Fungi can wreak havoc on our nations food supply, and therefore, understanding how fungi grow and respond to changing environmental conditions is of vital importance. The work in this proposal examines how a specific subset of proteins regulate the timing of specific growth phases. This proposal will examine how all the genes are affected by loss of specific proteins and in turn how this cause changes in developmental timing using new techniques to examine gene expression of the whole organism. It will also examine how these protein control the structural architecture of the nucleus, the subcellular compartment where gene expression occurs. Finally, this proposal examines a potential new mode of regulation not previously described, namely that the nuclear organization is of vital importance to regulation of genes.
|Effective start/end date||12/1/10 → 11/30/15|
- National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))