FAMILIAL CANCER AND RECESSIVE ONCOGENES

  • Grumet, Martin (PI)
  • Pellicer, Angel (PI)
  • Ziff, Edward (PI)
  • Moscatelli, David (PI)
  • Zeleniuch-Jacquotte, Anne (PI)
  • Hayes, Roberta (PI)
  • Miller, Douglas (PI)
  • Allen, Jeffrey (PI)
  • Allen, Jeffrey (PI)
  • GRUMET, MARTIN (PI)

Project Details

Description

This project is devoted to test the hypothesis that brain tumors in high
risk groups could be triggered by the presence of a germ line mutation in
tumor suppressor genes, specifically in p53.

The study will consist of screening several groups of pediatric and adult
brain tumor patients including those with first degree relatives suffering
from other malignancies, those with multiple primary neoplasms and infants
under two years of age.

Once the incidence of p53 germ line mutations in these high risk
populations is determined, further studies will analyze the molecular and
cellular evidence supporting or challenging the hypothesis that these
mutations play an important role in the development of brain tumors in
these selected populations.
StatusFinished
Effective start/end date1/1/018/31/95

ASJC

  • Genetics
  • Oncology
  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Cell Biology
  • Immunology