• 3967 Citations
  • 33 h-Index
1990 …2023

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2019

Gαq Sensitizes TRPM8 to Inhibition by PI(4,5)P2 Depletion upon Receptor Activation

Liu, L., Yudin, Y., Nagwekar, J., Kang, C., Shirokova, N. & Rohacs, T., Jul 31 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 31, p. 6067-6080 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular mechanism of TRPV2 channel modulation by cannabidiol

Pumroy, R. A., Samanta, A., Liu, Y., Hughes, T. E. T., Zhao, S., Yudin, Y., Rohacs, T., Han, S. & Moiseenkova-Bell, V. Y., Sep 2019, In : eLife. 8

Research output: Contribution to journalArticle

3 Scopus citations

Structure-based characterization of novel TRPV5 inhibitors

Hughes, T. E. T., Rosario, J. S. D., Kapoor, A., Yazici, A. T., Yudin, Y., Fluck, E. C., Filizola, M., Rohacs, T. & Moiseenkova-Bell, V. Y., Oct 2019, In : eLife. 8, e49572.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels

Yudin, Y. & Rohacs, T., Jan 1 2019, In : British Journal of Pharmacology. 176, 17, p. 3110-3125 16 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine

Kasimova, M. A., Yazici, A. T., Yudin, Y., Granata, D., Klein, M. L., Rohacs, T. & Carnevale, V., Nov 1 2018, In : Journal of General Physiology. 150, 11, p. 1554-1566 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

Kasimova, M. A., Yazici, A., Yudin, Y., Granata, D., Klein, M. L., Rohacs, T. & Carnevale, V., Mar 15 2018, In : Journal of Physical Chemistry Letters. 9, 6, p. 1260-1264 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

Hughes, T. E. T., Lodowski, D. T., Huynh, K. W., Yazici, A., Del Rosario, J., Kapoor, A., Basak, S., Samanta, A., Han, X., Chakrapani, S., Zhou, Z. H., Filizola, M., Rohacs, T., Han, S. & Moiseenkova-Bell, V. Y., Jan 1 2018, In : Nature Structural and Molecular Biology. 25, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Structural insights on TRPV5 gating by endogenous modulators

Hughes, T. E. T., Pumroy, R. A., Yazici, A. T., Kasimova, M. A., Fluck, E. C., Huynh, K. W., Samanta, A., Molugu, S. K., Zhou, Z. H., Carnevale, V., Rohacs, T. & Moiseenkova-Bell, V. Y., Dec 1 2018, In : Nature communications. 9, 1, 4198.

Research output: Contribution to journalArticle

29 Scopus citations
2017

Inhibition of transient receptor potential Melastatin 3 ion channels by G-protein βγ subunits

Badheka, D., Yudin, Y., Borbiro, I., Hartle, C. M., Yazici, A., Mirshahi, T. & Rohacs, T., Aug 15 2017, In : eLife. 6, e26147.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of Piezo Channels by Cellular Signaling Pathways

Borbiro, I. & Rohacs, T., Jan 1 2017, In : Current Topics in Membranes. 79, p. 245-261 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Beckerman, P., Bi-Karchin, J., Park, A. S. D., Qiu, C., Dummer, P. D., Soomro, I., Boustany-Kari, C. M., Pullen, S. S., Miner, J. H., Hu, C. A. A., Rohacs, T., Inoue, K., Ishibe, S., Saleem, M. A., Palmer, M. B., Cuervo, A. M., Kopp, J. B. & Susztak, K., Apr 1 2017, In : Nature medicine. 23, 4, p. 429-438 10 p.

Research output: Contribution to journalArticle

104 Scopus citations
2016

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels

Velisetty, P., Borbiro, I., Kasimova, M. A., Liu, L., Badheka, D., Carnevale, V. & Rohacs, T., Jun 13 2016, In : Scientific reports. 6, 27652.

Research output: Contribution to journalArticle

10 Scopus citations

Phospholipase C δ4 regulates cold sensitivity in mice

Yudin, Y., Lutz, B., Tao, Y. X. & Rohacs, T., Jul 1 2016, In : Journal of Physiology. 594, 13, p. 3609-3628 20 p.

Research output: Contribution to journalArticle

10 Scopus citations

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin

Elokely, K., Velisetty, P., Delemotte, L., Palovcak, E., Klein, M. L., Rohacs, T. & Carnevale, V., Jan 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. E137-E145

Research output: Contribution to journalArticle

54 Scopus citations
2015

Activation of TRPV1 channels inhibits mechanosensitive piezo channel activity by depleting membrane phosphoinositides

Borbiro, I., Badheka, D. & Rohacs, T., Feb 10 2015, In : Science signaling. 8, 363, ra15.

