• 13012 Citations
  • 53 h-Index
1976 …2021
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Fingerprint Dive into the research topics where Konstantin Severinov is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
DNA-Directed RNA Polymerases Medicine & Life Sciences
Clustered Regularly Interspaced Short Palindromic Repeats Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences
Bacteriophages Medicine & Life Sciences
Bacterial RNA Medicine & Life Sciences
DNA Medicine & Life Sciences
Transcription Chemical Compounds
CRISPR-Cas Systems Medicine & Life Sciences

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Projects 1976 2021

Clustered Regularly Interspaced Short Palindromic Repeats
Viral RNA
Escherichia coli
CRISPR-Associated Proteins
Intergenic DNA
DNA Restriction-Modification Enzymes
Protein C
Gene Expression
DNA Restriction Enzymes
Methyltransferases
Plasmids
microcin
Bacterial RNA
Genes
Amino Acids

Northeast Biodefense Center

Perlin, D., Severinov, K., Palacios, G. F., Basler, C., Alaedini, A., Fries, B., Briese, T., Rice, C., [No Value], C. R., Chave, K. J., Kielian, M., Bliska, J., Levy, D., Lipkin, W., Brady, S., Rose, J. K., García-Sastre, A., Gulcicek, E., Moscona, A., Casadevall, A., Palese, P., Califano, A., Buck, J., Belfort, M., Pei-Yong, S., Crystal, R., Scharff, M., Sturman, L., Bernard, K., Galan, J., MacKow, E. R. & Egan, C.

National Institutes of Health

9/4/032/28/15

Project: Research project

Burkholderia mallei
Extensively Drug-Resistant Tuberculosis
Yersinia pestis
Animal Care Committees
Animal Models
DNA-Directed RNA Polymerases
Taq Polymerase
Thermus
Bacterial RNA
Enzymes

Research Output 1990 2019

5 Citations (Scopus)

Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison

Ghilarov, D., Stevenson, C. E. M., Travin, D. Y., Piskunova, J., Serebryakova, M., Maxwell, A., Lawson, D. M. & Severinov, K., Feb 21 2019, In : Molecular cell. 73, 4, p. 749-762.e5

Research output: Contribution to journalArticle

Open Access
DNA Gyrase
Poisons
Ligases
Peptides
Topoisomerase Inhibitors
3 Citations (Scopus)

Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor

Dong, S. H., Kulikovsky, A., Zukher, I., Estrada, P., Dubiley, S., Severinov, K. & Nair, S. K., Jan 1 2019, In : Chemical Science. 10, 8, p. 2391-2395 5 p.

Research output: Contribution to journalArticle

Open Access
Biosynthesis
Nucleotides
Anti-Bacterial Agents
Peptides
Ubiquitin-Activating Enzymes
4 Citations (Scopus)

BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site

Gordeeva, J., Morozova, N., Sierro, N., Isaev, A., Sinkunas, T., Tsvetkova, K., Matlashov, M., Truncaite, L., Morgan, R. D., Ivanov, N. V., Siksnys, V., Zeng, L. & Severinov, K., Jan 10 2019, In : Nucleic acids research. 47, 1, p. 253-265 13 p.

Research output: Contribution to journalArticle

Bacteriophages
Methylation
Escherichia coli
DNA
CRISPR-Cas Systems

CRISPR–Cas molecular beacons as tool for studies of assembly of CRISPR–Cas effector complexes and their interactions with DNA

Mekler, V., Kuznedelov, K., Minakhin, L., Murugan, K., Sashital, D. G. & Severinov, K., Jan 1 2019, Methods in Enzymology. Bailey, S. (ed.). Academic Press Inc., p. 337-363 27 p. (Methods in Enzymology; vol. 616).

Research output: Chapter in Book/Report/Conference proceedingChapter

Clustered Regularly Interspaced Short Palindromic Repeats
DNA
Nucleic acid sequences
RNA
Prokaryotic Cells
6 Citations (Scopus)

Cryo-EM structure and in vitro DNA packaging of a thermophilic virus with supersized T=7 capsids

Bayfield, O. W., Klimuk, E., Winkler, D. C., Hesketh, E. L., Chechik, M., Cheng, N., Dykeman, E. C., Minakhin, L., Ranson, N. A., Severinov, K., Steven, A. C. & Antson, A. A., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3556-3561 6 p.

Research output: Contribution to journalArticle

DNA Packaging
Capsid
Viruses
DNA
Product Packaging