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Research Output 1983 2018

  • 6299 Citations
  • 45 h-Index
  • 89 Article
  • 4 Review article
  • 1 Chapter
2018
1 Citation (Scopus)

Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis

Nemtsova, Y., Wiseman, J. A., El-Banna, M., Lobel, P. & Sleat, D. E., Feb 1 2018, In : PloS one. 13, 2, e0192286.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
peptidases
animal models
gene expression
6 Citations (Scopus)

Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain

Solé-Domènech, S., Rojas, A. V., Maisuradze, G. G., Scheraga, H. A., Lobel, P. & Maxfield, F. R., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1493-1498 6 p.

Research output: Contribution to journalArticle

Enzymes
Endopeptidases
Cathepsin B
Peptides
Microglia
2017
4 Citations (Scopus)

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism

Meng, Y., Wiseman, J. A., Nemtsova, Y., Moore, D., Guevarra, J., Reuhl, K., Banks, W. A., Daneman, R., Sleat, D. E. & Lobel, P., Jul 5 2017, In : Molecular Therapy. 25, 7, p. 1531-1543 13 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Blood-Brain Barrier
Neuronal Ceroid-Lipofuscinoses
Peptides
Brain
19 Citations (Scopus)

Accounting for protein subcellular localization: A compartmental map of the rat liver proteome

Jadot, M., Boonen, M., Thirion, J., Wang, N., Xing, J., Zhao, C., Tannous, A., Qian, M., Zheng, H., Everett, J. K., Moore, D., Sleat, D. E. & Lobel, P., Feb 2017, In : Molecular and Cellular Proteomics. 16, 2, p. 194-212 19 p.

Research output: Contribution to journalArticle

Proteome
Liver
Rats
Organelles
Proteins
5 Citations (Scopus)

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease

Wiseman, J. A., Meng, Y., Nemtsova, Y., Matteson, P. G., Millonig, J., Moore, D., Sleat, D. E. & Lobel, P., Mar 17 2017, In : Molecular Therapy - Methods and Clinical Development. 4, p. 204-212 9 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Phenotype
Brain
Enzymes
Enzyme Replacement Therapy
2 Citations (Scopus)

Proteomic analysis of brain and cerebrospinal fluid from the three major forms of neuronal ceroid lipofuscinosis reveals potential biomarkers

Sleat, D. E., Tannous, A., Sohar, I., Wiseman, J. A., Zheng, H., Qian, M., Zhao, C., Xin, W., Barone, R., Sims, K. B., Moore, D. & Lobel, P., Oct 6 2017, In : Journal of Proteome Research. 16, 10, p. 3787-3804 18 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Cerebrospinal fluid
Biomarkers
Proteomics

Using whole-exome sequencing to investigate the genetic bases of lysosomal storage diseases of unknown etiology

Wang, N., Zhang, Y., Gedvilaite, E., Loh, J. W., Lin, T., Liu, X., Liu, C. G., Kumar, D., Donnelly, R., Raymond, K., Schuchman, E. H., Sleat, D. E., Lobel, P. & Xing, J., Nov 1 2017, In : Human mutation. 38, 11, p. 1491-1499 9 p.

Research output: Contribution to journalArticle

Lysosomal Storage Diseases
Exome
Mutation
Genes
Phenotype
2016
12 Citations (Scopus)

Analysis of large-scale whole exome sequencing data to determine the prevalence of genetically-distinct forms of neuronal ceroid lipofuscinosis

Sleat, D. E., Gedvilaite, E., Zhang, Y., Lobel, P. & Xing, J., Nov 30 2016, In : Gene. 593, 2, p. 284-291 8 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Exome
Databases
Alleles
Lysosomal Storage Diseases
2014
35 Citations (Scopus)

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

Meng, Y., Sohar, I., Sleat, D. E., Richardson, J. R., Reuhl, K., Jenkins, R. B., Sarkar, G. & Lobel, P., Jan 1 2014, In : Molecular Therapy. 22, 3, p. 547-553 7 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Blood-Brain Barrier
Neuronal Ceroid-Lipofuscinoses
Lysosomal Storage Diseases
Peptides
23 Citations (Scopus)

Potential pitfalls and solutions for use of fluorescent fusion proteins to study the lysosome

Huang, L., Pike, D., Sleat, D. E., Nanda, V. & Lobel, P., Feb 21 2014, In : PloS one. 9, 2, e88893.

