CARDIOVASCULAR CONTROL IN NORMAL AND DISEASE STATES

Project Details

Description

The major goals of this research proposal are to describe and analyze
cardiovascular control mechanisms with particular emphasis on the autonomic
nervous system in normal healthy conscious animals, instrumented for direct and
instantaneous measurements and radiotelemetry of coronary and regional blood
flows and vascular resistances, ventricular function and myocardial
contractility. Miniature pressure gauges will be implanted in the left and
right ventricles and aorta, ultrasonic dimension transducers will be opposed on
the endocardial surfaces of the left ventricle and Doppler ultrasonic or
electromagnetic flow probes will be placed on the ascending aorta, coronary,
mesenteric, renal and iliac arteries. In order to achieve these goals several
specific interlocking groups of projects are planned. First of all, the
afferent limb of the autonomic nervous system controlling the circulation will
be examined, e.g., regulation by arterial baroreceptors, chemoreceptors,
pulmonary inflation receptors, and low pressure vagal afferents. Secondly
efferent autonomic control of ventricular performance, the coronary circulation,
and the regional circulations will be studied. Thirdly, autonomic control
during exercise will be examined. Thus, the aim of this research proposal is to
gain a clearer understanding of the control of the cardiovascular system by the
autonomic nervous system in the normal conscious animal.
StatusFinished
Effective start/end date12/31/894/30/13

Funding

  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute

ASJC

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine
  • Physiology

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