BALZERS BAF 500K ULTRA HIGH VACCUM FREEZE ETCH SYSTEM

Project Details

Description

The methods of rotary shadowing, freeze-etch and freeze-
fracture have had significant impact on our ability to elucidate
the structure of macromolecules and the architectural structures
they assemble into, both in vitro and in situ. Improvements in
instrumentation for these methods have substantially improved
their use in the study of molecular fine structure and
supramolecular assemblies of increasing complexity. At Rutgers Medical School there is a group of highly qualified
investigators of matrix structure and function; of matrix
molecular biology; of the relationships between matrix and cells
in growth and development; and of the alterations which occur in
matrix in a variety of diseases. These funded investigators are
currently attempting to dissect the architecture of
macromolecular complexes of matrix components by x-ray
diffraction; low, intermediate and high voltage TEM; SEM; and
computer assisted reconstruction of serial TEM sections.
Essential for many of these studies is the use of state-of-the-art
rotary shadow, freeze-etch and freeze-fracture to examine
matrix structure. We request funds for the purchase of an ultra high vacuum freeze-
etch unit equipped with frozen microtome, electron beam guns,
quartz crystal thickness monitor from Balzers, as well as a
stereoscope.
StatusFinished
Effective start/end date2/23/872/22/88

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)

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