
Learning systems Chemical Compounds
Pharmaceutical Preparations Medicine & Life Sciences
Acyl Carrier Protein Chemical Compounds
Molecules Chemical Compounds

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Projects 2014 2024

Drug Discovery
Pharmaceutical Preparations
Mycobacterium tuberculosis
Phloroglucinol
Cell Respiration
Mycobacterium tuberculosis
Isoniazid
Tuberculosis
Multidrug-Resistant Tuberculosis
Mycobacterium Infections

Center to develop therapeutic countermeasures to high-threat bacterial agents

Ebright, R., Dartois, V., Freundlich, J., Alland, D., Connell, N., Perlin, D., Brady, S., Lu, M. I. N. & Bartizal, K.

National Institutes of Health

4/25/1411/30/19

Project: Research project

National Institute of Allergy and Infectious Diseases (U.S.)
Drug Discovery
Anti-Bacterial Agents
Pharmaceutical Preparations
Phloroglucinol

Research Output 1994 2019

3 Citations (Scopus)

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

Anantpadma, M., Lane, T., Zorn, K. M., Lingerfelt, M. A., Clark, A. M., Freundlich, J. S., Davey, R. A., Madrid, P. B. & Ekins, S., Jan 30 2019, In : ACS Omega. 4, 1, p. 2353-2361 9 p.

Research output: Contribution to journalArticle

Viruses
Learning systems
Tilorone
Quinacrine
Molecules

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

Wang, X., Perryman, A. L., Li, S. G., Paget, S. D., Stratton, T. P., Lemenze, A., Olson, A. J., Ekins, S., Kumar, P. & Freundlich, J. S., Jan 1 2019, In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Amines
Preclinical Drug Evaluations
Drug Discovery
Biotransformation
2 Citations (Scopus)

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

Gallardo-Macias, R., Kumar, P., Jaskowski, M., Richmann, T., Shrestha, R., Russo, R., Singleton, E., Zimmerman, M. D., Ho, H. P., Dartois, V., Connell, N., Alland, D. & Freundlich, J. S., Feb 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 4, p. 601-606 6 p.

Research output: Contribution to journalArticle

Nitrofurans
Antitubercular Agents
Cytotoxicity
Vero Cells
Pharmacokinetics
1 Citation (Scopus)

Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis

Ordonez, A. A., Carroll, L. S., Abhishek, S., Mota, F., Ruiz-Bedoya, C. A., Klunk, M. H., Singh, A. K., Freundlich, J. S., Mease, R. C. & Jain, S. K., Dec 13 2019, In : ACS Infectious Diseases. 5, 12, p. 1996-2002 7 p.

Research output: Contribution to journalArticle

bedaquiline
Positron-Emission Tomography
Tuberculosis
Autoradiography
Pharmaceutical Preparations
1 Citation (Scopus)

Structural basis of DSF recognition by its receptor rpfr and its regulatory interaction with the DSF synthase RpfF

Waldron, E. J., Snyder, D., Fernandez, N. L., Sileo, E., Inoyama, D., Freundlich, J. S., Waters, C. M., Cooper, V. S. & Neiditch, M. B., Feb 2019, In : PLoS biology. 17, 2, e3000123.

Research output: Contribution to journalArticle

Open Access
Virulence Factors
pathogenicity
receptors
crystal structure
Burkholderia