AGROCHEMICAL IMPACTS ON HUMAN AND ENVIRONMENTAL HEALTH: MECHANISMS AND MITIGATION

Project Details

Description

The current issue is the evaluation of impact of multiple pesticides entering into surface and groundwater and the effects that these levels have on aquatic species inhabiting these rivers and lakes.Pesticides are designed to inhibit or block pathways that are involved in neurotransmission, and other hormonal related targets that can alter normal developmenteven at low level exposure because of impacts on developing organisms.Recent studies by the USGS have illustrated that a number of commonly used pesticides are present as mixturesin streams and lakes in agricultural, rural and urban environments. Some of these are what are refered to as legacy pesticides or their metabolites that have been not used for many years but are still present and likely impacting aquatic life.Research has shown that in lower vertebrates (finfish, reptiles)and higher vertebrates (rodents, mammals) the embryonic andearly development stages are much more sensitive to a large number oftoxic compounds than adults. This is in part due to the disruption of normal development at the cellular and subcellular levels that results in embryonic death, structural damage or effectswhich may not be manifested untilsexual maturity oradulthood. Our studies will address, the additive or non-additive effects of these pesticides on theembryo, juvenile and adult zebrafish model system. The ultimate goal is touseexisting computersoftware (Bench Mark Dose software USEPA)tocalculate levels that would be protectivebased on statistical values. Based on these values, policy decisions can be made as to what if any remedial activities might be needed to protectaquatic species.If highly conserved pathways are involved then this could be applicable to humans utilizing these water for drinking water or recreational fishing and hunting.
StatusActive
Effective start/end date10/1/109/30/20

Funding

  • National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))

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