Project Details


This application is for a Biacore 2000 Instrument to be located at the
Public Health Research Institute. A group of five principal
investigators, all of whom are recipients of NIH grants, will comprise the
major user group. In addition, minor users both inside and outside the
Institute will have access to the instrument on a selective basis. The
projects to which the Biacore instrument will be applied are varied in
nature. Two of them (Drs. Pinter and Tilley) are HIV -related. Dr. Pinter
is concerned with vaccine development and will use SPR to explore the
affinities of various monoclonals to defined epitopes in the V1/V2 domain.
Dr. Tilley will use the instrument to study the reactivities of
monoclonals, and seropositive sera with HIV-1 envelope glycoproteins and
epitopes thereof. Dr. Penetsky will use SPR to explore the assembly of
the F1/F0 ATPase. Dr. Dubnau will use the Biacore 2000 to study a variety
of protein-protein and protein-DNA interactions involved in the regulation
of competence development and the uptake of transforming DNA by competent
bacteria. Dr. Pine will explore the influence of M. tuberculosis infection
of macrophages on the DNA-binding activities of several transcription
Effective start/end date3/1/982/28/99


  • Medicine(all)


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