Projects per year
Personal profile
Research interests
We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.
Education/Academic qualification
Cellular and Molecular Biology, Ph.D., Structure and expression of a 5S ribosomal RNA gene from the Syrian hamster genome, University of Michigan
Sep 1 1977 → Aug 20 1981
Award Date: Aug 20 1981
Biology, B.S., University of Connecticut
Sep 1 1973 → May 23 1977
Award Date: May 23 1977
Molecular Biology, Postdoctoral Training, Sequences required for poly(A) processing of mRNAs, Rockefeller University
Sep 1 1982 → Aug 31 1985
Molecular Biology, Postdoctoral Training, Ribosomal RNA gene expression, University of Michigan
Sep 1 1981 → Aug 31 1982
External positions
Member, Scientific Advisory Board, Neucyte, Inc.
Sep 1 2017 → …
Member, State of Connecticut Regenerative Medicine Research Fund
Jun 1 2009 → …
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Projects
- 7 Finished
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High throughput multicompartment culture chambers to develop neurocircuit models of addiction risk
National Institute on Drug Abuse
4/1/15 → 3/31/18
Project: Research project
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Developing an In Vitro Neurocircuitry Model of Addiction using Risk-Associated Hu
National Institute on Drug Abuse
4/1/13 → 3/31/16
Project: Research project
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Phenotypic analysis of human iPSC carrying addiction-associated gene variants
Hart, R., TISCHFIELD, J. A., Hart, R. & TISCHFIELD, J. A.
National Institute on Drug Abuse
9/15/11 → 6/30/14
Project: Research project
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Genome-wide chromatin modification targeting by endogenous small RNAs
Hart, R. & Kellis, M.
3/24/10 → 8/28/12
Project: Research project
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Epigenetic regulation of microRNAs in neurogenesis
National Institute of Mental Health
9/30/09 → 9/29/11
Project: Research project
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Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Popova, D., Gameiro-Ros, I., Youssef, M. M., Zalamea, P., Morris, A. D., Prytkova, I., Jadali, A., Kwan, K. Y., Kamarajan, C., Salvatore, J. E., Xuei, X., Chorlian, D. B., Porjesz, B., Kuperman, S., Dick, D. M., Goate, A., Edenberg, H. J., Tischfield, J. A., Pang, Z. P., Slesinger, P. A., & 1 others, Feb 2023, In: Molecular psychiatry. 28, 2, p. 746-758 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Genetic nurture effects for alcohol use disorder
COGA Collaborators, Feb 2023, In: Molecular psychiatry. 28, 2, p. 759-766 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
Wang, L., Mirabella, V. R., Dai, R., Su, X., Xu, R., Jadali, A., Bernabucci, M., Singh, I., Chen, Y., Tian, J., Jiang, P., Kwan, K. Y., Pak, C. H., Liu, C., Comoletti, D., Hart, R. P., Chen, C., Südhof, T. C. & Pang, Z., 2022, (Accepted/In press) In: Molecular psychiatry.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer’s Disease Risk
Eid, A., Mhatre-Winters, I., Sammoura, F. M., Edler, M. K., von Stein, R., Hossain, M. M., Han, Y., Lisci, M., Carney, K., Konsolaki, M., Hart, R. P., Bennett, J. W. & Richardson, J. R., Aug 2022, In: Environmental health perspectives. 130, 8, 087005.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
MRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development
Salamon, I., Palsule, G., Luo, X., Roque, A., Tucai, S., Khosla, I., Volk, N., Liu, W., Cui, H., Pozzo, V. D., Zalamea, P., Jiao, X., D'Arcangelo, G., Hart, R. P., Rasin, M. R. & Kiledjian, M., Apr 1 2022, In: Cerebral Cortex. 32, 7, p. 1494-1507 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations