CALCIUM ENTRY &ACTION AT THE PRESYNAPTIC NERVE TERMINAL

Project Details

Description

We have planned a conference, under the auspices of the New York Academy of
Sciences, on the calciUM-dependent release of neurotransmitter substances
from the presynaptic nerve terminal. Synaptic transmission is a fundamental
processes in brain function but transmitter release mechanisms remain
poorly understood. This conference will focus on nerve terminals but will
draw on findings from other cell types in the discussion of the biophysical
and pharmacological properties of nerve terminal calcium channels, the
entry and distribution of calcium ions after the nerve impulse, the
physiology of calcium-dependent transmitter release, and the mechanism
whereby calcium triggers secretory vesicle fusion. In addition, new
experimental techniques will be highlighted that allow direct
experimentation on vertebrate nerve terminals. The intent of this meeting
is to offer an opportunity for investigators in these fields to become
aware of, and to contribute to each others interests and, by identifying
gaps in our knowledge, to indicate promising lines of research. The
importance of synaptic transmission to brain research in general, and the
rapid advance of research on all aspects of the biology of calcium ions,
make a focussed conference on this issue particularly timely.
StatusFinished
Effective start/end date8/1/907/31/91

Funding

  • National Institute of Mental Health

ASJC

  • Physiology

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