• 4082 Citations
  • 32 h-Index
1990 …2022

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Article
2020

Lateral hypothalamic orexin glucose-inhibited neurons may regulate reward-based feeding by modulating glutamate transmission in the ventral tegmental area

Teegala, S. B., Sheng, Z., Dalal, M. S., Hirschberg, P. R., Beck, K. D. & Routh, V. H., Mar 15 2020, In : Brain research. 1731, 145808.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Hypoglycemia: Role of hypothalamic glucose-inhibited (GI) neurons in detection and correction

Zhou, C., Teegala, S. B., Khan, B. A., Gonzalez, C. & Routh, V. H., Mar 9 2018, In : Frontiers in Psychiatry. 9, MAR, 192.

Research output: Contribution to journalArticle

6 Scopus citations

Oleic Acid in the Ventral Tegmental Area Inhibits Feeding, Food Reward, and Dopamine Tone

Hryhorczuk, C., Sheng, Z., Décarie-Spain, L., Giguère, N., Ducrot, C., Trudeau, L. É., Routh, V. H., Alquier, T. & Fulton, S., Feb 1 2018, In : Neuropsychopharmacology. 43, 3, p. 607-616 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
10 Scopus citations
2017

Brain GLUT4 knockout mice have impaired glucose tolerance, decreased insulin sensitivity, and impaired hypoglycemic counterregulation

Reno, C. M., Puente, E. C., Sheng, Z., Daphna-Iken, D., Bree, A. J., Routh, V. H., Kahn, B. B. & Fisher, S. J., Mar 1 2017, In : Diabetes. 66, 3, p. 587-597 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons

Hashiguchi, H., Sheng, Z., Routh, V., Gerzanich, V., Simard, J. M. & Bryan, J., Sep 2017, In : PloS one. 12, 9, e0184261.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons

Santiago, A. M., Clegg, D. J. & Routh, V., Oct 1 2016, In : Molecular Metabolism. 5, 10, p. 823-833 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Homeostasis meets motivation in the battle to control food intake

Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S. & O’Connor, E. C., Nov 9 2016, In : Journal of Neuroscience. 36, 45, p. 11469-11481 13 p.

Research output: Contribution to journalArticle

51 Scopus citations
5 Scopus citations

Ventromedial hypothalamic glucose sensing and glucose homeostasis vary throughout the estrous cycle

Santiago, A. M., Clegg, D. J. & Routh, V. H., Dec 1 2016, In : Physiology and Behavior. 167, p. 248-254 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Direct effects of recurrent hypoglycaemia on adrenal catecholamine release

Orban, B. O., Routh, V. H., Levin, B. E. & Berlin, J. R., Jan 16 2015, In : Diabetes and Vascular Disease Research. 12, 1, p. 2-12 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry

Sheng, Z., Santiago, A. M., Thomas, M. P. & Routh, V. H., Sep 2014, In : Molecular and Cellular Neuroscience. 62, p. 30-41 12 p.

Research output: Contribution to journalArticle

48 Scopus citations
2013

Hypothalamic S-Nitrosylation Contributes to the Counter-Regulatory Response Impairment following Recurrent Hypoglycemia

Fioramonti, X., Deak, A., Deshpande, S., Carneiro, L., Zhou, C., Sayed, N., Orban, B., Berlin, J. R., Pénicaud, L., Leloup, C., Beuve, A. & Routh, V. H., Jul 19 2013, In : PloS one. 8, 7, e68709.

Research output: Contribution to journalArticle

13 Scopus citations

Membrane potential dye imaging of ventromedial hypothalamus neurons from adult mice to study glucose sensing

Vazirani, R. P., Fioramonti, X. & Routh, V. H., Jan 1 2013, In : Journal of visualized experiments : JoVE. 81

Research output: Contribution to journalArticle

4 Scopus citations
2012

Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy

Garcia, C. C., Potian, J. G., Hognason, K., Thyagarajan, B., Sultatos, L., Souayah, N., Routh, V. & McArdle, J. J., Aug 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 303, 4

Research output: Contribution to journalArticle

10 Scopus citations
2010

Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia

Diggs-Andrews, K. A., Zhang, X., Song, Z., Daphna-Iken, D., Routh, V. H. & Fisher, S. J., Sep 2010, In : Diabetes. 59, 9, p. 2271-2280 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Glucose sensing neurons in the ventromedial hypothalamus

Routh, V. H., Oct 2010, In : Sensors (Switzerland). 10, 10, p. 9002-9025 24 p.

Research output: Contribution to journalArticle

59 Scopus citations
11 Scopus citations

Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation

Fioramonti, X., Marsollier, N., Song, Z., Fakira, K. A., Patel, R. M., Brown, S., Duparc, T., Pica-Mendez, A., Sanders, N. M., Knauf, C., Valet, P., McCrimmon, R. J., Beuve, A., Magnan, C. & Routh, V. H., Feb 1 2010, In : Diabetes. 59, 2, p. 519-528 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
2009
84 Scopus citations

Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide

Marsollier, N., Kassis, N., Mezghenna, K., Soty, M., Fioramonti, X., Lacombe, A., Joly, A., Pillot, B., Zitoun, C., Vilar, J., Mithieux, G., Gross, R., Lajoix, A. D., Routh, V., Magnan, C. & Cruciani-Guglielmacci, C., Aug 14 2009, In : PloS one. 4, 8, e6649.

Research output: Contribution to journalArticle

10 Scopus citations

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose

Murphy, B. A., Fioramonti, X., Jochnowitz, N., Fakira, K., Gagen, K., Contie, S., Lorsignol, A., Penicaud, L., Martin, W. J. & Routh, V. H., Apr 1 2009, In : American Journal of Physiology - Cell Physiology. 296, 4, p. C746-C756

Research output: Contribution to journalArticle

50 Scopus citations
39 Scopus citations

Motor unit number estimate as a predictor of motor dysfunction in an animal model of type 1 diabetes

Souayah, N., Potian, J. G., Garcia, C. C., Krivitskaya, N., Boone, C., Routh, V. H. & McArdle, J. J., Sep 1 2009, In : American Journal of Physiology - Endocrinology and Metabolism. 297, 3, p. E602-E608

Research output: Contribution to journalArticle

27 Scopus citations
2008

Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons

Kang, L., Sanders, N. M., Dunn-Meynell, A. A., Gaspers, L. D., Routh, V. H., Thomas, A. P. & Levin, B. E., Mar 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 3, p. R784-R792

Research output: Contribution to journalArticle

28 Scopus citations
2007

Characterization of glucosensing neuron subpopulations in the arcuate nucleus: Integration in neuropeptide y and pro-opio melanocortin networks?

Fioramonti, X., Contié, S., Song, Z., Routh, V. H., Lorsignol, A. & Pénicaud, L., May 1 2007, In : Diabetes. 56, 5, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

161 Scopus citations
77 Scopus citations
38 Scopus citations
2006

Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation

McCrimmon, R. J., Song, Z., Cheng, H., McNay, E. C., Weikart-Yeckel, C., Fan, X., Routh, V. H. & Sherwin, R. S., Jun 1 2006, In : Journal of Clinical Investigation. 116, 6, p. 1723-1730 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels

Wang, R., Cruciani-Guglielmacci, C., Migrenne, S., Magnan, C., Cotero, V. E. & Routh, V. H., Mar 1 2006, In : Journal of neurophysiology. 95, 3, p. 1491-1498 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Fatty acid signaling in the hypothalamus and the neural control of insulin secretion

Migrenne, S., Cruciani-Guglielmacci, C., Kang, L., Wang, R., Rouch, C., Lefèvre, A. L., Ktorza, A., Routh, V. H., Levin, B. E. & Magnan, C., Dec 1 2006, In : Diabetes. 55, SUPPL. 2, p. S139-S144

Research output: Contribution to journalArticle

42 Scopus citations

Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing

Kang, L., Dunn-Meynell, A. A., Routh, V. H., Gaspers, L. D., Nagata, Y., Nishimura, T., Eiki, J., Zhang, B. B. & Levin, B. E., Feb 1 2006, In : Diabetes. 55, 2, p. 412-420 9 p.

Research output: Contribution to journalArticle

141 Scopus citations
58 Scopus citations
2005

Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus

Song, Z. & Routh, V. U., Jan 1 2005, In : Diabetes. 54, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

128 Scopus citations
2004

Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons

Kang, L., Routh, V. H., Kuzhikandathil, E. V., Gaspers, L. D. & Levin, B. E., Mar 1 2004, In : Diabetes. 53, 3, p. 549-559 11 p.

Research output: Contribution to journalArticle

228 Scopus citations

The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides

Wang, R., Liu, X., Hentges, S. T., Dunn-Meynell, A. A., Levin, B. E., Wang, W. & Routh, V. H., Aug 1 2004, In : Diabetes. 53, 8, p. 1959-1965 7 p.

Research output: Contribution to journalArticle

209 Scopus citations
2002

Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons

Dunn-Meynell, A. A., Routh, V. H., Kang, L., Gaspers, L. & Levin, B. E., Jan 1 2002, In : Diabetes. 51, 7, p. 2056-2065 10 p.

