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Personal profile

Research interests

We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.

Education/Academic qualification

Cellular and Molecular Biology, Ph.D., University of Michigan

Sep 1 1977Aug 20 1981

Biology, B.S., University of Connecticut

Sep 1 1973May 23 1977

Molecular Biology, Postdoctoral Training, Rockefeller University

Sep 1 1982Aug 31 1985

Molecular Biology, Postdoctoral Training, University of Michigan

Sep 1 1981Aug 31 1982

External positions

Member, Scientific Advisory Board, Neucyte, Inc.

Sep 1 2017 → …

Member, State of Connecticut Regenerative Medicine Research Fund

Jun 1 2009 → …

Fingerprint Dive into the research topics where Ronald Hart is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Messenger RNA Medicine & Life Sciences
Neurons Medicine & Life Sciences
Substance P Medicine & Life Sciences
Spinal Cord Injuries Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Sympathetic Ganglia Medicine & Life Sciences
Interleukin-1 Medicine & Life Sciences
Genes Medicine & Life Sciences

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Projects 2009 2018

Induced Pluripotent Stem Cells
Alcoholism
Addictive Behavior
Neurons
Cocaine-Related Disorders
Histone Code
Epigenomics
Chromatin
Genome
RNA
Neurogenesis
MicroRNAs
Epigenomics
Valproic Acid
Histone Deacetylase Inhibitors

Research Output 1982 2019

Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. & Pang, Z., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

mu Opioid Receptor
Neurons
Synaptic Transmission
Opioid Analgesics
Single Nucleotide Polymorphism
3 Citations (Scopus)

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

Chow, H. M., Cheng, A., Song, X., Swerdel, M. R., Hart, R. & Herrup, K., Mar 1 2019, In : Journal of Cell Biology. 218, 3, p. 909-928 20 p.

Research output: Contribution to journalArticle

Purkinje Cells
Adenosine Triphosphate
Ataxia Telangiectasia
Mitochondrial Genes
Dimerization
1 Citation (Scopus)

OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., Pang, Z., Kim, W. Y., Hart, R., Liu, Y. & Jiang, P., Jun 6 2019, In : Cell Stem Cell. 24, 6, p. 908-926.e8

Research output: Contribution to journalArticle

Organoids
Down Syndrome
Phenotype
Interneurons
Induced Pluripotent Stem Cells

Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad

Vajtay, T. J., Bandi, A., Upadhyay, A., Swerdel, M. R., Hart, R., Lee, C. R. & Margolis, D., Apr 1 2019, In : Journal of neurophysiology. 121, 4, p. 1491-1500 10 p.

Research output: Contribution to journalArticle

Open Access
Optogenetics
Vibrissae
Muscles
Muscle Denervation
Facial Nerve

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding

Grudzien-Nogalska, E., Wu, Y., Jiao, X., Cui, H., Mateyak, M. K., Hart, R., Tong, L. & Kiledjian, M., Jun 1 2019, In : Nature Chemical Biology. 15, 6, p. 575-582 8 p.

Research output: Contribution to journalArticle

NAD
RNA
Messenger RNA
Enzymes
Adenosine Monophosphate