Projects per year
Personal profile
Research interests
We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.
Education/Academic qualification
Cellular and Molecular Biology, Ph.D., University of Michigan
Sep 1 1977 → Aug 20 1981
Award Date: Aug 20 1981
Biology, B.S., University of Connecticut
Sep 1 1973 → May 23 1977
Award Date: May 23 1977
Molecular Biology, Postdoctoral Training, Rockefeller University
Sep 1 1982 → Aug 31 1985
Molecular Biology, Postdoctoral Training, University of Michigan
Sep 1 1981 → Aug 31 1982
External positions
Member, Scientific Advisory Board, Neucyte, Inc.
Sep 1 2017 → …
Member, State of Connecticut Regenerative Medicine Research Fund
Jun 1 2009 → …
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Projects
- 7 Finished
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High throughput multicompartment culture chambers to develop neurocircuit models of addiction risk
National Institute on Drug Abuse
4/1/15 → 3/31/18
Project: Research project
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Developing an In Vitro Neurocircuitry Model of Addiction using Risk-Associated Hu
National Institute on Drug Abuse
4/1/13 → 3/31/16
Project: Research project
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Phenotypic analysis of human iPSC carrying addiction-associated gene variants
Hart, R., TISCHFIELD, J. A., Hart, R. & TISCHFIELD, J. A.
National Institute on Drug Abuse
9/15/11 → 6/30/14
Project: Research project
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Genome-wide chromatin modification targeting by endogenous small RNAs
Hart, R. & Kellis, M.
3/24/10 → 8/28/12
Project: Research project
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Epigenetic regulation of microRNAs in neurogenesis
National Institute of Mental Health
9/30/09 → 9/29/11
Project: Research project
Research output
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mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development
Salamon, I., Palsule, G., Luo, X., Roque, A., Tucai, S., Khosla, I., Volk, N., Liu, W., Cui, H., Pozzo, V. D., Zalamea, P., Jiao, X., D'Arcangelo, G., Hart, R., Rasin, M. R. & Kiledjian, M., Mar 30 2022, In: Cerebral cortex (New York, N.Y. : 1991). 32, 7, p. 1494-1507 14 p.Research output: Contribution to journal › Article › peer-review
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Optimized splitting of mixed-species RNA sequencing data
Song, X., Gao, H. Y., Herrup, K. & Hart, R. P., 2022, (Accepted/In press) In: Journal of bioinformatics and computational biology. 2250001.Research output: Contribution to journal › Article › peer-review
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Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations
Lai, D., Kapoor, M., Wetherill, L., Schwandt, M., Ramchandani, V. A., Goldman, D., Chao, M., Almasy, L., Bucholz, K., Hart, R. P., Kamarajan, C., Meyers, J. L., Nurnberger, J. I., Tischfield, J., Edenberg, H. J., Schuckit, M., Goate, A., Scott, D. M., Porjesz, B., Agrawal, A. & 1 others, , Apr 2021, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 186, 3, p. 151-161 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes
Chow, H. M., Sun, J. K. L., Hart, R. P., Cheng, K. K. Y., Hung, C. H. L., Lau, T. M. & Kwan, K. M., Aug 18 2021, In: Advanced Science. 8, 16, 2004993.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases
The Collaborative Study on the Genetics of Alcoholism (COGA), Dec 2021, In: Nature communications. 12, 1, 5071.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations