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1995 …2024

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  • 2024

    A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

    Naaldijk, Y., Fernández, B., Fasiczka, R., Fdez, E., Leghay, C., Croitoru, I., Kwok, J. B., Boulesnane, Y., Vizeneux, A., Mutez, E., Calvez, C., Destée, A., Taymans, J. M., Aragon, A. V., Yarza, A. B., Padmanabhan, S., Delgado, M., Alcalay, R. N., Chatterton, Z. & Dzamko, N. & 4 others, Halliday, G., Ruiz-Martínez, J., Chartier-Harlin, M. C. & Hilfiker, S., Dec 2024, In: npj Parkinson's Disease. 10, 1, 12.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease

    Alexander, K. K., Naaldijk, Y., Fasiczka, R., Brahmia, B., Chen, T., Hilfiker, S. & Kennedy, E. J., May 2024, In: Journal of Peptide Science. 30, 5, e3563.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • 2023

    A blood-based marker of mitochondrial DNA damage in Parkinson's disease

    Qi, R., Sammler, E., Gonzalez-Hunt, C. P., Barraza, I., Pena, N., Rouanet, J. P., Naaldijk, Y., Goodson, S., Fuzzati, M., Blandini, F., Erickson, K. I., Weinstein, A. M., Lutz, M. W., Kwok, J. B., Halliday, G. M., Dzamko, N., Padmanabhan, S., Alcalay, R. N., Waters, C. & Hogarth, P. & 9 others, Simuni, T., Smith, D., Marras, C., Tonelli, F., Alessi, D. R., West, A. B., Shiva, S., Hilfiker, S. & Sanders, L. H., Aug 2023, In: Science translational medicine. 15, 711, eabo1557.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    21 Scopus citations
  • Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy

    Fdez, E., Fasiczka, R., Lara Ordóñez, A. J., Fernández, B., Naaldijk, Y. & Hilfiker, S., Mar 17 2023, In: STAR Protocols. 4, 1, 102024.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • 2022

    Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity

    Fernández, B., Chittoor-Vinod, V. G., Kluss, J. H., Kelly, K., Bryant, N., Nguyen, A. P. T., Bukhari, S. A., Smith, N., Lara Ordóñez, A. J., Fdez, E., Chartier-Harlin, M. C., Montine, T. J., Wilson, M. A., Moore, D. J., West, A. B., Cookson, M. R., Nichols, R. J. & Hilfiker, S., 2022, In: Journal of Parkinson's Disease. 12, 5, p. 1423-1447 25 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations
  • Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB

    Fernández, B., Olmedo, P., Gil, F., Fdez, E., Naaldijk, Y., Rivero-Ríos, P., Bracher, F., Grimm, C., Churchill, G. C. & Hilfiker, S., Dec 2022, In: Cell Death and Disease. 13, 12, 1047.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    6 Scopus citations
  • Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

    Fdez, E., Madero-Pérez, J., Lara Ordóñez, A. J., Naaldijk, Y., Fasiczka, R., Aiastui, A., Ruiz-Martínez, J., López de Munain, A., Cowley, S. A., Wade-Martins, R. & Hilfiker, S., Jun 17 2022, In: iScience. 25, 6, 104476.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations
  • The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

    Lara Ordóñez, A. J., Fasiczka, R., Fernández, B., Naaldijk, Y., Fdez, E., Ramırez, M. B., Phan, S., Boassa, D. & Hilfiker, S., Aug 2022, In: Biology Open. 11, 8, bio059468.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations
  • Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease

    Iovino, L., Giusti, V., Pischedda, F., Giusto, E., Plotegher, N., Marte, A., Battisti, I., Di Iacovo, A., Marku, A., Piccoli, G., Bandopadhyay, R., Perego, C., Bonifacino, T., Bonanno, G., Roseti, C., Bossi, E., Arrigoni, G., Bubacco, L., Greggio, E. & Hilfiker, S. & 1 others, Civiero, L., Jul 2022, In: Acta Neuropathologica. 144, 1, p. 81-106 26 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    25 Scopus citations
  • 2020

    Distinct roles for RAB10 and RAB29 in pathogenic LRRK2-mediated endolysosomal trafficking alterations

    Rivero-Ríos, P., Romo-Lozano, M., Fernández, B., Fdez, E. & Hilfiker, S., Jul 2020, In: Cells. 9, 7, p. 1-20 20 p., 1719.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

    Obergasteiger, J., Frapporti, G., Lamonaca, G., Pizzi, S., Picard, A., Lavdas, A. A., Pischedda, F., Piccoli, G., Hilfiker, S., Lobbestael, E., Baekelandt, V., Hicks, A. A., Corti, C., Pramstaller, P. P. & Volta, M., Dec 1 2020, In: Cell Death Discovery. 6, 1, 45.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • 2019

    Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

    Fernández, B., Lara Ordóñez, A. J., Fdez, E., Mutez, E., Comptdaer, T., Leghay, C., Kreisler, A., Simonin, C., Vandewynckel, L., Defebvre, L., Destée, A., Bleuse, S., Taymans, J. M., Chartier-Harlin, M. C. & Hilfiker, S., Oct 11 2019, In: Biochemical Journal. 476, 19, p. 2797-2813 17 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    26 Scopus citations
  • RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

    Lara Ordónez, A. J., Fernández, B., Fdez, E., Romo-Lozano, M., Madero-Pérez, J., Lobbestael, E., Baekelandt, V., Aiastui, A., López De Munaín, A., Melrose, H. L., Civiero, L. & Hilfiker, S., Nov 1 2019, In: Human molecular genetics. 28, 21, p. 3552-3568 17 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    59 Scopus citations
  • The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

    Rivero-Ríos, P., Romo-Lozano, M., Madero-Pérez, J., Thomas, A. P., Biosa, A., Greggio, E. & Hilfiker, S., Mar 29 2019, In: Journal of Biological Chemistry. 294, 13, p. 4738-4758 21 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    54 Scopus citations
  • 2018

    Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

    Madero-Pérez, J., Fdez, E., Fernández, B., Lara Ordóñez, A. J., Blanca Ramírez, M., Gómez-Suaga, P., Waschbüsch, D., Lobbestael, E., Baekelandt, V., Nairn, A. C., Ruiz-Martínez, J., Aiastui, A., López De Munain, A., Lis, P., Comptdaer, T., Taymans, J. M., Chartier-Harlin, M. C., Beilina, A., Gonnelli, A. & Cookson, M. R. & 2 others, Greggio, E. & Hilfiker, S., Jan 23 2018, In: Molecular neurodegeneration. 13, 1, 3.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    67 Scopus citations
  • RAB7L1-mediated relocalization of LRRK2 to the golgi complex causes centrosomal deficits via RAB8A

    Madero-Pérez, J., Fernández, B., Lara Ordóñez, A. J., Fdez, E., Lobbestael, E., Baekelandt, V. & Hilfiker, S., Nov 13 2018, In: Frontiers in Molecular Neuroscience. 11, 417.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    32 Scopus citations
  • 2017

    Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

    Fernández, B., Ferrer, I., Gil, F. & Hilfiker, S., 2017, In: Toxicology Reports. 4, p. 188-193 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2

    Ramírez, M. B., Ordóñez, A. J. L., Fdez, E., Madero-Pérez, J., Gonnelli, A., Drouyer, M., Chartier-Harlin, M. C., Taymans, J. M., Bubacco, L., Greggio, E. & Hilfiker, S., Jul 2017, In: Human molecular genetics. 26, 14, p. 2747-2767 21 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    55 Scopus citations
  • 2016

    Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A

    Fernández, B., Fdez, E., Gómez-Suaga, P., Gil, F., Molina-Villalba, I., Ferrer, I., Patel, S., Churchill, G. C. & Hilfiker, S., Sep 1 2016, In: Autophagy. 12, 9, p. 1487-1506 20 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    32 Scopus citations
  • 2014

    In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

    López-Viseras, M. E., Fernández, B., Hilfiker, S., González, C. S., González, J. L., Calahorro, A. J., Colacio, E. & Rodríguez-Diéguez, A., 2014, In: Journal of Inorganic Biochemistry. 131, p. 64-67 4 p.

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations
  • LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

    Gómez-Suaga, P., Rivero-Ríos, P., Fdez, E., Ramírez, M. B., Ferrer, I., Aiastui, A., De Munain, A. L. & Hilfiker, S., Dec 2014, In: Human molecular genetics. 23, 25, p. 6779-6796 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    128 Scopus citations
  • Upstream deregulation of calcium signaling in Parkinson's disease

    Rivero-Ríos, P., Gómez-Suaga, P., Fdez, E. & Hilfiker, S., Jun 17 2014, In: Frontiers in Molecular Neuroscience. 7, JUNE, 53.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    40 Scopus citations
  • 2012

    Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J. U., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L. & Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F. R., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. H. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W. L., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H. I., Cho, D. H., Choi, A. M. K., Choi, D. S., Choi, K. S. O., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M. A., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., de Groot, J. F., de Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z. H., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Eng, K. E. R., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M. A., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A. N., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E. L., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M. I., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J. I., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H. W., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B. E., Kang, K. I. L., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R. Y., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H. U., Kim, J. C. H., Kim, J. K., Kim, P. K., Kim, S. W. H., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H. O., Koike, M., Komatsu, M., Kominami, E., Kong, H. J. E., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovács, A. L., Kraft, C., Krainc, D., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Krüger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J. E., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., László, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J. X., Lee, B. W., Lee, G. M. I., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H. Y., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., Levenson, V. V., Levine, B., Levy, E., Li, F., Li, J. L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., López-Otín, C., Lossi, L., Lotze, M. T., Lőw, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C. H., Malagoli, D., Malicdan, M. C. H. V., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Mariño, G., Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B. A., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Meléndez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A. M., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. N., Mora, R., Moreau, K., Moreira, P. I., Moriyasu, Y., Moscat, J., Mostowy, S., Mottram, J. C., Motyl, T., Moussa, C. E. H., Müller, S., Muller, S., Münger, K., Münz, C., Murphy, L. O., Murphy, M. E., Musarò, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nair, U., Nakagawa, T., Nakahira, K., Nakano, H., Nakatogawa, H., Nanjundan, M., Naqvi, N. I., Narendra, D. P., Narita, M., Navarro, M., Nawrocki, S. T., Nazarko, T. Y., Nemchenko, A., Netea, M. G., Neufeld, T. P., Ney, P. A., Nezis, I. P., Nguyen, H. P. H., Nie, D., Nishino, I., Nislow, C., Nixon, R. A., Noda, T., Noegel, A. A., Nogalska, A., Noguchi, S., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nürnberger, T., Nyfeler, B., Obara, K., Oberley, T. D., Oddo, S., Ogawa, M., Ohashi, T., Okamoto, K., Oleinick, N. L., Oliver, F. J., Olsen, L. J., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Ou, J. H. J., Ouimet, M., Overholtzer, M., Ozpolat, B., Paganetti, P., Pagnini, U., Pallet, N., Palmer, G. E., Palumbo, C., Pan, T., Panaretakis, T., Pandey, U. B. H., Papackova, Z., Papassideri, I., Paris, I., Park, J., Park, O. K., Parys, J. B., Parzych, K. R., Patschan, S., Patterson, C., Pattingre, S., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Pervaiz, S., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Phang, J. M., Piacentini, M., Pierre, P., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Pöggeler, S., Poirot, M., Poletti, A., Poüs, C., Pozuelo-Rubio, M., Prætorius-Ibba, M., Prasad, A., Prescott, M., Priault, M., Produit-Zengaffinen, N., Progulske-Fox, A., Proikas-Cezanne, T., Przedborski, S., Przyklenk, K., Puertollano, R., Puyal, J., Qian, S. B., Qin, L., Qin, Z. H., Quaggin, S. E., Raben, N., Rabinowich, H., Rabkin, S. W., Rahman, I., Rami, A., Ramm, G., Randall, G., Randow, F., Rao, V. A., Rathmell, J. C., Ravikumar, B., Ray, S. K., Reed, B. H., Reed, J. C., Reggiori, F., Régnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., Rodríguez de Córdoba, S., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E. R., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H. O., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M. J., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H. V., Scharl, M., Schätzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schüller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B. O., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Silva-Zacarin, E. C. M., Simmons, A., Simon, A. K. A., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W. A., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stenmark, H., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Strålfors, P., Subauste, C. S., Sui, X., Sulzer, D., Sun, J., Sun, S. Y., Sun, Z. J., Sung, J. J. Y., Suzuki, K., Suzuki, T., Swanson, M. S., Swanton, C., Sweeney, S. T., Sy, L. K., Szabadkai, G., Tabas, I., Taegtmeyer, H., Tafani, M., Takács-Vellai, K., Takano, Y., Takegawa, K., Takemura, G., Takeshita, F., Talbot, N. J., Tan, K. S. W., Tanaka, K., Tanaka, K., Tang, D., Tang, D., Tanida, I., Tannous, B. A., Tavernarakis, N., Taylor, G. S., Taylor, G. A., Taylor, J. P., Terada, L. S., Terman, A., Tettamanti, G., Thevissen, K., Thompson, C. B., Thorburn, A., Thumm, M., Tian, F. F., Tian, Y., Tocchini-Valentini, G., Tolkovsky, A. M., Tomino, Y., Tönges, L., Tooze, S. A., Tournier, C., Tower, J., Towns, R., Trajkovic, V., Travassos, L. H., Tsai, T. F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M. A., Van den Berghe, G., van der Klei, I. J., van Doorn, W., van Dyk, L. F., van Egmond, M., van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M. I., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T. E., Voitsekhovskaja, O. V., von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C. H., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y. U., Yang, W., Yang, W. Y. U., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J. I., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H. A., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., Zacks, D., Zacksenhaus, E., Zaffaroni, N., Zakeri, Z., Zeh, H. J., Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D. O., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 1 2012, In: Autophagy. 8, 4, p. 445-544 100 p.