Research output: Contribution to journalArticle

lysosomes
Lysosomes
Fusion reactions
Artifacts
glycyl-seryl-alanine
2013
21 Citations (Scopus)

Extending the mannose 6-phosphate glycoproteome by high resolution/accuracy mass spectrometry analysis of control and acid phosphatase 5-deficient mice

Sleat, D. E., Sun, P., Wiseman, J. A., Huang, L., El-Banna, M., Zheng, H., Moore, D. & Lobel, P., Jul 1 2013, In : Molecular and Cellular Proteomics. 12, 7, p. 1806-1817 12 p.

Research output: Contribution to journalArticle

Acid Phosphatase
Mass spectrometry
Mass Spectrometry
Proteins
Lysosomes
1 Citation (Scopus)

Tripeptidyl Peptidase I

Sohar, I., Sleat, D. E. & Lobel, P., Aug 29 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3350-3356 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

tripeptidyl-peptidase 1
2012
11 Citations (Scopus)

Proteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain

Sleat, D. E., Wiseman, J. A., Sohar, I., El-Banna, M., Zheng, H., Moore, D. & Lobel, P., Dec 1 2012, In : Proteomics. 12, 23-24, p. 3499-3509 11 p.

Research output: Contribution to journalArticle

Niemann-Pick Diseases
Proteomics
Brain
Cholesterol
Lipids
18 Citations (Scopus)

Systemic administration of tripeptidyl peptidase i in a mouse model of late infantile neuronal ceroid lipofuscinosis: Effect of glycan modification

Meng, Y., Sohar, I., Wang, L., Sleat, D. E. & Lobel, P., Jul 6 2012, In : PloS one. 7, 7, e40509.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Ceroid
Neuronal Ceroid-Lipofuscinoses
peptidases
Polysaccharides
2011
19 Citations (Scopus)

Classification of subcellular location by comparative proteomic analysis of native and density-shifted lysosomes

Della Valle, M. C., Sleat, D. E., Zheng, H., Moore, D., Jadot, M. & Lobel, P., Apr 1 2011, In : Molecular and Cellular Proteomics. 10, 4

Research output: Contribution to journalArticle

Lysosomes
Proteomics
Proteins
Centrifugation
Organelles
43 Citations (Scopus)

Intrathecal tripeptidyl-peptidase 1 reduces lysosomal storage in a canine model of late infantile neuronal ceroid lipofuscinosis

Vuillemenot, B. R., Katz, M. L., Coates, J. R., Kennedy, D., Tiger, P., Kanazono, S., Lobel, P., Sohar, I., Xu, S., Cahayag, R., Keve, S., Koren, E., Bunting, S., Tsuruda, L. S. & O'Neill, C. A., Nov 1 2011, In : Molecular Genetics and Metabolism. 104, 3, p. 325-337 13 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Canidae
Dogs
tripeptidyl-peptidase 1
36 Citations (Scopus)

Large-volume intrathecal enzyme delivery increases survival of a mouse model of late infantile neuronal ceroid lipofuscinosis

Xu, S., Wang, L., El-Banna, M., Sohar, I., Sleat, D. E. & Lobel, P., Jan 1 2011, In : Molecular Therapy. 19, 10, p. 1842-1848 7 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Enzymes
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Lysosomal Storage Diseases
Therapeutics
18 Citations (Scopus)

Loss of niemann-pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway

Dixit, S. S., Jadot, M., Sohar, I., Sleat, D. E., Stock, A. & Lobel, P., Aug 24 2011, In : PloS one. 6, 8, e23677.

