Projects per year
Personal profile
Research interests
We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.
Education/Academic qualification
Cellular and Molecular Biology, Ph.D., University of Michigan
Sep 1 1977 → Aug 20 1981
Biology, B.S., University of Connecticut
Sep 1 1973 → May 23 1977
Molecular Biology, Postdoctoral Training, Rockefeller University
Sep 1 1982 → Aug 31 1985
Molecular Biology, Postdoctoral Training, University of Michigan
Sep 1 1981 → Aug 31 1982
External positions
Member, Scientific Advisory Board, Neucyte, Inc.
Sep 1 2017 → …Member, State of Connecticut Regenerative Medicine Research Fund
Jun 1 2009 → …Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 1 Similar Profiles
Messenger RNA
Medicine & Life Sciences
Substance P
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Spinal Cord Injuries
Medicine & Life Sciences
MicroRNAs
Medicine & Life Sciences
Sympathetic Ganglia
Medicine & Life Sciences
Interleukin-1
Medicine & Life Sciences
Ataxia Telangiectasia
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2009 2018
- 3 Finished
High Throughput Multicompartment Culture Chambers To Develop Neurocircuit Models Of Addiction Risk
National Institutes of Health (NIH)
4/1/15 → 3/31/18
Project: Research project
Induced Pluripotent Stem Cells
Alcoholism
Addictive Behavior
Neurons
Cocaine-Related Disorders
Genome-Wide Chromatin Modification Targeting By Endogenous Small Rnas
National Institutes of Health (NIH)
3/24/10 → 8/28/12
Project: Research project
Histone Code
Epigenomics
Chromatin
Genome
RNA
Epigenetic Regulation Of Micrornas In Neurogenesis
National Institutes of Health (NIH)
9/30/09 → 9/29/11
Project: Research project
Neurogenesis
MicroRNAs
Epigenomics
Valproic Acid
Histone Deacetylase Inhibitors
Research Output 1982 2019
1
Citation
(Scopus)
ATM is activated by ATP depletion and modulates mitochondrial function through NRF1
Chow, H. M., Cheng, A., Song, X., Swerdel, M. R., Hart, R. & Herrup, K., Mar 1 2019, In : Journal of Cell Biology. 218, 3, p. 909-928 20 p.Research output: Contribution to journal › Article
Purkinje Cells
Adenosine Triphosphate
Ataxia Telangiectasia
Mitochondrial Genes
Dimerization
Compartmentalized devices as tools for investigation of human brain network dynamics
Fantuzzo, J. A., Hart, R. P., Zahn, J. D. & Pang, Z. P., Aug 17 2018, In : Developmental Dynamics.Research output: Contribution to journal › Review article
Organoids
Induced Pluripotent Stem Cells
Equipment and Supplies
Brain
Preclinical Drug Evaluations
4
Citations
(Scopus)
DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice
Guo, Y., Wu, R., Gaspar, J. M., Sargsyan, D., Su, Z. Y., Zhang, C., Gao, L., Cheng, D., Li, W., Wang, C., Yin, R., Fang, M., Verzi, M., Hart, R. & Kong, A-N., May 3 2018, In : Carcinogenesis. 39, 5, p. 669-680 12 p.Research output: Contribution to journal › Article
Curcumin
Colitis
Transcriptome
Colonic Neoplasms
Azoxymethane
DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice
Guo, Y., Wu, R., Gaspar, J. M., Sargsyan, D., Su, Z-Y., Zhang, C., Gao, L., Cheng, D., Li, W., Wang, C., Yin, R., Fang, M., Verzi, M. P., Hart, R. P. & Kong, A-N., May 3 2018, In : Carcinogenesis. 39, 5, p. 669-680 12 p.Research output: Contribution to journal › Article
Curcumin
Colitis
Transcriptome
Colonic Neoplasms
Azoxymethane
Epigenetic alterations in TRAMP mice: Epigenome DNA methylation profiling using MeDIP-seq
Li, W., Huang, Y., Sargsyan, D., Khor, T. O., Guo, Y., Shu, L., Yang, A. Y., Zhang, C., Paredes-Gonzalez, X., Verzi, M., Hart, R. & Kong, A-N., Jan 12 2018, In : Cell and Bioscience. 8, 1, 3.Research output: Contribution to journal › Article
Methylation
DNA Fingerprinting
DNA Methylation
Immunoprecipitation
Epigenomics