EVALUATION OF WITHDRAWAL BEHAVIORAL CHANGES IN RATS EXPOSED TO ETHANOL VAPORS

Project Details

Description

Rats that inhaled ethanol vapors for 7 or 14 days underwent a withdrawal
syndrome following removal from the inhalation chambers. Approximately 60%
of rats exposed to the vapors for 3 days also exhibited various withdrawal
symptoms, but rats exposed to vapors for 24 hours showed no marked
withdrawal reaction. In a holeboard test performed approximately 11 hours after removal from the
chambers, when blood alcohol concentrations were below the limits of
detection, rats exposed to ethanol vapors for 24 hours or for 3, 7, or 14
days all had reduced exploratory and locomotor activities. Whether or not this hypoactivity is a manifestation of a withdrawal
reaction or refects some other effect of exposure to ethanol vapors is
currently under investigation.
StatusFinished
Effective start/end date9/1/786/30/93

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $203,249.00

ASJC

  • Medicine(all)

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