Research output: Contribution to journalArticle

53 Scopus citations

Phosphoinositide sensitivity of ion channels, a functional perspective

Gamper, N. & Rohacs, T., Jan 1 2015, In : Sub-Cellular Biochemistry. 59, p. 289-333 45 p.

Research output: Contribution to journalArticle

23 Scopus citations

Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel

Badheka, D., Borbiro, I. & Rohacs, T., Jan 1 2015, In : Journal of General Physiology. 146, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons

Lukacs, V., Yudin, Y., Hammond, G. R., Sharma, E., Fukami, K. & Rohacs, T., Jul 26 2013, In : Journal of Neuroscience. 33, 28, p. 11451-11463 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels

Cao, C., Zakharian, E., Borbiro, I. & Rohacs, T., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5278-5290 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Polyester modification of the mammalian trpm8 channel protein: Implications for structure and function

Cao, C., Yudin, Y., Bikard, Y., Chen, W., Liu, T., Li, H., Jendrossek, D., Cohen, A., Pavlov, E., Rohacs, T. & Zakharian, E., Jul 25 2013, In : Cell Reports. 4, 2, p. 302-315 14 p.

Research output: Contribution to journalArticle

31 Scopus citations
37 Scopus citations
2011

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels

Yudin, Y., Lukacs, V., Cao, C. & Rohacs, T., Dec 1 2011, In : Journal of Physiology. 589, 24, p. 6007-6027 21 p.

Research output: Contribution to journalArticle

52 Scopus citations

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2

Zakharian, E., Cao, C. & Rohacs, T., Nov 1 2011, In : FASEB Journal. 25, 11, p. 3915-3928 14 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers

Zakharian, E., Cao, C. & Rohacs, T., Sep 15 2010, In : Journal of Neuroscience. 30, 37, p. 12526-12534 9 p.

Research output: Contribution to journalArticle

95 Scopus citations
2009

Inorganic polyphosphate modulates TRPM8 channels

Zakharian, E., Thyagarajan, B., French, R. J., Pavlov, E. & Rohacs, T., Apr 30 2009, In : PloS one. 4, 4, e5404.

Research output: Contribution to journalArticle

95 Scopus citations

Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca 2+ transport

Thyagarajan, B., Benin, B. S., Christakos, S. & Rohacs, T., Mar 1 2009, In : Molecular Pharmacology. 75, 3, p. 608-616 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2008

Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels

Thyagarajan, B., Lukacs, V. & Rohacs, T., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 14980-14987 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
2007

Dual regulation of TRPV1 by phosphoinositides

Lukacs, V., Thyagarajan, B., Varnai, P., Balla, A., Balla, T. & Rohacs, T., Jun 27 2007, In : Journal of Neuroscience. 27, 26, p. 7070-7080 11 p.

Research output: Contribution to journalArticle

202 Scopus citations

Protein kinase a modulates plc-dependent regulation and PIP2-sensitivity of K+ channels

Lopes, C. M. B., Remon, J. I., Matavel, A., Sui, J. L., Keselman, I., Medei, E., Shen, Y., Rosenhouse-Dantsker, A., Rohacs, T. & Logothetis, D. E., Jan 1 2007, In : Channels. 1, 2, p. 124-134 11 p.

Research output: Contribution to journalArticle

39 Scopus citations
2006

Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells

Varnai, P., Thyagarajan, B., Rohacs, T. & Balla, T., Nov 6 2006, In : Journal of Cell Biology. 175, 3, p. 377-382 6 p.

Research output: Contribution to journalArticle

252 Scopus citations
2005

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain

Rohacs, T., Lopes, C. M. B., Michailidis, I. & Logothetis, D. E., May 1 2005, In : Nature Neuroscience. 8, 5, p. 626-634 9 p.

Research output: Contribution to journalArticle

410 Scopus citations

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels

Lopes, C. M. B., Rohács, T., Czirják, G., Balla, T., Enyedi, P. & Logothetis, D. E., Apr 1 2005, In : Journal of Physiology. 564, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

129 Scopus citations

Teaching resources. TRP channels.

Rohacs, T., May 3 2005, In : Science's STKE : signal transduction knowledge environment. 2005, 282, p. tr14

Research output: Contribution to journalArticle

2 Scopus citations
2004

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of Kir channels by diverse modulators

Du, X., Zhang, H., Lopes, C., Mirshahi, T., Rohacs, T. & Logothetis, D. E., Sep 3 2004, In : Journal of Biological Chemistry. 279, 36, p. 37271-37281 11 p.

