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Personal profile

Research interests

We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.

Education/Academic qualification

Cellular and Molecular Biology, Ph.D., University of Michigan

Sep 1 1977Aug 20 1981

Award Date: Aug 20 1981

Biology, B.S., University of Connecticut

Sep 1 1973May 23 1977

Award Date: May 23 1977

Molecular Biology, Postdoctoral Training, Rockefeller University

Sep 1 1982Aug 31 1985

Molecular Biology, Postdoctoral Training, University of Michigan

Sep 1 1981Aug 31 1982

External positions

Member, Scientific Advisory Board, Neucyte, Inc.

Sep 1 2017 → …

Member, State of Connecticut Regenerative Medicine Research Fund

Jun 1 2009 → …

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Projects

  • Research Output

    Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

    Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P. & Pang, Z. P., Jul 1 2020, In : Molecular psychiatry. 25, 7, p. 1406-1419 14 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications

    Fantuzzo, J. A., Robles, D. A., Mirabella, V. R., Hart, R. P., Pang, Z. P. & Zahn, J. D., Mar 21 2020, In : Lab on a Chip. 20, 6, p. 1140-1152 13 p.

    Research output: Contribution to journalArticle

  • Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol

    Scarnati, M. S., Boreland, A. J., Joel, M., Hart, R. P. & Pang, Z. P., Sep 2020, In : Alcohol. 87, p. 97-109 13 p.

    Research output: Contribution to journalArticle

  • Elevated choline kinase α–mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes

    Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D. & Xie, P., 2020, In : Journal of Immunology. 204, 2, p. 459-471 13 p.

    Research output: Contribution to journalArticle

  • Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations

    Lai, D., Kapoor, M., Wetherill, L., Schwandt, M., Ramchandani, V. A., Goldman, D., Chao, M., Almasy, L., Bucholz, K., Hart, R. P., Kamarajan, C., Meyers, J. L., Nurnberger, J. I., Tischfield, J., Edenberg, H. J., Schuckit, M., Goate, A., Scott, D. M., Porjesz, B., Agrawal, A. & 1 others, Foroud, T., 2020, (Accepted/In press) In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

    Research output: Contribution to journalArticle