ALLELE SHARING ALGORITHMS

Project Details

Description

A computer algorithm is being developed to count the number of
alleles that siblings and half siblings have in common, after the
mother's alleles are subtracted from each child. These allele counts
are averaged for each pair of people in question. Deviations from
expected average values give an indication of problems in the
pedigree structure (e.g., non-paternity, mislabeled DNA samples) when
a large number of genetic markers are tested. The method has been
used to examine 60 JP pedigrees with favorable preliminary results.
When conducting linkage analysis studies using family pedigrees, it
is important that the family structure is accurately reported, in
order to detect linkage between an inherited disease and genetic
marker. To improve our ability to verify family structures, we have
developed a new strategy to evaluate allele sharing among family
members.
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Genetics

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