Research output: Contribution to journalArticle

242 Scopus citations

Glucose-sensing neurons: Are they physiologically relevant?

Routh, V., Jan 1 2002, In : Physiology and Behavior. 76, 3, p. 403-413 11 p.

Research output: Contribution to journalArticle

181 Scopus citations
2001

Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus

Song, Z., Levin, B. E., McArdle, J. J., Bakhos, N. & Routh, V. H., Dec 2001, In : Diabetes. 50, 12, p. 2673-2681 9 p.

Research output: Contribution to journalArticle

220 Scopus citations

Workshop on hypoglycemia and the brain

Alavi, A., Chamberlain, J., Cherrington, A. D., Convit, A., Craft, S., Cryer, P. E., Davis, S. N., Davison, S., De Leon, M., DeRosa, M., Drucker, D., Albert, M., Evans, M., Feldman, E., Fischbach, G. D., Fradkin, J., Furlanetto, R., Galassetti, P., Garfield, S., Ginsberg, M. D. & 62 others, Goldberg, M. P., Goldstein, R., Amiel, S. A., Gruetter, R., Guastaferro, C., Harmon, J., Herbel, G., Himelfarb, M., Hurlbert, M., Jacobson, L., Kumagai, A. K., Landis, D., Laughlin, M., Atwell, C. W., Levin, B. E., Linder, B., McCall, A., Mobbs, C., Moncrief, M. B., Novotny, J., Pampanelli, S., Pellerin, L., Penn, A., Petersen, M., Banarer, S., Porro, J., Powers, W. J., Puczynski, S., Queenan, C., Ransom, B., Reagan, L., Ritter, S., Rothman, D. L., Rothman, S. M., Routh, V., Behar, T., Ryan, C., Schnieder, V., Seaquist, E. R., Sharp, F. R., Sherwin, R. S., Siegel, B., Sigal, C., Shiota, C., Simpson, I. A., Smith, P. F., Bolli, G. B., Sokoloff, L., Spiegel, A. M., Stoffel, M., Swanson, R., Tamborlane, W., Tekkök, S. B., Tkacs, N. C., Vannucci, S., Wieloch, T., Ye, Z., Boyle, P., Ying, W., Winfield, D., Pekar, N. & Brown, A., Nov 15 2001, In : Diabetes Technology and Therapeutics. 3, 3, p. 469-516 48 p.

Research output: Contribution to journalArticle

2000

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H. & Ashford, M. L. J., Aug 7 2000, In : Nature Neuroscience. 3, 8, p. 757-758 2 p.

Research output: Contribution to journalArticle

403 Scopus citations
1998

Adiposity and serum leptin increase in fatty (fa/fa) BNZ neonates without decreased VMH serotonergic activity

Horwitz, B. A., Hamilton, J. S., Routh, V. H., Green, K., Havel, P. & Chan, A., Jun 1 1998, In : American Journal of Physiology - Endocrinology and Metabolism. 274, 6 37-6, p. E1009-E1017

Research output: Contribution to journalArticle

5 Scopus citations

Adiposity and serum leptin increase in fatty (fa/fa) BNZ neonates without decreased VMH serotonergic activity

Horwitz, B. A., Hamilton, J. S., Routh, V. H., Green, K., Havel, P. & Chan, A., Dec 1 1998, In : American Journal of Physiology. 274, 6 PART 1

Research output: Contribution to journalArticle

6 Scopus citations
1997
8 Scopus citations

Low-affinity solfonylurea binding sites reside on neuronal cell bodies in the brain

Dunn-Meynell, A. A., Routh, V. H., McArdle, J. J. & Levin, B. E., Jan 16 1997, In : Brain research. 745, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Phosphorylation modulates the activity of the ATP-sensitive K+ channel in the ventromedial hypothalamic nucleus

Routh, V. H., McArdle, J. J. & Levin, B. E., Dec 5 1997, In : Brain research. 778, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

35 Scopus citations
1996
1 Scopus citations

Role of the brain in energy balance and obesity

Levin, B. E. & Routh, V. H., Dec 1 1996, In : American Journal of Physiology. 271, 3 PART 2, p. R491-R500

Research output: Contribution to journalArticle

114 Scopus citations
1995

Adrenalectomy increases serotonin turnover in brains of obese Zucker rats

Routh, V. H., Stern, J. S. & Horwitz, B. A., Sep 1995, In : Physiology and Behavior. 58, 3, p. 491-499 9 p.

Research output: Contribution to journalArticle

8 Scopus citations