If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Neuronal Ceroid-Lipofuscinoses Medicine & Life Sciences
Ceroid Chemical Compounds
IGF Type 2 Receptor Medicine & Life Sciences
Lysosomes Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Proteins Medicine & Life Sciences
Glycoproteins Medicine & Life Sciences
Lysosomal Storage Diseases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1998 2016

Mass spectrometers
Mass spectrometry
Biomarkers
Design of experiments
Proteins
Mass spectrometry
Neurodegenerative diseases
Liquid chromatography
Mass spectrometers
Pathogens
Inborn Genetic Diseases
Medical Genetics
Enzymes
Genes
Proteome
Neuronal Ceroid-Lipofuscinoses
Enzymes
Therapeutics
Enzyme Replacement Therapy
Disease Progression

Research Output 1983 2018

  • 6205 Citations
  • 45 h-Index
  • 89 Article
  • 4 Review article
  • 1 Chapter
1 Citation (Scopus)

Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis

Nemtsova, Y., Wiseman, J. A., El-Banna, M., Lobel, P. & Sleat, D. E., Feb 1 2018, In : PloS one. 13, 2, e0192286.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
peptidases
animal models
gene expression
4 Citations (Scopus)

Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain

Solé-Domènech, S., Rojas, A. V., Maisuradze, G. G., Scheraga, H. A., Lobel, P. & Maxfield, F. R., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1493-1498 6 p.

Research output: Contribution to journalArticle

Enzymes
Endopeptidases
Cathepsin B
Peptides
Microglia
3 Citations (Scopus)

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism

Meng, Y., Wiseman, J. A., Nemtsova, Y., Moore, D., Guevarra, J., Reuhl, K., Banks, W. A., Daneman, R., Sleat, D. E. & Lobel, P., Jul 5 2017, In : Molecular Therapy. 25, 7, p. 1531-1543 13 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Blood-Brain Barrier
Neuronal Ceroid-Lipofuscinoses
Peptides
Brain
17 Citations (Scopus)

Accounting for protein subcellular localization: A compartmental map of the rat liver proteome

Jadot, M., Boonen, M., Thirion, J., Wang, N., Xing, J., Zhao, C., Tannous, A., Qian, M., Zheng, H., Everett, J. K., Moore, D., Sleat, D. E. & Lobel, P., Feb 1 2017, In : Molecular and Cellular Proteomics. 16, 2, p. 194-212 19 p.

Research output: Contribution to journalArticle

Proteome
Liver
Rats
Organelles
Proteins
5 Citations (Scopus)

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease

Wiseman, J. A., Meng, Y., Nemtsova, Y., Matteson, P. G., Millonig, J., Moore, D., Sleat, D. E. & Lobel, P., Mar 17 2017, In : Molecular Therapy - Methods and Clinical Development. 4, p. 204-212 9 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Phenotype
Brain
Enzymes
Enzyme Replacement Therapy