• 1878 Citations
  • 17 h-Index
19992022

Research output per year

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Research Output

  • 1878 Citations
  • 17 h-Index
  • 23 Article
  • 4 Review article
  • 3 Comment/debate
  • 1 Chapter
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Article
2019

S-nitrosylation of connexin43 hemichannels elicits cardiac stress–induced arrhythmias in Duchenne muscular dystrophy mice

Lillo, M. A., Himelman, E., Shirokova, N., Xie, L. H., Fraidenraich, D. & Contreras, J. E., Nov 12 2019, In : JCI Insight. 4, 24, e130091.

Research output: Contribution to journalArticle

Open Access

The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening

Capuccino, J. M. V., Chatterjee, P., García, I. E., Botello-Smith, W. M., Zhang, H., Harris, A. L., Luo, Y. & Contreras, J. E., Mar 1 2019, In : Journal of General Physiology. 151, 3, p. 328-341 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Normalization of connexin 43 protein levels prevents cellular and functional signs of dystrophic cardiomyopathy in mice

Gonzalez, J. P., Ramachandran, J., Himelman, E., Badr, M. A., Kang, C., Nouet, J., Fefelova, N., Xie, L. H., Shirokova, N., Contreras, J. E. & Fraidenraich, D., Apr 2018, In : Neuromuscular Disorders. 28, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

García, I. E., Villanelo, F., Contreras, G. F., Pupo, A., Pinto, B. I., Contreras, J. E., Pérez-Acle, T., Alvarez, O., Latorre, R., Martínez, A. D. & González, C., May 1 2018, In : Journal of General Physiology. 150, 5, p. 697-711 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

Garg, C., Seo, J. H., Ramachandran, J., Loh, J. M., Calderon, F. & Contreras, J. E., Feb 13 2018, In : Journal of Neuroinflammation. 15, 1, 42.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Hepatitis e virus ORF3 is a functional ion channel required for release of infectious particles

Ding, Q., Heller, B., Capuccino, J. M. V., Song, B., Nimgaonkar, I., Hrebikova, G., Contreras, J. E. & Ploss, A., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1147-1152 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization

Trease, A. J., Capuccino, J. M. V., Contreras, J., Harris, A. L. & Sorgen, P. L., Oct 2017, In : Journal of Molecular and Cellular Cardiology. 111, p. 69-80 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

S-nitrosylation of VASP at cysteine 64 mediates the inflammation-stimulated increase in microvascular permeability

Zamorano, P., Marín, N., Córdova, F., Aguilar, A., Meininger, C., Boric, M. P., Golenhofen, N., Contreras, J. E., Sarmiento, J., Durán, W. N. & Sánchez, F. A., Jan 1 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 1, p. H66-H71

Research output: Contribution to journalArticle

6 Scopus citations
2016

Mechanism of gating by calcium in connexin hemichannels

Lopez, W., Ramachandran, J., Alsamarah, A., Luo, Y., Harris, A. L. & Contreras, J. E., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. E7986-E7995

Research output: Contribution to journalArticle

27 Scopus citations
2015

Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules

Tong, X., Lopez, W., Ramachandran, J., Ayad, W. A., Liu, Y., Lopez-Rodriguez, A., Harris, A. L. & Contreras, J. E., Sep 1 2015, In : Journal of General Physiology. 146, 3, p. 245-254 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43

García, I. E., Maripillán, J., Jara, O., Ceriani, R., Palacios-Muñoz, A., Ramachandran, J., Olivero, P., Perez-Acle, T., González, C., Sáez, J. C., Contreras, J. E. & Martínez, A. D., May 22 2015, In : Journal of Investigative Dermatology. 135, 5, p. 1338-1347 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice

Patrick Gonzalez, J., Ramachandran, J., Xie, L. H., Contreras, J. E. & Fraidenraich, D., Aug 27 2015, In : Scientific reports. 5, 13490.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Insights on the mechanisms of Ca2+ regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y)

Lopez, W., Gonzalez, J., Liu, Y., Harris, A. L. & Contreras, J. E., Jul 1 2013, In : Journal of General Physiology. 142, 1, p. 23-45 23 p.

Research output: Contribution to journalArticle

38 Scopus citations

State-dependent FRET reports calcium- and voltagedependent gating-ring motions in BK channels

Miranda, P., Contreras, J. E., Plested, A. J. R., Sigworth, F. J., Holmgren, M. & Giraldez, T., Mar 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 13, p. 5217-5222 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2010

Voltage profile along the permeation pathway of an open channel

Contreras, J. E., Chen, J., Lau, A. Y., Jogini, V., Roux, B. & Holmgren, M., Nov 3 2010, In : Biophysical Journal. 99, 9, p. 2863-2869 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

Gating at the selectivity filter in cyclic nucleotide-gated channels

Contreras, J. E., Srikumar, D. & Holmgren, M., Mar 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3310-3314 5 p.

Research output: Contribution to journalArticle

61 Scopus citations
2006
28 Scopus citations
2004

Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue

Contreras, J. E., Sánchez, H. A., Véliz, L. P., Bukauskas, F. F., Bennett, M. V. L. & Sáez, J. C., Dec 1 2004, In : Brain Research Reviews. 47, 1-3, p. 290-303 14 p.

Research output: Contribution to journalArticle

198 Scopus citations
2003

Functioning of Cx43 hemichannels demonstrated by single channel properties

Contreras, J. E., Sáez, J. C., Bukauskas, F. F. & Bennett, M. V. L., Jul 1 2003, In : Cell Communication and Adhesion. 10, 4-6, p. 245-249 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Gating and regulation of connexin 43 (Cx43) hemichannels

Contreras, J. E., Sáez, J. C., Bukauskas, F. F. & Bennett, M. V. L., Sep 30 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 20, p. 11388-11393 6 p.

Research output: Contribution to journalArticle

288 Scopus citations
2002

Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins

Brañes, M. C., Contreras, J. E. & Sáez, J. C., Aug 1 2002, In : Medical Science Monitor. 8, 8, p. BR313-BR323

Research output: Contribution to journalArticle

43 Scopus citations

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

Contreras, J. E., Sánchez, H. A., Eugenin, E. A., Speidel, D., Theis, M., Willecke, K., Bukauskas, F. F., Bennett, M. V. L. & Sáez, J. C., Jan 8 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 1, p. 495-500 6 p.

Research output: Contribution to journalArticle

429 Scopus citations
1999

Chapter 25: Gap Junctions in Inflammatory Responses: Connexins, Regulation and Possible Functional Roles

Sáez, J. C., Araya, R., Brañes, M. C., Concha, M., Contreras, J. E., Eugenín, E. A., Martinez, A. D., Palisson, F. & Sepúlveda, M. A., Dec 1 1999, In : Current Topics in Membranes and Transport. 49, C, p. 555-579 25 p.

Research output: Contribution to journalArticle

12 Scopus citations