CANCER CENTER

  • Bertino, Joseph (PI)
  • Hochster, Howard (PI)
  • Kluger, Harriet (PI)
  • Jones, Beth (PI)
  • Garofalo, Robert S. (PI)
  • Crews, Craig (PI)
  • Haberman, Ann (PI)
  • Janeway, Charles (PI)
  • Bosenberg, Marcus (PI)
  • Mothes, Walther (PI)
  • Chen, Lieping (PI)
  • Curnen, Mary G. (PI)
  • Petrylak, Daniel Peter (PI)
  • Anderson, Karen S. (PI)
  • Carter, Darryl (PI)
  • Shuangge, Ma (PI)
  • Jamieson, James (PI)
  • Weissman, Sherman (PI)
  • Irwin, Melinda (PI)
  • Mane, Shrikant (PI)
  • Sartorelli, Alan (PI)
  • Nath, Ravinder (PI)
  • Costa, Jose (PI)
  • Pizzorno, Giuseppe (PI)
  • Brownstein, David (PI)
  • Devita, Vincent (PI)
  • Rimm, David (PI)
  • Mehta, Rajni (PI)
  • Glazer, Peter (PI)
  • Bale, Allen Everett (PI)
  • Schlessinger, Joseph (PI)
  • Edelson, Richard (PI)
  • Hager, Janet (PI)
  • McGrath, James (PI)
  • Kelly, William Kevin (PI)
  • Matloff, Ellen Tzivia (PI)
  • Mayne, Susan (PI)
  • Miller, Perry (PI)
  • McMurray, Walter (PI)
  • Cheng, Yung- (PI)
  • Dimaio, Daniel (PI)
  • Shlomchik, Mark (PI)
  • Sklar, Jeffrey (PI)
  • Holford, Theodore (PI)
  • Mellman, Ira (PI)
  • Lynch, Thomas James (PI)
  • Fuchs, Charles (PI)
  • Schulam, Peter (PI)
  • Deiseroth, Albert (PI)
  • Anderson, Susan (PI)
  • McGarth, James (PI)
  • Zelterman, Daniel (PI)
  • Fine, Judith (PI)
  • Carbone, Rocco (PI)
  • Matloff, Ellen (PI)
  • Nath, Ravinder (PI)
  • Sznol, Mario (PI)

Project Details

Description

The YCCC requests continued support for grant related activities that
include 9 shared resources, 14 established research programs, 1 developing
program and a new clinical trials protocol review and development system.
These programs are managed under the direction of four associate
directors, working in conjunction with the Director, and an Associate
Director, and his administrative staff in four areas: Basic Science,
Clinical Science, and Cancer Prevention Research, and Community Research.
An Associate Director of Education oversees the Education and training
programs of the center. We request continued support for this senior
leadership and leaders of established research programs, for planning and
evaluation, and developmental funds, and administration.
Interdisciplinary coordination in the clinical areas is facilitated by the
use of disease oriented units in Breast, GU, GI and Head and Neck cancers;
Melanoma, Lymphomas, Brain tumor and a support unit on bone marrow
transplantation. Yale's extraordinary depth in Molecular Biology provides
focus for the centers translational research. The clinical Research
programs are organized around major specialties and have been augmented in
this grant cycle by an expanded emphasis on the use of new technology to
overcome the major limitations of cancer treatment and prevention by
transferring through the means of a shared resource, formerly the tissue
retrieval resource, and now the Critical technologies Shared Resource, the
capability to include sophisticated molecular technologies in clinical
trials in diagnosis, treatment and Prevention, to allow the proper
preservation of tissue, and the measurement of both structure and function
to correlate with outcome. A new shared resource since the last grant
cycle, Clinical Pharmacology, takes advantage of the YCCC's strength in
Cancer Pharmacology. Other shared resources include, Flow Cytometry,
Animal Tumor Models, Tissue Culture/Media Preparation, Mass Spectrometry,
a Cesium-13T Irradiator, and a Transgenic Mouse Shared Resource. The
basic research programs in Pathology, Molecular Oncology and Development,
Molecular Virology and Cell Biology all emphasize research on oncogenes
and suppressor oncogenes vis-a-vis the cell signaling systems. The
Program in Immunology focuses on regulation of antigen and growth control
processing by T-cells. The Developmental Therapeutics?Chemotherapy
Program aims at developing anticancer agents directed at newly identified
molecular targets. A developing program in Cancer Genetics will attempt
to translate these activities into clinically useful tools.
StatusActive
Effective start/end date12/1/777/31/23

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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