Projects per year
Personal profile
Research interests
We use human induced pluripotent stem cells (iPSC) to model neurons with specific genetic variants to study Alzheimer's disease, Ataxia-telangiectasia, and addiction disorders.
Education/Academic qualification
Cellular and Molecular Biology, Ph.D., University of Michigan
Sep 1 1977 → Aug 20 1981
Award Date: Aug 20 1981
Biology, B.S., University of Connecticut
Sep 1 1973 → May 23 1977
Award Date: May 23 1977
Molecular Biology, Postdoctoral Training, Rockefeller University
Sep 1 1982 → Aug 31 1985
Molecular Biology, Postdoctoral Training, University of Michigan
Sep 1 1981 → Aug 31 1982
External positions
Member, Scientific Advisory Board, Neucyte, Inc.
Sep 1 2017 → …Member, State of Connecticut Regenerative Medicine Research Fund
Jun 1 2009 → …Fingerprint
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Projects
- 7 Finished
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High throughput multicompartment culture chambers to develop neurocircuit models of addiction risk
National Institute on Drug Abuse
4/1/15 → 3/31/18
Project: Research project
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Developing an In Vitro Neurocircuitry Model of Addiction using Risk-Associated Hu
Hart, R., Pang, Z., Hart, R. P., Pang, Z. P., Hart, R. P. & Pang, Z. P.
National Institute on Drug Abuse
4/1/13 → 3/31/16
Project: Research project
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Phenotypic analysis of human iPSC carrying addiction-associated gene variants
Hart, R., TISCHFIELD, J. A., Hart, R., TISCHFIELD, J. A., Hart, R. P. & TISCHFIELD, J. A.
National Institute on Drug Abuse
9/15/11 → 6/30/14
Project: Research project
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Genome-wide chromatin modification targeting by endogenous small RNAs
Hart, R., Kellis, M., Hart, R. P. & Kellis, M.
3/24/10 → 8/28/12
Project: Research project
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Epigenetic regulation of microRNAs in neurogenesis
Hart, R. & Hart, R. P.
National Institute of Mental Health
9/30/09 → 9/29/11
Project: Research project
Research output
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Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons
Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P. & Pang, Z. P., Jul 1 2020, In: Molecular psychiatry. 25, 7, p. 1406-1419 14 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications
Fantuzzo, J. A., Robles, D. A., Mirabella, V. R., Hart, R. P., Pang, Z. P. & Zahn, J. D., Mar 21 2020, In: Lab on a Chip. 20, 6, p. 1140-1152 13 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol
Scarnati, M. S., Boreland, A. J., Joel, M., Hart, R. P. & Pang, Z. P., Sep 2020, In: Alcohol. 87, p. 97-109 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Elevated choline kinase α–mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes
Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D. & Xie, P., 2020, In: Journal of Immunology. 204, 2, p. 459-471 13 p.Research output: Contribution to journal › Article › peer-review
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Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations
Lai, D., Kapoor, M., Wetherill, L., Schwandt, M., Ramchandani, V. A., Goldman, D., Chao, M., Almasy, L., Bucholz, K., Hart, R. P., Kamarajan, C., Meyers, J. L., Nurnberger, J. I., Tischfield, J., Edenberg, H. J., Schuckit, M., Goate, A., Scott, D. M., Porjesz, B., Agrawal, A. & 1 others, , 2020, (Accepted/In press) In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.Research output: Contribution to journal › Article › peer-review