Research output: Contribution to journalArticle

lysosomes
cholesterol
Lysosomes
Type C Niemann-Pick Disease
Proteins
2010
42 Citations (Scopus)

Functions of the α, β, and γsubunits of UDP-GlcNAc:Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase

Qian, Y., Lee, I., Lee, W. S., Qian, M., Kudo, M., Canfield, W. M., Lobel, P. & Kornfeld, S., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3360-3370 11 p.

Research output: Contribution to journalArticle

Uridine Diphosphate
Hydrolases
Acids
Enzymes
Phosphorylation
6 Citations (Scopus)
Ceroid
Neuronal Ceroid-Lipofuscinoses
Lysosomal Storage Diseases
Glial Fibrillary Acidic Protein
Lysosomes
2009
33 Citations (Scopus)
Ceroid
Crystal structure
Enzymes
Enzyme Precursors
Peptide Hydrolases
7 Citations (Scopus)

Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice

Kim, K. H., Sleat, D. E., Bernard, O. & Lobel, P., Mar 27 2009, In : Neuroscience Letters. 453, 1, p. 27-30 4 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Cell Death
tripeptidyl-peptidase 1
Neurodegenerative Diseases
Therapeutics
36 Citations (Scopus)

Mass spectrometry-based protein profiling to determine the cause of lysosomal storage diseases of unknown etiology

Sleat, D. E., Ding, L., Wang, S., Zhao, C., Wang, Y., Xin, W., Zheng, H., Moore, D., Sims, K. B. & Lobel, P., Dec 8 2009, In : Molecular and Cellular Proteomics. 8, 7, p. 1708-1718 11 p.

Research output: Contribution to journalArticle

Lysosomal Storage Diseases
Mass spectrometry
Mass Spectrometry
Mutation
Proteins
135 Citations (Scopus)

Proteomics of the lysosome

Lübke, T., Lobel, P. & Sleat, D. E., Apr 1 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 4, p. 625-635 11 p.

Research output: Contribution to journalReview article

Lysosomes
Proteomics
Proteins
Lysosomal Storage Diseases
Medical Genetics
2008
39 Citations (Scopus)

Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins

Sun, P., Sleat, D. E., Lecocq, M., Hayman, A. R., Jadot, M. & Lobel, P., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16590-16595 6 p.

Research output: Contribution to journalArticle

Acid Phosphatase
Lysosomes
P-Glycoproteins
Enzymes
Neuroblastoma
6 Citations (Scopus)

A method to assess the lysosomal residence of proteins in cultured cells

Gasingirwa, M. C., Thirion, J., Costa, C., Flamion, B., Lobel, P. & Jadot, M., Mar 1 2008, In : Analytical Biochemistry. 374, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Lysosomes
Progesterone
Cultured Cells
Cells
Lysosome-Associated Membrane Glycoproteins
52 Citations (Scopus)

Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages

Majumdar, A., Chung, H., Dolios, G., Wang, R., Asamoah, N., Lobel, P. & Maxfield, F. R., May 1 2008, In : Neurobiology of Aging. 29, 5, p. 707-715 9 p.

Research output: Contribution to journalArticle

Amyloid
Microglia
Macrophages
Peptides
Lysosomes
2 Citations (Scopus)

Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis

Kim, K. H., Pham, C. T., Sleat, D. E. & Lobel, P., Oct 15 2008, In : Biochemical Journal. 415, 2, p. 225-232 8 p.

Research output: Contribution to journalArticle

Cathepsin C
Ceroid
Neurodegenerative diseases
Neuronal Ceroid-Lipofuscinoses
Neurodegenerative Diseases
112 Citations (Scopus)

Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis

Chang, M., Cooper, J. D., Sleat, D. E., Cheng, S. H., Dodge, J. C., Passini, M. A., Lobel, P. & Davidson, B. L., Jan 1 2008, In : Molecular Therapy. 16, 4, p. 649-656 8 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Phenotype
Enzymes
Central Nervous System
Lysosomal Storage Diseases
55 Citations (Scopus)
IGF Type 2 Receptor
Proteomics
Serum
Proteins
Cations
33 Citations (Scopus)