    Research output: Contribution to journalArticlepeer-review

    2923 Scopus citations
  • Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

    Gómez-Suaga, P., Luzón-Toro, B., Churamani, D., Zhang, L., Bloor-Young, D., Patel, S., Woodman, P. G., Churchill, G. C. & Hilfiker, S., Feb 2012, In: Human molecular genetics. 21, 3, p. 511-525 15 p., ddr481.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    262 Scopus citations
  • 2011

    Posttranslational modifications as versatile regulators of parkin function

    Rubio De La Torre, E., Gómez-Suaga, P., Martínez-Salvador, M. & Hilfiker, S., Jun 2011, In: Current Medicinal Chemistry. 18, 16, p. 2477-2485 9 p.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • 2010

    Transmembrane-domain determinants for SNARE-mediated membrane fusion

    Fdez, E., Martínez-Salvador, M., Beard, M., Woodman, P. & Hilfiker, S., Jul 15 2010, In: Journal of cell science. 123, 14, p. 2473-2480 8 p.

    Research output: Contribution to journalArticlepeer-review

    42 Scopus citations
  • 2009

    Combined kinase inhibition modulates parkin inactivation

    de la Torre, E. R., Luzón-Toro, B., Forte-Lago, I., Minguez-Castellanos, A., Ferrer, I. & Hilfiker, S., 2009, In: Human molecular genetics. 18, 5, p. 809-823 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    52 Scopus citations
  • 2008

    A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion

    Fdez, E., Jowitt, T. A., Wang, M. C., Rajebhosale, M., Foster, K., Bella, J., Baldock, C., Woodman, P. G. & Hilfiker, S., Aug 2008, In: Molecular biology of the cell. 19, 8, p. 3379-3389 11 p.

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations
  • Hydroxytyrosol increases norepinephrine transporter function in pheochromocytoma cells

    Luzón-Toro, B., Geerlings, A. & Hilfiker, S., Oct 2008, In: Nuclear Medicine and Biology. 35, 7, p. 801-804 4 p.

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations
  • 2007

    A delayed response enhancement during hippocampal presynaptic plasticity in mice

    Jensen, V., Walaas, S. I., Hilfiker, S., Ruiz, A. & Hvalby, Ø., Aug 15 2007, In: Journal of Physiology. 583, 1, p. 129-143 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    31 Scopus citations
  • Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

    Luzón-Toro, B., de la Torre, E. R., Delgado, A., Pérez-Tur, J. & Hilfiker, S., Sep 1 2007, In: Human molecular genetics. 16, 17, p. 2031-2039 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    119 Scopus citations
  • 2006

    Vesicle pools and synapsins: New insights into old enigmas

    Fdez, E. & Hilfiker, S., Jun 2006, In: Brain Cell Biology. 35, 2-3, p. 107-115 9 p.

