GENETIC ANALYSIS OF POLARITY

Project Details

Description

Two maternal effect mutations with drastic effects on polarity in early
embryos have been mapped very close to one another and both fall into a
small deficiency interval. One mutant, Bicaudal-b (Bic-b), is a dominant
and lays bicaudal eggs. Females homozygous for the other mutation, dorsal
(dl), produce embryos that lack all ventral structures. We propose a
number of genetic and molecular studies on the organization of these genes,
their time and mode of action, and their role and importance in the
establishment of polarity in the developing egg and during embryogenesis.
We plan to study the interaction of these genes with other genes involved
in polarity decisions. Transformation experiments will be done first to
study how the expression of these genes is controled and second to learn
more about their function. We also plan to isolate antibodies directed
against Bic-B and dl gene products and these will be used to study the
distribution and intracellular localization of the Bic-b and dl gene
products.
StatusFinished
Effective start/end date12/31/898/31/12

Funding

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $348,203.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $319,511.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $212,215.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $348,475.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $386,250.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $386,250.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $348,056.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $348,342.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: $326,623.00
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development

ASJC

  • Medicine(all)
  • Genetics
  • Molecular Biology
  • Cell Biology

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