Residual levels of tripeptidyl-peptidase I activity dramatically ameliorate disease in late-infantile neuronal ceroid lipofuscinosis

Sleat, D. E., El-Banna, M., Sohar, I., Kim, K. H., Dobrenis, K., Walkley, S. U. & Lobel, P., Jun 1 2008, In : Molecular Genetics and Metabolism. 94, 2, p. 222-233 12 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Gene therapy
Genetic Therapy
Nervous System Heredodegenerative Disorders
42 Citations (Scopus)

The mannose 6-phosphate glycoprotein proteome

Sleat, D. E., Valle, M. C. D., Zheng, H., Moore, D. & Lobel, P., Jul 1 2008, In : Journal of Proteome Research. 7, 7, p. 3010-3021 12 p.

Research output: Contribution to journalArticle

Proteome
Glycoproteins
Proteins
Purification
P-Glycoproteins
2007
142 Citations (Scopus)

Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils

Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P. & Maxfield, F. R., Apr 1 2007, In : Molecular Biology of the Cell. 18, 4, p. 1490-1496 7 p.

Research output: Contribution to journalArticle

Microglia
Lysosomes
Amyloid
Macrophage Colony-Stimulating Factor
Macrophages
28 Citations (Scopus)

Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?

Dixit, S. S., Sleat, D. E., Stock, A. & Lobel, P., Nov 15 2007, In : Biochemical Journal. 408, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Intestinal Absorption
Cholesterol
Type C Niemann-Pick Disease
Proteins
Drosophila
18 Citations (Scopus)

Lysosomal proteomics and disease

Sleat, D. E., Jadot, M. & Lobel, P., Sep 1 2007, In : Proteomics - Clinical Applications. 1, 9, p. 1134-1146 13 p.

Research output: Contribution to journalReview article

Proteomics
Organelles
Lysosomes
Macromolecular Substances
Inborn Genetic Diseases
130 Citations (Scopus)

Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease

Xu, S., Benoff, B., Liou, H. L., Lobel, P. & Stock, A., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23525-23531 7 p.

Research output: Contribution to journalArticle

Sterols
Cholesterol
Ligands
Sulfates
Tunnels
22 Citations (Scopus)

The human urine mannose 6-phosphate glycoproteome

Sleat, D. E., Zheng, H. & Lobel, P., Mar 1 2007, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 3, p. 368-372 5 p.

Research output: Contribution to journalArticle

Urine
Proteins
Proteomics
Glycoproteins
Lysosomal Storage Diseases
54 Citations (Scopus)

Timing of therapeutic intervention determines functional and survival outcomes in a mouse model of late infantile batten disease

Cabrera-Salazar, M. A., Roskelley, E. M., Bu, J., Hodges, B. L., Yew, N., Dodge, J. C., Shihabuddin, L. S., Sohar, I., Sleat, D. E., Scheule, R. K., Davidson, B. L., Cheng, S. H., Lobel, P. & Passini, M. A., Oct 1 2007, In : Molecular Therapy. 15, 10, p. 1782-1788 7 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Injections
Survival
Nerve Degeneration
Dependovirus
2006
81 Citations (Scopus)

A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis

Awano, T., Katz, M. L., O'Brien, D. P., Sohar, I., Lobel, P., Coates, J. R., Khan, S., Johnson, G. C., Giger, U. & Johnson, G. S., Nov 1 2006, In : Molecular Genetics and Metabolism. 89, 3, p. 254-260 7 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Frameshift Mutation
Canidae
Alleles
93 Citations (Scopus)

A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis

Awano, T., Katz, M. L., O'Brien, D. P., Taylor, J. F., Evans, J., Khan, S., Sohar, I., Lobel, P. & Johnson, G. S., Apr 1 2006, In : Molecular Genetics and Metabolism. 87, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

Ceroid
Neuronal Ceroid-Lipofuscinoses
Cathepsin D
Brain
Genes
16 Citations (Scopus)

Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method

Della Valle, M. C., Sleat, D. E., Sohar, I., Wen, T., Pintar, J., Jadot, M. & Lobel, P., Nov 17 2006, In : Journal of Biological Chemistry. 281, 46, p. 35436-35445 10 p.

