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Ronald Hart

 https://orcid.org/0000-0003-4836-8712
  • 5464 Citations
  • 40 h-Index
1982 …2020

Research output per year

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Personal profile

Research interests

We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.

Education/Academic qualification

Cellular and Molecular Biology, Ph.D., University of Michigan

Sep 1 1977 → Aug 20 1981

Award Date: Aug 20 1981

Biology, B.S., University of Connecticut

Sep 1 1973 → May 23 1977

Award Date: May 23 1977

Molecular Biology, Postdoctoral Training, Rockefeller University

Sep 1 1982 → Aug 31 1985

Molecular Biology, Postdoctoral Training, University of Michigan

Sep 1 1981 → Aug 31 1982

External positions

Member, Scientific Advisory Board, Neucyte, Inc.

Sep 1 2017 → …

Member, State of Connecticut Regenerative Medicine Research Fund

Jun 1 2009 → …

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Projects

High throughput multicompartment culture chambers to develop neurocircuit models of addiction risk

Hart, R., Pang, Z. & Zahn, J.

National Institutes of Health

4/1/15 → 3/31/18

Project: Research project

    • Developing an In Vitro Neurocircuitry Model of Addiction using Risk-Associated Hu

    Hart, R. & Pang, Z.

    National Institutes of Health

    4/1/13 → 3/31/16

    Project: Research project

    • Phenotypic analysis of human iPSC carrying addiction-associated gene variants

    Tischfield, J. & Hart, R.

    National Institutes of Health

    9/15/11 → 6/30/14

    Project: Research project

    • Genome-wide chromatin modification targeting by endogenous small RNAs

    Hart, R. & Kellis, M.

    National Institutes of Health

    3/24/10 → 8/28/12

    Project: Research project

    • Epigenetic regulation of microRNAs in neurogenesis

    Hart, R.

    National Institutes of Health

    9/30/09 → 9/29/11

    Project: Research project

    • Research Output

    Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications

    Fantuzzo, J. A., Robles, D. A., Mirabella, V. R., Hart, R. P., Pang, Z. P. & Zahn, J. D., Mar 21 2020, In : Lab on a Chip. 20, 6, p. 1140-1152 13 p.

    Research output: Contribution to journal › Article

    • Elevated choline kinase α–mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes

    Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D. & Xie, P., Jan 1 2020, In : Journal of Immunology. 204, 2, p. 459-471 13 p.

    Research output: Contribution to journal › Article

    • Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

    Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P. & Pang, Z. P., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

    Chow, H. M., Cheng, A., Song, X., Swerdel, M. R., Hart, R. P. & Herrup, K., Mar 1 2019, In : Journal of Cell Biology. 218, 3, p. 909-928 20 p.

    Research output: Contribution to journal › Article

    • 7 Scopus citations

    OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

    Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., Pang, Z. P., Kim, W. Y., Hart, R. P., Liu, Y. & Jiang, P., Jun 6 2019, In : Cell Stem Cell. 24, 6, p. 908-926.e8

    Research output: Contribution to journal › Article

    • 7 Scopus citations