The occurrence of type 2 diabetes continues to soar to epidemic proportions reaching almost 8% (23.6 million) of the population in the U.S. alone. Another 57 million Americans have prediabetes, defined by an impaired fasting glucose values as a result of insulin resistance. Insulin resistance is a key pathophysiologic feature of the 'metabolic syndrome' and is strongly associated with co-existing cardiovascular risk factors and accelerated atherosclerosis. Due to the clinical consequences associated with insulin resistance in subjects with metabolic syndrome and type 2 diabetes, clinical regimens directed at increasing insulin sensitivity in vivo remain one of the most desirable goals of treatment. Although it is well established that lifestyle modification can improve insulin resistance and effectively improve many of the risk factors associated with metabolic syndrome, the success of maintaining lifestyle changes in humans over a chronic period is poor. Therefore, strategies to improve insulin resistance by pharmacological means have represented the traditional approach for clinical medicine. However, because of the widespread use of dietary supplements by the general public, nutritional supplementation with the use of botanicals that effectively increase insulin sensitivity represent a very attractive and novel approach for future studies designed to intervene in the development of metabolic syndrome. The proposed study will benefit the value added agriculture of the State of NJ and provide tangible benefits to the biotechnology and pharmaceutical industries in the State. NJ farmers will benefit from the technologies because they will be provided with the opportunity to grow new crops with a greater value since the crops will contain bioactive compounds useful for the treatment and prevention of diabetes and metabolic syndrome. Pharmaceutical and nutraceutical companies will use the processed plants as the source of novel ingredients for drugs, foods and or dietary supplements. Therefore, the proposed research will enable agriculture to generate tremendous value through pharmaceutical and nutraceutical manufacturing of products that will promote a healthier population and greener planet. Products that may prevent the onset of metabolic syndrome and diabetes will also save the health care system and State of NJ tremendous amounts of money.
|Effective start/end date||9/1/09 → 8/31/14|
- National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))