Research output: Contribution to journalArticle

Demonstrations
Lysosomes
Proteins
Proteomics
Lysosome-Associated Membrane Glycoproteins
30 Citations (Scopus)
Peptide Library
Substrate Specificity
Fluorescent Dyes
Substrates
Assays
51 Citations (Scopus)

Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins

Sleat, D. E., Wang, Y., Sohar, I., Lackland, H., Li, Y., Li, H., Zheng, H. & Lobel, P., Oct 1 2006, In : Molecular and Cellular Proteomics. 5, 10, p. 1942-1956 15 p.

Research output: Contribution to journalArticle

Plasma (human)
Glycoproteins
Proteins
Blood Proteins
Phosphorylation
74 Citations (Scopus)

Identification of sites of mannose 6-phosphorylation on lysosomal proteins

Sleat, D. E., Zheng, H., Qian, M. & Lobel, P., Apr 1 2006, In : Molecular and Cellular Proteomics. 5, 4, p. 686-701 16 p.

Research output: Contribution to journalArticle

Phosphorylation
Mannose
Glycoproteins
Proteins
Lysosomes
91 Citations (Scopus)

Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis

Passini, M. A., Dodge, J. C., Bu, J., Yang, W., Zhao, Q., Sondhi, D., Hackett, N. R., Kaminsky, S. M., Mao, Q., Shihabuddin, L. S., Cheng, S. H., Sleat, D. E., Stewart, G. R., Davidson, B. L., Lobel, P. & Crystal, R. G., Feb 1 2006, In : Journal of Neuroscience. 26, 5, p. 1334-1342 9 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Dependovirus
Pathology
Brain
Lysosome-Associated Membrane Glycoproteins
148 Citations (Scopus)

Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport

Cheruku, S. R., Xu, Z., Dutia, R., Lobel, P. & Storch, J., Oct 20 2006, In : Journal of Biological Chemistry. 281, 42, p. 31594-31604 11 p.

Research output: Contribution to journalArticle

Cholesterol
Membranes
Proteins
Phospholipids
Tryptophan
79 Citations (Scopus)

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols

Liou, H. L., Dixit, S. S., Xu, S., Tint, G. S., Stock, A. & Lobel, P., Dec 1 2006, In : Journal of Biological Chemistry. 281, 48, p. 36710-36723 14 p.

Research output: Contribution to journalArticle

Niemann-Pick Diseases
Sterols
Cholesterol
Glycoside Hydrolases
Proteins
2005
65 Citations (Scopus)

The human brain mannose 6-phosphate glycoproteome: A complex mixture composed of multiple isoforms of many soluble lysosomal proteins

Sleat, D. E., Lackland, H., Wang, Y., Sohar, I., Xiao, G., Li, H. & Lobel, P., Jan 1 2005, In : Proteomics. 5, 6, p. 1520-1532 13 p.

Research output: Contribution to journalArticle

Complex Mixtures
Brain
Protein Isoforms
Mass spectrometry
Lysosomes
2004
91 Citations (Scopus)

A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration

Sleat, D. E., Wiseman, J. A., El-Banna, M., Kim, K. H., Mao, Q., Price, S., Macauley, S. L., Sidman, R. L., Shen, M. M., Zhao, Q., Passini, M. A., Davidson, B. L., Stewart, G. R. & Lobel, P., Oct 13 2004, In : Journal of Neuroscience. 24, 41, p. 9117-9126 10 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Genes
Clinical Pathology
Purkinje Cells
Serine Proteases
225 Citations (Scopus)

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

Sleat, D. E., Wiseman, J. A., El-Banna, M., Price, S. M., Verot, L., Shen, M. M., Tint, G. S., Vanier, M. T., Walkley, S. U. & Lobel, P., Apr 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 16, p. 5886-5891 6 p.

Research output: Contribution to journalArticle

Lipids
Niemann-Pick Diseases
Lysosomes
Proteins
Cholesterol