• Petropulu, Athina (PI)
  • Reid, John (PI)
  • Shankar, P. (PI)
  • Cohen, Fernand (PI)
  • Onaral, Banu (PI)
  • Lewin, Peter A. (PI)
  • Donohue, Kevin (PI)
  • Wheatley, Margaret (PI)
  • Goldberg, Barry (PI)

Project Details


This program project seeks to enhance the ability of ultrasonic imaging to
detect and characterize tumors. This area was chosen because of the
widespread use of ultrasonic imaging in practically all specialties and
medical environments. The improvements that we seek, selected to make
ultrasonic imaging even more useful, would thus have a large impact on
medical practice. They would contribute to oncology through improved
detection, diagnosis and treatment monitoring. The program consists of three projects that take different approaches to
the problem of collecting and processing data to form images. These
projects are based on new approaches as well as on adaptations of
approaches that have been successful in industrial non-destructive testing
and in optics. Our program is also based on laboratory and clinical cores
for assuring interaction and co-ordination between the projects and
between imaging modalities (US, CT and MRI) and pathology. This structure
should remove many of the problems that have been encountered when
attempting to improve the ultrasonic tissue characterization through
individual research projects. Also, the clinical collaborators will
benefit from having available a variety of image formation methods to
evaluate for different purposes. The inter-comparison with other
modalities can thus be efficiently handled. One project will gather animal and human in-vivo data on the ultrasonic
properties of tissues and tumors. These data will be used to assess the
accuracy of the quantitative methods being developed for clinical use.
Another project will be assessing the often neglected effects of
anisotropy in tissue properties on present and future imaging methods, as
well seek to use such effects to characterize tissues. To assure that this program remains current as ultrasonic methodology
advances during the term of the grant we have included work in related
areas. Some type of contrast agent will most likely be widely used in the
near future. Therefore we have included a project that will be developing
a promising new contrast agent. This project will allow us to gain
experience with characterizing these materials and offer guidance on the
use of contrast in enhancing image features associated with tumors. Questions of patient safety must not be ignored. A transducer and
measurement system project has been included so that we will be able to
refine our ultrasonic dosimetry methods. This project also will develop
transducers for wideband data collection that is needed for accurate
modeling, essential for developing new methods, and high frequency
transducers for the new areas of skin and intraluminal
Effective start/end date9/30/9012/31/03


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)

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