EARLY ONSET PERIODONTITIS GENE MAPPING

Project Details

Description

Previous studies suggested that genetic variation in the HLA region
of chromosome 6p may influence susceptibility to early onset
periodontitis (EOP). Results of segregation analyses support the
possibility that risk of EOP may be due to a single major gene. We
conducted linkage analyses to evaluate the hypothesis that a gene
within the HLA region significantly contributes to risk of EOP.
Fifty families, with two or more close relatives affected by EOP,
were ascertained in Virginia, USA and Chile. DNA was extracted from
blood and a highly polymorphic marker located within the HLA region
(near the Tumor Necrosis Factor Beta locus) was typed using the
polymerase chain reaction. Linkage analyses were performed using a
dominant model of disease transmission which is most strongly
supported by previous studies. For the dominant model, assuming that
EOP is a homogeneous disorder, our results statistically exclude the
hypothesis that a susceptibility gene lies within 10cM (approximately
10 million bases of approximately 0.5% of the human genome.
Additional analyses are planned for alternative modes of disease gene
transmission. Under the assumption that EOP may actually consist of
several etiologically distinct diseases having very similar clinical
presentations our data still provide no support for HLA region
involvement. However, our data do not statistically exclude (LOD
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Medicine(all)
  • Dentistry(all)
  • Genetics
  • Periodontics

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