Projects per year
Personal profile
Research interests
We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.
Education/Academic qualification
Cellular and Molecular Biology, Ph.D., University of Michigan
Sep 1 1977 → Aug 20 1981
Biology, B.S., University of Connecticut
Sep 1 1973 → May 23 1977
Molecular Biology, Postdoctoral Training, Rockefeller University
Sep 1 1982 → Aug 31 1985
Molecular Biology, Postdoctoral Training, University of Michigan
Sep 1 1981 → Aug 31 1982
External positions
Member, Scientific Advisory Board, Neucyte, Inc.
Sep 1 2017 → …Member, State of Connecticut Regenerative Medicine Research Fund
Jun 1 2009 → …Fingerprint Dive into the research topics where Ronald Hart is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Messenger RNA
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Substance P
Medicine & Life Sciences
Spinal Cord Injuries
Medicine & Life Sciences
MicroRNAs
Medicine & Life Sciences
Sympathetic Ganglia
Medicine & Life Sciences
Interleukin-1
Medicine & Life Sciences
Genes
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2009 2018
- 3 Finished
High Throughput Multicompartment Culture Chambers To Develop Neurocircuit Models Of Addiction Risk
National Institutes of Health (NIH)
4/1/15 → 3/31/18
Project: Research project
Induced Pluripotent Stem Cells
Alcoholism
Addictive Behavior
Neurons
Cocaine-Related Disorders
Genome-Wide Chromatin Modification Targeting By Endogenous Small Rnas
National Institutes of Health (NIH)
3/24/10 → 8/28/12
Project: Research project
Histone Code
Epigenomics
Chromatin
Genome
RNA
Epigenetic Regulation Of Micrornas In Neurogenesis
National Institutes of Health (NIH)
9/30/09 → 9/29/11
Project: Research project
Neurogenesis
MicroRNAs
Epigenomics
Valproic Acid
Histone Deacetylase Inhibitors
Research Output 1982 2019
Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons
Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. & Pang, Z., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.Research output: Contribution to journal › Article
mu Opioid Receptor
Neurons
Synaptic Transmission
Opioid Analgesics
Single Nucleotide Polymorphism
3
Citations
(Scopus)
ATM is activated by ATP depletion and modulates mitochondrial function through NRF1
Chow, H. M., Cheng, A., Song, X., Swerdel, M. R., Hart, R. & Herrup, K., Mar 1 2019, In : Journal of Cell Biology. 218, 3, p. 909-928 20 p.Research output: Contribution to journal › Article
Purkinje Cells
Adenosine Triphosphate
Ataxia Telangiectasia
Mitochondrial Genes
Dimerization
1
Citation
(Scopus)
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome
Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., Pang, Z., Kim, W. Y., Hart, R., Liu, Y. & Jiang, P., Jun 6 2019, In : Cell Stem Cell. 24, 6, p. 908-926.e8Research output: Contribution to journal › Article
Organoids
Down Syndrome
Phenotype
Interneurons
Induced Pluripotent Stem Cells
Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad
Vajtay, T. J., Bandi, A., Upadhyay, A., Swerdel, M. R., Hart, R., Lee, C. R. & Margolis, D., Apr 1 2019, In : Journal of neurophysiology. 121, 4, p. 1491-1500 10 p.Research output: Contribution to journal › Article
Open Access
Optogenetics
Vibrissae
Muscles
Muscle Denervation
Facial Nerve
Structural and mechanistic basis of mammalian Nudt12 RNA deNADding
Grudzien-Nogalska, E., Wu, Y., Jiao, X., Cui, H., Mateyak, M. K., Hart, R., Tong, L. & Kiledjian, M., Jun 1 2019, In : Nature Chemical Biology. 15, 6, p. 575-582 8 p.Research output: Contribution to journal › Article
NAD
RNA
Messenger RNA
Enzymes
Adenosine Monophosphate