Microorganisms are a source of enzymes and secondary metabolites with unlimited (and mostly unknown) potential in biotechnological applications. It is expected that microorganisms obtained in the course of the proposed study will provide the primary material to chemists to investigate potential biotechnological applications. For instance, the knowledge gained in the course of the proposed study on the physiology of hydrocarbonoclastic organisms and their enzymes will be critical to understand the biochemical mechanisms underlying alkane oxidation (Bertrand et al, in revision). Newly isolated organisms, as well as those currently maintained in the our laboratory culture collection will be screened, in collaborations with other laboratories at Rutgers University, for the production of bioactive compounds with antimicrobial and/or anti cancer activity. Several small molecular weight molecules that induce apoptotic responses in cancer cell lines have already been identified and purified from representative organisms, and their activity is currently being investigated (Andrianasolo et al., 2009, 2012).
|Effective start/end date||6/1/13 → 5/31/18|
- National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))