    Research output: Contribution to journalArticlepeer-review

    77 Scopus citations
  • 2005

    Structural domains involved in the regulation of transmitter release by synapsins

    Hilfiker, S., Benfenati, F., Doussau, F., Nairn, A. C., Czernik, A. J., Augustine, G. J. & Greengard, P., Mar 9 2005, In: Journal of Neuroscience. 25, 10, p. 2658-2669 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    116 Scopus citations
  • 2003

    Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages

    Brough, D., Le Feuvre, R. A., Wheeler, R. D., Solovyova, N., Hilfiker, S., Rothwell, N. J. & Verkhratsky, A., Mar 15 2003, In: Journal of Immunology. 170, 6, p. 3029-3036 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    135 Scopus citations
  • Neuronal calcium sensor-1: A multifunctional regulator of secretion

    Hilfiker, S., Aug 2003, In: Biochemical Society transactions. 31, 4, p. 828-832 5 p.

    Research output: Contribution to journalArticlepeer-review

    48 Scopus citations
  • Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells

    Rajebhosale, M., Greenwood, S., Vidugiriene, J., Jeromin, A. & Hilfiker, S., Feb 21 2003, In: Journal of Biological Chemistry. 278, 8, p. 6075-6084 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    62 Scopus citations
  • 2002

    Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase β interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis

    Taverna, E., Francolini, M., Jeromin, A., Hilfiker, S., Roder, J. & Rosa, P., Oct 15 2002, In: Journal of cell science. 115, 20, p. 3909-3922 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    58 Scopus citations
  • 2001

    Identification of synapsin I peptides that insert into lipid membranes

    Cheetham, J. J., Hilfiker, S., Benfenati, F., Weber, T., Greengard, P. & Czernik, A. J., Feb 15 2001, In: Biochemical Journal. 354, 1, p. 57-66 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    54 Scopus citations
  • Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse

    Hilfiker, S., Czernik, A. J., Greengard, P. & Augustine, G. J., Feb 15 2001, In: Journal of Physiology. 531, 1, p. 141-146 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    37 Scopus citations
  • 2000

    Decrease in phorbol ester-induced potentiation of noradrenaline release in synapsin I-deficient mice

    Walaas, S. I., Hilfiker, S., Li, L., Chin, L. S. & Greengard, P., 2000, In: Synapse. 36, 2, p. 114-119 6 p.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • 1999

    Molecular evolution of the synapsin gene family

    Kao, H. T., Porton, B., Hilfiker, S., Stefani, G., Pieribone, V. A., DeSalle, R. & Greengard, P., Dec 15 1999, In: Journal of Experimental Zoology. 285, 4, p. 360-377 18 p.

    Research output: Contribution to journalArticlepeer-review

    101 Scopus citations
  • Regulation of synaptotagmin I phosphorylation by multiple protein kinases

    Hilfiker, S., Pieribone, V. A., Nordstedt, C., Greengard, P. & Czernik, A. J., 1999, In: Journal of neurochemistry. 73, 3, p. 921-932 12 p.

    Research output: Contribution to journalArticlepeer-review

    88 Scopus citations
  • Synapsins as regulators of neurotransmitter release

    Hilfiker, S., Pieribone, V. A., Czernik, A. J., Kao, H. T., Augustine, G. J. & Greengard, P., Feb 28 1999, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 354, 1381, p. 269-279 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    466 Scopus citations
  • 1998

    Two sites of action for synapsin domain E in regulating neurotransmitter release

    Hilfïker, S., Schweizer, F. E., Kao, H. T., Czernik, A. J., Greengard, P. & Augustine, G. J., 1998, In: Nature Neuroscience. 1, 1, p. 29-35 7 p.

    Research output: Contribution to journalArticlepeer-review

    136 Scopus citations
  • 1995

    Distinct pools of synaptic vesicles in neurotransmitter release

    Pieribone, V. A., Shupliakov, O., Brodin, L., Hilfiker-Rothenfluh, S., Czernik, A. J. & Greengard, P., Jun 8 1995, In: Nature. 375, 6531, p. 493-497 5 p.

    Research output: Contribution to journalArticlepeer-review

    451 Scopus citations
  • Dynamic interaction of the protein translocation systems in the inner and outer membranes of yeast mitochondria

    Horst, M., Hilfiker-Rothenfluh, S., Oppliger, W. & Schatz, G., 1995, In: EMBO Journal. 14, 10, p. 2293-2297 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    83 Scopus citations