COLLAGEN FIBRILLOGENESIS: MOLECULAR AND CELLULAR STEPS

Project Details

Description

Collagen fibrillogenesis involves the stepwise formation of linear and lateral
aggregates from collagen molecules. Characterization of these aggregates in
vitro and in vivo is being pursued using laser light scattering and electron
microscopy. These studies focus on identifying the chemical and physical forces
that promote assembly.
Laser light scattering studies suggest that collagen assembly occurs by the
formation of linear trimers, lateral aggregates of linear trimers, and linear
and lateral aggregation of twisted units. The exact mechanism beyond the
formation of twisted units is currently being investigated.
Electron microscopy of SLS derived from collagen linear aggregates show the
presence of two major types of associations. The associations between collagen
molecules in vitro and in vivo are being studied.
StatusFinished
Effective start/end date9/1/8112/31/85

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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