Research output: Contribution to journalArticle

147 Scopus citations
2003

PIP2 activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents

Zhang, H., Craciun, L. C., Mirshahi, T., Rohács, T., Lopes, C. M. B., Jin, T. & Logothetis, D. E., Mar 27 2003, In : Neuron. 37, 6, p. 963-975 13 p.

Research output: Contribution to journalArticle

366 Scopus citations

Sorcin regulates excitation-contraction coupling in the heart

Meyers, M. B., Fischer, A., Sun, Y. J., Lopes, C. M. B., Rohacs, T., Nakamurall, T. Y., Zhoull, Y. Y., Lee, P. C., Altschuld, R. A., McCune, S. A., Coetzeell, W. A. & Fishman, G. I., Aug 1 2003, In : Journal of Biological Chemistry. 278, 31, p. 28865-28871 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Specificity of activation by phosphoinositides determines lipid regulation of Kir channels

Rohács, T., Lopes, C. M. B., Jin, T., Ramdya, P. P., Molnár, Z. & Logothetis, D. E., Jan 21 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 2, p. 745-750 6 p.

Research output: Contribution to journalArticle

152 Scopus citations
2002

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

Lopes, C. M. B., Zhang, H., Rohacs, T., Jin, T., Yang, J. & Logothetis, D. E., Jun 13 2002, In : Neuron. 34, 6, p. 933-944 12 p.

Research output: Contribution to journalArticle

302 Scopus citations

The βγ subunits of G proteins gate a K+ channel by pivoted bending of a transmembrane segment

Jin, T., Peng, L., Mirshahi, T., Rohacs, T., Chan, K. W., Sanchez, R. & Logothetis, D. E., Sep 1 2002, In : Molecular cell. 10, 3, p. 469-481 13 p.

Research output: Contribution to journalArticle

108 Scopus citations
2001

Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

Spät, A., Pitter, J. G., Rohács, T. & Szabadkai, G., Oct 1 2001, In : News in Physiological Sciences. 16, 5, p. 197-200 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
2000

Calcium signal and mitochondrial metabolism in steroid producing cells

Spät, A., Pitter, J., Rohacs, T. & Szabadkai, G., Jan 1 2000, In : Endocrine Research. 26, 4, p. 615-616 2 p.

Research output: Contribution to journalArticle

1999

Distinct specificities of inwardly rectifying K+ channels for phosphoinositides

Rohács, T., Chen, J., Prestwich, G. D. & Logothetis, D. E., Dec 17 1999, In : Journal of Biological Chemistry. 274, 51, p. 36065-36072 8 p.

Research output: Contribution to journalArticle

156 Scopus citations
1997

Cytoplasmic Ca2+ and mitochondrial NAD(P)H signal in adrenal glomerulosa cells

Rohacs, T. & Spät, A., Dec 1 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

47 Scopus citations

Intracellular calcium release is more efficient than calcium influx in stimulating mitochondrial NAD(P)H formation in adrenal glomerulosa cells

Rohács, T., Tory, K., Dobos, A. & Spät, A., Dec 1 1997, In : Biochemical Journal. 328, 2, p. 525-528 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
1996

Expression of inositol 1,4,5-trisphosphate receptors in rat adrenocortical zones

Szabadkai, G., Horváth, A., Rohács, T., Vimláti, L., Spät, A. & Enyedi, P., Jan 1996, In : Journal of Steroid Biochemistry and Molecular Biology. 57, 1-2, p. 13-17 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of voltage-dependent calcium channels in angiotensin-stimulated glomerulosa cells

Spät, A., Rohacs, T., Horváth, A., Szabadkai, G. & Enyedi, P., Jan 1 1996, In : Endocrine Research. 22, 4, p. 569-576 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
1994

Capacitative Ca2+ influx in adrenal glomerulosa cells: Possible role in angiotensin II response

Rohacs, T., Bago, A., Deak, F., Hunyady, L. & Spat, A., Jan 1 1994, In : American Journal of Physiology - Cell Physiology. 267, 5 36-5

Research output: Contribution to journalArticle

Capacitative Ca 2+ influx in adrenal glomerulosa cells: Possible role in angiotensin II response

Rohacs, T., Bago, A., Deak, F., Hunyady, L. & Spat, A., Jan 1 1994, In : American Journal of Physiology - Cell Physiology. 267, 5 36-5

Research output: Contribution to journalArticle

38 Scopus citations

Dihydropyridine-sensitive initial component of the ANG II-induced Ca2+ response in rat adrenal glomerulosa cells

Hunyady, L., Rohacs, T., Bago, A., Deak, F. & Spat, A., Feb 21 1994, In : American Journal of Physiology - Cell Physiology. 266, 1 35-1

Research output: Contribution to journalArticle

20 Scopus citations