EFFECTS OF TEA ON CARCINOGENESIS

Project Details

Description

Tea is one of the most popular beverages worldwide. Whereas
epidemiological studies have so far yielded inconclusive results,
laboratory studies by us and others clearly indicate that green and black
tea extracts inhibited carcinogenesis in animal models.
In this project, we plan to further investigate the inhibitory actions of
green an black teas and their components on nitrosamine-induced
carcinogenesis in animal models with the following specific aims: 1. To determine the effects of green and black tea extracts and selected
tea components on lung, forestomach, and esophageal carcinogenesis induced
by specific nitrosoamines in animal models. The dose-response of the
active components given at different stages of carcinogenesis will be
studied systematically. 2. To elucidate the mechanisms of the inhibition of carcinogenesis by tea
and tea components in the above models. Parameters related to their
antioxidative, nucleophilic, and other properties pertaining to the
carcinogenic processes will be examined. 3. To understand the biological effect of (-)-epigallocatechin gallate and
other tea components by studying their absorption, metabolism,
bioavailability, and tissue levels. 4. To fractionate green and black tea components, characterize their
properties, determine their activities in short-term assays and prepare
selected compounds in large quantities for the above studies. The project is expected to provide information fundamental to the
understanding of the relationship between tea consumption and
carcinogenesis. It will develop theoretical basis and laboratory methods
for future epidemiological and intervention studies on tea and human
cancer.
StatusFinished
Effective start/end date4/1/9212/31/06

Funding

  • National Institutes of Health: $338,957.00
  • National Institutes of Health: $131,623.00
  • National Institutes of Health: $250,200.00
  • National Institutes of Health: $273,513.00
  • National Institutes of Health: $131,623.00
  • National Institutes of Health
  • National Institutes of Health: $131,623.00
  • National Institutes of Health: $232,552.00
  • National Institutes of Health: $318,811.00
  • National Institutes of Health: $131,623.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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